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Analysis

1 / 106,903
1.WO/2025/139979CHIMERIC ANTIGEN RECEPTOR TARGETING LY6G6D AND USE THEREOF
WO - 03.07.2025
Int.Class C07K 19/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
 Appl.No PCT/CN2024/140478 Applicant SUNSHINE LAKE PHARMA CO., LTD. Inventor CHEN, Shiyou
Provided are a chimeric antigen receptor targeting Ly6G6D and the use thereof. Specifically, provided is a CAR that can specifically bind to Ly6G6D, which contains an Ly6G6D binding domain, a transmembrane domain, a co-stimulatory domain and an intracellular signal transduction domain. Further provided is the use of the CAR in the treatment of diseases or conditions related to the expression of Ly6G6D.
2.WO/2025/140489MULTISPECIFIC ANTIBODIES AND USES THEREOF
WO - 03.07.2025
Int.Class C07K 19/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
 Appl.No PCT/CN2024/142997 Applicant VIBRANT PHARMA LIMITED Inventor WANG, Luquan
Provided are multispecific antibodies (e.g., bispecific antibodies or trispecific antibodies) or antigen-binding fragments thereof. In one aspect, the multispecific antibodies or antigen-binding fragments thereof can bind to a T cell antigen (e.g., CD3) and/or one or two tumor-associated antigens (e.g., CAIX, EGFR), or a combination thereof.
3.WO/2025/140504T CELL RECEPTOR TARGETING POLYPEPTIDE WITH KRAS G12V MUTATION AND USE OF T CELL RECEPTOR
WO - 03.07.2025
Int.Class C07K 14/725
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
725T-cell receptors
 Appl.No PCT/CN2024/143046 Applicant IMMUXELL BIOTECH LTD. Inventor HU, Hong-Ming
Provided in the present invention are a T cell receptor targeting a polypeptide with a KRAS G12V mutation and the use of the T cell receptor. The T cell receptor molecule of the present invention specifically targets the KRAS G12V mutation, and the CDR3 sequence of the α chain variable region of the T cell receptor molecule contains CAVNPNTGNQFYF (SEQ ID NO: 1) or a mutant of SEQ ID NO: 1, and/or the CDR3 sequence of the β chain variable region contains CASSQDYGPQETQYF (SEQ ID NO: 2) or a mutant of SEQ ID NO: 2. Further provided in the present invention are a nucleic acid molecule encoding the T cell receptor molecule, a multivalent complex and dual-targeting protein molecule containing the T cell receptor molecule, a nucleic acid construct, a cell expressing the T cell receptor molecule, etc.
4.WO/2025/140069APPLICATION OF REDUCING AGENT IN PEROXIDASE CATALYTIC REACTION
WO - 03.07.2025
Int.Class C12N 9/02
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
02Oxidoreductases (1.), e.g. luciferase
 Appl.No PCT/CN2024/141277 Applicant HUBEI UNIVERSITY Inventor LI, Aitao
Disclosed in the present invention is an application of a reducing agent in a heme peroxidase catalytic reaction. The reducing agent is selected from ascorbic acid, dehydroascorbic acid, gallic acid and pyrogallic acid. The reducing agent has a significant promotion effect on oxidation reaction and hydroxylation reaction catalyzed by heme peroxidase.
5.WO/2025/140654ANTI-CDH17 ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF AND USE THEREOF
WO - 03.07.2025
Int.Class C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
 Appl.No PCT/CN2024/143461 Applicant GUANGDONG FAPON BIOPHARMA INC. Inventor ZHANG, Yibo
An anti-CDH17 antibody or an antigen-binding fragment thereof and the use thereof. The antibody can specifically bind to one or more extracellular domains in extracellular domains 1-7 of CDH17, has an ADCC activity, and can mediate cell endocytosis, thereby providing a new possibility for the treatment and/or prevention of cancers.
6.WO/2025/140609METHOD FOR CONSTRUCTING CELL WHICH PRODUCES DEFUCOSYLATED PROTEIN AND USE OF CELL
WO - 03.07.2025
Int.Class C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
 Appl.No PCT/CN2024/143321 Applicant WUXI BIOLOGICS (SHANGHAI) CO., LTD. Inventor ZHOU, Yangfang
Provided is a method for constructing a cell which produces defucosylated protein using a zinc finger nuclease which contains a zinc finger protein capable of binding to the FUT8 gene in a targeted manner and a DNA cleavage domain or cleavage half-domain. Also provided are a polynucleotide which encodes the zinc finger protein and the zinc finger nuclease, and a cell containing the polynucleotide and the zinc finger nuclease.
7.WO/2025/138194HPPD INHIBITOR HERBICIDE RESISTANCE RELATED GENE, AND ENCODED PROTEIN AND USE THEREOF
WO - 03.07.2025
Int.Class C12N 15/82
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
82for plant cells
 Appl.No PCT/CN2023/143511 Applicant UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA Inventor XIANG, Chengbin
Provided are an HPPD inhibitor herbicide resistance gene BPR1, and an encoded protein and a use thereof. The loss of function of the protein encoded by this gene confers broad-spectrum resistance to HPPD inhibitor herbicides in rice. Evolutionary analysis of the BPR1 gene finds that homologous genes thereof exist in gramineous food crops such as rice, maize, wheat, millet, sorghum, barley, oat and millet, as well as in crops such as tobacco, cotton, grape, soybean and rapeseed. Technologies such as gene editing and RNAi can be used to reduce the expression level of the BPR1 gene and homologous genes thereof in different species, or disrupt coding reading frames thereof, leading to the loss of function of the BPR1 protein and the homologous proteins thereof in different species, thereby making the corresponding plants broad-spectrum resistant to HPPD inhibitor herbicides. The present invention has broad application prospects in the field of cultivating crops resistant to HPPD inhibitor herbicides.
8.WO/2025/140324USE OF ANTI-PD-1 ANTIBODY COMBINED WITH CHEMOTHERAPEUTIC AGENT IN TREATMENT OF TUMORS
WO - 03.07.2025
Int.Class C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
 Appl.No PCT/CN2024/142361 Applicant BIO-THERA SOLUTIONS, LTD. Inventor WANG, Hao
Provided is a use of an anti-PD-1 antibody combined with a chemotherapeutic agent in the treatment of tumors such as cervical cancer or endometrial cancer. In some embodiments, the chemotherapeutic agent comprises a taxane drug and/or a platinum drug. In some embodiments, the use further comprises a use of the anti-PD-1 antibody combined with bevacizumab.
9.WO/2025/143579NOVEL PEPTIDE
WO - 03.07.2025
Int.Class C07K 7/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
 Appl.No PCT/KR2024/018986 Applicant HYSENSBIO CO., LTD Inventor PARK, Joo Hwang
The present invention relates to a novel peptide, a polynucleotide encoding the peptide, an expression vector comprising the polynucleotide, and a pharmaceutical composition, a quasi-drug composition, and a health-functional food composition that include the peptide.
10.WO/2025/143714DIAGNOSTIC KIT FOR BOVINE DIARRHEA-CAUSING VIRUS
WO - 03.07.2025
Int.Class C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
 Appl.No PCT/KR2024/020949 Applicant BOREDA BIOTECH Inventor CHOI, Dong Ok
The present invention relates to a diagnostic kit for bovine viral diarrhea virus (BVDV), which enables rapid on-site identification and diagnosis of BVDV1 and BVDV2, which are genotypes of the BVD virus that are pathogens causing bovine diarrhea, within a short time of approximately 15 minutes.
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