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1.WO/2021/011881IMMOBILIZED ENZYME COMPOSITIONS FOR THE PRODUCTION OF HEXOSES
WO 21.01.2021
Int.Class C12N 9/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
Appl.No PCT/US2020/042562 Applicant BONUMOSE LLC Inventor WICHELECKI, Daniel, Joseph
The invention relates to immobilized enzyme compositions for the preparation of a hexose. Hexoses include, for example, tagatose, psicose, fructose, allose, mannose, galactose, altrose, talose, sorbose, gulose, idose, and inositol. The invention also relates to an enzymatic process for preparing a hexose from a saccharide by contacting a starch derivative with an immobilized enzyme composition of the invention.
2.WO/2021/010822INTEGRATED SYSTEM FOR BIOCATALYTICALLY PRODUCING AND RECOVERING AN ORGANIC SUBSTANCE
WO 21.01.2021
Int.Class C12P 5/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
5Preparation of hydrocarbons
Appl.No PCT/NL2020/050421 Applicant DELFT ADVANCED BIOFUELS B.V. Inventor OUDSHOORN, Arjan
The invention relates to a method for recovering a biocatalytically produced organic substance from a reaction mixture, comprising - providing a reaction mixture, wherein the organic substance is produced using a biocatalyst, which reaction mixture comprises a substrate for the biocatalyst in a continuous aqueous phase, and wherein further a product recovery phase is present into which the organic substance migrates or onto which the organic substance absorbs or adsorbs; and - separating the product recovery phase comprising the produced substance from the aqueous phase and the biocatalyst. The invention further relates to a bioreactor system for biocatalytically producing a substance, comprising an apparatus, said apparatus comprising a reaction compartment (11) situated in a lower part of the apparatus and a separator compartment (9).
3.WO/2021/010101FUSION PROTEIN, SUBSTANCE PRODUCTION METHOD, VECTOR, TRANSFORMED CELL, PNEUMATIC TIRE PRODUCTION METHOD, AND RUBBER PRODUCT PRODUCTION METHOD
WO 21.01.2021
Int.Class C12N 15/62
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
62DNA sequences coding for fusion proteins
Appl.No PCT/JP2020/024525 Applicant SUMITOMO RUBBER INDUSTRIES, LTD. Inventor YAMAGUCHI, Haruhiko
The present invention aims to provide: a fusion protein that has enzymatic activity for synthesizing a hydrophobic compound and can bind to oil droplets; a method for producing a substance that accumulates a hydrophobic compound inside an oil droplet, using the fusion protein; a vector that improves the productivity of the hydrophobic compound by being introduced to cells using genetic recombination technology; and transformed cells that have introduced thereto the vector or a gene that codes the fusion protein. This invention pertains to a fusion protein that has: an amino acid sequence (first amino acid sequence) that can bind to oil droplets (lipid droplets); and an amino acid sequence (second amino acid sequence) having an enzymatic activity that binds hydrophobic compounds. The first amino acid sequence and the second amino acid sequence fuse via a linker sequence (third amino acid sequence) and the enzymatic activity of the second amino acid sequence is maintained.
4.WO/2021/010341PRODUCTION METHOD OF ORGANISM-DERIVED SUBSTANCE, PRODUCTION METHOD OF PRODUCT, AND VOLTAGE APPLICATION DEVICE
WO 21.01.2021
Int.Class C12M 1/42
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
42Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave
Appl.No PCT/JP2020/027109 Applicant FUJIFILM CORPORATION Inventor NAGAI, Yoichi
The production method according to the present disclosure is for producing an organism-derived substance having introduced therein a bioactive substance, the production method including a step for causing a suspension including the bioactive substance and the organism-derived substance yet to be introduced with the bioactive substance, to pass through a first electric field region having a first electric field intensity, and a step for causing the suspension, after passing through the first electric field region, to pass through a second electric field region having a second electric field intensity which is lower than the first electric field intensity. The organism-derived substance is a human-derived cell.
5.WO/2021/011211A THERMOCYCLING PCR CHIP MADE OF TRANSPARENT GRAPHENE CONDUCTIVE FILM
WO 21.01.2021
Int.Class C12Q 1/686
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
686Polymerase chain reaction
Appl.No PCT/US2020/040848 Applicant ZHU, Guozhi Inventor ZHU, Guozhi
In the present invention, graphene Transparent Conductive Film (TCF) is integrated into a disposable PCR chip in which PCR reaction containers are sandwiched by two graphene TCFs. PCR is performed by thermocycling of the on-chip two graphene TCF simultaneously. A temperature sensor in the PCR chip is to measure the chip temperature in a real-time manner during PCR reaction, and to provide a feedback to control the thermocycling of the graphene TCF.
6.WO/2021/010264BIOSURFACTANT-PRODUCING RECOMBINANT MICROORGANISM
WO 21.01.2021
Int.Class C12P 19/44
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
44Preparation of O-glycosides, e.g. glucosides
Appl.No PCT/JP2020/026760 Applicant NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY Inventor MORITA, Tomotake
Provided is a means for increasing mannosylerythritol lipid (MEL) production efficiency. The present invention is a mannosylerythritol lipid-producing microorganism transformed by an expression vector having a gene that encodes a lipase under regulation by E5Pgap promoter or E5Ptef promoter.
7.WO/2021/011793IMPROVED METHOD FOR PRODUCING ISOMALTO-OLIGOSACCHARIDES
WO 21.01.2021
Int.Class C12P 19/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
04Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
Appl.No PCT/US2020/042367 Applicant DANISCO US INC Inventor KOOPS, Bart C.
Described is a method for producing improved isomalto-oligosaccharides (IMO) from maltodextrins. The improved method involves the complete or partial replacement of β-amylase, as used in a conventional method, with a selected α-amylase. The resulting IMO have longer chain-length and reduced residual glucose content compared to IMO produced using a conventional method.
8.WO/2021/008549NOVEL COMPOUND AND PHARMACEUTICAL COMPOSITION
WO 21.01.2021
Int.Class C07H 17/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04Heterocyclic radicals containing only oxygen as ring hetero atoms
08Hetero rings containing eight or more ring members, e.g. erythromycins
Appl.No PCT/CN2020/102060 Applicant SHENYANG FUYANG PHARMACEUTICAL TECHNOLOGY CO., LTD. Inventor JIANG, Enhong
The present invention belongs to the field of pharmaceutical chemistry. Specifically, the present invention relates to a novel compound and a pharmaceutical composition. The novel compound has a structural formula represented by formula (1). A method to obtain the novel compound is simple to implement, and therein a novel separation and purification method is used to separate and purify Carrimycin. It was unexpectedly found that when a small amount of the novel compound was contained in a Carrimycin composition, a synergistic effect was produced, and the antibacterial effect was improved.
9.WO/2021/010346NEUTRALIZING ANTIBODY FOR TOOTH REGENERATION TREATMENT TARGETING USAG-1 MOLECULE
WO 21.01.2021
Int.Class A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
Appl.No PCT/JP2020/027127 Applicant KYOTO UNIVERSITY Inventor TAKAHASHI, Katsu
Provided are: an antibody which specifically binds to and neutralizes USAG-1 or an antigen-binding fragment thereof; and a pharmaceutical composition containing the antibody or the antigen-binding fragment.
10.WO/2021/009550PREPARATION OF IMMOBILIZED ENZYMES
WO 21.01.2021
Int.Class C12N 11/14
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
11Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
14Enzymes or microbial cells immobilised on or in an inorganic carrier
Appl.No PCT/IB2019/056159 Applicant RHODIA BRASIL LTDA Inventor GODOY, Laura
A process for the preparation of a catalytic system comprising an enzyme covalently bound to the surface of a precipitated silica carrier, the catalytic system obtained therefrom and its uses. The catalytic system may be advantageously used for the transesterification reaction of fatty acid feedstock with short chain alcohols to obtain fatty acid esters of short chain alcohols.