Colecciones nacionales e internacionales de patentes

1. (WO2013142901) SILK POLYPEPTIDES

Pub. No.:    WO/2013/142901    International Application No.:    PCT/AU2013/000308
Publication Date: Fri Oct 04 01:59:59 CEST 2013 International Filing Date: Wed Mar 27 00:59:59 CET 2013
IPC: C12N 15/12
C07K 14/435
A61K 38/17
Applicants: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
Inventors: WALKER, Andrew Allan
WEISMAN, Sarah
SUTHERLAND, Tara
Title: SILK POLYPEPTIDES
Abstract:
The present disclosure provides polypeptides which encode a silk polypeptide, wherein at least a portion of the polypeptide has a coiled coil structure comprising at least 10 copies of the heptad sequence abcdefg, and wherein at least 25% of the amino acids at position a are alanine residues and at least 20% of the amino acids at position d are aromatic residues. The present disclosure also provides nucleic acids encoding such polypeptides, and recombinant cells and/or organisms which synthesize the polypeptides. The polypeptides can be used for a variety of purposes such as in the production of personal care products, plastics, textiles, and biomedical products.