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Analysis

1 / 65,957
1.WO/2025/238267MONITORING BIOLOGICAL PATHOGENS
WO - 20.11.2025
Int.Class C12Q 1/6888
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6888for detection or identification of organisms
 Appl.No PCT/EP2025/063677 Applicant KROMEK LIMITED Inventor DEMONTIS, Marco
A method and a system for the monitoring and analysis of a sample of biological material are described. The method comprises, on a sample to be tested for presence of at least one biological material: performing a first test for the possible presence of biological material in the sample, or for the presence of biological material in the sample at above a predetermined threshold level, the first test comprising a test selected to determine that a particular biological material is present indicative of a source of biological material in a category, which category is at a level more general than a species level; if the test is negative, recoding the sample as negative, but if the test is positive performing one or both of: a second test for the biological material in the sample, the second test comprising a test selected to determine the source of the present biological material at the species level; a third test for the biological material in the sample, the third test comprising a test selected to determine the source of the present biological material at a sub-species/ variant level
2.WO/2025/239452SPONTANEOUS MUTATION DETECTION METHOD, DEVICE, PROGRAM, AND STORAGE MEDIUM
WO - 20.11.2025
Int.Class C12Q 1/6869
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6869Methods for sequencing
 Appl.No PCT/JP2025/017897 Applicant HITACHI HIGH-TECH CORPORATION Inventor SUMIDA Noriyuki
The present invention provides a spontaneous mutation detection method capable of accurately detecting a low-frequency DNA chain base spontaneous mutation. A spontaneous mutation detection method according to the present invention comprises: a waveform data acquisition step (S101) for acquiring waveform data including at least base sequence information and peak waveform appearance position information, by using a plurality of reference DNA samples that do not contain a mutation; a noise model data creation step (S102) for creating noise model data using a set of peak waveforms of the waveform data of the plurality of reference DNA samples; a test data acquisition step (S103) for acquiring test data that is waveform data of the test sample; an alignment step (S104) for comparing the noise model data with the test data base sequence and aligning the test data with respect to the noise model data so as to pair the same bases with one another; and an exclusion step (S105) for excluding a peak waveform which appears at the same position as the noise model data from among the peak waveforms in the test data.
3.WO/2025/240502HIGH-THROUGHPUT ANALYSIS OF N-LINKED GLYCOSYLATION SITE OCCUPANCY IN PROTEINS AND PEPTIDES
WO - 20.11.2025
Int.Class C12Q 1/25
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
25involving enzymes not classifiable in groups C12Q1/26-C12Q1/7097
 Appl.No PCT/US2025/029176 Applicant ENCODIA, INC. Inventor MURANAKA, Norihito
The present disclosure relates to methods for high-throughput analysis of proteins and peptides employing a set of engineered binders that recognize terminal amino acid residues of peptide analytes. In particular, disclosed herein is the analysis of occupancy of N-linked glycosylation sites in proteins and peptides. The disclosure finds utility at large-scale profiling of N-linked glycosylation sites, as well as monitoring changes in glycosylation patterns associated with numerous disease conditions.
4.WO/2025/240937HUMAN INDUCED PLURIPOTENT STEM CELL (IPSC)-DERIVED FETAL AND NEONATAL HEPATOCYTE-LIKE CELL MODEL FOR DRUG AND TOXICANT SCREENING
WO - 20.11.2025
Int.Class C12N 5/071
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
 Appl.No PCT/US2025/029873 Applicant THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE Inventor LAMPE, Jed
In a first embodiment, a method for producing fetal and/or neonatal hepatocyte-like cells (fnHLCs) is disclosed. The method includes producing a definitive endoderm cell population by a stage 1 process, producing a hepatoblast-like progenitor cell population from the definitive endoderm cell population by a stage 2 process, and producing a fetal and/or neonatal hepatocyte-like cell population from the hepatoblast-like progenitor cell population by a stage 3 process. In another embodiment a method for screening a target is disclosed. The method includes co-culturing and incubating the target with a fetal and/or neonatal hepatocyte-like cell (fnHLC), retrieving a sample of a fnHLC after the co-culturing and incubating and determining one or more characteristics of the fnHLC based on analysis of the sample of the fnHLC.
5.WO/2025/237186POCT KIT, AMPLIFICATION DETECTION METHOD USING SAME, AND MANUFACTURING METHOD THEREFOR
WO - 20.11.2025
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
 Appl.No PCT/CN2025/093768 Applicant SUZHOU TIANLONG BIOTECHNOLOGY CO. LTD. Inventor LI, Ming
Disclosed in the present invention are a POCT kit, an amplification detection method using same, and a manufacturing method therefor. In the POCT kit, an external gas source driving element coordinates with a liquid separation driving part of the kit to serve as a kinetic source for liquid transfer between different chambers in different periods. Different kinetic sources also adapt to the differentiation requirements for different driving forces and driving precision. When the kit is in use, by means of destructively sealing a connecting flow channel, the pressure in an amplification chamber is reliably ensured, and an amplification system liquid can avoid the generation of bubbles in high- and low-temperature cyclic amplification. Moreover, the destructive sealing operation also enables a plurality of amplification chambers to be in an independent and closed state, and there are almost no problems of steam generation and mutual interference.
6.WO/2025/238371POLYMER ANALYSIS USING TRANSFORMER NEURAL NETWORK
WO - 20.11.2025
Int.Class G16B 40/10
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
40ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
10Signal processing, e.g. from mass spectrometry or from PCR
 Appl.No PCT/GB2025/051061 Applicant OXFORD NANOPORE TECHNOLOGIES PLC Inventor VELLA, Michael
A method of estimating a sequence of polymer units of a polymer comprising measurements of a signal generated during translocation of the polymer with respect to a nanopore includes determining a sequence of hidden states associated with the signal using a transformer encoder network, and processing the sequence of hidden states using a network head to estimate a sequence of polymer units of the polymer. The processing by the network head includes generating a respective array of values for each hidden state indicating an estimated likeliness of the hidden state being associated with each of a set of symbols, where the set of symbols includes symbols associated with respective types of canonical polymer unit, and analysing the generated arrays of values to estimate the sequence of polymer units of the polymer.
7.WO/2025/237297CODOMINANT MOLECULAR MARKER OF POTATO LONG-DAY ADAPTIVE GENE STCDF1.4 AND USE OF CODOMINANT MOLECULAR MARKER
WO - 20.11.2025
Int.Class C12Q 1/6895
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6888for detection or identification of organisms
6895for plants, fungi or algae
 Appl.No PCT/CN2025/094609 Applicant AGRICULTURAL GENOMICS INSTITUTE, CHINESE ACADEMY OF AGRICULTURAL SCIENCES Inventor ZHANG, Chunzhi
Provided are a codominant molecular marker of a potato long-day adaptive gene StCDF1.4 and a use of the codominant molecular marker, relating to the technical field of molecular biology. The codominant molecular marker alone is sufficient to identify the homozygous or heterozygous genotype of StCDF1.4, overcoming the shortcoming that existing molecular markers need combination of a plurality of pairs of primers to identify the genotype of StCDF1.4.
8.WO/2025/239952VIRAL CANCER DETECTION TESTS
WO - 20.11.2025
Int.Class G06N 20/00
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
20Machine learning
 Appl.No PCT/US2025/014046 Applicant MASSACHUSETTS EYE AND EAR INFIRMARY Inventor FADEN, Daniel L.
Methods and systems of determining a cancer score, including: receiving a sample collected from a subject, in which the sample includes sequences of circulating tumor DNA (ctDNA); providing the sample to an analysis pipeline, in which the analysis pipeline detects and synthesizes a plurality of features; and determining, with the analysis pipeline, the cancer score based on the synthesized plurality of features.
9.WO/2025/240492METHODS FOR DETECTING AND TREATING HEAD AND NECK CANCER
WO - 20.11.2025
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
 Appl.No PCT/US2025/029164 Applicant THE UNIVERSITY OF CHICAGO Inventor IZUMCHENKO, Evgeny G.
Aspects herein include methods, kits, and systems for evaluating a subject comprising detecting genetic mutation(s) in the DNA sequence of one or more oral cavity squamous cell carcinoma (OCSCC) biomarker(s) in a biological sample from the subject comprising DNA, wherein the OCSCC biomarker(s) comprise TP53, CDKN2A, FAT1, CASP8, NOTCH1, PIK3CA, and/or HRAS along with detecting or determining an HPV infection.
10.WO/2025/239771MEANS AND METHODS FOR COMBINED PHENOTYPICAL AND GENE EXPRESSION (OR GENOTYPICAL) ANALYSIS IN SINGLE CELLS
WO - 20.11.2025
Int.Class C12Q 1/6806
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction assay
 Appl.No PCT/NL2025/050224 Applicant KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN Inventor TANENBAUM, Marvin Eric
Conventional methods for obtaining phenotype and genotype information from single cells are hampered by the fact that methods cannot (easily) be coupled, in particular when cells are contained in an environment wherein these are desirably studied, i.e. being comprised in a plurality of cells. The present invention can provide individual cells in a plurality of cells with a unique combination and/or expression level of cell surface receptors, of which representative information can be retrieved both in imaging and sequencing methods. This highly advantageously allows for coupling different informations, e.g. imaging information and sequencing information, at the single cell level.
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