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IC:C12M

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1 / 29,300
1.WO/2026/028182EXTRACORPOREAL HUMAN BRAIN PERFUSION APPARATUS WITH NEURAL COMMUNICATION CAPABILITY
WO - 05.02.2026
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
 Appl.No PCT/IB2025/057878 Applicant UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION Inventor ZINN, Pascal, Oliver
Provided herein is a bioreactor system for neural tissue, including a bioreactor configured to hold a neural tissue sample therein; a media reservoir in fluid communication with the bioreactor and configured to hold a fluid media; one or more fluid conduits fluidly connecting the bioreactor to the media reservoir; a cannula in fluid communication with the media reservoir and configured to couple to a blood vessel of the neural tissue sample; one or more sensors configured to measure one or more parameters of the fluid media and/or the neural tissue sample; and one or more pumps configured to cause media to flow from the media reservoir through the cannula.
2.WO/2026/028677METHOD AND APPARATUS FOR CULTURING HYDROGEN-OXIDIZING BACTERIUM
WO - 05.02.2026
Int.Class C12M 1/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
04with gas introduction means
 Appl.No PCT/JP2025/023162 Applicant INSTITUTE OF SCIENCE TOKYO Inventor TSUGE, Takeharu
The present invention provides a method for culturing a hydrogen-oxidizing bacterium that utilizes a gas including a combustible gas, with which it becomes possible to improve both culturing efficiency and safety in the proliferation of the hydrogen-oxidizing bacterium and/or the production of a useful substance by the hydrogen-oxidizing bacterium.　Provided are: a method for culturing a hydrogen-oxidizing bacterium, the method being characterized by comprising (i) a step for supplying an oxygen-containing gas and carbon dioxide gas to a fermentation tank that contains the hydrogen-oxidizing bacterium and a liquid culture medium and (ii) a step for supplying hydrogen gas to the fermentation tank separately from the oxygen-containing gas, wherein the hydrogen gas supply step includes a step (a) for controlling the supplying of the hydrogen gas to the fermentation tank in such a manner that the hydrogen gas concentration in the gas in a head space of the fermentation tank after the supply of the gases becomes less than 4.0 vol%; and a culture apparatus for the method.
3.WO/2026/030357MICROFLUIDIC ENGINEERING OF IMMUNE CELLS FOR IMPROVED THERAPEUTIC EFFICIENCY
WO - 05.02.2026
Int.Class C12M 3/06
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
06with filtration, ultrafiltration, inverse osmosis or dialysis means
 Appl.No PCT/US2025/039715 Applicant GEORGIA TECH RESEARCH CORPORATION Inventor THOMAS, Susan Napier
Disclosed herein is a microfluidic device for priming, collection and recovery of immune cells comprising: a) two separate fluidic channels: i) a first channel, wherein the first channel is infused with immune cells, and ii) a second channel, wherein the second channel acts as a collection reservoir for transmigrated cells, and; b) a microporous membrane interface, present between the first channel and the second channel, wherein the microporous membrane is functionalized on the first channel surface with adhesion molecules. Also disclosed are methods of creating enhanced cells, and using them in treatment of individuals in need thereof.
4.WO/2026/027986SYSTEM FOR STUDYING BIOLOGICAL MATERIAL ALSO BY POSITRON ANNIHILATION SPECTROSCOPY
WO - 05.02.2026
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
 Appl.No PCT/IB2025/057008 Applicant POLITECNICO DI MILANO Inventor FERRAGUT, Rafael Omar
A system for studying biological material by microscopic and spectroscopic techniques comprising a bioreactor (10) having a culture chamber; said bioreactor (10) comprises a lower body (11 ) and an upper body (12) that can be joined to each other; a seal (27) interposed between said lower body (11 ) and said upper body (12); said lower body (11 ) comprises a through hole (17) closed by a membrane (19); said upper body (12) comprises a through hole (23) closed by an element transparent to visible radiation (28); said seal (27) delimits said culture chamber; said culture chamber being connected to two fluidic channels (18) which extend externally to said lower and upper bodies (11 and 12) via the through holes (25).
5.WO/2026/029141MICROTUBE AND KIT
WO - 05.02.2026
Int.Class C12M 1/24
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
24tube or bottle type
 Appl.No PCT/JP2025/027154 Applicant RACTHERA CO., LTD. Inventor NAKAGAWA, Takashi
Provided is a microtube which includes a container body with an open upper end side and a closed lower end side. The container body includes: a bottom part which includes a bottom surface; a linear part which is arranged on an upper side of the bottom part and has an inner peripheral surface that is continuous with the bottom surface and linearly extends along a vertical direction in a cross section orthogonal to a radial direction; and a reduced-diameter part which is arranged on an upper side of the linear part and is formed so that an inner peripheral surface is continuous with the inner peripheral surface of the linear part and the inner diameter is tapered downward. The inner diameter of the linear part is 2.5 mm or less.
6.WO/2026/027836MICROFLUIDIC DEVICE FOR MODELING MECHANICAL STRESSES IN AN ORGAN-ON-A-CHIP
WO - 05.02.2026
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
 Appl.No PCT/FR2025/050724 Applicant INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE Inventor GRASSART, Alexandre
The invention relates to a microfluidic device (10) comprising, in an overlaid manner: a plurality of upper channels (12) forming a plurality of compression chambers (18) in the same plane; an intermediate channel (14) forming an intermediate chamber (15); a lower channel (16) forming a lower chamber (17); a porous membrane (30) separating the intermediate chamber (15) from the lower chamber (17); wherein each of the compression chambers (18) is configured to vertically compress, in operation, a section of the intermediate chamber (15) and optionally a section of the lower chamber (17); each of the compression chambers (18) comprising at least one access port (20) for control thereof.
7.WO/2026/025196IDENTIFYING RAW MATERIALS AND GAS PRODUCTION DATA
WO - 05.02.2026
Int.Class G01N 21/27
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
27using photo-electric detection
 Appl.No PCT/CA2025/051029 Applicant FERMENTRICS TECHNOLOGIES INC. Inventor JOHNSTON, James
Systems and methods relating to identifying raw materials and predicting gas production based on the identified raw materials. Machine learning models are used to identify (through pattern matching or curve fitting) raw materials. Once the raw materials are identified, expected gases and their quantities produced through fermentation are determined using another machine learning model. The predicted gases and amounts are then sent to a user.
8.WO/2026/0274523D PERFUSABLE TISSUE CONSTRUCT WITH CROSSLINKING INITIATOR
WO - 05.02.2026
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
 Appl.No PCT/EP2025/071593 Applicant JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG, IN VERTRETUNG DES FREISTAATES BAYERN Inventor RYMA, Matthias
41 ABSTRACT A method of genera ng a perfusable structure for cell and/or ssue cul va on is provided, the method comprising the steps of: providing a crosslinkable composi on (20), providing a sacrificial scaffold (10) separately from the crosslinkable composi on (20), wherein the sacrificial scaffold (10) comprises a matrix polymer and a crosslinking ini ator for ini a ng crosslinking of the crosslinkable composi on (20), wherein the matrix polymer is configured for releasing the crosslinking ini ator when the sacrificial scaffold (10) is in contact with the crosslinkable composi on (20), a er separately providing the sacrificial scaffold (10), embedding the sacrificial scaffold (10) in the crosslinkable composi on (20) such that the sacrificial scaffold (10) comes into contact with the crosslinkable composi on (20), and releasing the crosslinking ini ator from the matrix polymer into the crosslinkable composi on (20) to crosslink a layer (22) of the crosslinkable composi on around the sacrificial scaffold (10), the crosslinked layer (22) forming at least one channel (28). Figure 3A
9.WO/2026/030407CELL CULTURE CONTAINERS AND FLUID HANDLING FOR SCALABLE CELL MANUFACTURING
WO - 05.02.2026
Int.Class C12M 1/36
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
36including condition or time responsive control, e.g. automatically controlled fermentors
 Appl.No PCT/US2025/039796 Applicant CELLINO BIOTECH, INC. Inventor WAGNER, Matthias
Systems and methods for cell culturing and manufacturing are disclosed herein. A cell manufacturing platform comprises an enclosure providing a sterile environment; a plurality of pluggable cell culture cassettes, each cell culture cassette supporting a cell culture; an optical engine configured to capture images of the cell cultures and optically remove cells from the cell cultures; a fluid management system configured to exchange fluid media for each of the plurality of cell culture cassettes; one or more incubators for storing the plurality of cell culture cassettes; and a transport system configured to move the plurality of cell culture cassettes between the one or more incubators, the optical engine, and the fluid management system.
10.WO/2026/028112CHIP DEVICE FOR AN ORGAN-ON-A CHIP (OOC)
WO - 05.02.2026
Int.Class C12M 3/06
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
06with filtration, ultrafiltration, inverse osmosis or dialysis means
 Appl.No PCT/IB2025/057721 Applicant UNIVERSITA' DEGLI STUDI DEL PIEMONTE ORIENTALE "AMEDEO AVOGADRO" Inventor POLINI, Alessandro
Chip device (10) for an organ-on-a chip (OOC), comprising: - a chip (20) comprising a culture chamber (22) for housing a cellular structure; - a pressure generating system for exerting a compression action upon the cellular structure housed in the culture chamber (22); wherein the pressure generating system comprises: - a chamber body (40) having a pressure chamber (42); - a membrane (80) having a first side (82) facing the culture chamber (22) and a second side (84) facing the pressure chamber (42), - a pressure generator (90) for supplying a work fluid to the pressure chamber (22) and building a pressure in the pressure chamber (22) that moves said membrane in the direction of the culture chamber (22) to execute a compression action upon the cellular structure contained therein. The chip device is characterized in that it comprises a support element (60) supporting the membrane (80), which is arranged between the chip (20) and the chamber body (40) of the pressure generating system.
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