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1 / 64,811
1.20250223643REAGENT KIT AND SEQUENCING METHOD USING THE SAME
US - 10.07.2025
Int.Class C12Q 1/6874
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6869Methods for sequencing
6874involving nucleic acid arrays, e.g. sequencing by hybridisation
 Appl.No 19090505 Applicant MGI Tech Co., Ltd. Inventor Man JIA

Provided are a reagent kit and use thereof in sequencing. The reagent kit includes a first reagent and a second reagent. The first reagent is selected from a disulfide bond reducing agent. The second reagent is selected from a blocking reagent suited to blocking a disulfide bond.

2.20250223651METHODS AND COMPOSITIONS FOR TREATMENT OF MEDULLOBLASTOMA
US - 10.07.2025
Int.Class C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
 Appl.No 18960079 Applicant Children's Hospital Medical Center Inventor Qing Lu

Disclosed are methods of treating a medulloblastoma (MB) tumor in an individual in need thereof, comprising administering to the individual a composition comprising one or more of a nucleic acid having specific binding to a SOX11 mRNA, a nucleic acid having specific binding to an HNRNPH1 mRNA and/or a nucleic acid having specific binding to a MYC enhancer region. In aspects, the nucleic acid has specific binding to a MYC enhancer region and impedes binding of one or both of a SOX11 protein and a HNRNPH1 protein to the MYC enhancer region. CRISPRi and/or CRISPR methods may be used for delivery of the nucleic acids contemplated herein.

3.20250223657IDENTIFICATION OF A UNIQUE BACTERIAL STRAIN THAT CONFERS RISK OF RHEUMATOID ARTHRITIS AND RELATED MATERIALS AND METHODS
US - 10.07.2025
Int.Class C12Q 1/689
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6888for detection or identification of organisms
689for bacteria
 Appl.No 18880133 Applicant THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate Inventor Kristine KUHN

Methods for the early detection of subjects at risk of developing rheumatoid arthritis, and subjects having early rheumatoid arthritis thus allowing for early intervention.

4.WO/2025/146550NUCLEIC ACID BARCODES
WO - 10.07.2025
Int.Class C12Q 1/6816
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6813Hybridisation assays
6816characterised by the detection means
 Appl.No PCT/GB2025/050011 Applicant CAMBRIDGE ENTERPRISE LIMITED Inventor MEDCALF, Elliot James
Provided are dual modality nucleic acid barcodes that include a programmed identifiable signature and sequence signature allowing for real time identification of the barcodes to be linked with downstream analysis by linking the identifiable signature with the sequence signature. Also provided are methods of making said barcodes, libraries of said barcodes and libraries of supports attached to said barcodes. Further provided are uses and methods of using said barcodes.
5.WO/2025/147585USE OF EPIGENETIC AND GENOMIC BIOMARKERS FOR ASSESSING DRUG RESPONSE TO TYPE 2 INFLAMMATORY DISEASES
WO - 10.07.2025
Int.Class C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
 Appl.No PCT/US2025/010196 Applicant THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Inventor RAHMANI, Elior
Identifying and refining clinically significant patient stratification is a critical step toward realizing the promise of precision medicine in a number of medical conditions such as asthma. In this context, we describe the construction unbiased patient stratification scores based on DNA methylation (DNAm) patterns and gene expression patterns and their utilization to refine the efficacy of hallmark biomarkers for predicting drug response in asthma patients, as well as patients having diseases/conditions caused by excessive Type 2 inflammation, such as atopic dermatitis.
6.20250223631METHODS AND KITS FOR DETECTION OF TARGETS USING PCR AND PADLOCK PROBES
US - 10.07.2025
Int.Class C12Q 1/6825
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6813Hybridisation assays
6816characterised by the detection means
6825Nucleic acid detection involving sensors
 Appl.No 18864675 Applicant APLEX BIO AB Inventor Ruben Rafael Gonçalves Soares

Described is a method for determining the presence of a target nucleic acid sequence in a sample, the method includes the steps of:

    • a) providing a sample to be tested, wherein the sample has one or more nucleic acid molecule(s);
    • b) subjecting the sample to at least one cycle of PCR to generate one or more PCT-product(s), in the presence of one or more padlock probes (PLP), which are capable of hybridizing to at least a portion of the target nucleic acid sequence, or a complimentary sequence thereof, in the PCR-product(s) generated by the at least one cycle of PCR to generate one or more PCR-PLP-product(s), wherein following hybridisation the hybridised PLP are ligated;
    • c) subjecting the one or more PCR-PLP-product(s) to rolling circle amplification (RCA) to generate one or more RCA-product(s); and
    • d) determining the presence and/or amount of the target nucleic acid sequence in the sample based on the presence and/or amount of the RCA-product(s) generated in step (c).

7.20250221375SOYBEAN CULTIVAR 24060356
US - 10.07.2025
Int.Class A01H 6/54
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
HNEW PLANTS OR PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
6Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy
54Leguminosae or Fabaceae, e.g. soybean, alfalfa or peanut
 Appl.No 18406789 Applicant M.S. Technologies, L.L.C. Inventor Justin T. Mason

A soybean cultivar designated 24060356 is disclosed. The invention relates to the seeds of soybean cultivar 24060356, to the plants of soybean cultivar 24060356, to the plant parts of soybean cultivar 24060356, and to methods for producing progeny of soybean cultivar 24060356. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 24060356. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 24060356, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 24060356 with another soybean cultivar.

8.202025102754System zum Schnellnachweis von Virusinfektionen in Blutproben
DE - 10.07.2025
Int.Class G01N 33/53
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
 Appl.No 202025102754 Applicant Abbasi Banzeer Ahsan Inventor

Ein System zum schnellen Nachweis viraler Infektionen in Blutproben, bestehend aus: ein mikrofluidisches Verarbeitungsmodul, das so konfiguriert ist, dass es eine Vollblutprobe im Mikrolitermaßstab aufnimmt und durch aufeinanderfolgende Schritte verarbeitet, darunter Plasmatrennung, Lyse viraler Partikel und Extraktion von Biomarkern; eine Biosensor-Array-Einheit, die eine Vielzahl nanostrukturierter Sensorelemente umfasst, die mit pathogenspezifischen Liganden funktionalisiert sind, wobei das Biosensor-Array in das Mikrofluidikmodul integriert ist, um eine Echtzeiterkennung viraler Nukleinsäuren oder Antigene zu ermöglichen; ein temperaturgesteuertes Amplifikationsmodul, das in den Mikrofluidkanal eingebettet ist und für die Durchführung einer isothermen Nukleinsäureamplifikation mittels Rekombinase -Polymerase-Amplifikation (RPA), Loop-vermittelter isothermer Amplifikation (LAMP) oder Helikase-abhängiger Amplifikation (HDA) konfiguriert ist; ein Signalerfassungssubsystem, das optische, elektrochemische oder piezoelektrische Wandler umfasst, die mit dem Biosensor-Array gekoppelt sind, wobei das Subsystem molekulare Interaktionsdaten in digitale Signale umwandelt; einen Prozessor für maschinelles Lernen, der operativ mit dem Signalerfassungssubsystem verbunden ist und so konfiguriert ist, dass er den Infektionsstatus mithilfe vorab trainierter Klassifizierungsmodelle mit Vertrauensbewertung und Anomaliemarkierung klassifiziert; eine drahtlose Kommunikationsschnittstelle, die operativ mit dem Prozessor für maschinelles Lernen verbunden ist, um die Ergebnisse per Fernzugriff zu verbreiten, wobei das gesamte System in einem tragbaren Gehäuse untergebracht ist, das über eine grafische Benutzeroberfläche oder einen Touchscreen bedienbar ist. embedded image

9.20250221643ANALYTE SENSORS AND SENSING METHODS FOR DUAL DETECTION OF GLUCOSE AND ETHANOL
US - 10.07.2025
Int.Class A61B 5/1486
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes ; Identification of persons
145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
1468using chemical or electrochemical methods, e.g. by polarographic means
1486using enzyme electrodes, e.g. with immobilised oxidase
 Appl.No 19003007 Applicant Abbott Diabetes Care Inc. Inventor Tianmei OUYANG

Multiple enzymes may be present in one or more active areas of an electrochemical analyte sensor for detecting one or more different analytes. In particular, an analyte sensor may comprise a sensor tail configured for insertion into a tissue and one or more working electrodes having a glucose-responsive active area and an ethanol-responsive active area to detect glucose and ethanol in vivo.

10.20250223574Mutant Taq Polymerase for Fast Speed Amplification
US - 10.07.2025
Int.Class C12N 9/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
12transferring phosphorus containing groups, e.g. kinases (2.7)
 Appl.No 19068241 Applicant AbClonal Science, Inc. Inventor Zhenyu Zhu

The invention includes a mutant Taq polymerase, which can significantly extend and amplify a target sequence where the extension conditions are time limited to as little as one second. The mutant Taq polymerase, or a biologically active fragment thereof, has one or more substitutions differing from the wild type as shown in Table I.

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