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Analysis

1.826621TARGET DETECTION USING TEMPERATURE CONTROLLED PROBES
NZ 28.11.2025
Int.Class C12Q 1/6818
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6813Hybridisation assays
6816characterised by the detection means
6818involving interaction of two or more labels, e.g. resonant energy transfer
Appl.No 826621 Applicant SpeeDx Pty Ltd Inventor KIM, Ryung Rae
The present invention provides oligonucleotides and methods for their use in the detection and/or differentiation of one or more targets in a sample. In some examples, the oligonucleotides and methods find particular application in amplifying, detecting, and/or discriminating multiple targets simultaneously.
2.827278NON-INVASIVE IN-VITRO METHOD FOR SOMATIC MUTATION DETECTION
NZ 28.11.2025
Int.Class C12Q 1/6827
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6813Hybridisation assays
6827for detection of mutation or polymorphism
Appl.No 827278 Applicant MEDICOVER BIOTECH LTD. Inventor KOUMBARIS, George
The invention relates to an in-vitro method of detecting a somatic mutation in a human comprising the steps of, (i) providing for a human sample, preferably a blood sample from a subject, more preferably a plasma sample, or a serum sample or a buffy coat sample, (ii) preparing a first nucleic acid sequencing library from the nucleic acids present in said sample, (iii) hybridizing one or more TAC oligonucleotides from a first TAC oligonucleotide pool (TAC oligonucleotide-1) to said first nucleic acid library thereby isolating a first subset of library nucleic acid molecules, (iv) sequencing said first subset of library nucleic acid molecules and comparing the sequences determined to a human reference sequence, thereby creating a first group of putatively informative sequence variants (PISV1), (v) hybridizing one or more TAC oligonucleotides from a second smaller TAC oligonucleotide pool comprising TAC oligonucleotides (TAC oligonucleotide-2) which are specific for the nucleic acid molecules of said first group of putatively informative sequence variants, to said first library of nucleic acid molecules thereby isolating a second subset of library nucleic acid molecules, (vi) sequencing said second subset of library nucleic acid molecules and comparing the sequences determined to a human reference sequence, thereby creating a second group of putatively informative sequence variants (PISV2), (vii) analyzing the putatively informative sequence variants (PISV2) thereby detecting a somatic mutation in the sample from the subject. Steps (i) to (iv) are also referred to together as step A. Steps (v) to (vii) are also referred to together as step B.
3.3045482ADAPTORS AND METHODS FOR HIGH EFFICIENCY CONSTRUCTION OF GENETIC LIBRARIES AND GENETIC ANALYSIS
ES 28.11.2025
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Appl.No 21867505 Applicant Resolution Bioscience, Inc. Inventor GUO, Jiannan
4.827202GENOTYPING OF CELL-FREE DNA FROM EMBRYO CULTURE MEDIA
NZ 28.11.2025
Int.Class C12Q 1/6879
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6879for sex determination
Appl.No 827202 Applicant VYTELLE LLC Inventor GRUHOT, Tasha
The present disclosure provides, inter alia, techniques, technologies, and methods for non-invasive genotyping and/or embryo sexing, which methods include obtaining media containing cell-free DNA sluffed from an embryo, amplifying the cell-free DNA, and determining the genotype and/or sex of the embryo. In further aspects, the present disclosure provides methods for obtaining estimated breeding values from embryos non-invasively. Also provided are amplification processes to determine embryo genotype including sex.
5.827319NON-INVASIVE IN-VITRO METHOD OF DIAGNOSIS
NZ 28.11.2025
Int.Class C12Q 1/6827
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6813Hybridisation assays
6827for detection of mutation or polymorphism
Appl.No 827319 Applicant MEDICOVER BIOTECH LTD. Inventor KOUMBARIS, George
The invention relates to an in-vitro method of diagnosis, prognosis, treatment response control, response prediction, of a particular human disease comprising the steps of: (i) providing for a human sample, preferably a blood sample from a subject, more preferably a plasma sample, or a serum sample or a buffy coat sample; (ii) preparing a first nucleic acid sequencing library from the nucleic acids present in said sample; (iii) hybridizing one or more TAC oligonucleotides from a first TAC oligonucleotide pool (TAC oligonucleotide-1) to said first nucleic acid library thereby isolating a first subset of library nucleic acid molecules; (iv) sequencing said first subset of library nucleic acid molecules and comparing the sequences determined to a human reference sequence, thereby creating a first group of putatively informative sequence variants (PISV 1); (v) hybridizing one or more TAC oligonucleotides from a second smaller TAC oligonucleotide pool comprising TAC oligonucleotides (TAC oligonucleotide-2) which are specific for the nucleic acid molecules of said first group of putatively informative sequence variants, to said first library of nucleic acid molecules thereby isolating a second subset of library nucleic acid molecules; (vi) sequencing said second subset of library nucleic acid molecules and comparing the sequences determined to a human reference sequence, thereby creating a second group of putatively informative sequence variants (PISV2); (vii) analyzing the putatively informative sequence variants (PISV2) thereby diagnosing, prognosing, controlling the response to a drug, for a particular human disease state. Steps (i) to (iv) are also referred to together as step A. Steps (v) to (vii) are also referred to together as step B.
6.827107SYSTEMS AND METHODS FOR SEQUENCING OF CELL-FREE RNA
NZ 28.11.2025
Int.Class C12Q 1/6806
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction assay
Appl.No 827107 Applicant THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY Inventor DIEHN, Maximilian
Systems and methods for sequencing of cell-free RNAs are provided. Targeted sequencing can be performed using a panel of transcripts that are genes of rare abundance within a population of control samples of cell-free nucleic acids.
7.20240006795SISTEMA INTELIGENTE PARA EL CONTROL, DIAGNÓSTICO Y PRONÓSTICO DE COSECHAS EN CULTIVOS AGRÍCOLAS
CO 28.11.2025
Int.Class B65B 25/04
BPERFORMING OPERATIONS; TRANSPORTING
65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
25Packaging other articles presenting special problems
02Packaging agricultural or horticultural products
04Packaging fruit or vegetables
Appl.No 20240006795 Applicant ECOMONTE COLOMBIA SAS Inventor Pablo César Guevara Barbosa
Sistema conformado por elementos de hardware que toman información de los frutos en un cultivo y en general de otros parámetros del entorno (suelo, clima y otras características) en combinación con elementos de software orientados al control, diagnóstico y pronóstico de cosechas en cultivos agrícolas. Estos elementos combinados tienen funcionalidades específicas en el proceso de captura, recopilación, transmisión, control y análisis de datos mediante un componente de inteligencia artificial.
8.827218MOLECULAR MARKERS FOR REDUCED PYRUVATE LEVEL TRAIT IN ALLIUM CEPA
NZ 28.11.2025
Int.Class C12Q 1/6895
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6888for detection or identification of organisms
6895for plants, fungi or algae
Appl.No 827218 Applicant NUNHEMS B.V. Inventor HOWELL, Tyson, Ronald
The present invention relates to a genetic marker for determining the presence or absence of one or more QTLs conferring a reduced pyruvate level in an Allium cepa plant or plant part, wherein the marker is selected from the group consisting of a marker linked to a reduced pyruvate conferring QTL located on chromosome 2, a marker linked to a reduced pyruvate conferring QTL located on chromosome 1 and a marker linked to a reduced pyruvate conferring QTL located on chromosome 7. The present invention further relates to the use of the marker of the invention for determining the presence or absence of one or more QTLs conferring a reduced pyruvate level in an Allium cepa plant or plant part. The present invention further relates to a method for identifying and/or selecting an Allium cepa plant or plant part comprising determining in said plant or plant part the presence or absence of one or more markers of the invention. The present invention relates to isolated nucleic acid and the use of the nucleotide sequences as provided herein for marker assisted selection of an Allium cepa plant or plant part.
9.827456METHODS FOR THE TREATMENT AND PREVENTION OF GENERALIZED POSTULAR PSORIASIS (GPP)
NZ 28.11.2025
Int.Class C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
Appl.No 827456 Applicant Boehringer Ingelheim International GmbH Inventor VISVANATHAN, Sudha
The present invention relates to the treatment of generalized pustular psoriasis (GPP), including the treatment and prevention of flares in adults and adolescents from 12 years of age with a history of generalized pustular psoriasis (GPP) with anti-IL36R antibodies administered subcutaneously at a first dose of 300mg or 600mg, followed by a dose of 150mg or 300mg q4w or q12w. Use of microRNA RNA 223-3p and 223-5p as biomarkers to monitor treatment.
10.20250361547DIAGNOSTIC MICROPARTICLE PROBE COMPRISING MAGNETIC PARTICLE AND INACTIVATED GENETIC SCISSORS, AND MULTI-DIAGNOSTIC SYSTEM AND METHOD INVOLVING PROBE
US 27.11.2025
Int.Class C12Q 1/6825
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6813Hybridisation assays
6816characterised by the detection means
6825Nucleic acid detection involving sensors
Appl.No 18874143 Applicant EZDIATECH INC. Inventor Yong-Gyun JUNG

The present invention relates to a diagnostic microparticle probe comprising a magnetic particle and an inactivated genetic scissors, and a multi-diagnostic system and multi-diagnostic method comprising the same, which may not only perform a rapid and accurate diagnosis compared to conventional diagnostic methods but also may be used for multiple diagnoses, by introducing genetic scissors technology into a diagnostic microparticle probe.