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IC_EX:G16B* AND EN_ALLTXT:(coronavirus OR coronaviruses OR coronaviridae OR coronavirinae OR orthocoronavirus OR orthocoronaviruses OR orthocoronaviridae OR orthocoronavirinae OR betacoronavirus OR betacoronaviruses OR betacoronaviridae OR betacoronavirinae OR sarbecovirus OR sarbecoviruses OR sarbecoviridae OR sarbecovirinae OR "severe acute respiratory syndrome" OR sars OR "2019 ncov" OR covid)

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Analysis

1.3093147AN AUTOMATED, CLOUD-BASED, POINT-OF-CARE (POC) PATHOGEN AND ANTIBODY ARRAY DETECTION SYSTEM AND METHOD
CA 17.11.2020
Int.Class G01N 35/00
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
35Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/-G01N33/148; Handling materials therefor
Appl.No 3093147 Applicant AUTONOMOUS MEDICAL DEVICES, INC. Inventor

An automated method of assaying a viral and antibody analyte in a sample in a
portable, handheld microfluidic reader having a SAW detector with a minimal
mass
sensitivity limitation includes the steps of automatically performing the
assay with the
SAW detector with enhanced sensitivity, but also includes the steps of
automatically
disposing a second portion of the sample on a microarray, selectively
automatically
probing the second portion of the sample for antibodies corresponding to the
at least one
selected virus using the microarray, and automatically reading the microarray
using a
fluorescent camera to identify antibodies in the second portion of the sample.

2.WO/2020/198865OLIGOPEPTIDES FOR QUANTITATIVE VIRAL PROTEOMIC ANALYSIS METHODS AND USES
WO 08.10.2020
Int.Class C07K 14/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
18Togaviridae, e.g. flavivirus, pestivirus, yellow fever virus, hepatitis C virus, japanese encephalitis virus
Appl.No PCT/CA2020/050431 Applicant THE UNIVERSITY OF BRITISH COLUMBIA Inventor JEAN, François
Provided are purified oligopeptides, labelled oligopeptides, and stable isotope labelled oligopeptides, methods for their use in determining the maturation status of the flaviruses or coronaviruses in a human biological sample. The purified oligopeptides, labelled oligopeptides, and stable isotope labelled oligopeptides may also be used to measure the level of the flavirus protein or coronavirus protein in a human biological sample. Methods are also provided for treating a subject based on the maturation status of the flaviruses or the coronaviruses in the subject's biological sample and/or based on the level of the flavirus or coronavirus protein in the subject's biological sample.
3.20180265935Virome capture sequencing platform, methods of designing and constructing and methods of using
US 20.09.2018
Int.Class C12Q 1/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
Appl.No 15759937 Applicant The Trustees of Columbia University in the City of New York Inventor Walter Ian Lipkin

The present invention provides novel methods, systems, tools, and kits for the simultaneous detection, identification and/or characterization of all viruses known or suspected to infect vertebrates. The methods, systems, tools, and kits described herein are based upon the virome capture sequencing platform (“VirCapSeq-VERT”), a novel platform developed by the inventors. The invention also provides methods and kits for designing and constructing of the virome capture sequencing platform.

4.111334868Construction method of novel coronavirus whole-genome high-throughput sequencing library, and kit for library construction
CN 26.06.2020
Int.Class C40B 50/08
CCHEMISTRY; METALLURGY
40COMBINATORIAL TECHNOLOGY
BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
50Methods of creating libraries, e.g. combinatorial synthesis
08Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
Appl.No 202010225821.0 Applicant FUZHOU FURUI MEDICAL INSPECTION LABORATORY CO., LTD. Inventor WANG YANG
The invention provides a construction method of a novel coronavirus whole-genome high-throughput sequencing library, and a kit for library construction. The method comprises the following steps: 1) carrying out reverse transcription on virus RNA; (2) carrying out a first round of PCR reaction by utilizing multiple amplification primers of an anchoring part Illumina linker sequence; and 3) carryingout a second round of PCR reaction by using a labeled Illumina library amplification primer, and purifying the amplification product to obtain the high-throughput sequencing library. The anchoring multiplex amplification primer combination provided by the invention is utilized, so the efficient targeted enrichment can be performed on the genome of the novel coronavirus COVID-19, the influence that an existing method is low in targeting, low in experimental timeliness and prone to being brought into host background pollution is overcome, COVID-19 virus whole genome sequencing can be completedwithin a short time with the small sequencing data volume and cost, so differential diagnosis and virus mutation identification of the COVID-19 virus are achieved.
5.WO/2020/256868IMMUNE SYSTEM MODULATORS FOR THE TREATMENT OF SQUAMOUS LUNG PREMALIGNANCY
WO 24.12.2020
Int.Class C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
Appl.No PCT/US2020/033191 Applicant TRUSTEES OF BOSTON UNIVERSITY Inventor BEANE-EBEL, Jennifer E.
The methods and assays described herein relate to detection, diagnosis, and treatment of aberrant immune system activity (e.g., in bronchial premaglinant lesions), e.g., by detecting the level of expression of certain immune regulators described herein and/or by therapeutically modulating the level of those immune regulators.
6.20200020420Method for Establishing Machine Learning Model for Predicting Toxicity of siRNA to Certain Type of Cells and Application Thereof
US 16.01.2020
Int.Class G16B 40/20
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
40ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
20Supervised data analysis
Appl.No 16465303 Applicant Hangzhou Converd Co., Ltd. Inventor Jinlu Cai

Provided is a method of establishing a machine learning model for predicting toxicity of siRNA to certain type of cells and application thereof. The method includes A) providing n siRNAs of 19-29 bp, wherein n≥2; B) obtaining input and output values for establishing the model from each siRNA, the input values being obtained by i) aligning each siRNA with genomic mRNAs and selecting complementary off-target genes having no more than 7 mismatched bases; ii) obtaining off-target weights according to mismatched bases' characteristic and mRNA's secondary structure in complementary region; iii) obtaining omic weights of the off-target genes using databases; iv) calculating omic eigenvalues as the input values, based on omic and off-target weights of all the off-target genes; the output values being obtained by conducting experiments with the siRNAs to obtain cell survival indexes; and C) calculating the input and output values of the n siRNAs through machine learning algorithm.

7.111081316Method and device for screening candidate drugs for COVID-19
CN 28.04.2020
Int.Class G16B 20/30
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
20ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
30Detection of binding sites or motifs
Appl.No 202010216192.5 Applicant GENEIS TECHNOLOGY (BEIJING) CO., LTD. Inventor PENG LIHONG
The invention discloses a method and device for screening COVID-19 drugs. On the basis of obtaining sequence similarity information between viruses and structure similarity information between pharmaceutical chemical structures, a heterogeneous network based on virus sequence similarity and drug similarity is constructed, and training is performed on the constructed data set by using a random walkalgorithm so as to obtain a COVID-19 drug screening model. Based on the drug screening model, drugs related to new coronal pneumonia can be effectively screened. According to the method, the researchand development cost of the COVID-19 drugs can be reduced, and the screening speed and accuracy of the COVID-19 drugs exceed those of representative methods applied to other bioinformatics fields.
8.2974199SYSTEMS AND METHODS FOR RESPONSE PREDICTION TO CHEMOTHERAPY IN HIGH GRADE BLADDER CANCER
CA 28.07.2016
Int.Class G16B 40/00
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
40ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
Appl.No 2974199 Applicant NANTOMICS, LLC Inventor
Contemplated systems and methods allow for prediction of chemotherapy outcome for patients diagnosed with high-grade bladder cancer. In particularly preferred aspects, the prediction is performed using a model based on machine learning wherein the model has a minimum predetermined accuracy gain and wherein a thusly identified model provides the identity and weight factors for omics data used in the outcome prediction.

9.WO/2020/242985METHODS AND KITS FOR DETECTING PATHOGENS
WO 03.12.2020
Int.Class G16B 30/00
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
30ICT specially adapted for sequence analysis involving nucleotides or amino acids
Appl.No PCT/US2020/034329 Applicant CLEAR LABS, INC. Inventor AMINI, Sasan
Food processing facilities should employ environmental sampling programs to monitor for general levels of hygiene (the efficacy of general cleaning and sanitation for the removal of transient microorganisms).
10.20160320406Detection of an antibody against a pathogen
US 03.11.2016
Int.Class C40B 30/04
CCHEMISTRY; METALLURGY
40COMBINATORIAL TECHNOLOGY
BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
30Methods of screening libraries
04by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
Appl.No 15105722 Applicant THE BRIGHAM AND WOMEN'S HOSPITAL, INC. Inventor Stephen J. Elledge

Provided herein are methods of detecting an antibody directed against a pathogen and uses thereof. One aspect provided herein relates to a method for detecting an antibody against a pathogen in a subject, the method comprising: (a) contacting a reaction sample comprising a display library with a biological sample comprising antibodies, wherein the display library comprises a plurality of peptides derived from a plurality of pathogens, and (b) detecting a peptide bound to at least one antibody, thereby detecting an antibody capable of binding the peptide.