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1. (WO2016010178) NOVEL CRYSTALLINE FORM OF 5-CHLORO-N-({(5S)-2-OXO-3-[4-(5,6-DIHYDRO-4H-[1,2,4]TRIAZIN-1-YL)PHENYL]-1,3-OXAZOLIDIN-5-YL}METHYL)THIOPHENE-2-CARBOXAMIDE METHANESULFONATE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
Datos bibliográficos más recientes de la Oficina Internacional   

TranslationTraducir: Original-->español
Nº de publicación:    WO/2016/010178    Nº de la solicitud internacional:    PCT/KR2014/006555
Fecha de publicación: 21.01.2016 Fecha de presentación de la solicitud internacional: 18.07.2014
CIP:
C07D 413/14 (2006.01), C07D 413/10 (2006.01), A61K 31/53 (2006.01), A61P 9/10 (2006.01), A61P 29/00 (2006.01)
Solicitantes: GREEN CROSS CORPORATION [KR/KR]; 107, Ihyeon-ro 30beon-gil, Giheung-gu, Yongin-si, Gyeonggi-do 446-770 (KR).
LEGOCHEM BIOSCIENCES, INC. [KR/KR]; 8-26, Munpyeongseo-ro, Daedeok-gu, Daejeon 306-220 (KR)
Personas inventoras: CHOI, Soongyu; (KR).
CHOI, Jungsub; (KR).
YOON, So-Hyun; (KR).
KIM, Yoo Hoon; (KR).
KIM, Jae Yeon; (KR).
LEE, Suk Ho; (KR).
CHO, Young Lag; (KR).
SONG, Ho Young; (KR).
LEE, Dae Yon; (KR).
BAEK, Sung Yoon; (KR).
CHAE, Sang Eun; (KR).
PARK, Tae Kyo; (KR).
WOO, Sung Ho; (KR).
KIM, Yong Zu; (KR)
Mandataria/o: FIRSTLAW P.C.; 60 Mabang-Ro Seocho-Ku Seoul 137-739 (KR)
Datos de prioridad:
Título (EN) NOVEL CRYSTALLINE FORM OF 5-CHLORO-N-({(5S)-2-OXO-3-[4-(5,6-DIHYDRO-4H-[1,2,4]TRIAZIN-1-YL)PHENYL]-1,3-OXAZOLIDIN-5-YL}METHYL)THIOPHENE-2-CARBOXAMIDE METHANESULFONATE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
(FR) NOUVELLE FORME CRISTALLINE DE MÉTHANESULFONATE DE 5-CHLORO-N-({(5S)-2-OXO-3-[4-(5,6-DIHYDRO-4H-[1,2,4]TRIAZIN-1-YL)PHÉNYL]-1,3-OXAZOLIDIN-5-YL}MÉTHYL)THIOPHÈNE-2-CARBOXAMIDE ET COMPOSITION PHARMACEUTIQUE LE CONTENANT
(KO) 5-클로로-N-({(5S)-2-옥소-3-[4-(5,6-디하이드로-4H-[1,2,4]트리아진-1-일)페닐]-1,3-옥사졸리딘-5-일}메틸)티오펜-2-카르복사미드 메탄설폰산염의 신규 결정형 및 이를 포함하는 약학 조성물
Resumen: front page image
(EN)The present invention relates to a novel crystalline form of 5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide methanesulfonate and a pharmaceutical composition containing the same. The novel crystalline form of a compound according to the present invention exhibits excellent stability even in high-temperature and humidity environments, and thus can be favorably used to prevent or treat diseases, such as thrombosis, myocardial infarction, atherosclerosis, inflammation, stroke, angina pectoris, restenosis after angioplasty, and thromboembolism.
(FR)La présente invention concerne une nouvelle forme cristalline de méthanesulfonate de 5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]triazin-1-yl)phényl]-1,3-oxazolidin-5-yl}méthyl)thiophène-2-carboxamide et une composition pharmaceutique le contenant. La nouvelle forme cristalline d'un composé selon la présente invention présente une excellente stabilité, même dans des environnements à haute température et haute humidité et peut donc être utilisée favorablement pour prévenir ou traiter des maladies, telles qu'une thrombose, un infarctus du myocarde, l'athérosclérose, une inflammation, un AVC, une angine de poitrine, une resténose après angioplastie et la thromboembolie.
(KO)본 발명은 5-클로로 -N -({ (5 S)-2-옥소-3- [4-(5, 6-디하이드로 -4H- [ 1, 2, 4]트리아진-1-일)페닐] -1, 3-옥사졸리딘 -5-일 }메틸)티오펜-2-카르복사미드 메탄설폰산염의 신규 결정형 및 이를 포함하는 약학 조성물에 관한 것으로서, 본 발명에 따른 신규 결정형 화합물은 고온 및 가습 환경에서도 우수한 안정성을 나타내므로, 혈전증, 심근 경색, 동맥경화, 염증, 뇌졸중, 협심증, 혈관 성형술 후의 재발협착증 및 혈전색전증 등의 질환의 예방 또는 치료에 유용하게 사용될 수 있다.
Estados designados: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
Organización Regional Africana de la Propiedad Intelectual (ORAPI) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Organización Eurasiática de Patentes (OEAP) (AM, AZ, BY, KG, KZ, RU, TJ, TM)
Oficina Europea de Patentes (OEP) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
Organización Africana de la Propiedad Intelectual (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Idioma de publicación: coreano (KO)
Idioma de la solicitud: coreano (KO)