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1. (WO2018088566) THERAPEUTIC OR PROPHYLATIC DRUG FOR ISCHEMIC DISEASE, GLAUCOMA, OPTIC NERVE DISEASE, RETINAL DEGENERATIVE DISEASE, ANGIOGENIC RETINAL DISEASE, CANCER, NEURODEGENERATION, OR AUTOIMMUNE DISEASE, AND HYPOXIA INDUCIBLE FACTOR INHIBITOR

Pub. No.:    WO/2018/088566    International Application No.:    PCT/JP2017/040884
Publication Date: Fri May 18 01:59:59 CEST 2018 International Filing Date: Wed Nov 15 00:59:59 CET 2017
IPC: A61K 36/185
A61K 31/517
A61K 35/60
A61K 36/05
A61K 36/07
A61K 36/15
A61K 36/22
A61K 36/258
A61K 36/31
A61K 36/33
A61K 36/42
A61K 36/48
A61K 36/736
A61K 36/758
A61K 36/76
A61K 36/81
A61K 36/82
A61K 36/87
A61K 36/88
A61K 36/888
A61K 36/894
A61K 36/896
A61K 36/9066
A61P 25/28
A61P 27/02
A61P 35/00
A61P 37/00
A61P 43/00
Applicants: KEIO UNIVERSITY
学校法人慶應義塾
Inventors: KURIHARA Toshihide
栗原 俊英
MIWA Yukihiro
三輪 幸裕
TSUBOTA Kazuo
坪田 一男
INOUE Hiroyoshi
井上 浩義
Title: THERAPEUTIC OR PROPHYLATIC DRUG FOR ISCHEMIC DISEASE, GLAUCOMA, OPTIC NERVE DISEASE, RETINAL DEGENERATIVE DISEASE, ANGIOGENIC RETINAL DISEASE, CANCER, NEURODEGENERATION, OR AUTOIMMUNE DISEASE, AND HYPOXIA INDUCIBLE FACTOR INHIBITOR
Abstract:
Provided are a novel HIF inhibitor, and a therapeutic or prophylactic drug for ischemic disease, glaucoma, optic nerve disease, retinal degenerative disease, angiogenic retinal disease, cancer, neurodegeneration, or autoimmune disease, with both inhibitor and drug having low cytotoxicity and being suitable for ophthalmic treatment. The present invention is a therapeutic or prophylactic drug for ischemic disease, glaucoma, optic nerve disease, retinal degenerative disease, angiogenic retinal disease, cancer, neurodegeneration, or autoimmune disease, said drug containing, as an active ingredient, at least one selected from the group consisting of plants belonging to the genus Hydrangea, plants belonging to the genus Narcissus, plants belonging to the genus Vitis, plants belonging to the genus Brassica, and fish belonging to the genus Spratelloides, or an extract thereof.