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Analysis

1.WO/2021/008867REINFORCED BIOREACTOR COMPONENT STRUCTURE SYSTEM FOR CELL CULTIVATION
WO 21.01.2021
Int.Class B01L 3/02
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
02Burettes; Pipettes
Appl.No PCT/EP2020/068356 Applicant GLOBAL LIFE SCIENCES SOLUTIONS USA LLC Inventor TUOHEY, Colin
The present invention relates to a bioprocess bag (118) comprising a bag wall defining an enclosed volume for holding biomaterials. The bag wall comprises at least one inlet port (142) and at least one outlet port (146). The bioprocess bag (118) also comprises a tube structure (400) comprising a first opened-end proximate the bag wall and a second distal end, the tube extending into the enclosed volume, and the tube structure (400) comprising a reinforced portion (402) proximate the first opened-end.
2.WO/2021/010822INTEGRATED SYSTEM FOR BIOCATALYTICALLY PRODUCING AND RECOVERING AN ORGANIC SUBSTANCE
WO 21.01.2021
Int.Class C12P 5/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
5Preparation of hydrocarbons
Appl.No PCT/NL2020/050421 Applicant DELFT ADVANCED BIOFUELS B.V. Inventor OUDSHOORN, Arjan
The invention relates to a method for recovering a biocatalytically produced organic substance from a reaction mixture, comprising - providing a reaction mixture, wherein the organic substance is produced using a biocatalyst, which reaction mixture comprises a substrate for the biocatalyst in a continuous aqueous phase, and wherein further a product recovery phase is present into which the organic substance migrates or onto which the organic substance absorbs or adsorbs; and - separating the product recovery phase comprising the produced substance from the aqueous phase and the biocatalyst. The invention further relates to a bioreactor system for biocatalytically producing a substance, comprising an apparatus, said apparatus comprising a reaction compartment (11) situated in a lower part of the apparatus and a separator compartment (9).
3.WO/2021/011512SAMPLE PREPARATION CARTRIDGES AND APPARATUSES
WO 21.01.2021
Int.Class B01D 27/14
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
27Cartridge filters of the throw-away type
14having more than one filtering element
Appl.No PCT/US2020/041875 Applicant LEXAGENE, INC. Inventor NAIR, Manojkumar, M.
The invention includes sample preparation cartridges and apparatuses. The invention provides means for lysing and optionally selectively capturing at least one compound in a sample to purify, concentrate, and/or select for the at least one compound. The invention can be used in conjunction with a sample processing instrument to create a fully-automated or near-fully-automated sample workflow.
4.WO/2021/008046SYSTEM AND METHOD FOR PREPARING MRNA
WO 21.01.2021
Int.Class C12M 1/40
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
40Apparatus specially designed for the use of free, immobilised, or carrier-bound enzymes, e.g. apparatus containing a fluidised bed of immobilised enzymes
Appl.No PCT/CN2019/119385 Applicant ACADEMY OF MILITARY MEDICAL SCIENCES Inventor WANG, Shengqi
The present application belongs to the technical field of mRNA preparation, and discloses a system and a method for preparing mRNA, which can shorten a preparation period, and avoid degradation of an mRNA product due to the introduction of RNase by manual pipetting. The system for preparing mRNA comprises a PCR amplification device configured to amplify DNA; a plurality of raw reagent tubes, each of which is configured to provide a single reagent; and a reaction device configured to allow reagents to react. Specifically, the reaction device comprises a test tube rack configured to support reaction tubes, a semiconductor chilling plate connected to the test tube rack, a fin type radiator disposed under the test tube rack, and a cooling fan disposed under the fin type radiator; wherein the raw reagent tubes are connected to the reaction tubes via a solenoid valve module and a peristaltic pump module, and the solenoid valve module and the peristaltic pump module are connected with a control device and are controlled by an upper computer control program.
5.WO/2021/009201MICROFLUIDIC DEVICE
WO 21.01.2021
Int.Class C12M 1/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
12with sterilisation, filtration, or dialysis means
Appl.No PCT/EP2020/069954 Applicant ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM Inventor VAN GENT, Dirk Cornelis
A microfluidic device for holding three dimensional cell structures (2), with a top cover plate (3), a bottom cover plate (4), and an insert (5) having a membrane (6) provided in an aperture in the insert (5) and extending in a plane of the insert (5). In operation the insert (5) is positioned between the top cover plate (3) and bottom cover plate (4) to form two flow channels (3a; 4a) on either side of the insert (5). The membrane (6) is provided with a plurality of pores (6a) for holding three dimensional cell structures, with a pore size of at least 50pm. The microfluidic device (1) may be applied for a real-time imaging application.
6.WO/2021/009906CELL IMAGE ANALYSIS METHOD AND CELL IMAGE ANALYSIS DEVICE
WO 21.01.2021
Int.Class C12Q 1/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
Appl.No PCT/JP2019/028268 Applicant SHIMADZU CORPORATION Inventor TAKAHASHI, Wataru
This cell image analysis method comprises a step for performing segmentation processing on a first image (21) to specify regions (12) of cells that have already begun differentiating and regions (11) of undifferentiated cells and converting to a labelled image (21A), a step for acquiring shape feature quantities (25) from the labelled image, and a step for determining, on the basis of the shape feature quantities (25) and determination criteria (30), whether there are colony regions that could be the target of a search.
7.WO/2021/010341PRODUCTION METHOD OF ORGANISM-DERIVED SUBSTANCE, PRODUCTION METHOD OF PRODUCT, AND VOLTAGE APPLICATION DEVICE
WO 21.01.2021
Int.Class C12M 1/42
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
42Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave
Appl.No PCT/JP2020/027109 Applicant FUJIFILM CORPORATION Inventor NAGAI, Yoichi
The production method according to the present disclosure is for producing an organism-derived substance having introduced therein a bioactive substance, the production method including a step for causing a suspension including the bioactive substance and the organism-derived substance yet to be introduced with the bioactive substance, to pass through a first electric field region having a first electric field intensity, and a step for causing the suspension, after passing through the first electric field region, to pass through a second electric field region having a second electric field intensity which is lower than the first electric field intensity. The organism-derived substance is a human-derived cell.
8.WO/2021/009320METHOD FOR GENERATING AND/OR ARRANGING CELL CULTURES
WO 21.01.2021
Int.Class C12M 1/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
12with sterilisation, filtration, or dialysis means
Appl.No PCT/EP2020/070221 Applicant AXENOLL LIFE SCIENCES AG Inventor DECK, David L.
The invention relates to a method for generating and/or arranging cell cultures and/or cell agglomerations, in particular for carrying out medical and/or pharmaceutical searches in which a living cell containing a printing medium is provided and wherein the printing medium is printed through a printing screen and/or a printing stencil.
9.WO/2021/008988MULTI-WELL PLATE AND METHOD FOR PREPARING SAME
WO 21.01.2021
Int.Class B01L 3/00
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
Appl.No PCT/EP2020/069358 Applicant CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Inventor NICOLAS, Alice
The invention relates to a multi-well plate comprising a support (30), the upper surface (31) of which is at least partially covered with a continuous layer (32) of a hydrogel in contact with the lower surface (33) of a bottomless multi-well plate (34), the support (30), the continuous layer (32) and the bottomless multi-well pate (34) being adhered by means of an adhesive (37) which extends from at least certain portions (330) of the lower surface (33) of the bottomless multi-well plate (34) up to certain portions (310) of the upper surface (31) of the support (30) by passing through the continuous layer (32) of hydrogel, each well (35) of the bottomless multi-well plate (34) being entirely surrounded by the at least certain portions (330) of the lower surface (33). The application also relates to a method for preparing the multi-well plate and the use thereof for in vitro cell culture.
10.WO/2021/007710MICROFLUIDIC ELECTROSPRAY-BASED SINGLE-CELL WHOLE-GENOME AMPLIFICATION SYSTEM AND METHOD
WO 21.01.2021
Int.Class C12M 1/38
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
36including condition or time responsive control, e.g. automatically controlled fermentors
38Temperature-responsive control
Appl.No PCT/CN2019/095797 Applicant SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES Inventor MEN, Yong Fan
The present invention provides a microfluidic electrospray-based single-cell whole-genome amplification system and method. Said system includes a microfluidic chip and an alternating-current power supply module, the microfluidic chip being provided with a sample flow channel for injecting discrete and continuous phases, the alternating-current power supply module being used for applying an alternating current to a sample solution in the sample flow channel, the sample solution in the sample flow channel generating droplets under the effect of an electric field force and a liquid force, and the droplets being stretched by an alternating electric field and broken into ultra-small droplets over a distance. The present invention can generate ultra-small droplets by means of a microfluidic chip in an electrospray manner, thereby improving the accuracy of sequencing.