Colecciones nacionales e internacionales de patentes

1. (WO1997037982) NOVEL SUBSTITUTED [2-(1-PIPERAZINYL)ETHOXY]METHYL

Pub. No.:    WO/1997/037982    International Application No.:    PCT/BE1997/000038
Publication Date: Fri Oct 17 01:59:59 CEST 1997 International Filing Date: Sat Mar 29 00:59:59 CET 1997
IPC: C07D 295/088
C07D 295/205
Applicants: UCB S.A.
DUCHENE, Guy
DELEERS, Michel
BODSON, Guy
MOTTE, Geneviève
LURQUIN, Françoise
Inventors: DUCHENE, Guy
DELEERS, Michel
BODSON, Guy
MOTTE, Geneviève
LURQUIN, Françoise
Title: NOVEL SUBSTITUTED [2-(1-PIPERAZINYL)ETHOXY]METHYL
Abstract:
Novel substituted [2-(1-piperazinyl)ethoxy]methyl compounds of formula (I), wherein R1 is a -CONH2, -CN, -COOH, -COOM or -COOR3 group, where M is an alkali metal, R3 is a C1-4 alkyl radical; and R2 is a hydrogen atom or a -COR4 or -R5 group where R4 is selected from -OR6 or -R7 groups, wherein R5 is an allyl or alkylaryl radical, R6 is a straight or branched C1-4 alkyl radical, a haloalkyl radical, alkylaryl, alkylnitroaryl or alkylhaloaryl, and R7 is haloalkyl; a method for preparing said compounds, as well as the use thereof for preparing compounds that are themselves valuable intermediates for the preparation of 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid or 2-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]acetic acid and/or pharmaceutically acceptable salts thereof, are disclosed.