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1 / 65,403
1.WO/2025/188906MODIFIED ADENOSINE NUCLEOTIDES
WO - 11.09.2025
Int.Class C07H 19/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
14Pyrrolo-pyrimidine radicals
 Appl.No PCT/US2025/018587 Applicant ILLUMINA, INC. Inventor CRESSINA, Elena
Embodiments of the present disclosure relate to modified adenosine nucleosides and nucleotides. Also provided herein are methods and kits for sequencing applications using such nucleotides.
2.20250283144ELEVATION OF GLYCOSAMINOGLYCANS IN SUBJECTS WITHOUT MUCOPOLYSACCHARIDOSIS
US - 11.09.2025
Int.Class C12Q 1/527
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
527involving lyase
 Appl.No 18265076 Applicant THE NEMOURS FOUNDATION Inventor Shunji TOMATSU

Provided are methods of using glycosaminoglycans (GAGs) levels in a biological sample as a means to diagnose, assess prognosis, and ascertain whether treatment is efficacious in a wide variety of diseases other than mucopolysaccharidoses (MPS). In certain embodiments, the methods relate to clinical diagnosis of viral or non-viral encephalopathy.

3.20250283174METHODS FOR ASSESSING THE EXHAUSTION OF HEMATOPOIETIC STEM CELLS INDUCED BY CHRONIC INFLAMMATION
US - 11.09.2025
Int.Class C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
 Appl.No 18862787 Applicant INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE Inventor Emmanuelle SIX

Engraftment of hematopoietic stems cells (HSCs) is a potentially life-saving treatment therapy for various conditions including genetic blood cell diseases. In particular, the use of allogeneic HSCs to treat genetic blood cell diseases has become a clinical standard: HSCs can be modified ex vivo and transferred back to the recipient to produce functional, terminally-differentiated cells. There is a medical need for methods for assessing the exhaustion of HSCs for optimizing their therapeutic use, in particular in the context of gene therapy. The inventors performed a clinical trial of lentivirus-based gene therapy for the treatment of X-linked chronic granulomatous disease. Two patients showed stable engraftment and clinical benefits, whereas the other two progressively lost gene-corrected cells. Single-cell transcriptomic analysis revealed a significantly lower frequency of the most immature hematopoietic stem cell (HSC) in CGD patients, more pronounced in patients with defective engraftment. The two patients with defective engraftment presented a profound change in HSC status, a high interferon score, and elevated myeloid progenitor counts. The inventors used elastic-net logistic regression to identify a set of interferon genes and transcription factors that predicted the failure of HSC engraftment. They identified a set of 51 interferon genes and transcription factors that were upregulated specifically in P2 and P5 (including IFI44L, STAT2, IRF9, MX1, SAMD9L, and CEBPB) and that appeared to be predictive of defective HSC engraftment. Accordingly, the identified biomarkers can be very suitable for assessing the exhaustion of hematopoietic stems cells.

4.20250281928MICROFLUIDIC VALVE AND METHOD OF MAKING SAME
US - 11.09.2025
Int.Class B01L 3/00
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
 Appl.No 18924435 Applicant HandyLab, Inc. Inventor Kalyan Handique

The present technology provides for a microfluidic substrate configured to carry out PCR on a number of polynucleotide-containing samples in parallel. The substrate can be a single-layer substrate in a microfluidic cartridge. Also provided are a method of making a microfluidic cartridge comprising such a substrate. Still further disclosed are a microfluidic valve suitable for use in isolating a PCR chamber in a microfluidic substrate, and a method of making such a valve.

5.WO/2025/188561PREDICTIVE MARKERS FOR IMMUNOTHERAPY
WO - 11.09.2025
Int.Class C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
 Appl.No PCT/US2025/017825 Applicant KITE PHARMA, INC. Inventor FILOSTO, Simone
The disclosure relates to methods of prognosis and therapy, compositions for immunotherapies, methods of improving said compositions, and immunotherapies using the same (e.g., T cells, non-T cells, TCR-based therapies, and CAR-based therapies).
6.20250283141CULTURE MEDIUM FOR HIGH-THROUGHPUT SEPERATION OF RHIZOBACTERIA FROM CROPS, PREPARATION METHOD AND APPLICATION THEREOF
US - 11.09.2025
Int.Class C12Q 1/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
 Appl.No 19212678 Applicant ECOLOGY INSTITUTE OF SHANDONG ACADEMY OF SCIENCES THE SINO JAPANESE FRIENDSHIP BIOTECHNOLOGY RES CEN Inventor Xinjian Zhang

The present invention relates to the technical field of the environmental microbiology, especially to culture medium for high-throughput separation of rhizobacteria from crops, preparation method and application thereof. The culture medium for high-throughput separation of crop rhizobacteria comprises a 1/l0 TSB medium and a culture medium additive (solution), wherein culture medium additive (solution) is obtained by mixing the crop plants with TSB medium and then by crushing, fermenting, filtering as well as sterilizing. By utilizing the interaction network between multiple microorganisms, crop-source nutrients are fermented using microbiome in-situ in the rhizosphere, and the fermented products are used as carbon and nitrogen source for separation of rhizosphere microorganisms, which can simulate the in-situ environment of rhizosphere microorganisms to the maximum extent, thereby obtaining more microbial species. Combined with the high-throughput separation method, culture medium provided by present invention can obtain more than 60% of bacterial species obtained by high-throughput sequencing.

7.20250283158BEACON-MEDIATED EXPONENTIAL AMPLIFICATION REACTION (BEAR) USING A SINGLE ENZYME AND PRIMER
US - 11.09.2025
Int.Class C12Q 1/6844
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
 Appl.No 19217836 Applicant The Governors of the University of Alberta Inventor Xiaochun Chris Le

There is described Beacon-mediated Exponential Amplification Reaction (BEAR) Using a Single Enzyme and Primer.

8.WO/2025/186177IN VITRO METHOD FOR THE DIFFERENTIAL DIAGNOSIS BETWEEN VIRAL AND BACTERIAL PNEUMONIA IN A PATIENT
WO - 11.09.2025
Int.Class C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
 Appl.No PCT/EP2025/055685 Applicant FUNDACIÓN PÚBLICA GALEGA INSTITUTO DE INVESTIGACIÓN SANITARIA DE SANTIAGO DE COMPOSTELA Inventor GÓMEZ CARBALLA, Alberto
The present invention refers to an in vitro method for identifying biomarkers or biomarker signatures for the differential diagnosis between viral and bacterial pneumonia in a patient, for the differential diagnosis between viral and bacterial pneumonia in a patient and/or for selecting a therapy for a patient suffering from pneumonia.
9.WO/2025/185727NORMAL SALINE MEDIUM PREVENTS CLOTTING OF MENSTRUAL BLOOD
WO - 11.09.2025
Int.Class G01N 33/86
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
86involving blood coagulating time
 Appl.No PCT/CN2025/081199 Applicant THE CHINESE UNIVERSITY OF HONG KONG Inventor WANG, Chi Chiu
Provided are a collection medium and uses thereof for preventing menstrual blood clotting and preserving cell viability in menstrual blood samples. Also provided are methods of using such collection medium for finding novel and potentially diagnostic and prognostic biomarkers in menstrual blood for different gynecological disease such as endometriosis, gynecological cancers, and other non-reproductive diseases. Also included are methods for employing a dye test for distinguishing between living and dead cells in a sample.
10.WO/2025/185637METHODS, COMPOSITIONS, AND KITS USEFUL FOR INFLAMMATORY BOWEL DISEASE (IBD) AND IBD SUBTYPES
WO - 11.09.2025
Int.Class C12Q 1/06
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
06Quantitative determination
 Appl.No PCT/CN2025/080596 Applicant MICROBIOTA I-CENTER (MAGIC) LIMITED Inventor NG, Siew Chien
Provided are methods for determining the risk of, diagnosing, preventing, or treating Crohn's Disease (CD), ulcerative colitis (UC) and/or inflammatory bowel disease (IBD) in an individual. Some embodiments provide kits and computer program products for determining the risk of or diagnosing Crohn's Disease (CD), ulcerative colitis (UC) and/or inflammatory bowel disease (IBD) in an individual. Other example embodiments are described herein. In certain embodiments, the disclosed methods and kits are accurate, cost-effective and non-invasive.
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