Colecciones nacionales e internacionales de patentes

1. (WO2016139181) BICYCLIC TETRAHYDROTHIAZEPINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEOPLASTIC AND/OR INFECTIOUS DISEASES

Pub. No.:    WO/2016/139181    International Application No.:    PCT/EP2016/054228
Publication Date: Sat Sep 10 01:59:59 CEST 2016 International Filing Date: Tue Mar 01 00:59:59 CET 2016
IPC: C07D 417/12
C07D 417/14
C07D 281/10
A61K 31/55
Applicants: APEIRON BIOLOGICS AG
EVOTEC AG
Inventors: ERMANN, Monika
LAMETSCHWANDTNER, Guenther
AMOUZEGH, Patricia Léonie
CRAFT, Russell Stuart
HANKE, Thomas
JAMES, Timothy Robin
JONES, Severine Danielle
LOIBNER, Hans
LOKE, Pui Leng
STERNBERGER, Ina
STUETZ, Anton
WEHR, Roland
WHITTAKER, Mark
Title: BICYCLIC TETRAHYDROTHIAZEPINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEOPLASTIC AND/OR INFECTIOUS DISEASES
Abstract:
The present invention relates to bicyclic tetrahydrothiazepine of formula (I), wherein R1 to R3, X1, X2 and R18 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising such compounds as well as their use as medicaments, especially in methods for the treatment or prevention of a neoplastic and/or infectious disease and in vitro methods.