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Analysis

1 / 66,323
1.WO/2026/000762MICROFLUIDIC CHIP AND INFLUENZA A VIRUS DETECTION KIT
WO - 02.01.2026
Int.Class B01L 3/00
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
 Appl.No PCT/CN2024/130123 Applicant SHENZHEN YHLO BIOTECH CO., LTD. Inventor WANG, Yuning
The present application belongs to the field of in vitro diagnostics, and particularly relates to a microfluidic chip and an influenza A virus detection kit. The chip comprises a cover plate, a first holding plate, a second holding plate and a bottom plate arranged in sequence from top to bottom, wherein the cover plate is provided with a first sample-loading cavity; the first holding plate is provided with a second sample-loading cavity, a first buffer cavity and a test paper cavity that are connected in sequence by means of a flow channel; and the second holding plate is provided with a reaction cavity, a second buffer cavity and a water absorption cavity that are connected in sequence by means of a flow channel. The microfluidic chip is ingeniously configured as an integrated small detection device. The structure of the microfluidic chip is located on different chip layers, thereby ensuring the independent operation of each operation unit. The aligned buffer cavities are provided between two interlayers, and the design of the buffer cavities enables a product to be fully and uniformly diluted; a sliding device can precisely control the release of a dilution; and the water absorption cavity can absorb the redundant dilution, thereby ensuring that a chromatography test strip can clearly and accurately display the result. By means of the device, the effects of simplifying test steps and preventing contamination can be achieved.
2.WO/2026/000927CENTRIFUGAL MICROFLUIDIC PLATFORM AND NUCLEIC ACID EXTRACTION AND AMPLIFICATION METHOD THEREFOR
WO - 02.01.2026
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
 Appl.No PCT/CN2024/143860 Applicant ZHEJIANG PUSHKANG BIOTECHNOLOGY CO., LTD. Inventor YU, Bo
A centrifugal microfluidic platform and a nucleic acid extraction and amplification method therefor. The centrifugal microfluidic platform comprises a disk body and at least one microfluidic structure. Each of the at least one microfluidic structure comprises a sample storage tank, a first reaction tank, a non-polar solution storage tank, a non-polar solution accommodation tank, an elution tank, a polar solution storage tank, and a back-end reaction module. The first reaction tank is connected to the sample storage tank, and the non-polar solution storage tank is connected to the first reaction tank. A first end of the non-polar solution accommodation tank is connected to the first reaction tank by means of a bridge, and a first end of the elution tank is connected to a second end of the non-polar solution accommodation tank by means of a bridge. The polar solution storage tank is connected to the elution tank, and the back-end reaction module is connected to the elution tank.
3.WO/2026/001002DUAL-TARGET MIRNA DETECTION METHOD BASED ON CRISPR AND ROLLING CIRCLE AMPLIFICATION
WO - 02.01.2026
Int.Class C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
 Appl.No PCT/CN2025/076820 Applicant HAINAN YILING MEDICAL INDUSTRY & DEVELOPMENT CO.LTD Inventor SU, Xueming
A dual-target miRNA detection method based on CRISPR and rolling circle amplification, comprising the following steps: (1) mixing a padlock probe, a ligation DNA, miRNA-21, and miRNA-155, performing annealing, incubating with a DNA ligase in a ligase reaction buffer system, and then terminating the reaction by means of heat treatment to obtain a circular DNA template; (2) incubating the circular DNA template with a DNA polymerase, dNTPs, recombinant albumin, a primer, and a polymerase reaction buffer, and then terminating the reaction by means of heat treatment to obtain an RCA product; (3) adding pre-assembled Cas12a-crRNA, the RCA product, and an FQ fluorescent probe to a buffer, and incubating; and (4) measuring fluorescence signals. By means of optimizing the detection system, the detection of dual-target miRNAs is successfully achieved, and the detection sensitivity is high.
4.WO/2026/004362METHOD FOR PRODUCING MAMMALIAN CELLS LABELED BY CHROMOPROTEIN, AND METHOD FOR SCREENING CHROMOPROTEIN
WO - 02.01.2026
Int.Class C12N 5/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
 Appl.No PCT/JP2025/017189 Applicant HAMAMATSU PHOTONICS K.K. Inventor TAKEUCHI Kozo
Provided are: a method for producing mammalian cells labeled by a chromoprotein that includes culturing, at less than 37° C, mammalian cells into which a nucleic acid that expresses a chromoprotein has been introduced; and a method for screening a chromoprotein that includes culturing, at less than 37° C, mammalian cells into which a nucleic acid that expresses a candidate protein has been introduced and evaluating the visible light absorption of the mammalian cells.
5.WO/2026/001362BIOSYNTHESIS CHIP AND BIOSYNTHESIS DEVICE
WO - 02.01.2026
Int.Class C40B 40/06
CCHEMISTRY; METALLURGY
40COMBINATORIAL TECHNOLOGY
BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
40Libraries per se, e.g. arrays, mixtures
04Libraries containing only organic compounds
06Libraries containing nucleotides or polynucleotides, or derivatives thereof
 Appl.No PCT/CN2025/094276 Applicant BOE TECHNOLOGY GROUP CO., LTD. Inventor LIU, Haonan
Provided are a biosynthesis chip and a biosynthesis device. The biosynthesis chip comprises a substrate, a plurality of electrode units and a plurality of modification structures, wherein the plurality of electrode units are located on the substrate, and are configured to provide a voltage for monomer synthesis; and the plurality of modification structures are located on the substrate, and are configured to provide an active group for the monomer synthesis. Each electrode unit corresponds to at least two modification structures, and the at least two modification structures are arranged spaced apart from each other, such that a targeted and selective reaction with a biomonomer can be carried out, thereby improving the selectivity of biosynthesis and the accuracy of biodetection. Moreover, each modification structure facilitates the provision of sufficient reaction space and resources for biosynthesis, interference and competition between reaction regions are small, the plurality of modification structures which are arranged spaced apart from each other can respond quickly, and have high biosynthesis efficiency, which is beneficial to achieving a high-throughput biosynthesis effect.
6.WO/2026/003132NUCLEIC ACID NANOSTRUCTURE SENSOR DEVICE
WO - 02.01.2026
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
 Appl.No PCT/EP2025/067998 Applicant UCL BUSINESS LTD Inventor HOWORKA, Stefan
Nanostructure sensor devices are provided that are capable of measuring mechanical properties associated with semifluid membranes. The nanoscale structures comprise a probing tip that can apply a force to the membrane to induce a deformation. The determination of the amount of deformation of the semifluid membrane can be converted into a measurement of a mechanical property associated with the semifluid membrane. The membranes may be synthetic or comprised within biological systems such as vesicles or cells. Methods for using the nanostructure sensors are also provided.
7.WO/2026/005967SYSTEMS AND METHODS FOR DYNAMIC FORCE SPECTROSCOPY IN DRUG DISCOVERY
WO - 02.01.2026
Int.Class G01N 27/74
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
72by investigating magnetic variables
74of fluids
 Appl.No PCT/US2025/032488 Applicant ERUDIO BIO, INC. Inventor PAIK, Kee-Hyun
Described are systems and methods for identifying an analyte in drug discovery and development. A method can include directing a solution having the analyte to a surface having a capture moiety coupled thereto, wherein the analyte is coupled to a force transmitter comprising a magnetically-attractable particle; using the capture moiety to capture the analyte; applying a magnetic field to the magnetically-attractable particle, wherein the magnetic field has a magnetic field condition that is sufficient to direct the analyte and the magnetically-attractable particle coupled thereto away from the capture moiety; and using the magnetic field condition to identify at least one event of the analyte, wherein the magnetic field condition comprises a time-varying force, at least one period of time, at least one motion path, or any combination thereof.
8.WO/2026/006432SEQUENCING METHODS WITH PARTITIONING
WO - 02.01.2026
Int.Class C12Q 1/6869
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6869Methods for sequencing
 Appl.No PCT/US2025/035226 Applicant GUARDANT HEALTH, INC. Inventor KENNEDY, Andrew
Sequencing methods for sequencing populations of nucleic acid molecules in which sequencing reads of amplicons are grouped into families according to the nucleic acid molecule of origin by partitioning, sample indexes and information from the sequencing reads, such as start and end points. The methods described herein provide many advantages, including the identification of sequencing reads deriving from the same nucleic acid in the original sample while minimizing the number of aliquots that are processed.
9.WO/2026/003176BIOMARKERS FOR PRE-ECLAMPSIA
WO - 02.01.2026
Int.Class C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
 Appl.No PCT/EP2025/068081 Applicant QUEEN MARY UNIVERSITY OF LONDON Inventor MARULASIDDAPPA, Pradeepa Madapura
Provided herein are methods for diagnosing pre-eclampsia, methods for determining the risk of a subject developing pre-eclampsia, as well as methods for preventing and treating pre-eclampsia should the subject be found to have, or be at risk of developing, pre-eclampsia. The methods involve determining a level of at least three transposable element subfamilies in a sample, wherein differential expression of the transposable element subfamilies relative to reference values indicates that the subject is at risk of developing, or has, pre-eclampsia.
10.WO/2026/000326KASP MOLECULAR MARKER CLOSELY LINKED TO CHILI FRUIT LENGTH, PRIMER, KIT, AND USE
WO - 02.01.2026
Int.Class C12Q 1/6895
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6888for detection or identification of organisms
6895for plants, fungi or algae
 Appl.No PCT/CN2024/102202 Applicant HUNAN AGRICULTURAL UNIVERSITY Inventor OU, Lijun
A KASP molecular marker closely linked to chili fruit length. With the Zhangshugang version of the gene as a reference gene, the single nucleotide polymorphism at position 3333878 of chromosome 3 of chilies is a replacement of an A base with a T that occurs at the position. Also disclosed are a primer and kit for identifying the molecular marker closely linked to the chili fruit length gene and use thereof in identifying chili fruit length or in molecular-assisted breeding. The molecular marker can be used to rapidly screen for satisfactory plants, effectively reducing the planting scale, reducing the workload for subsequent identification, and improving the efficiency and accuracy of selection. The present invention is of great significance for the research on the fruit length formation mechanism. Therefore, the present invention is of great significance for the practice of fruit shape breeding of chili fruits and the research on the fruit shape change and regulation mechanisms.
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