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Analysis

1 / 66,585
1.20260022415METHOD FOR ASSESSING DIFFERENTIATION STATE OF CELLS, GELATIN NANOPARTICLES AND GELATIN NANOPARTICLE SET
US - 22.01.2026
Int.Class C12Q 1/6841
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6813Hybridisation assays
6841In situ hybridisation
 Appl.No 19295252 Applicant Konica Minolta, Inc. Inventor TEMMEI ITO

An object of the present invention is to provide a method for assessing a differentiation state of cells, capable of assessing a differentiation state of a wide variety of cells, and gelatin nanoparticles and a gelatin nanoparticle set that can be used in the method. The purpose is achieved by a method for assessing a differentiation state of cells, the method including a step of observing expression of an mRNA encoding a peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) or the peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) in cells. The method can be performed by gelatin nanoparticles for assessing a differentiation state of cells, the gelatin nanoparticles carrying a probe capable of detecting an mRNA encoding PGC-1α or PGC-1α.

2.20260022412METHOD AND KIT FOR DETECTING MICROORGANISM OR CELL, DETECTING MICROORGANISM RELATED SUBSTANCE OR CELL RELATED SUBSTANCE
US - 22.01.2026
Int.Class C12Q 1/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
 Appl.No 18997307 Applicant KIKKOMAN CORPORATION Inventor Yuko ICHIYANAGI

An object is to provide a simple method and kit for detecting a microorganism or cell. A method for detecting a microorganism or cell, including the steps of first extracting the microorganism or cell with an extracting agent containing a surfactant; then collecting a sample with a sampling portion containing a surfactant adsorbent, and measuring luminescence level with a luminescence reagent, and a kit for the method are provided.

3.20260020797ANALYTE SENSORS EMPLOYING MULTIPLE ENZYMES AND METHODS ASSOCIATED THEREWITH
US - 22.01.2026
Int.Class A61B 5/1486
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes ; Identification of persons
145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
1468using chemical or electrochemical methods, e.g. by polarographic means
1486using enzyme electrodes, e.g. with immobilised oxidase
 Appl.No 19340421 Applicant Abbott Diabetes Care Inc. Inventor Stephen OJA

Methods and analyte sensors including at least a first working electrode having a first active area thereon, and performing a dip coating operation to deposit a bilayer membrane upon the first working electrode and the first active area. The bilayer may include an inner layer having a first membrane polymer and an outer layer having a second membrane polymer, the first membrane polymer and the second membrane polymer differing from one another. The dip coating operation may comprise one or more first dips in a first membrane formulation to form the inner layer of the bilayer membrane and one or more second dips in a second membrane formulation to form the outer layer of the bilayer membrane upon the inner layer.

4.20260020798ANALYTE SENSORS EMPLOYING MULTIPLE ENZYMES AND METHODS ASSOCIATED THEREWITH
US - 22.01.2026
Int.Class A61B 5/1486
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes ; Identification of persons
145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
1468using chemical or electrochemical methods, e.g. by polarographic means
1486using enzyme electrodes, e.g. with immobilised oxidase
 Appl.No 19340445 Applicant Abbott Diabetes Care Inc. Inventor Stephen OJA

Methods and analyte sensors including at least a first working electrode having a first active area thereon, and performing a dip coating operation to deposit a bilayer membrane upon the first working electrode and the first active area. The bilayer may include an inner layer having a first membrane polymer and an outer layer having a second membrane polymer, the first membrane polymer and the second membrane polymer differing from one another. The dip coating operation may comprise one or more first dips in a first membrane formulation to form the inner layer of the bilayer membrane and one or more second dips in a second membrane formulation to form the outer layer of the bilayer membrane upon the inner layer.

5.20260020799ANALYTE SENSORS EMPLOYING MULTIPLE ENZYMES AND METHODS ASSOCIATED THEREWITH
US - 22.01.2026
Int.Class A61B 5/1486
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes ; Identification of persons
145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
1468using chemical or electrochemical methods, e.g. by polarographic means
1486using enzyme electrodes, e.g. with immobilised oxidase
 Appl.No 19340458 Applicant Abbott Diabetes Care Inc. Inventor Stephen OJA

Methods and analyte sensors including at least a first working electrode having a first active area thereon, and performing a dip coating operation to deposit a bilayer membrane upon the first working electrode and the first active area. The bilayer may include an inner layer having a first membrane polymer and an outer layer having a second membrane polymer, the first membrane polymer and the second membrane polymer differing from one another. The dip coating operation may comprise one or more first dips in a first membrane formulation to form the inner layer of the bilayer membrane and one or more second dips in a second membrane formulation to form the outer layer of the bilayer membrane upon the inner layer.

6.WO/2026/020029METHODS FOR ANALYZING CERVICOVAGINAL SAMPLES
WO - 22.01.2026
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
 Appl.No PCT/US2025/038108 Applicant NEXTGEN JANE, INC. Inventor LI, Xitong
Provided are systems and methods for analyzing vaginaliy derived samples and nucleic acids therefrom.
7.WO/2026/020059METHODS OF NUCLEIC ACID PREPARATION AND ANALYSIS
WO - 22.01.2026
Int.Class C12Q 1/6806
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction assay
 Appl.No PCT/US2025/038160 Applicant NATERA, INC. Inventor KAWLI, Trupti
The present disclosure provides methods and compositions for preparing and analyzing DNA molecules to identify at least one somatic mutation associated with cancer. Cell-free DNA is extracted from at least one plasma fraction of a blood sample of a subject, and optionally extracting cellular DNA from a fraction of the blood sample containing a plurality of leukocytes. Targeted multiplex amplification is performed on the extracted cell-free DNA or DNA derived therefrom to amplify 50-1,000 target loci each encompassing at least one somatic mutation associated with the cancer, and optionally on the extracted cellular DNA or DNA derived therefrom to amplify 10 or more of the 50-1,000 target loci. The amplified DNA is analyzed by sequencing to identify the at least one somatic mutation that is present in the plasma-derived amplified DNA and that is not a clonal hematopoiesis (CH) mutation present in the leukocyte-derived amplified DNA.
8.WO/2026/017734DOWNY MILDEW RESISTANCE IN SPINACH
WO - 22.01.2026
Int.Class A01H 6/02
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
HNEW PLANTS OR PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
6Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy
02Amaranthaceae or Chenopodiaceae, e.g. beet or spinach
 Appl.No PCT/EP2025/070326 Applicant KWS VEGETABLES B.V. Inventor DE VISSER, Jan
The current invention relates to spinach plants comprising a gene or locus which leads to a broad spectrum resistance to Peronospora effusa (Pe). The invention also relates to progeny of said 5 spinach plants, to propagation material of said spinach plants, to a cell of said spinach plants, to seed of said spinach plants, and to harvested leaves of said spinach plants. The invention also relates to use of said spinach plants in breeding to confer resistance against Peronospora effusa. The invention further relates to a method for generating a spinach plant having a broad spectrum resistance to Peronospora effusa.
9.WO/2026/016189METHYLATION TRANSFORMER FOR CANCER DETECTION
WO - 22.01.2026
Int.Class C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
 Appl.No PCT/CN2024/106577 Applicant ANTINOUS TECHNOLOGY COMPANY LIMITED Inventor ZHANG, Kang
Provided is a method for detecting early ovarian cancer (EOC) for a patient, comprising: obtaining one or more embedding representations for each of a plurality of chromosomes of the patient; inputting one or more embedding representations into a machine-learning model, wherein the machine-learning model is trained by: obtaining DNA methylation data of a plurality of subjects; pretraining, based on the DNA methylation data of the plurality of subjects, the machine-learning model to predict a methylation level of a masked CpG site; and training the pretrained model to detect EOC; and detecting EOC for the patient based on an output of the machine-learning model. Provided is transformer-based AI for early cancer diagnosis using cfDNA methylation markers, such as a transformer-based AI technology that improves early ovarian cancer diagnosis using cfDNA methylation markers.
10.WO/2026/019774METHODS AND SYSTEMS FOR TARGET IDENTIFICATION
WO - 22.01.2026
Int.Class C12Q 1/6806
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction assay
 Appl.No PCT/US2025/037669 Applicant PLENO, INC. Inventor BRODIN, Jeffrey
The present disclosure provides methods and systems for determining the presence of a target nucleic acid. Recognition elements comprising codes which can correlate to a target nucleic acid are used in combination with sequencing chemistries, wherein the code sequences either alone or in combination with sequencing methodologies can enable the identification of the presence or absence of a target nucleic acid in a sample of interest. The present disclosure provides for assay devices that can be leveraged for sequencing and non-sequencing methods. The present disclosure provides for digital partitioning of samples when physical partitions are not available or desirable for sample differentiation between multiplexed samples.
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