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Analysis

1 / 66,020
1.20250354136METHOD AND REAGENT FOR NUCLEIC ACID EXTRACTION AND PURIFICATION USING POROUS NANOMATERIAL
US - 20.11.2025
Int.Class C12N 15/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
 Appl.No 18867072 Applicant Hangzhou New Horizon Health Technology Co. Ltd. Inventor Jun LIU

A method for extracting nucleic acids from a biological sample (such as plasma) using nanopores in a porous material. The method induces nucleic acids into nanopores of the porous material to achieve separation and purification of nucleic acids. The method also has the advantage that the bound nucleic acids will not separate from the pores under separation and cleaning conditions, and thus has good application prospects. The material containing nanopores can have added paramagnetic cores (for example, magnetic microspheres of ferroferric oxide) and be applied to a full-automatic nucleic acid extraction workstation to improve nucleic acid extraction efficiency.

2.20250354158CIS CONJUGATIVE PLASMID SYSTEM
US - 20.11.2025
Int.Class C12N 15/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
70Vectors or expression systems specially adapted for E. coli
 Appl.No 19182554 Applicant THE UNIVERSITY OF WESTERN ONTARIO Inventor David R. EDGELL

A method for modulating a target organism in a microbiome, comprising contacting the microbiome with a cis-conjugative plasmid that can replicate and conjugate with organisms in the microbiome including the target organism, the conjugative plasmid comprising conjugation genes and a gene or a combination of genes capable of being expressed in the target organism and that only modulates the target organism in the microbiome. Also the isolated cis-conjugative plasmid comprising conjugation genes and a gene or a combination of genes capable of being expressed in a target bacteria within a microbiome or biofilm and that modulates the target bacteria in the microbiome or biofilm.

3.20250354200MULTIPLEXED AND SENSITIVE POINT-OF-CARE DIAGNOSTICS VIA INTEGRATED LATERAL FLOW AND IN-VITRO TRANSCRIPTION AND TRANSLATION
US - 20.11.2025
Int.Class C12Q 1/682
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6813Hybridisation assays
6816characterised by the detection means
682Signal amplification
 Appl.No 19210164 Applicant Georgia Tech Research Corporation Inventor Alexandra Patterson

Disclosed herein. is a method of detecting the presence of a target, the method comprising: providing an in vitro transcription and/or translation area comprising a plurality of regions, each region comprising at least one distinct immobilized capture strand, each of the distinct immobilized capture strands configured to bind to a predetermined tail strand; introducing one or more mobile tail strands to the in vitro transcription and/or translation area, the one or more tail strands generated due to the presence of a corresponding target; introducing an in vitro transcription and/or translation reagent to the in vitro transcription and/or translation area; and producing one or more reporters indicative of a presence of one or more targets.

4.20250352796System and Method to Induce Epigenetic Changes to the Cells and Tissue of the Eye and Orbit
US - 20.11.2025
Int.Class A61N 1/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
1Electrotherapy; Circuits therefor
18Applying electric currents by contact electrodes
32alternating or intermittent currents
36for stimulation, e.g. heart pace-makers
 Appl.No 19285153 Applicant University of Southern California Inventor Mark S. Humayun

Methods, systems, and apparatus for causing changes to cells or tissue within or adjacent to an eye. The system includes an external RF coil configured to transmit RF signals. The system also includes a wearable device configured to be removably disposed on the eye, the wearable device including a plurality of internal radiofrequency (RF) coils configured to receive the RF signals from the external RF coil and a plurality of stimulating electrodes configured to electromagnetically stimulate a portion of the eye or an area adjacent to the eye, causing changes to cells or tissue within or adjacent to the eye.

5.20250352517THERAPEUTIC OR PROPHYLACTIC AGENT FOR COVID19 WHICH COMPRISES SELENONEINE
US - 20.11.2025
Int.Class A61K 31/4172
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41641,3-Diazoles
4172Imidazole-alkanecarboxylic acids, e.g. histidine
 Appl.No 18278142 Applicant National University Corporation Chiba University Inventor Noriyuki Suzuki

An object is to provide a composition for treatment or prevention of an infection caused by SARS-COV-2 (COVID-19). Based on establishment of a screening method for drugs having an inhibitory activity against proteases of SARS-COV2, and discovery of an inhibitory activity of selenoneine against the proteases of SARS-COV2, a composition for treatment or prevention of COVID-19, which composition includes selenoneine, is provided.

6.WO/2025/236237DUAL-CONSTRICTION ZONE NANOPORE PROTEIN COMPLEX AND USE THEREOF
WO - 20.11.2025
Int.Class C07K 14/195
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
 Appl.No PCT/CN2024/093629 Applicant BEIJING POLYSEQ BIOTECH CO., LTD Inventor BEI, Weiwei
Provided are a dual-constriction zone nanopore protein complex, and a use thereof. The nanopore protein complex comprises an HfaB protein and a truncated HfaA protein, the truncated HfaA protein connecting to the HfaB protein and forming a constriction zone in the nanopore protein complex. By means of an in vitro assembly method, a novel dual-constriction zone nanopore protein complex is provided, enriching the variety of nanopore proteins; the dual-constriction zone nanopore protein complex has a more stable oligomeric state and sequencing current before assembly compared to a single-constriction zone nanopore protein oligomer.
7.WO/2025/237407METHODS FOR SPATIAL EPIGENOMIC ANALYSIS WITHIN SINGLE CELLS OF TISSUE SAMPLE
WO - 20.11.2025
Int.Class C12Q 1/6869
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6869Methods for sequencing
 Appl.No PCT/CN2025/095434 Applicant BEIJING CHANGPING LABORATORY Inventor DONG, Wenyang
Methods are provided for analyzing genomic DNA where the genomic DNA is subject to in situ fragmentation, in situ transcription, complementary DNA synthesis and barcoding complementary DNA.
8.WO/2025/240362DISCOVERY OF ENPP3 AS A CGAMP HYDROLASE WITH A ROLE IN ANTI-CANCER IMMUNITY
WO - 20.11.2025
Int.Class C12N 9/14
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
 Appl.No PCT/US2025/028970 Applicant THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY Inventor MARDJUKI, Rachel
The present disclosure relates generally to methods of inhibiting and preventing cancer, including melanoma, by administering to subjects having high levels of ENPP3 expression or having cancers classified as high ENPP3 cancers, an ENPP3 inhibitor and an additional inhibitor such as a PD1 inhibitor.
9.WO/2025/240737METHODS OF PRODUCING MEMORY T CELLS IN VITRO AND THEIR USE IN IMMUNOTHERAPY
WO - 20.11.2025
Int.Class C12N 5/0783
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
0783T cells; NK cells; Progenitors of T or NK cells
 Appl.No PCT/US2025/029554 Applicant RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY Inventor MATSUMURA, Shigeko
Methods of generating memory T cells in vitro are provided. The methods include culturing a population of T cells with a population of antigen-loaded dendritic cells for at least about 28-48 days in a culture medium and isolating memory T cells (such as CD4+ or CD8+ memory T cells) from the culture. Methods of treating a subject with cancer or infectious disease are also provided. The methods include administering to the subject memory T cells generated by the methods described herein, where the antigen-loaded dendritic cells are loaded with an antigen expressed by the cancer or the infectious agent causing the disease. Also provided are methods of identifying T cell receptors that specifically bind to an antigen recognized by a memory T cell, which include producing a population of memory T cells recognizing an antigen as described herein, and identifying the T cell receptor expressed by the memory T cells.
10.WO/2025/240122COMPOSITIONS AND METHODS FOR CRISPR-CAS GUIDE RNA DESIGN
WO - 20.11.2025
Int.Class G16B 20/00
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
20ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
 Appl.No PCT/US2025/027121 Applicant GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED Inventor LITTERMAN, Adam
Methods and compositions are provided for using transcription start site (TSS) profiling to identify alternate promoters that yield better transcription modulation (e.g., knockdown using CRISPRi or activation using CRISPRa). Methods can also include designing CRISPR-Cas guide RNAs to target CRISPRi or CRISPRa complexes to the identified alternative promoters, and methods can also include steps of generating such guide RNAs. Also provided are libraries of guide RNA, methods of modulating expression of a target gene. In some cases, multiple promoters for the same gene are targeted simultaneously.
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