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1 / 5,398
1.WO/2025/145124TARGET CELL SELECTION AND RELEASE USING MICROBUBBLE TECHNOLOGY IN A CELL PROCESSING SYSTEM
WO - 03.07.2025
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
 Appl.No PCT/US2024/062195 Applicant TRENCHANT BIOSYSTEMS, INC. Inventor COELHO, Philip, H.
A cell processing platform and method for selecting and isolating target cells, such as T-cells, NK-cells, or hematopoietic stem cells, from a biological sample using functionalized microbubbles. The platform employs microbubbles with lipid shells, functionalized with streptavidin and biotinylated linkers, to bind specific target cells and render them buoyant within the suspension. A centrifugation module separates non-target cells by sedimentation while maintaining the buoyancy of target cell-microbubble complexes. A pneumatic control system disrupts the microbubbles under controlled pressure or frequency, releasing the target cells for downstream processing without compromising viability. Additional features include a microbubble generation module capable of sequentially functionalizing ligands for multi-step cell selection and a temperature-controlled environment to ensure ligand stability. The system supports non-destructive cell release and sorting, enabling precise, contamination-free, and high-efficiency cell isolation for therapeutic and research applications.
2.WO/2025/140774BIOPROCESS CHAMBER WITH FRUSTUM-SHAPED SECTION
WO - 03.07.2025
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
 Appl.No PCT/EP2023/087909 Applicant LIMULA SA Inventor PIERSON, Yann
The invention refers to a processing chamber (100) shaped concentric around a center axis (101). The processing chamber (100) comprises a conical frustum shaped first body section (1) with a first base side (11) and a second base side (12). The second base side (12) opens into a second body section (2). The second body section extends along the center axis (101) with a first end of the second body section (2) pointing away from the first body section (1). The first end of the second body section (2) opens into a third body section (3). The third body section extends along the center axis (101) with a first end of the third body section (3) pointing in a direction away from the second body section (2) and wherein the first end of the third body section (3) is tapering into a second end (30) of the processing chamber (100).
3.WO/2025/142709FILTER DEVICE, FILTRATION DEVICE, AND CELL CULTURE SYSTEM
WO - 03.07.2025
Int.Class C12M 3/06
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
06with filtration, ultrafiltration, inverse osmosis or dialysis means
 Appl.No PCT/JP2024/044920 Applicant MITSUBISHI HEAVY INDUSTRIES, LTD. Inventor OKAMOTO Shinichi
A filter device according to the present disclosure comprises: a first filter that filters a culture solution by passing it downward; a second filter that is disposed below the first filter, is finer than the first filter, and filters the culture solution having passed through the first filter; and a first seal portion that seals a gap between the outer peripheral edge of the first filter and the outer peripheral edge of the second filter.
4.WO/2025/145125TARGETED CELL SELECTION AND RELEASE USING APTAMER COMPLEXES IN A CELL PROCESSING SYSTEM
WO - 03.07.2025
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
 Appl.No PCT/US2024/062196 Applicant TRENCHANT BIOSYSTEMS, INC. Inventor ELLIS, Jonathan
A cell processing platform and method for selective isolation and activation of target cells, such as T-cells, NK-cells, and hematopoietic stem cells, from a biological sample. The platform employs aptamer-functionalized microbubbles, which selectively bind to target cell surface antigens to create buoyant target cell-microbubble complexes. A centrifugation module separates buoyant target cells from non-target cells by exploiting their distinct buoyancy properties. The system includes advanced aptamer designs, such as Locked Nucleic Acid (LNA) modifications, temperature-controlled folding buffers, and reversible binding mechanisms using complementary strands or enzymatic cleavage to release target cells. Additional features include optimized spacer configurations to enhance binding accessibility and aptamer stability for high specificity and yield. This platform also enables selective removal of senescent cells using aptamer-functionalized microbubbles, facilitating continuous processing and supporting applications in cell therapy, research, and regenerative medicine.
5.WO/2025/140874MIXING DEVICE FOR A BIOLOGICAL LIQUID, MIXING SYSTEM FOR A BIOLOGICAL LIQUID, AND METHOD FOR OPERATING A MIXING DEVICE FOR A BIOLOGICAL LIQUID
WO - 03.07.2025
Int.Class B01F 31/31
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
31Mixers with shaking, oscillating, or vibrating mechanisms
30comprising a receptacle to only a part of which the shaking, oscillating, or vibrating movement is imparted
31using receptacles with deformable parts, e.g. membranes, to which a motion is imparted
 Appl.No PCT/EP2024/086325 Applicant CYTIVA SWEDEN AB Inventor LUNDKVIST, Mats
A mixing device (14) for a biological liquid is described. The mixing device (14) comprises a mixing chamber (38) delimited by a first flexible wall segment (20) and by a second flexible wall segment (30), wherein the first flexible wall segment (20) and the second flexible wall segment (30) are arranged on different sides of the mixing chamber (38). The first flexible wall segment (20) comprises a first actuator interface (26) configured to couple a first actuator to the first flexible wall segment (20) such that the first flexible wall segment (20) is displaceable by operating the first actuator. The second flexible wall segment (30) comprises a second actuator interface (36) configured to couple a second actuator to the second flexible wall segment (30) such that the second flexible wall segment (30) is displaceable by operating the second actuator. Additionally, a mixing system for a biological liquid is shown. The mixing system comprises such a mixing device (14), wherein a first actuator is coupled to the first actuator interface (26) and a second actuator is coupled to the second actuator interface (36). Moreover, a method for operating a mixing device (14) for a biological liquid is presented.
6.112024000169MIKROPHYSIOLOGISCHE SYSTEMVORRICHTUNG
DE - 03.07.2025
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
 Appl.No 112024000169 Applicant Ginreilab Inc. Inventor Tatsumi Satoshi

Mikrophysiologische Systemvorrichtung (1), die enthält: einen Behälter (2), in dem eine Vielzahl von Funktionseinheiten (6a bis 6d) in einer austauschbaren Weise angeordnet ist; und ein Kanalelement (3), das an einer Vorderseite des Behälters (2) angeordnet ist und wenigstens einen Teil eines Kanals (33a, 33b) definiert, der bewirkt, dass die Vielzahl von Funktionseinheiten (6a bis 6d), die in dem Behälter (2) angeordnet sind, miteinander kommunizieren. embedded image

7.WO/2025/145121FUNCTIONALLY CLOSED CELL PROCESSING SYSTEM
WO - 03.07.2025
Int.Class B04B 13/00
BPERFORMING OPERATIONS; TRANSPORTING
04CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
BCENTRIFUGES
13Control arrangements specially designed for centrifuges; Programme control of centrifuges
 Appl.No PCT/US2024/062192 Applicant TRENCHANT BIOSYSTEMS, INC. Inventor COELHO, Philip, H.
A functionally closed cell processing platform designed to minimize contamination and automate cell processing. The platform integrates multiple specialized cassettes, including a reagent sample cassette (RSC) for reagent delivery and sample collection, a process fluids cassette (PFC) for waste and buffer management, and a cell processing cassette (CPC) for cell handling, along with a transfer syringe cassette (TSC) for precise fluid transfer. The system features a centrifuge capable of multi-mode operation for cell concentration and mixing, pneumatic controls for fluid and microbubble manipulation, and UV sanitizers to maintain aseptic conditions. Advanced functionalities include optical and thermal sensors for real-time monitoring, automated control of fluid and reagent handling, and a microbubble cell selection system for precise target cell isolation. This innovative platform ensures efficient, contamination-free cell processing, supporting applications in gene therapy, cell manufacturing, and biomedical research.
8.WO/2025/143067CELL CULTURE CONTAINER AND CELL CULTURE METHOD USING SAME
WO - 03.07.2025
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
 Appl.No PCT/JP2024/046036 Applicant MIYAKAWA, Hiroyuki Inventor MIYAKAWA, Hiroyuki
Provided is a cell culture container that ensures a broad cell adhesion surface for adhesion and proliferation of cells inside the container. This cell culture container comprises a bottomed container body 1 that has a polygonal, columnar internal space, a polygonal, columnar first cylindrical body 2 that is provided inside the container body 1 so as to be coaxial with the container body 1, a lid body 4 that is attached to an axial end part of the container body, a cap 5 that is attached to a cylindrical neck part of the lid body 4, and first spacers 21, 22 that are corner parts of an outer circumferential surface of the first cylindrical body 2 at an axial end part of the first cylindrical body 2. The first spacers 21, 22 are fitted into corner parts of an inner circumferential surface of the container body 1.
9.WO/2025/145123AUTOMATED QUALITY CONTROL AND ASEPTIC TRANSFERS IN A CELL PROCESSING SYSTEM
WO - 03.07.2025
Int.Class B01D 65/10
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
65Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
10Testing of membranes or membrane apparatus; Detecting or repairing leaks
 Appl.No PCT/US2024/062194 Applicant TRENCHANT BIOSYSTEMS, INC. Inventor COELHO, Philip, H.
The invention relates to a method and system for maintaining aseptic conditions and verifying filter integrity in a cell processing platform. The platform features an integrated pressure decay testing module to evaluate the functionality of hydrophilic and hydrophobic filters before and after processing. The system operates by pressurizing filters, measuring pressure decay, and determining integrity based on predefined thresholds, with results logged for compliance. The platform includes a cell processing cassette (CPC) equipped for sequential cell processing steps, such as washing, selection, activation, and harvesting, within a single chamber. Automated fluid and gas transfer systems, incorporating filters and emergency recovery pathways, ensure contamination-free operations. Additional features include UV disinfection, adaptive control systems for parameter optimization, and temperature-controlled environments to support cell viability. This comprehensive system enhances reliability, precision, and sterility in automated cell processing for advanced therapeutic applications.
10.WO/2025/142843CONVEYANCE SYSTEM, CELL CULTURE SYSTEM, CONVEYANCE METHOD, SUPPORT MECHANISM, AND TRAY
WO - 03.07.2025
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
 Appl.No PCT/JP2024/045474 Applicant MITSUBISHI HEAVY INDUSTRIES, LTD. Inventor MATSUZAWA Takashi
In the present invention, a conveyance system comprises: a tray on which a container used for cell culture can be placed; and a support mechanism able to support the tray. The support mechanism comprises: a pair of support parts which each have a support surface able to support the tray and which are arranged so as to be spaced apart from each other; at least three pin parts which protrude upwards in a direction perpendicular from the support surface; and a drive part which is connected to the pair of support parts and alters the posture of the pair of support parts. The tray has a tray-supported part in which is formed insertion holes which have a fixed internal diameter and into which the pin parts can be inserted. The pin parts are tapered pins having diameters that decrease in an upwards direction in the perpendicular direction.
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