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IC:C12M

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1 / 29,009
1.WO/2025/245767MICROFLUIDIC APPARATUS AND SYSTEM, AND METHOD FOR CULTURING CELLS AND/OR TISSUES USING SAME
WO - 04.12.2025
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
 Appl.No PCT/CN2024/096257 Applicant ANIVANCE AI CORPORATION Inventor CHEN, Guan-Yu
Provided is a microfluidic apparatus comprising: a first substrate having a first microfluidic channel, a second substrate having a second microfluidic channel, and a membrane. The membrane is arranged between the first substrate and the second substrate. Also provided is a microfluidic system comprising: the microfluidic apparatus, a first pump, and a second pump. The first pump can form a first closed loop with the microfluidic apparatus by means of a first pipeline. The second pump can form a second closed loop with the microfluidic apparatus by means of a second pipeline. Also provided is a method for culturing cells and/or tissues, comprising: providing the microfluidic system, and culturing the cells and/or tissues in the microfluidic apparatus.
2.WO/2025/249700AUTOMATED SYSTEM AND METHOD FOR ANTICANCER DRUG SENSITIVITY TESTING BASED ON ORGANOID CELL CULTURE
WO - 04.12.2025
Int.Class C12M 1/36
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
36including condition or time responsive control, e.g. automatically controlled fermentors
 Appl.No PCT/KR2025/001043 Applicant MBD CO., LTD. Inventor JEON, Sangyoul
An automated system for anticancer drug sensitivity testing, according to an embodiment of the present invention, may comprise: a chopper configured to mince patient tissue; a cell dissociation device configured to apply a cell dissociation enzyme to the patient tissue minced by the chopper; a centrifuge configured to centrifuge cells to which the cell dissociation enzyme has been applied by the cell dissociation device; a liquid handler configured to mix the centrifuged cells with extracellular matrix to thereby generate a mixed sample and to inject the mixed sample into a nozzle tip; a spotter configured to dispense the mixed sample onto a pillar by using the nozzle tip; an automatic incubator configured to culture the mixed sample to generate cell organoids; a scanner configured to generate an image by scanning the cell organoids at high speed; and a multi-joint robot configured to move at least one of the patient tissue, the cells, and the mixed sample between at least some of the chopper, the cell dissociation device, the centrifuge, the liquid handler, the spotter, the automatic incubator, and the scanner. Thus, the entire process of cell extraction from tissue isolated from a patient to organoid culture, drug testing, and scanning can be performed fully automatically.
3.WO/2025/250270POINT-OF-CARE DETECTION SYSTEM FOR AQUATIC MICROORGANISMS
WO - 04.12.2025
Int.Class C12M 1/38
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
36including condition or time responsive control, e.g. automatically controlled fermentors
38Temperature-responsive control
 Appl.No PCT/US2025/025197 Applicant GIANNASCA, Nicholas Inventor GIANNASCA, Nicholas
A system and method are provided for detecting aquatic microorganisms. The system comprises a nucleic acid extraction step for extracting nucleic acid from aquatic samples, a nucleic acid amplification step for amplifying the extracted genomic material, and a nucleic acid detection step for detecting the presence of amplified nucleic acids, indicating the presence of microorganisms. The method and system are applicable to both marine and freshwater environments and can be used for point-of-care detection of pathogenic and/or beneficial aquatic microorganisms. A nucleic acid amplification component comprising a hand-held isothermal heater to amplify the extracted nucleic acid, and a nucleic acid detection component configured to detect amplified nucleic acid. The hand-held isothermal heater includes a main body, a sample port configured, to receive a sample tube, a viewing screen, a heat block, and an electronics compartment. The system enables rapid and efficient detection of pathogenic and beneficial aquatic microorganisms.
4.WO/2025/247839CELL KILLING MONITORING SYSTEM
WO - 04.12.2025
Int.Class C12M 1/32
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
26Inoculator or sampler
32multiple field or continuous type
 Appl.No PCT/EP2025/064521 Applicant IMEC VZW Inventor LIU, Chengxun
A system for monitoring effector cell mediated killing of target cells includes a containment unit with multiple discrete confinement locations, each capable of simultaneously holding at least one effector cell and one target cell. The system also features a lens-free imaging module for capturing images of all cells within the containment unit and a control unit configured to operate the imaging module to capture a sequence of images over time, extract features from these images, and monitor the effector cell mediated killing of the target cells.
5.WO/2025/250809ENZYME-DECORATED NANOCATALYSTS
WO - 04.12.2025
Int.Class C12P 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
3Preparation of elements or inorganic compounds except carbon dioxide
 Appl.No PCT/US2025/031448 Applicant CASSIOPEA LLC Inventor LADEROUTE, Keith
Provided herein are vesicular nanocatalysts decorated on their surface with enzymes, such as for industrial use. More particularly, the nanocatalysts include outer membrane vesicles (OMVs) presenting on their surface carbonic anhydrase or a functional fragment or derivative thereof. Uses, methods of manufacture, and compositions of the nanocatalysts are also disclosed herein.
6.WO/2025/250913FIXED BED BIOREACTOR FOR CELL CULTURE WITH REDUCED BYPASS
WO - 04.12.2025
Int.Class C12M 1/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
12with sterilisation, filtration, or dialysis means
 Appl.No PCT/US2025/031616 Applicant CORNING INCORPORATED Inventor GORAL, Vasiliy Nikolaevich
A bioreactor system for culturing cells is provided that include a cell culture vessel having an inlet, outlet, and interior reservoir. The cell culture matrix includes a plurality of substrates for adhering cells thereto, which are stacked in a stacking direction parallel to a flow direction through the reservoir. The cell culture matrix extends across the width of the reservoir such that fluid flow between the cell culture matrix and the interior wall is restricted. The substrates can be under compression with a compression force in a direction that is substantially parallel to the stacking direction and substantially perpendicular to the reservoir width to reduce bypass fluid flow between the cell culture matrix and the reservoir wall. Edges of some of the substrates can also be joined to increase rigidity against fluid flow and thus reduce bypass.
7.WO/2025/248420DEVICE DEDICATED TO MEDICALLY ASSISTED PROCREATION
WO - 04.12.2025
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
 Appl.No PCT/IB2025/055419 Applicant FUSCO SARA DITTA INDIVIDUALE Inventor DANI, Gianluca
A device (1) for the mobility of embryos in assisted reproduction technology, comprising (i) a developing plate (2) having at least one embryo development channel (3) suitable, in use, for housing a culture medium (ii) at least one pushing element (4) having a housing portion (5) of the embryo (E) arranged to slide in the embryo development channel (3) and defined by a retaining wall (12) in which a plurality of openings (13) are obtained to allow the crossing of the culture medium and holding of the embryo (E); and (iii) movement means (6, 16), suitable for moving the pushing element (4) to cause the sliding of the housing portion (5) in the embryo development channel (3) at a predetermined speed.
8.WO/2025/248884MICROFLUIDIC DEVICE
WO - 04.12.2025
Int.Class B81B 1/00
BPERFORMING OPERATIONS; TRANSPORTING
81MICROSTRUCTURAL TECHNOLOGY
BMICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
1Devices without movable or flexible elements, e.g. microcapillary devices
 Appl.No PCT/JP2025/006472 Applicant USHIO DENKI KABUSHIKI KAISHA Inventor YAMAMURO Akihiko
Provided is a microfluidic device that allows for easy entry of a cell culture medium or other liquid into a microfluidic channel when injecting the liquid into the microfluidic channel.　The microfluidic device has at least two or more plate-like members joined together and comprises: a port for supplying or discharging a liquid; and a channel formed inside the microfluidic device and in communication with the port. The channel has a tubular shape constituted by three or more inner wall surfaces, and a cross section of the channel has at least three or more corner portions that are acute in angle.
9.WO/2025/250654MEASUREMENT AND IMAGING OF VISCOELASTICITY, FAT AND COLLAGEN CONTENT OF SOFT TISSUES
WO - 04.12.2025
Int.Class A61B 8/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
8Diagnosis using ultrasonic, sonic or infrasonic waves
08Clinical applications
 Appl.No PCT/US2025/031217 Applicant NORTH CAROLINA STATE UNIVERSITY Inventor GUDDATI, Murthy
Various examples are provided related to viscoelasticity, fat and collagen determination in soft tissues. In one example, a method for evaluation of soft tissue includes obtaining measured particle velocities from generated mechanical waves in tissue of a subject; determining viscoelastic parameters of soft tissue at a point or in a region of interest (ROI) from wave propagation characteristics derived from the measured particle velocities; and determining fat or collagen content at the point or in the ROI from the wave propagation characteristics. In another example, a system includes an ultrasound scanner for SWE; and a computing device that can obtain measured particle velocities from generated mechanical waves in tissue of a subject; determine viscoelastic parameters of soft tissue at a point or ROI from wave propagation characteristics derived from the measured particle velocities; and determine fat or collagen content at the point or in the ROI.
10.WO/2025/249558METHOD AND SYSTEM FOR PRODUCING BASIC CHEMICAL
WO - 04.12.2025
Int.Class C12P 7/06
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
02containing a hydroxy group
04acyclic
06Ethanol, i.e. non-beverage
 Appl.No PCT/JP2025/019676 Applicant COSMO ENERGY HOLDINGS CO., LTD. Inventor CHIYODA, Norihito
The present invention relates to a method for producing a basic chemical that includes supplying and reacting carbon dioxide and hydrogen in a bioreactor. The bioreactor is provided with chemosynthetic bacteria, and the hydrogen is supplied by supplying a dissolved hydrogen solution to the bioreactor.
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