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1. (WO2018087644) IMMUNOGENIC GIANT EXTRACELLULAR VESICLES (VEGS) OF PARASITIC PROTOZOA AND METHODS FOR THEIR INDUCTION AND PURIFICATION
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TranslationTraducir: Original-->español
Nº de publicación:    WO/2018/087644    Nº de la solicitud internacional:    PCT/IB2017/056917
Fecha de publicación: 17.05.2018 Fecha de presentación de la solicitud internacional: 06.11.2017
CIP:
C12N 1/00 (2006.01), A61K 35/68 (2006.01), A61K 39/002 (2006.01)
Solicitantes: CENTRO DE INVESTIGACIÓN Y DE ESTUDIOS AVANZADOS DEL INSTITUTO POLITÉCNICO NACIONAL [MX/MX]; Av. Instituto Politécnico Nacional no. 2508, Col. San Pedro Zacatenco Ciudad de Mexico, 07360 (MX)
Personas inventoras: SIERRA LÓPEZ, Francisco; (MX).
CARREÑO SÁNCHEZ, Luis Antonio; (MX).
ROSALES ENCINA, José Luis; (MX)
Mandataria/o: CARREÑO SÁNCHEZ, Luis Antonio; (MX)
Datos de prioridad:
MX/a/2016/014875 11.11.2016 MX
Título (EN) IMMUNOGENIC GIANT EXTRACELLULAR VESICLES (VEGS) OF PARASITIC PROTOZOA AND METHODS FOR THEIR INDUCTION AND PURIFICATION
(ES) IMMUNOGENIC GIANT EXTRACELLULAR VESICLES (VEGS) OF PARASITIC PROTOZOA AND METHODS FOR THEIR INDUCTION AND PURIFICATION
(FR) VÉSICULES EXTRACELLULAIRES GÉANTES IMMUNOGÈNES (VEG) DE PROTOZOAIRES PARASITES ET PROCÉDÉS POUR LES INDUIRE ET LES PURIFIER
Resumen: front page image
(EN)The present invention relates to giant secreted (extracellular) vesicles (referred to as VEGs) that are associated with parasitic protozoan species, which have dimensions of 500-400 nm in diameter, and to methods to allow their induction, secretion and purification. These vesicles possess proteolytic activity and are composed of a large amount of proteins; in particular, they were obtained from Entamoeba histolytica trophozoites (referred to as EhVEG) and from other parasitic protozoa, such as Giardia lamblia and Trypanosoma cruzi. The invention also relates to the use of such vesicles, for example EhVEGs, to immunize mammals susceptible to infection by Entamoeba histolytica. The present invention also describes effective vaccine immunogenic pharmaceutical compositions comprising the induced and isolated VEGs, for example EhVEGs, which are useful for the treatment and prevention of amebic hepatic abscess. The present invention represents the first report that demonstrates and/or verifies that E. histolytica secretes extracellular vesicles of large dimensions into the culture medium.
(ES)Abstract. The present invention relates to giant secreted (extracellular) vesicles (referred to as VEGs) that are associated with parasitic protozoan species, which have dimensions of 500-400 nm in diameter, and to methods to allow their induction, secretion and purification. These vesicles possess proteolytic activity and are composed of a large amount of proteins; in particular, they were obtained from Entamoeba histolytica trophozoites (referred to as Eh VEG) and from other parasitic protozoa, such as Giardia lamblia and Trypanosoma cruzi. The invention also relates to the use of such vesicles, for example Eh VEGs, to immunize mammals susceptible to infection by Entamoeba histolytica. The present invention also describes effective vaccine immunogenic pharmaceutical compositions comprising the induced and isolated VEGs, for example Eh VEGs, which are useful for the treatment and prevention of amebic hepatic abscess. The present invention represents the first report that demonstrates and/or verifies that E. histolytica secretes extracellular vesicles of large dimensions into the culture medium.
(FR)La présente invention concerne des vésicules (extracellulaires) sécrétées géantes (appelées VEG) qui sont associées à des espèces de protozoaires parasites, qui ont des dimensions de 500 à 400 nm de diamètre, et des procédés pour permettre leur induction, leur sécrétion et leur purification. Ces vésicules possèdent une activité protéolytique et sont composées d'une grande quantité de protéines; en particulier, elles ont été obtenues à partir de trophozoïtes d'Entamoeba histolytica (appelés EhVEG) et d'autres protozoaires parasites, tels que Giardia lamblia et Trypanosoma cruzi. L'invention concerne également l'utilisation de telles vésicules, par exemple des EhVEG, pour immuniser des mammifères susceptibles d'être infectés par Entamoeba histolytica. La présente invention concerne en outre des compositions pharmaceutiques immunogènes vaccinales efficaces comprenant les VEG induites et isolées, par exemple des EhVEG, qui sont utiles pour le traitement et la prévention de l'abcès hépatique amibienne. La présente invention représente le premier rapport qui démontre et/ou vérifie que E histolytica sécrète des vésicules extracellulaires de grandes dimensions dans le milieu de culture.
Estados designados: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
Organización Regional Africana de la Propiedad Intelectual (ORAPI) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Organización Eurasiática de Patentes (OEAP) (AM, AZ, BY, KG, KZ, RU, TJ, TM)
Oficina Europea de Patentes (OEP) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
Organización Africana de la Propiedad Intelectual (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Idioma de publicación: inglés (EN)
Idioma de la solicitud: inglés (EN)