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1. (WO2018205286) CONJUGATE AND BLOCK COPOLYMER CONTAINING FLUORESCENT CHROMOPHORE AND PREPARATION METHOD THEREFOR AND USE THEREOF

Pub. No.:    WO/2018/205286    International Application No.:    PCT/CN2017/084503
Publication Date: Fri Nov 16 00:59:59 CET 2018 International Filing Date: Wed May 17 01:59:59 CEST 2017
IPC: C07D 311/16
C07D 405/06
C07H 15/252
C09K 11/06
C07K 14/765
C07K 14/585
A61K 47/62
A61K 47/54
A61K 49/00
A61K 31/704
A61P 35/00
Applicants: UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
中国科学技术大学
Inventors: LIU, Shiyong
刘世勇
LIU, Guhuan
刘固寰
JIANG, Yanyan
姜琰琰
Title: CONJUGATE AND BLOCK COPOLYMER CONTAINING FLUORESCENT CHROMOPHORE AND PREPARATION METHOD THEREFOR AND USE THEREOF
Abstract:
Provided is a conjugate containing a fluorescent chromophore, which has any structure selected from C1 to C3. The conjugate containing the fluorescent chromophore provided by the present invention comprises one fluorescent chromophore and two highly reactive groups R1 and R2 linked to the fluorescent chromophore by a covalent bond. The fluorescent chromophore in the conjugate initially has no or only weak fluorescence emission capability, and only after the two highly reactive groups react together with the corresponding molecule, the fluorescent chromophore has strong fluorescence emission. Therefore, the efficiency of conjugation of drug molecules to targeting molecules can be monitored in situ by the infrared fluorescence emission intensity and applied to the target-mediated drug delivery.