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Analysis

1 / 65,904
1.WO/2025/231517INTERNAL CONTROLS FOR STANDARDISATION OF QUANTIFICATION OF CIRCULAR RNAS
WO - 13.11.2025
Int.Class C12Q 1/6876
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
 Appl.No PCT/AU2025/050476 Applicant FLINDERS UNIVERSITY Inventor CONN, Simon, James
A method for normalizing or quantifying the abundance of a target circular RNA in a sample by adding to the sample a defined quantity of a reference circular RNA having a defined and artificial sequence, thereby allowing the calculation of a correction factor that can be used to determine a normalised abundance of the target RNA.
2.WO/2025/232867METHODS AND SYSTEMS FOR DETECTING METABOLITES AND MICROBIOMES ASSOCIATED WITH ANXIETY AND/OR DEPRESSION IN IRRITABLE BOWEL SYNDROME PATIENTS
WO - 13.11.2025
Int.Class G16B 40/00
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
40ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
 Appl.No PCT/CN2025/093680 Applicant CENTRE FOR CHINESE HERBAL MEDICINE DRUG DEVELOPMENT LIMITED Inventor BIAN, Zhaoxiang
A method for detecting anxiety and/or depression metabolic and microbiome markers in a patient with irritable bowel syndrome (IBS) is provided. The method begins with obtaining a serum sample and a fecal sample from the patient. Both samples are processed to extract a gut metagenome, including a bacteriome, a mycobiome, and a virome of the patient, and metabolic features. A classifier is utilized to detect whether a marker set of microbial species and metabolites for depression and anxiety is present in the gut metagenome and the metabolic features.
3.WO/2025/232927DIFFERENCE QUANTIFICATION COMPARISON METHOD FOR ADAPTIVE IMMUNE SYSTEM, AND USE THEREOF
WO - 13.11.2025
Int.Class C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
 Appl.No PCT/CN2025/095859 Applicant NANJING UNIVERSITY OF CHINESE MEDICINE Inventor CAO, Peng
Provided are a difference quantification comparison method for an adaptive immune system, and the use thereof. The method comprises obtaining at least one of a BCR heavy chain sequence of a B cell, a BCR light chain sequence of the B cell and a TCR β chain sequence of a T cell of a sample to undergo comparison, and sequencing same; comparing the determined sequence with a gene sequence in the IMGT database to obtain sequence annotation information of the corresponding sequence, and further constructing a 3D graph displaying the adaptive immune condition of the sequence; then by means of using a minimum transformation cost method, quantifying an immune state difference between samples to be tested and between a sample to be tested and the database that has undergone the test. The method for quantifying immune differences can be used for evaluating the immune state of biological samples, and can also be used for evaluating influences of various therapy and intervention methods on the immune system, so as to judge the effects of the therapies and interventions, including but not limited to the drug efficacy, the vaccine efficacy, etc.
4.WO/2025/233947PREDICTING PATIENT RESPONSE
WO - 13.11.2025
Int.Class C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
 Appl.No PCT/IL2025/050387 Applicant ONCOHOST LTD. Inventor LAHAV, Coren
Methods of predicting response of a subject suffering from cancer to a therapy, comprising calculating a resistance score for factors expressed by the subject, summing the resistance score to produce a total resistance score, wherein a total resistance score beyond a predetermined threshold indicates a subject is predicted to be resistant to the therapy, are provided.
5.WO/2025/235462SELECTIVE BLOCKING TO DETECT AND AMPLIFY LOW ABUNDANT TEMPLATE
WO - 13.11.2025
Int.Class C12Q 1/6809
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6809Methods for determination or identification of nucleic acids involving differential detection
 Appl.No PCT/US2025/027912 Applicant GT MOLECULAR, INC. Inventor KANE, Sarah
Provided herein are methods, kits, and related compositions useful for detecting from a biological sample a low variant allele frequency (VAF) by conventional PCR methods by use of two or more specially configured probes. A first universal-type labelled probe would, normally, when hybridized to a sequence, generate an optically-detectable signal by PCR. Provided herein, however, are specially configured oligonucleotides that, when bound, either prevents non-specific binding of labelled probe to the sequence and/or inhibits reference sequence synthesis by PCR. In this manner, even very low populations of sequences in the presence of another population of sequence that could differ by as little as one nucleotide, can be reliably detected by commercially-available PCR systems.
6.WO/2025/235567DNAZYME DETECTION OF METAL IONS AND GENE EXPRESSION IN TISSUES
WO - 13.11.2025
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
 Appl.No PCT/US2025/028075 Applicant BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM Inventor LU, Yi
Nucleic acid enzymes such as DNAzymes are provided, including nucleic acid enzymes that can be used for detection or quantification of a cofactor, such as a metal ion, in a cell. Methods for concurrent detection of mRNA from cells are also provided and can benefit from modifications to the nucleic acid enzyme such as, e.g., inclusion of a polyadenine (poly-A) tail and/or nonnative chemical groups. The methods may utilize SNAIL probes for spatial transcriptomics, combining SNAIL probes with DNAzymes for spatial metallomics, e.g., to image metal ions spatially.
7.WO/2025/235642METHODS FOR TREATMENT AND ASSESSMENT OF MULTIPLE MYELOMA OR PRECURSORS THEREOF
WO - 13.11.2025
Int.Class G01N 33/50
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
 Appl.No PCT/US2025/028186 Applicant DANA-FARBER CANCER INSTITUTE, INC. Inventor GETZ, Gad
Methods for treating and/or assessing a subject having a symptomatic multiple myeloma or a precursor thereof, where the methods involve characterizing a plasma cell dyscrasia (e.g., monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, multiple myeloma, plasma cell leukemia) in a biological sample from a subject as being high, medium, or low risk by assigning to the plasma cell dyscrasia a multiple myeloma (MM)-like score. The methods may involve sequencing DNA from the biological sample using whole-genome sequencing (WGS).
8.WO/2025/235657CELLULAR ENCAPSULATION METHODS FOR IMPROVED SINGLE CELL SEQUENCING
WO - 13.11.2025
Int.Class B01L 3/00
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
 Appl.No PCT/US2025/028204 Applicant SHENNON BIOTECHNOLOGIES INC. Inventor CHEN, Yih Yang
Disclosed are methods and microfluidic devices for successfully co-encapsulating single cells and single beads in single droplets in a high-throughput, high efficiency manner. Cells and beads are organized into two or more ordered streams flowing through separate microchannels of the microfluidic device, which can include non-rectangular microchannels. Cells and beads in the ordered streams are sufficiently spaced such that at a junction of the microfluidic device, single droplets are generated at higher co-encapsulation efficiencies that beat Poisson statistics. Single droplets including a cell and a bead can undergo single-cell sequencing.
9.WO/2025/235792COMPOSITIONS AND METHODS FOR DETECTING ALLELIC VARIANTS
WO - 13.11.2025
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
 Appl.No PCT/US2025/028459 Applicant STANDARD BIOTOOLS INC. Inventor RAMALINGAM, Naveen
Compositions and methods for allele-specific assays for HLA genotyping.
10.WO/2025/232431SYSTEM AND METHOD FOR SCREENING FOR GENE AFFECTING UPTAKE OF EXTRACELLULAR VESICLE
WO - 13.11.2025
Int.Class C07K 19/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
 Appl.No PCT/CN2025/087864 Applicant TINGO EXOSOMES TECHNOLOGY CO, . LTD. Inventor GE, Xiaohu
The present invention relates to a system and method for screening for a gene affecting the uptake of an extracellular vesicle. The screening system comprises: an extracellular vesicle-targeting region represented by formula A-B, a screening region represented by formula C-D-E, a first cell for integrating the extracellular vesicle-targeting region and/or the screening region, and a second cell for uptake of an extracellular vesicle, wherein A is a polypeptide localized to the extracellular vesicle, or a functional variant thereof, or a nucleotide sequence encoding the polypeptide or the functional variant, B is an RNA-binding polypeptide, or a functional variant thereof, or a nucleotide sequence encoding the polypeptide or the functional variant, C is a nucleotide sequence encoding a first RNA motif, D is a barcode sequence, E is a nucleotide sequence encoding a second RNA motif, the first RNA motif is complementary to a target sequence, and the second RNA motif is an RNA sequence specifically recognized and bound by B.
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