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Analysis

1 / 66,072
1.WO/2025/245662METHOD FOR RECONSTRUCTING LINEAGE OF MULTIPLE CELLS DIFFERENTIATED FROM COMMON ANCESTOR, COMPUTER PROGRAM AND RECORDING CARRIER THEREOF, AND DEVICE
WO - 04.12.2025
Int.Class A61K 35/545
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
48Reproductive organs
54Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
545Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
 Appl.No PCT/CN2024/095497 Applicant WESTLAKE LABORATORY OF LIFE SCIENCES AND BIOMEDICINE Inventor WANG, Shouwen
A method for reconstructing a lineage of multiple cells differentiated from a common ancestor. A computer program for reconstructing a lineage of multiple cells differentiated from a common ancestor and a recording carrier thereof. A device for reconstructing a lineage of multiple cells differentiated from a common ancestor.
2.WO/2025/249862ISOTHERMAL SINGLE-REACTION PROBE SET FOR ON-SITE DETECTION OF GENE MUTATIONS AND USE THEREOF
WO - 04.12.2025
Int.Class C12Q 1/6862
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
6862Ligase chain reaction
 Appl.No PCT/KR2025/007140 Applicant POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION Inventor LEE, Jeong Wook
The present invention relates to a method for detecting a target gene and a gene mutation using isothermal single reaction and lateral flow immunoassay. The detection method according to the present invention enables sequence-specific nucleic acid detection and mutation detection at the level of single nucleotide polymorphism (SNP) discrimination, thereby providing a method capable of sensitively distinguishing mutations within a short time. In particular, since sequence-specific nucleic acid detection and single nucleotide polymorphism (SNP) discrimination can be visually confirmed directly through the LFA system, the method has high utility for on-site diagnosis.
3.WO/2025/250747GUT MICROBIOME-DERIVED METABOLITE(S) PROMOTE SKELETAL MUSCLE ADAPTATION TO EXERCISE
WO - 04.12.2025
Int.Class A61K 35/66
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
 Appl.No PCT/US2025/031354 Applicant UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION Inventor MCCARTHY, John Joseph
Regular exercise yields a multitude of systemic benefits, many of which may be mediated through the gut microbiome. The present disclosure identifies that cecal microbial transplants (CMTs) from exercise-trained vs. sedentary animals provides benefits in reducing skeletal muscle atrophy using a mouse model of unilaterally hindlimb-immobilization. Direct administration of top microbial-derived exerkines from an exercise-trained gut microbiome preserves muscle function and prevented skeletal muscle atrophy.
4.WO/2025/251032LIVER CANCER METHYLATION MARKERS AND MACHINE MODELS
WO - 04.12.2025
Int.Class G16H 50/20
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
50ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
20for computer-aided diagnosis, e.g. based on medical expert systems
 Appl.No PCT/US2025/031786 Applicant HELIO HEALTH INC. Inventor MAHAJAN, Shivani
In certain aspects, the present disclosure is directed to methods for the determination of a methylation cancer score and/or a demographic -protein cancer score in an individual suspected of having a liver cancer using machine learning models. More specifically, the present invention relates to methods for the determination of a liver cancer status in an individual based on a methylation cancer score and/or a demographic -protein cancer score using machine learning models.
5.WO/2025/246381USE OF AROMATIC L-AMINO ACID DECARBOXYLASE AS MARKER IN DETECTION PRODUCT FOR HEPATIC ENCEPHALOPATHY
WO - 04.12.2025
Int.Class C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
 Appl.No PCT/CN2025/071033 Applicant ZHUJIANG HOSPITAL, SOUTHERN MEDICAL UNIVERSITY Inventor GAO, Jie
Use of an aromatic L-amino acid decarboxylase as a marker in a detection product for hepatic encephalopathy. It has been confirmed that the abundance of aromatic L-amino acid decarboxylase genes encoded by gut microbiota, as well as the product of aromatic L-amino acid decarboxylase, phenylethylamine, are increased in patients with hepatic encephalopathy; and compared with blood ammonia, hepatic encephalopathy can be more accurately diagnosed by means of phenylethylamine. This suggests that the occurrence of hepatic encephalopathy and the degree of progression of the disease can be quickly confirmed by detecting the patients' feces and serum, which increases the demand for clinical detection of hepatic encephalopathy. It has been confirmed that the baseline serum phenylethylamine level can effectively predict the incidence of hepatic encephalopathy at 3 months after TIPS surgery, which provides a detection means for early warning of hepatic encephalopathy.
6.WO/2025/247251DIGITAL DROPLET RNA AMPLIFICATION DETECTION SYSTEM FOR PROSTATE CANCER AND METHOD FOR REDUCING FALSE NEGATIVE RATE OF PROSTATE CANCER
WO - 04.12.2025
Int.Class C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
 Appl.No PCT/CN2025/097657 Applicant SHANGHAI RENDU BIOTECHNOLOGY CO., LTD. Inventor JU, Jinliang
Disclosed in the present invention are a digital droplet RNA amplification detection system for prostate cancer and a method for reducing the false negative rate of prostate cancer. The provided digital droplet RNA amplification detection system for prostate cancer comprises reagents for respectively and specifically detecting the following genes on the basis of a real-time fluorescent nucleic acid constant-temperature amplification method: PCA3, ERG and SPDEF, and a digital PCR system.
7.WO/2025/249786HIERARCHICAL CONTRASTIVE LEARNING SYSTEM AND METHOD FOR PREDICTING PROTEIN FUNCTION
WO - 04.12.2025
Int.Class G16B 40/30
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
40ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
30Unsupervised data analysis
 Appl.No PCT/KR2025/005995 Applicant LG MANAGEMENT DEVELOPMENT INSTITUTE CO., LTD. Inventor KIM, Kiyoung
The present invention relates to a protein function prediction system comprising: a memory storing one or more instructions; and at least one processor that executes the one or more instructions stored in the memory, wherein steps performed by the one or more instructions include the steps of: obtaining protein amino acid sequence information; and predicting, by using at least one artificial intelligence model trained through hierarchical contrastive learning, an EC number of a protein having the protein amino acid sequence information, wherein the hierarchical contrastive learning involves training using hierarchical multi-label contrastive loss.
8.WO/2025/250686METHODS AND SYSTEMS FOR PARALLEL SPATIALLY RESOLVED SINGLE-CELL PROFILING
WO - 04.12.2025
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
 Appl.No PCT/US2025/031259 Applicant THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Inventor REN, Bing
Provided herein are, inter alia, are systems and methods for detecting the transcriptional activity of an enhancer. In addition, provided herein are, inter alia, are systems and methods for use in parallel spatially resolved single-cell profiling. Also provided herein are, inter alia, compositions and kits for use in methods of detecting the transcriptional activity of an enhancer.
9.WO/2025/249537MESENCHYMAL STEM CELL
WO - 04.12.2025
Int.Class C12N 5/0789
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
0789Stem cells; Multipotent progenitor cells
 Appl.No PCT/JP2025/019589 Applicant NATIONAL UNIVERSITY CORPORATION SHIMANE UNIVERSITY Inventor YOSHIKAWA Rintaro
Provided are mesenchymal stem cells that express at least one gene selected from the group consisting of TNFAIP6, CYP1B1, EREG, MME, and CXCL5.
10.WO/2025/246192USE OF PTO-RAD50 GENE HAPLOTYPE IN EVALUATION OF PLANT PHOTOSYNTHETIC EFFICIENCY
WO - 04.12.2025
Int.Class C12Q 1/6895
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6888for detection or identification of organisms
6895for plants, fungi or algae
 Appl.No PCT/CN2024/132189 Applicant BEIJING FORESTRY UNIVERSITY Inventor QUAN, Mingyang
Use of a Pto-RAD50 gene haplotype in the evaluation of plant photosynthetic efficiency. The present invention belongs to the technical field of plant molecular breeding. The nucleotide sequence of the Pto-RAD50 gene is set forth in SEQ ID NO: 1. The Pto-RAD50 gene haplotype is determined according to nucleotides of SNP1, SNP2, and InDel. The SNP1 is a nucleotide at position 172 of SEQ ID NO: 1, the nucleotide being C or A; the SNP2 is a nucleotide at position 442 of SEQ ID NO: 1, the nucleotide being A or G; and the InDel is nucleotides after position 422 of SEQ ID NO: 1, and is ATTATTTTAATA or a deletion of ATTATTTTAATA. By means of determining the genotype combination of the three described sites, the photosynthetic efficiency of poplar trees can be accurately judged, and optimal strains with high photosynthetic efficiency can be accurately and efficiently screened in the early growth stage of poplar trees, thereby effectively shortening the breeding period.
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