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1. (WO2001032604) ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE

Pub. No.:    WO/2001/032604    International Application No.:    PCT/GB2000/004249
Publication Date: Fri May 11 01:59:59 CEST 2001 International Filing Date: Tue Nov 07 00:59:59 CET 2000
IPC: C07C 233/36
C07C 233/37
C07C 233/40
C07C 233/62
C07C 233/78
C07C 235/34
C07C 235/50
C07C 235/60
C07C 235/78
C07C 235/82
C07C 235/84
C07C 237/40
C07C 275/16
C07C 275/24
C07C 275/26
C07C 275/30
C07C 275/36
C07C 275/38
C07C 275/42
C07C 323/62
C07C 323/67
C07D 207/16
C07D 207/34
C07D 209/18
C07D 209/22
C07D 209/42
C07D 213/643
C07D 213/82
C07D 215/42
C07D 215/52
C07D 231/14
C07D 231/16
C07D 231/40
C07D 237/30
C07D 239/38
C07D 239/95
C07D 241/24
C07D 277/28
C07D 277/30
C07D 277/56
C07D 295/13
C07D 307/68
C07D 311/24
C07D 333/36
C07D 333/38
C07D 333/56
C07D 401/12
C07D 405/04
C07D 409/04
C07D 417/04
C07D 471/04
C07D 495/04
Applicants: UNIVERSITY COLLEGE LONDON
SELWOOD, David
GLEN, Robert
REYNOLDS, Karen
WISHART, Grant
Inventors: SELWOOD, David
GLEN, Robert
REYNOLDS, Karen
WISHART, Grant
Title: ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE
Abstract:
Use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in the activation of soluble guanylate cyclase, wherein: R1 and R2 are the same or different and each represent a C1-C6 alkyl group, or R1 and R2 together form a C3-C6 alkylene group; Z is a C1-C4 alkylene group; P is a direct bond or a moiety -X-, -Y-, -W-, -XY-, -YW- or -XYW-, wherein; W is -O-, -S-, or -NR3, wherein R3 is hydrogen or C1-C6 alkyl; Y is a moiety -U-V- wherein V is a direct bond or a C1-C6 alkylene group and U is -CS-, -CO-, -S(O)2- or -C(=NR)- wherein R is hydrogen, hydroxy or C1-C6 alkyl; X is -O- or -NR6- wherein R6 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, aryl or heteroaryl; and R4 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, a group -R-A wherein R is -(C1-C6 alkyl)-, -(C2-C6 alkenyl)- or -(C2-C6 alkynyl)- and A is aryl, heteroaryl, carbocyclyl or heterocyclyl, or R4 is a group -COR', -CO2R', -S(O)2R' or -CONR'R' wherein R' is hydrogen, C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl and R' is aryl, heteroaryl, carbocyclyl or heterocyclyl.