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Analysis

1.WO/2020/104577USE OF BACTERIAL EXTRACELLULAR VESICLES AS A BIOMARKER FOR INTESTINAL BARRIER PERMEABILITY AND MICROBIAL DYSBIOSIS
WO 28.05.2020
Int.Class C12Q 1/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
Appl.No PCT/EP2019/082054 Applicant UNIVERSITEIT GENT Inventor HENDRIX, An
The present invention relates to a method of analyzing a biofluid of a subject for the presence of bacterial extracellular vesicles (EV), said method comprising the steps of a) extracting bacterial EV from said biofluid, b) analyzing said bacterial EV-extracted molecular patterns for the presence of a disease marker, wherein said disease marker is a disease-specific molecular pattern of said subject; and said subject comprising patients diagnosed with HIV, IBD or cancer or said subject receiving a treatment.
2.WO/2020/106887SYSTEMS AND METHODS USING BACTERIOPHAGE-MEDIATED LYSIS FOR DETECTION AND IDENTIFICATION OF MICROORGANISMS IN A FLUID SAMPLE
WO 28.05.2020
Int.Class C12Q 1/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
Appl.No PCT/US2019/062480 Applicant BACTERIOSCAN, INC. Inventor TOMARAS, Andrew
An optical measurement instrument includes an optical cavity with a light source, a plurality of fluid containers, and an optical sensor. Each fluid container holds a test portion of a fluid sample containing an unknown microorganism, and either a distinct microorganism- attracting substance or a distinct growth-inhibiting substance. Each distinct microorganism- attracting or growth-inhibiting substance is configured to react with a single type of microorganism. The instrument incubates the test portions of the fluid sample within the fluid containers. When using microorganism-attracting substances, the presence of microorganism growth within one of the fluid containers simultaneously indicates the presence and identity of the unknown microorganism. When using growth-inhibiting substances, the absence of microorganism growth within one of the fluid containers simultaneously indicates the presence and identity of the unknown microorganism. The incubated test portions of the fluid sample can be compared to an incubated control portion of the fluid sample.
3.WO/2020/106897METHODS AND MATERIALS FOR DETECTING SALMONELLA IN BEEF
WO 28.05.2020
Int.Class G01N 1/28
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
1Sampling; Preparing specimens for investigation
28Preparing specimens for investigation
Appl.No PCT/US2019/062493 Applicant BRANDT, Alex Inventor BRANDT, Alex
Materials and methods for detecting Salmonella in beef are provided herein.
4.WO/2020/105626MARKER FOR PREDICTING PROGNOSIS OF PANCREATIC TUMOR
WO 28.05.2020
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
Appl.No PCT/JP2019/045244 Applicant KANSAI MEDICAL UNIVERSITY EDUCATIONAL CORPORATION Inventor ISHIDA, Mitsuaki
The present invention addresses the problem of providing a biomarker which enables prediction of the prognosis of a patient with a tumor on the basis of the nature of tumor cells themselves. In the present invention, the prognosis of a pancreatic tumor of a subject is predicted by a method for detecting a marker for predicting the prognosis of a pancreatic tumor, the method comprising the step of detecting adipophilin in pancreatic tumor cells collected from the subject.
5.WO/2020/106906METHODS FOR TARGETED NUCLEIC ACID LIBRARY FORMATION
WO 28.05.2020
Int.Class C12N 15/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
Appl.No PCT/US2019/062507 Applicant AVIDA BIOMED, INC. Inventor WANG, Heng
The present disclosure provides targeted hybridization and/or proximity ligation of a probe for amplification and analysis of target sequences. The hybridization of the probe to the target sequences can be direct or through indirect association.
6.WO/2020/106915METHODS OF TREATING CANCERS
WO 28.05.2020
Int.Class A61K 31/7048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7048having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
Appl.No PCT/US2019/062525 Applicant FOGHORN THERAPEUTICS INC. Inventor CENTORE, Richard, C.
The present invention relates to methods and compositions for the treatment of BAF-related disorders such as melanoma, prostate cancer, breast cancer, bone cancer, renal cell carcinoma, and hematologic cancer.
7.WO/2020/105873DIGNOSTIC KIT AND WHOLE GENOME SEQUENCE IDENTIFICATION METHOD WHICH USE AMPLIFICATION OF WHOLE GENOME OF HUMAN ALPHA CORONAVIRUS
WO 28.05.2020
Int.Class C12Q 1/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
Appl.No PCT/KR2019/013984 Applicant KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE Inventor KIM, Seil
The present invention relates to a method for obtaining a whole genome sequence for determining the presence of infection by coronavirus, and a use thereof. A method, a kit and a composition of the present invention comprise a set of 11 universal primers capable of amplifying the genomic sequence of coronavirus, thereby enabling easy and rapid identification of the presence of a target virus in a sample and related diseases. In addition, through whole genome sequencing, mutations of novel coronavirus can be identified so as to be effectively used in the identification of novel viruses.
8.WO/2020/106483USE OF IRE1ALPHA-XBP1 SIGNALING PATHWAY BIOMARKERS FOR MODULATING IMMUNE RESPONSES
WO 28.05.2020
Int.Class A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Appl.No PCT/US2019/060749 Applicant DANA-FARBER CANCER INSTITUTE, INC. Inventor GLIMCHER, Laurie, H.
The present invention is based, in part, on the identification of an IRE1α-XBP1- cMyc axis in NK cell immunity. The present invention provides compositions and methods for treating conditions that would benefit from modulating (e.g., upregulating or downregulating) an immune response using an agent that modulates the IRE1α-XBP1 pathway, or a composition comprising modified NK cells.
9.WO/2020/106633COMPOSITIONS AND METHODS FOR DETECTION OF CLEAVAGE OF GENOMIC DNA BY A NUCLEASE
WO 28.05.2020
Int.Class C12Q 1/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
34involving hydrolase
Appl.No PCT/US2019/062040 Applicant STAMATOYANNOPOULOS, John Inventor STAMATOYANNOPOULOS, John
Provided herein are methods and compositions for use in detecting on-target and/or off-target cleavage of genomic DNA in a cell by a nuclease. The on-target and off-target cleavage is detected by using oligonucleotides that bind to the single-stranded 3'-overhang created at the cleavage site. The nuclease may be an engineered nuclease comprising a nucleic acid binding domain that binds to a target nucleic acid of interest.
10.WO/2020/106853COMPOSITIONS AND METHODS FOR INTERNAL CONTROLS OF MICROVESICLE ISOLATIONS
WO 28.05.2020
Int.Class C12N 7/02
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
02Recovery or purification
Appl.No PCT/US2019/062429 Applicant EXOSOME DIAGNOSTICS, INC. Inventor STOLL, Georg
The present disclosure provides compositions, methods and kits for internal controls of microvesicle isolations. The compositions, methods and kits can comprise enveloped viruses, including, but not limited to, inactive mouse hepatitis virus (MHV).