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Analysis

1.WO/2021/009242HYBRID HTIRNA/NANOPARTICLE COMPLEX AND USE THEREOF FOR TREATING A DISEASE OF THE DIGESTIVE SYSTEM
WO 21.01.2021
Int.Class C07H 21/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Appl.No PCT/EP2020/070022 Applicant COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES Inventor NAVARRO Y GARCIA, Fabrice
The invention relates to a hybrid DNA/RNA molecule, to the complex thereof with at least one nanoparticle and to the use of this complex for the prevention or treatment of a disease, in particular a disease of the digestive system.
2.WO/2021/011434METHODS AND SYSTEMS FOR AUTHENTICATING GOODS AND SERVICES USING ELECTRONIC ANALYSIS OF ANALYTE ENCODED COMPOSITIONS
WO 21.01.2021
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
Appl.No PCT/US2020/041739 Applicant VILLWOCK, Thomas Inventor VILLWOCK, Thomas
Methods for product authentication, which include: providing an article having a substrate with an analyte encoded composition; obtaining a sample of the composition; applying the sample to a test device to obtain test results, analyzing test results from the test device using an electronic device communicatively connected to an authentication authority, wherein the electronic device transmits the test device code and the test results to the authentication authority and confirms or denies authentication after comparison to an authentication database of authentic test results.
3.WO/2021/011803SYNTHETIC NUCLEIC ACIDS HAVING NON-NATURAL STRUCTURES
WO 21.01.2021
Int.Class C12N 15/64
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
64General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
Appl.No PCT/US2020/042380 Applicant OMNIOME, INC. Inventor OLIPHANT, Arnold
Nucleic acid compositions having nucleotide sequences that do not occur in nature are provided. Also provided are populations of different nucleic acids having universal adapters or universal primer binding sites. Methods of capturing, copying or amplifying nucleic acids of interest using universal adapters, universal primer binding sites and/or universal primers are also provided.
4.WO/2021/005541ADMINISTRATION OF STING AGONIST AND CHECKPOINT INHIBITORS
WO 14.01.2021
Int.Class A61K 31/7084
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7084Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
Appl.No PCT/IB2020/056440 Applicant TAKEDA PHARMACEUTICAL COMPANY LIMITED Inventor LIGHTCAP, Eric Scott
The present disclosure provides methods, pharmaceutical compositions, and kits for treating cancer in patients in need thereof. The methods comprise administering to a patient in need a STING (stimulator of interferon genes) agonist, such as Compound No. 14 as defined in the description, or a pharmaceutically acceptable salt thereof, in combination with one or more checkpoint inhibitors. Also provided are medicaments for use in treating cancer.
5.WO/2021/007160TRANS-CYCLOOCTENE BIOORTHOGONAL AGENTS AND USES IN CANCER AND IMMUNOTHERAPY
WO 14.01.2021
Int.Class A61K 47/54
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
54the modifying agent being an organic compound
Appl.No PCT/US2020/040891 Applicant TAMBO, INC. Inventor MEJIA ONETO, Jose Manuel
Trans-cyclooctene conjugates of therapeutic agents may be used for bioorthogonal delivery to a targeted location in a subject. The compositions and methods have applications in the treatment of various diseases or conditions including cancer, tumor growths, and bacterial infections.
6.WO/2021/007233RNA REPLICATION USING TRANSCRIPTION POLYMERASES
WO 14.01.2021
Int.Class C12P 19/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
Appl.No PCT/US2020/041046 Applicant JAIN, Nimit Inventor JAIN, Nimit
Compositions and methods for amplifying RNA by replication using transcription polymerases are disclosed. Such replicated RNAs can be used in various applications such as RNAi therapeutics, diagnostic probes, RNA sequencing, directed evolution of RNA aptamers without intermediate conversion to DNA, and RNA vaccines. The transcription polymerases comprise T7 bacteriophage RNA polymerase.
7.WO/2021/007458NOVEL NUCLEOTIDE ANALOGUES AND METHODS FOR USE
WO 14.01.2021
Int.Class C07H 21/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Appl.No PCT/US2020/041455 Applicant THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK Inventor JU, Jingyue
The invention provides various orthogonal nucleotide analogues and methods for using combinations of said various orthogonal nucleotide analogues for sequencing by synthesis.
8.WO/2021/004379FLUORESCENTLY LABELED NUCLEIC ACID AND SYNTHESIS METHOD THEREFOR
WO 14.01.2021
Int.Class C07H 21/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Appl.No PCT/CN2020/100030 Applicant NANJING GENSCRIPT BIOTECH CO., LTD. Inventor CHEN, Jinsen
The present invention relates to the field of nucleic acid fluorescence labeling. The present invention provides a fluorescently labeled nucleic acid and synthesis method therefor, to solve the problem in the prior art where detection is difficult for signals in high wavelength ranges of the red and violet regions of visible light. The present invention provides a fluorescently labeled nucleic acid containing a first dye and a second dye, characterized in that, the first dye, under an excitation light source having a wavelength of 488-515 nm, produces after excitation an emission spectrum and the emission spectrum is absorbed by the second dye, and the second dye, after absorbing the emission spectrum of the first dye, further emits a spectrum having a wavelength of 590-750 nm. The fluorescently labeled nucleic acid of the present invention can be applied to fluorescence detection in the red and violet regions of visible light.
9.WO/2021/004977PROCESS FOR THE DEPROTECTION OF OLIGONUCLEOTIDES
WO 14.01.2021
Int.Class C07H 21/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Appl.No PCT/EP2020/068922 Applicant F. HOFFMANN-LA ROCHE AG Inventor CHOI, Yong Rag
The invention relates to a new process for the purification of oligonucleotides which comprises the removal of an acid labile 5'hydroxy protecting group at the 5'- O-oligonucleotide terminus of the oligonucleotide by means of an on-column de-protection with an acid.
10.102019118332VERFAHREN UND TESTKIT ZUR BISULFITMODIFIZIERUNG VON DNA
DE 07.01.2021
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
Appl.No 102019118332 Applicant AJ INNUSCREEN GMBH Inventor Erfinder wird später genannt werden

Die vorliegende Anmeldung betrifft ein Verfahren und ein Testkit zur Durchführung einer Reaktion zur Bisulfitmodifizierung von DNA zur Bestimmung der Methylierungsmuster der DNA, dadurch gekennzeichnet, dass nach erfolgter Desaminierungsreaktion unter Verwendung von Bisulfit (z.B. Natriumbisulfit oder Ammoniumbisulfit) die modifizierte DNA an eine raue feste Phase gebunden wird und alle weiteren notwendigen Prozessschritte an dieser rauen festen Phase durchgeführt werden. Final erfolgt die Ablösung der modifizierten hochreinen DNA von dieser festen Phase. Das Verfahren kann manuell oder auch automatisiert durchgeführt werden Bei der rauen festen Phase handelt es sich um ein nicht-mineralisches Material mit einer rauen Oberfläche. embedded image