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Analysis

1.WO/2021/000969NUCLEIC ACID SEQUENCE EXPRESSING SARS-COV-2 VIRUS ANTIGEN PEPTIDE AND USE THEREOF
WO 07.01.2021
Int.Class C12N 15/50
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31Genes encoding microbial proteins, e.g. enterotoxins
33Genes encoding viral proteins
40Proteins from RNA viruses, e.g. flaviviruses
50Coronaviridae, e.g. infectious bronchitis virus, transmissible gastroenteritis virus
Appl.No PCT/CN2020/110086 Applicant GUANGZHOU N BIOMED LTD. Inventor CHEN, Ling
Provided are a nucleic acid expressing SARS-CoV-2 virus antigen peptide and a use thereof. The sequence of the nucleic acid is Seq ID No. 1 or 2, or a sequence having at least 90% homology thereto. The nucleic acid sequences can be effectively expressed in human cells, produce corresponding polypeptides, and induce the production of a corresponding immunological protective response.
2.111996216腺相关病毒介导的新型冠状病毒抗体诱导物及疫苗组合物
CN 27.11.2020
Int.Class C12N 15/864
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
864Parvoviral vectors
Appl.No 202010903143.9 Applicant 中国科学技术大学 Inventor 薛天
本发明提供一种基于腺相关病毒的新型冠状病毒的抗体诱导物,其能够在体内诱导产生针对新型冠状病毒的抗体,以及提供包含该抗体诱导物的病毒载体及疫苗组合物。
3.111978377COVID-19抗原、制备方法和应用
CN 24.11.2020
Int.Class C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No 202010657369.5 Applicant 苏州和锐生物科技有限公司 Inventor 陈菲
本发明公开了COVID‑19抗体检测的重要抗原表位SEQ ID:01和SEQ ID:02,含有该抗原表位的重组蛋白可用于抗COVID‑19的IgM和IgG等抗体检测的制备。抗COVID‑19的抗体检测试剂是新冠病毒核酸检测的有效补充,可用于筛查新冠病毒的接触者,以及获得免疫力的人群。本发明克服了单一S蛋白抗原表位不足,抗COVID‑19的IgM抗体检测灵敏度不足等问题,用含有SEQ01‑04新表位的重组蛋白制备的抗新冠抗体检测试剂具有灵敏度高、性能稳定、定性准确等优点。
4.WO/2020/229249MODIFIED S2 SUBUNIT OF THE CORONAVIRUS SPIKE PROTEIN
WO 19.11.2020
Int.Class C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No PCT/EP2020/062528 Applicant BOEHRINGER INGELHEIM VETMEDICA GMBH Inventor KRAEMER-KUEHL, Annika
The present invention relates i.a. to a recombinant avian coronavirus spike protein or fragment thereof comprising a mutation at amino acid position 865. Further, the present invention relates to an immunogenic composition comprising an avian coronavirus with such spike protein.
5.111925998模拟SARS-CoV-2感染的系统及其制备方法与应用
CN 13.11.2020
Int.Class C12N 7/01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
01Viruses, e.g. bacteriophages, modified by introduction of foreign genetic material
Appl.No 202010518211.X Applicant 广州再生医学与健康广东省实验室 Inventor 李鹏
本发明涉及生物技术领域,具体而言,涉及一种模拟SARS‑CoV‑2感染的系统及其制备方法与应用。所述系统包括含有SARS‑CoV‑2的S蛋白及报告基因的假病毒以及宿主细胞;所述宿主细胞过表达人ACE2基因,并表达胞内信号缺失型CD19基因。该系统不需要BSL‑3级别实验室即可进行SARS‑CoV‑2相关的中和抗体以及药物筛选等研究,降低实验成本;并且过表达人ACE2的细胞可以通过胞内信号缺失的CD19标签被磁珠分选和富集,缩短了细胞系建模时间并且节约大量建模成本。
6.111848754新型冠状病毒N蛋白重组抗原及其用途
CN 30.10.2020
Int.Class C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No 202010798708.1 Applicant 四川大学华西医院 Inventor 李为民
本发明公开了一种新型冠状病毒N蛋白重组抗原及其用途,属于蛋白免疫检测试剂领域。所述重组抗原是一种蛋白,其氨基酸序列如SEQ ID NO.1或3所示。将该重组抗原用于制备检测N蛋白抗体的试剂,相比N蛋白全长抗原,能提高试剂的热稳定性和检测的准确性。
7.111793651用于COVID-19药物筛选的慢病毒表达载体及其构建方法
CN 20.10.2020
Int.Class C12N 15/867
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
867Retroviral vectors
Appl.No 202010700324.1 Applicant 广东源心再生医学有限公司 Inventor 林彬
本发明公开了一种用于COVID‑19药物筛选的慢病毒表达载体的构建方法,其是以pCW‑Cas9‑Blast为骨架载体,将nCoVN cDNA亚克隆到所述骨架载体中,构成新型冠状病毒核衣壳蛋白的慢病毒表达载体pCW‑Puro‑T2A‑nCoVN;其中,所述nCoVN cDNA带有一个6×his标签和嘌呤霉素抗性基因。本发明所构建的用于COVID‑19药物筛选的慢病毒表达载体对实验环境要求低,常规实验室即可操作,可高通量操作,仅需2天即可构建载体并大量获得。
8.111778264基于新型腺病毒载体Sad23L和/或Ad49L的新型冠状病毒肺炎疫苗
CN 16.10.2020
Int.Class C12N 15/50
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31Genes encoding microbial proteins, e.g. enterotoxins
33Genes encoding viral proteins
40Proteins from RNA viruses, e.g. flaviviruses
50Coronaviridae, e.g. infectious bronchitis virus, transmissible gastroenteritis virus
Appl.No 202010675912.4 Applicant 广州佰芮慷生物科技有限公司 Inventor 罗升学
本发明公开了一种基于新型腺病毒载体Sad23L和/或Ad49L的新型冠状病毒肺炎COVID‑19疫苗。通过优化外源基因使得外源蛋白的表达能够明显提高,同时进一步尝试使用人稀有或者猴的腺病毒作为载体,逃避预存的针对常见腺病毒的免疫反应,本发明获得的新型冠状病毒肺炎COVID‑19疫苗能够在动物体内诱导产生高水平的体液和细胞免疫,在动物免疫之后没有发现副作用的出现。本发明新型冠状病毒肺炎COVID‑19疫苗是安全有效且可以进行快速大量的制备,因此是可用于预防SARS‑CoV‑2的感染的候选疫苗株。
9.111778271一种表达SARS-CoV-2 N蛋白的重组质粒、重组菌及构建方法和应用
CN 16.10.2020
Int.Class C12N 15/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
70Vectors or expression systems specially adapted for E. coli
Appl.No 202010706688.0 Applicant 梁建国 Inventor 梁建国
本发明提供了一种表达SARS‑CoV‑2 N蛋白的重组质粒、重组菌及构建方法和应用,属于疫苗技术领域,所述重组质粒以pET‑N‑GST‑Thrombin‑C‑His为骨架质粒,插入有编码SARS‑CoV‑2 N蛋白的基因的全长序列。本发明采用pET‑N‑GST‑Thrombin‑C‑His表达载体表达SARS‑CoV‑2 N蛋白(新冠病毒核蛋白),SARS‑CoV‑2 N蛋白的表达量高,且表达得到的SARS‑CoV‑2 N蛋白能够保持良好的蛋白活性,进而能够应用于多个免疫学检测平台,来辅助监控新冠病毒的感染和爆发。
10.111732638一种针对SARS-CoV-2的疫苗
CN 02.10.2020
Int.Class C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No 202010632922.X Applicant 重庆博唯佰泰生物制药有限公司 Inventor 傅文彬
本发明提供一种针对SARS‑CoV‑2的疫苗。本发明采用改造后的SARS‑CoV‑2的S蛋白,尤其是氨基酸序列如SEQ ID NO:2、如SEQ ID NO:3或者SEQ ID NO:4所示蛋白质用于制备疫苗制剂,具有较好的免疫原性,为治疗SARS‑CoV‑2引起的疾病提供了新的方案。