Colecciones nacionales e internacionales de patentes

1. (WO2002008202) ALPHA AMINO ACID DERIVATIVES--INHIBITORS OF LEUKOCYTE ADHESION MEDIATED BY VLA-4

Pub. No.:    WO/2002/008202    International Application No.:    PCT/US2001/023075
Publication Date: Fri Feb 01 00:59:59 CET 2002 International Filing Date: Sat Jul 21 01:59:59 CEST 2001
IPC: C07D 239/48
C07D 239/52
C07D 401/12
C07D 417/12
Applicants: ELAN PHARMACEUTICALS, INC.
WYETH
Inventors: KONRADI, Andrei, W.
PLEISS, Michael, A.
THORSETT, Eugene, D.
ASHWELL, Susan
WELMAKER, Gregory, S.
KREFT, Anthony
SARANTAKIS, Dimitrios
DRESSEN, Darren, B.
GRANT, Francine, S.
SEMKO, Christopher
XU, Ying-Zi
Title: ALPHA AMINO ACID DERIVATIVES--INHIBITORS OF LEUKOCYTE ADHESION MEDIATED BY VLA-4
Abstract:
Disclosed are certain alpha amino acid compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.