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1.20250015154MUTANTES DE ACETIL-COENZIMA A CARBOXILASA
CO 07.11.2025
Int.Class C12N 15/82
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
82for plant cells
Appl.No 20250015154 Applicant CIBUS EUROPE B.V. Inventor Gregory F.W. GOCAL
La presente descripción proporciona plantas y/o células vegetales que portan una o más mutaciones en un gen de acetil-coenzima A carboxilasa (ACCasa), y métodos para elaborar y utilizar dichas plantas. En algunas modalidades, las plantas y/o células vegetales son resistentes o tolerantes a un herbicida que se dirige a la acetil-coenzima A carboxilasa.
2.P20251060SELF-ASSEMBLING PROTEIN NANOSTRUCTURES DISPLAYING PARAMYXOVIRUS AND/OR PNEUMOVIRUS F PROTEINS AND THEIR USE
HR 07.11.2025
Int.Class C07K 14/195
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
Appl.No P20251060T Applicant University of Washington Inventor Neil P. King
3.20250015120PROTEÍNA DE UNIÓN A ANTÍGENO PARA HCLDN6 Y USO DE LA MISMA
CO 07.11.2025
Int.Class C12N 15/13
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
13Immunoglobulins
Appl.No 20250015120 Applicant AXCYNSIS THERAPEUTICS PTE. LTD. Inventor Bin ZOU
Se proporciona una proteína de unión a antígeno para hCLDN6 y su uso. Dicha proteína de unión a antígeno comprende una región variable de cadena pesada. La región variable de cadena pesada tiene HCDR1 con una secuencia de aminoácidos de X1YTMS; HCDR2 con una secuencia de aminoácidos de TISSGGGX2TYYPDSVKG en donde X2 = R, N, Q, D o E; y HCDR3 con una secuencia de aminoácidos de GDX4RYDX3FAY en donde X4 = Y, N o Q, en donde (1) X1 = Y, M, Q, D o E, y X3 = G; o (2) X1 = S o D, y X3 = A. Se proporcionan nuevos anticuerpos humanizados dirigidos contra CLDN6, y diferentes composiciones basadas en estos anticuerpos, que tienen mejor actividad inhibidora de la proliferación celular y actividad inhibidora de tumores, proporcionando así nuevos medios para el diagnóstico y tratamiento del cáncer.
4.20250015075PLÁSMIDOS REP-CAP MODIFICADOS Y USOS DE LOS MISMOS
CO 07.11.2025
Int.Class C12N 15/86
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
Appl.No 20250015075 Applicant DECIBEL THERAPEUTICS, INC. Inventor Sandra Danielle ABBOTT
La descripción proporciona plásmidos rep-cap modificados que contienen un sistema de expresión inducible por tetraciclina que puede usarse para producir vectores de VAA1 recombinantes
5.3041112SYNTHETIC GENOME EDITING SYSTEM
ES 07.11.2025
Int.Class C12N 15/62
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
62DNA sequences coding for fusion proteins
Appl.No 22793205 Applicant Pencil Biosciences Limited Inventor IBRAHIM, Mohamed Rajik Mohamed
6.20250015177COMPUESTOS Y MÉTODOS PARA REDUCIR LA EXPRESIÓN DE PLN
CO 07.11.2025
Int.Class A61K 31/712
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
712Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
Appl.No 20250015177 Applicant IONIS PHARMACEUTICALS, INC. Inventor Dieter A. KUBLI
Se proporcionan compuestos oligoméricos, métodos, y composiciones farmacéuticas para reducir la cantidad o actividad de ARN de PLN en una célula o animal, y en ciertos casos reducir la cantidad de la proteína fosfolamban en una célula o animal. Tales compuestos oligoméricos, métodos, y composiciones farmacéuticas son útiles para tratar la miocardiopatía, insuficiencia cardíaca, o arritmia.
7.P20251051ANTI-CD3 ANTIBODY, AND MOLECULE CONTAINING SAID ANTIBODY
HR 07.11.2025
Int.Class C12N 15/09
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
Appl.No P20251051T Applicant Daiichi Sankyo Company, Limited Inventor Tohru Takahashi
8.20250015074TERAPIA GÉNICA DIRIGIDA PARA LA DISTROFIA MIOTÓNICA DM-1
CO 07.11.2025
Int.Class C12N 7/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
Appl.No 20250015074 Applicant GENZYME CORPORATION Inventor Sarah Melissa JACOBO
En la presente se proporcionan moléculas de ARNi para tratar la distrofia miotónica tipo 1 (DM1). En la presente se proporcionan además casetes de expresión, vectores (por ejemplo, rAAV), partículas virales y composiciones farmacéuticas que contienen el ARNi. Aún más, en la presente se proporcionan métodos y kits relacionados con el uso del ARNi, por ejemplo, para tratar DM1.
9.3041133NEW RECOMBINANT DIAMINE OXIDASE AND ITS USE FOR THE TREATMENT OF DISEASES CHARACTERIZED BY EXCESS HISTAMINE
ES 07.11.2025
Int.Class C12N 9/06
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
02Oxidoreductases (1.), e.g. luciferase
06acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7)
Appl.No 20704547 Applicant Medizinische Universität Wien Inventor BÖHM, Thomas
10.P20251062NON-HUMAN ANIMALS HAVING A HUMANIZED SIGNAL-REGULATORY PROTEIN GENE
HR 07.11.2025
Int.Class A01K 67/027
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
027New or modified breeds of vertebrates
Appl.No P20251062T Applicant Regeneron Pharmaceuticals, Inc. Inventor Andrew J Murphy