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Analysis

1 / 66,027
1.WO/2025/242077COMPOSITION AND METHOD FOR STABILIZING COELENTERAZINE AND ANALOG THEREOF
WO - 27.11.2025
Int.Class C12Q 1/66
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
66involving luciferase
 Appl.No PCT/CN2025/095973 Applicant SHENZHEN LOGGENE LIFE SCIENCE & TECHNOLOGY CO., LTD Inventor YANG, Zheng
Provided is a composition for stabilizing coelenterazine and an analog thereof, which composition contains coelenterazine and/or an analog thereof, and an aqueous-phase protective solution or an organic-phase protective solution. The coelenterazine and/or analog thereof is dissolved in the aqueous phase or organic phase, wherein the aqueous-phase protective solution has a pH≤5.5, and the organic-phase protective solution contains an organic acid or an inorganic acid. The composition can improve the stability of the substrates of coelenterazine and an analog thereof, can be directly used in an aqueous-phase substrate mother liquor without requiring pretreatment, has high substrate stability when used in an organic-phase substrate mother liquor, and can reduce inter-batch variation in experimental results and improve the stability of experimental results.
2.WO/2025/242752LABEL, MARKER AND METHOD FOR ANALYSING A BIOLOGICAL SAMPLE
WO - 27.11.2025
Int.Class C12Q 1/6818
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6813Hybridisation assays
6816characterised by the detection means
6818involving interaction of two or more labels, e.g. resonant energy transfer
 Appl.No PCT/EP2025/064017 Applicant LEICA MICROSYSTEMS CMS GMBH Inventor ALSHEIMER, Soeren
A label (100, 200, 500, 702, 802, 900, 901, 1000, 1200, 1300, 1600) for analysing a biological sample is provided. The label (100, 200, 500, 702, 802, 900, 901, 1000, 1200, 1300, 1600) comprises a nucleic acid backbone (102, 502, 1002, 1102, 1202, 1301) and a first plurality of labelling moieties (104). The nucleic acid backbone (102, 502, 1002, 1102, 1202, 1301) has a duplex structure comprising at least 50% of nucleotides of the nucleic acid backbone (102, 502, 1002, 1102, 1202, 1301). In further aspects a marker (700, 800) comprising the label and a method for analysing biological samples is provided.
3.WO/2025/244972MICROBIAL SENSING AND PREDICTIVE GROWTH MODELING
WO - 27.11.2025
Int.Class G16B 20/00
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
20ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
 Appl.No PCT/US2025/029941 Applicant H2OK INNOVATIONS INC. Inventor LU, David
Disclosed are systems and methods for microbial sensing and predictive growth modeling. A system can include one or more processors, coupled with memory, to receive genetic information of a microbe in a production system, the genetic information sequenced from a sample taken from the production system. The one or more processors can execute at least one model trained by machine learning using the genetic information to identify the microbe or determine a characteristic of the microbe. The one or more processors can update operation of the production system using the identity of the microbe or the characteristic of the microbe.
4.WO/2025/245227BACTERIAL CELL WALL COMPONENTS AS PROBES FOR A LABEL-FREE BINDING ASSAY AND THE USE THEREOF
WO - 27.11.2025
Int.Class C12Q 1/18
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
18Testing for antimicrobial activity of a material
 Appl.No PCT/US2025/030374 Applicant ACADEMIA SINICA Inventor CHENG, Wei-Chieh
The present disclosure provides peptidoglycan precursors and the use thereof in the study of binding between antibiotic and peptidoglycan. Specifically, the peptidoglycan precursors disclosed herein are used in a method for the screening of peptidoglycan-targeting antibiotics and identifying the binding moiety on a peptidoglycan.
5.WO/2025/245302METHODS, KITS AND SYSTEMS FOR DETERMINING ER ACTIVITY OF CANCER AND METHODS FOR TREATING CANCER BASED ON SAME
WO - 27.11.2025
Int.Class C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
 Appl.No PCT/US2025/030476 Applicant PRECEDE BIOSCIENCES, INC. Inventor EATON, Matthew
The present disclosure includes, among other things, methods, kits, and systems for determining ER activity of cancer, e.g., a breast cancer. In various embodiments, the present disclosure relates to the use of one or more histone modifications, chromatin accessibility, binding of one or more transcription factors, and/or DNA methylation to measure ER activity of a cancer. In some embodiments, differential modifications and/or differential accessibility are detected and quantified at one or more genomic loci of a biological sample, e.g., in cell-free DNA (cfDNA) from a liquid biopsy sample obtained or derived from a subject with cancer. In various embodiments a determined ER activity is useful, e.g., in selecting treatment for and/or treating a cancer, e.g., a breast cancer.
6.WO/2025/241071MULTIPLEX NUCLEIC ACID DETECTION SYSTEM AND USE THEREOF
WO - 27.11.2025
Int.Class C12Q 1/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
 Appl.No PCT/CN2024/094292 Applicant GUANGZHOU KINGCREATE BIOTECHNOLOGY CO., LTD. Inventor LIU, Yunxiao
A multiplex nucleic acid detection system and a use thereof. The system comprises a Target probe and a common beacon probe. The Target probe sequentially comprises a probe primer region, a Tag exonuclease site, and a Target region, wherein the 5' end of the probe primer region is modified by a fluorescence quenching group 1; the 3' end of the probe primer region is connected to a fluorescent reporter group; and the 5' end of the Target region is modified by a fluorescent quenching group 2. The common beacon probe is divided into 10-20 primer binding regions by means of C3 Spacers. By utilizing the multiplex nucleic acid detection system, non-specific background peaks can be effectively eliminated, and false positive peaks possibly occurring in the presence of multi-channel targets are also eliminated, so that the false positive misjudgment rate of a result is reduced, thereby achieving more accurate, highly sensitive and highly specific detection of a target sequence.
7.WO/2025/244116BIOSENSOR AND USE THEREOF
WO - 27.11.2025
Int.Class G01N 27/327
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
26by investigating electrochemical variables; by using electrolysis or electrophoresis
28Electrolytic cell components
30Electrodes, e.g. test electrodes; Half-cells
327Biochemical electrodes
 Appl.No PCT/JP2025/018646 Applicant KYOTO UNIVERSITY Inventor SOWA, Keisei
The purpose of the present invention is to provide a means with which it is possible to electrochemically measure a coenzyme in real time. Provided is an enzyme electrode including an electrode base material and a formic acid dehydrogenase β subunit (FoDH1B) fixed to the electrode base material via at least one compound selected from the group consisting of (1) and (2): (1) aromatic compounds having an aromatic hydrocarbon ring skeleton or a nitrogen-containing heterocyclic skeleton; and (2) compounds represented by general formula (2a). Formula 2a: HS-(CH2)m-OH [where m is an integer of 1-10].
8.WO/2025/245136METHODS AND SYSTEMS FOR ADJUVANT THERAPY
WO - 27.11.2025
Int.Class C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
 Appl.No PCT/US2025/030231 Applicant FORESIGHT DIAGNOSTICS INC. Inventor KURTZ, David M.
Provided herein are methods for identifying a subject for an adjuvant therapy by detecting MRD. In some embodiments, detecting MRD comprises identifying circulating tumor DNA in cell-free DNA from a biological sample of the subject. In some embodiments, it includes methods for identifying a subject as a candidate for adjuvant therapy, the method comprising: a) isolating cell-free DNA (cfDNA) from a biological sample obtained from the subject; detecting minimal residual disease (MRD) of the subject by assessing presence of circulating tumor DNA (ctDNA) molecules in the cfDNA; and identifying the subject as a candidate for adjuvant therapy if MRD is detected, wherein the subject has previously undergone curative-intent resection of a cancer.
9.WO/2025/245166BIOMARKERS FOR XENOGRAFT REJECTION
WO - 27.11.2025
Int.Class C12Q 1/6876
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
 Appl.No PCT/US2025/030276 Applicant NEW YORK UNIVERSITY Inventor KEATING, Brendan
The present invention relates to methods of detecting a xenograft rejection in a subject, monitoring a xenograft rejection in a subject, or predicting a likelihood of a xenograft rejection in a subject, wherein the subject has received a xenograft transplantation, said methods comprising determination of expression levels of certain human or porcine genes and comparing expression levels of said genes.
10.WO/2025/241167SEQUENCING BUFFER SOLUTION AND METHOD FOR NANOPORE-BASED CAPTURE OF TARGET NUCLEIC ACID SEQUENCE
WO - 27.11.2025
Int.Class C12Q 1/6869
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6869Methods for sequencing
 Appl.No PCT/CN2024/095093 Applicant BGI SHENZHEN Inventor ZHONG, Peibin
Provided is a sequencing buffer solution and a method for the nanopore-based capture of a target nucleic acid sequence. The sequencing buffer solution comprises a molecular crowding agent. The method employs a nanopore to capture a target nucleic acid sequence from a sequencing buffer solution. The sequencing buffer solution and the method increase the probability that a sequencing library (or other target analyte) is captured by the nanopore protein during the sequencing process, thereby increasing sequencing data output.
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