Colecciones nacionales e internacionales de patentes

1. (WO2004004696) CONTROLLED RELEASE COMPOSITION

Pub. No.:    WO/2004/004696    International Application No.:    PCT/GB2003/002911
Publication Date: Fri Jan 16 00:59:59 CET 2004 International Filing Date: Sat Jul 05 01:59:59 CEST 2003
IPC: A61K 9/50
Applicants: TEMREL INC.
SPEIRS, Christopher, J.
MOIR, Peter
WILLIAMS, Richard
CLARK, Michael
Inventors: SPEIRS, Christopher, J.
MOIR, Peter
WILLIAMS, Richard
CLARK, Michael
Title: CONTROLLED RELEASE COMPOSITION
Abstract:
An improved composition for controlling the release profile of an active compound through the intestinal tract comprises particles, especially pellets, containing the active compound, which are coated with a pH dissolution dependent coating material or a polymethacrylate material, which is preferably pH dissolution dependent, to a certain thickness depending upon the location and rate of release of the active compound that is desired. In preferred compositions, two or more pluralities of particles, in which particles of each plurality are coated with pH dissolution dependent coating material or polymethacrylate material to a different thickness to those of each other plurality, are contained within an enterically coated capsule and provide release of the active compound at various desired locations in the intestinal tract.