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1.WO/2021/008867REINFORCED BIOREACTOR COMPONENT STRUCTURE SYSTEM FOR CELL CULTIVATION
WO 21.01.2021
Int.Class B01L 3/02
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
02Burettes; Pipettes
Appl.No PCT/EP2020/068356 Applicant GLOBAL LIFE SCIENCES SOLUTIONS USA LLC Inventor TUOHEY, Colin
The present invention relates to a bioprocess bag (118) comprising a bag wall defining an enclosed volume for holding biomaterials. The bag wall comprises at least one inlet port (142) and at least one outlet port (146). The bioprocess bag (118) also comprises a tube structure (400) comprising a first opened-end proximate the bag wall and a second distal end, the tube extending into the enclosed volume, and the tube structure (400) comprising a reinforced portion (402) proximate the first opened-end.
2.WO/2021/009201MICROFLUIDIC DEVICE
WO 21.01.2021
Int.Class C12M 1/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
12with sterilisation, filtration, or dialysis means
Appl.No PCT/EP2020/069954 Applicant ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM Inventor VAN GENT, Dirk Cornelis
A microfluidic device for holding three dimensional cell structures (2), with a top cover plate (3), a bottom cover plate (4), and an insert (5) having a membrane (6) provided in an aperture in the insert (5) and extending in a plane of the insert (5). In operation the insert (5) is positioned between the top cover plate (3) and bottom cover plate (4) to form two flow channels (3a; 4a) on either side of the insert (5). The membrane (6) is provided with a plurality of pores (6a) for holding three dimensional cell structures, with a pore size of at least 50pm. The microfluidic device (1) may be applied for a real-time imaging application.
3.WO/2021/009320METHOD FOR GENERATING AND/OR ARRANGING CELL CULTURES
WO 21.01.2021
Int.Class C12M 1/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
12with sterilisation, filtration, or dialysis means
Appl.No PCT/EP2020/070221 Applicant AXENOLL LIFE SCIENCES AG Inventor DECK, David L.
The invention relates to a method for generating and/or arranging cell cultures and/or cell agglomerations, in particular for carrying out medical and/or pharmaceutical searches in which a living cell containing a printing medium is provided and wherein the printing medium is printed through a printing screen and/or a printing stencil.
4.WO/2021/009465DEVICE FOR OBSERVING A LIVING CELL OR A SET OF LIVING CELLS
WO 21.01.2021
Int.Class G02B 21/00
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21Microscopes
Appl.No PCT/FR2020/051277 Applicant UNIVERSITÉ DE VERSAILLES SAINT-QUENTIN-EN-YVELINES Inventor VIALARD, François
The present invention relates to an imaging device (100) for observing the development of a living cell or a set of living cells such as embryos (80), comprising a lighting system (110), means for relative displacement and an imaging system (120) equipped with a wide-field camera (121) which is adapted to allow the identification, the imaging and the observation of one or more living cells or sets of living cells (80) to be observed. The invention also relates to a method for observing the development of embryos by means of such a device (100).
5.WO/2021/008472CELL SHEET TRANSFER DEVICE AND TRANSPORT APPARATUS, AND METHOD FOR TRANSFERRING CELL SHEET
WO 21.01.2021
Int.Class B01L 3/00
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
Appl.No PCT/CN2020/101540 Applicant BOE TECHNOLOGY GROUP CO., LTD. Inventor GAO, Shuang
A cell sheet transfer device (20), a cell sheet transport apparatus (30), and a method for transferring a cell sheet (11) by using the cell sheet transport apparatus (30). The cell sheet transfer device (20) comprises: a bottom plate (201) and a lifting portion (202) provided at the edge of the bottom plate (201), wherein the bottom plate (201) is configured to carry the cell sheet (11). The bottom plate (201) is provided with a liquid channel (203), and the liquid channel (203) is configured to penetrate through the bottom plate (201) along the thickness direction of the bottom plate (201). The cell sheet transfer device (20) is provided in the cell sheet transport apparatus (30). The cell sheet transfer device (20) can ensure that the cell sheet (11) is not damaged during the process of transporting the cell sheet (11); moreover, the cell sheet (11) can be quickly and accurately transferred and attached to the surface of an organ or tissue to be repaired.
6.WO/2021/009491APPARATUS AND METHODS FOR MANIPULATING MICRODROPLETS
WO 21.01.2021
Int.Class B01L 3/00
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
Appl.No PCT/GB2020/051665 Applicant LIGHTCAST DISCOVERY LTD Inventor FRAYLING, Cameron
A device for manipulating microdroplets, the device comprising a microfluidic chip adapted to receive and manipulate microdroplets dispersed in carrier fluid flowing along pathways on a surface of the chip, wherein the microdroplets are manipulated using an optically-mediated electrowetting (oEWOD) force; characterised in that the surface of the chip comprises a coating structure configured to allow controlled attachment and /or detachment of adherent cells contained within the microdroplets by application of the oEWOD force.
7.WO/2021/006242ANTISTATIC TREATMENT AGENT FOR FIBERS AND USE THEREOF
WO 14.01.2021
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
Appl.No PCT/JP2020/026399 Applicant KINKI UNIVERSITY Inventor KUSUNOKI Masanobu
The present invention addresses the problem of providing: a cell culture scaffold from which a cell culture can be recovered without being destroyed after culturing cells; and a method for producing a cell culture. The cell culture scaffold according to the present invention is provided with a base having a water-repellent surface and a cell adhesion molecule formed on the water-repellent surface of the base. In addition, the method for producing a cell culture according to the present invention includes a step for using the cell culture scaffold to culture cells on the surface of the cell adhesion molecule. The cell culture scaffold according to the present invention can allow cells to be recovered in a spheroid shape without being damaged.
8.WO/2021/006286CELL CLUSTER CONTRACTION-RELAXATION MOVEMENT CHARACTERISTIC CALCULATION METHOD
WO 14.01.2021
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
Appl.No PCT/JP2020/026636 Applicant STEM CELL & DEVICE LABORATORY, INC. Inventor HORI Kosuke
[Problem] To provide a cell cluster contraction-relaxation movement characteristic calculation method that enables easy culturing of homogenized contractile cell clusters and easy calculation of contraction-relaxation movement characteristics of the cultured cell clusters. [Solution] This cell cluster contraction-relaxation movement characteristic calculation method involves: culturing of contractile cell clusters in replaceable cell holding devices 100; image-capturing, by using a cell cluster contraction-relaxation movement image, cell cluster contraction-relaxation movement information indicating the contraction-relaxation movement state of contractile cell clusters cultured in a cell culturing part 105 of a first cell holding device 100; and calculating, by using the acquired cell cluster contraction-relaxation movement information, contraction-relaxation movement characteristics of contractile cell clusters cultured in a cell culturing part 105 of a second cell holding device 100.
9.WO/2021/007233RNA REPLICATION USING TRANSCRIPTION POLYMERASES
WO 14.01.2021
Int.Class C12P 19/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
Appl.No PCT/US2020/041046 Applicant JAIN, Nimit Inventor JAIN, Nimit
Compositions and methods for amplifying RNA by replication using transcription polymerases are disclosed. Such replicated RNAs can be used in various applications such as RNAi therapeutics, diagnostic probes, RNA sequencing, directed evolution of RNA aptamers without intermediate conversion to DNA, and RNA vaccines. The transcription polymerases comprise T7 bacteriophage RNA polymerase.
10.WO/2021/006075METHOD FOR INDUCING NEURONAL SYNAPSE FORMATION AND MICROBEADS USED IN SAID METHOD
WO 14.01.2021
Int.Class C07K 14/705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
Appl.No PCT/JP2020/025313 Applicant JIKSAK BIOENGINEERING INC. Inventor YUMOTO Norihiro
The purpose of the present invention is to provide a method for inducing a presynapse formation in human neurons. According to the present invention, provided are: a method for inducing a presynapse formation in human neurons, the method comprising co-culturing the peripheral neurons with at least one LRRTM (Leucine-rich repeat transmembrane neuronal protein) molecule selected from the group consisting of LRRTM family molecules or microbeads of which a fusion protein including the same is immobilized on the surface (here, the LRRTM molecules or the fusion protein including the molecules are immobilized via a linker on the surface of the microbeads); and microbeads used in said method.