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1. (WO1987003477) TRANSDERMAL METHODS AND ADHESIVES
Nota: Texto obtenido mediante procedimiento automático de reconocimiento óptico de caracteres.
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WHAT IS CLAIMED IS:
1. A fluid parmeabls adhesive, comprising a presaurs asnsitivs polymer and
a cross-linked polysiloxana blended with said polymer.
2. The adhesive of claim 1 wherein said polymer is selected from the class consisting of acrylics, urethanes, elastomers and blends thereof.
3. The adhesive of claim 1 wherein said cross-linked polysiloxane ia formed by the cross-linking of a plurality of subordinate siloxanes.
4. The adhesive of claim 3 wherein aaid subordinate siloxanea are aryl and/or alkyl.
5. The adhesive of claim 3 wherein said polysiloxane ia formed by cross-linking with a resin.
6. The adhesive of claim 5 wherein said resin is MQ organopolysiloxane or a fluororesin.
7. The adhesive of claim 1 wherein said polysiloxane is cross-linked by a catalyst further including a peroxide.

8. The adhesive of claim 7 wherein said peroxide is 2,4 dichlorobensoyl peroxide.
9. The adhasive of claim 1 wherein said cross-linked polysiloxane ranges from more than zero to less than 100 percent of the total adhesive composition.
10. The adhesive of claim 9 wherein said cross-linked polysiloxane ranges up to 10 percent.

11. The method of preparing a fluid permeable adhesive which comprises the steps of
(a) providing a cross-linked polysiloxane; and
(b) blending said cross-linked polysiloxane with a nonsilicone adhesive polymer.
12. The method of claim 11 wherein said adhesive polymer is an acrylic, a urethane, an elastomer, or a blend of the foregoing.
13. The method of administering fluids through the skin which comprises the steps of
(a) applying a blend of a cross-linked polysiloxane adhesive and a non-ailicone pressure sensitive polymer in contact with an epidermal layer; and
(b) applying fluid to said blend to permit passage therethrough at a prescribed rate.
14. A fluid permeable adhesive as defined in claim 1 further comprising a medical device at least partially coated by said adhesive.
15. A fluid permeable adhesive as defined in claim 14 further including an epidermal layer adhered to said medical device by said adhesive.
16. A method as defined in claim 10 wherein the ratio of said cross-linked polysiloxane to said adhesive polymer determines the vapor transmission therethrough.
17. The method as defined in claim 16 wherein the vapor transmission through said adhesive increases as said polysiloxane is added until it reaches a first maximum and thereafter decreases for further polysiloxane additions.

18. The method as defined in claim 16 wherein the vapor transmission through said adhesive increases and decreases in sawtooth fashion as the ratio of polysiloxane to said polymer increases.
19. The method of claim 16 wherein said cross-linked polysiloxane is up to 10 percent of said adhesive polymer.
20. The method of claim 16 wherein said cross-linked polysiloxane is up to 30 percent of the adhesive polymer.