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IC:C07H

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1 / 28,074
1.WO/2025/248512PROCESS FOR PREPARING NAMODENOSON
WO - 04.12.2025
Int.Class C07H 1/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
 Appl.No PCT/IL2025/050227 Applicant CAN-FITE BIOPHARMA LTD. Inventor YU, Xiang Yang
The present invention provides a process for preparing namodenoson. More specifically, the present disclosure provides a simple and high yield process for Good Manufacturing Practice of namodenoson. The process involves the steps of protection, oxidation, chlorination, amination, reaction and final deprotection.
2.WO/2025/250521POLYACETAMIDOSACCHARIDES AND METHODS OF MAKING AND USE THEREOF
WO - 04.12.2025
Int.Class C07H 1/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
 Appl.No PCT/US2025/030999 Applicant BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM Inventor CALLMANN, Cassandra
The present invention relates to a polysaccharide comprising pendant amides, methods of making thereof, and copolymers, nanoparticles, compositions, thermoplastics, and membranes comprising the polysaccharide.
3.WO/2025/245592MULTI-TARGET COMPOUNDS, PROCESS FOR THE PREPARATION OF THE COMPOUNDS, INTERMEDIATES, PHARMACEUTICAL COMPOSITION, PHARMACEUTICALLY ACCEPTABLE SALTS, COMBINATION, MEDICAMENT, USE OF A COMPOUND AND METHOD OF TREATMENT
WO - 04.12.2025
Int.Class C07H 7/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
7Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
06Heterocyclic radicals
 Appl.No PCT/BR2024/050228 Applicant ACHÉ LABORATÓRIOS FARMACÊUTICOS S.A. Inventor DE AZEVEDO, Hatylas Felype Zaneti
The present invention relates to novel compounds of general Formula I with multifaceted pharmacological activities. The compounds of the invention exhibit SGLT1, SGLT2, and DPP4 inhibition. The present invention also provides processes and intermediates to obtain the compounds of the invention, pharmaceutical compositions comprising encompasses the compounds, processes and intermediates for the synthesis of the compounds, pharmaceutical compositions, combinations, medicaments, therapeutical uses and methods for the treatment of diseases, for instance, cardiovascular and renal diseases, including heart failure, chronic kidney disease, diabetes mellitus, diabetic nephropathy and myocardial infarction.
4.WO/2025/247331MODIFIED NUCLEOSIDE MONOMER AND OLIGONUCLEOTIDE PREPARED THEREFROM
WO - 04.12.2025
Int.Class C07H 19/20
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
16Purine radicals
20with the saccharide radical being esterified by phosphoric or polyphosphoric acids
 Appl.No PCT/CN2025/098080 Applicant CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD. Inventor ZHAO, Chenglong
The present invention relates to the field of biomedicine, and specifically relates to a modified nucleoside monomer compound, and an oligonucleotide prepared therefrom. The modified oligonucleotide has an extrahepatic delivery targeting effect, has high stability and high inhibitory activity, and can provide a more excellent treatment solution for treating diseases at targeted positions such as the CNS and ophthalmologic targeted positions, or delaying the progress of said diseases.
5.WO/2025/250766METHODS AND COMPOSITIONS FOR RAPID DETECTION AND ANALYSIS OF RNA AND DNA MODIFICATIONS
WO - 04.12.2025
Int.Class C01D 5/00
CCHEMISTRY; METALLURGY
01INORGANIC CHEMISTRY
DCOMPOUNDS OF ALKALI METALS, i.e. LITHIUM, SODIUM, POTASSIUM, RUBIDIUM, CAESIUM, OR FRANCIUM
5Sulfates or sulfites of sodium, potassium, or alkali metals in general
 Appl.No PCT/US2025/031380 Applicant THE UNIVERSITY OF CHICAGO Inventor LYU, Ruitu
Aspects of the present disclosure are directed to methods, compositions, and kits for detection and analysis of DNA and RNA cytosine methylation and/or RNA pseudouridylation. Certain aspects include methods, compositions and kits useful in bisulfite sequencing of methylated and/or pseudouridinylated nucleic acids, including methylated and/or pseudouridinylated nucleic acids from low-input samples such as cell-free DNA (cfDNA) and cell-free RNA, long fragment polynucleotides, and/or cfDNA and DNA from formalin-fixed paraffin-embedded (FFPE) samples. Also disclosed herein are methods, compositions and kits useful in bisulfite sequencing of methylated and/or pseudouridinylated nucleic acids with low nucleic acid damage, higher true positive results, and/or lower false negative results.
6.WO/2025/245770DEHYDROXYLATED BROWN ALGAE OLIGOSACCHARIDE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
WO - 04.12.2025
Int.Class C07H 7/033
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
7Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
02Acyclic radicals
033Uronic acids
 Appl.No PCT/CN2024/096265 Applicant HAITANG (JIANGSU) BIOTECHNOLOGY COMPANY, LTD. Inventor LIU, Zhende
The present invention relates to a dehydroxylated brown algae oligosaccharide derivative, and a preparation method therefor and a use thereof. The dehydroxylated brown algae oligosaccharide derivative provided by the present invention is formed by linking G or M with dihydroxylation at the 4-position of a non-reducing end to monosaccharide G and/or M by means of a 1,4-glycosidic bond. A dehydroxylated brown algae oligosaccharide acid derivative provided by the present invention is formed by linking G or M with dihydroxylation at the 4-position of a non-reducing end, G or M with oxidization into carboxyl at the 1-position of a reducing end, and monosaccharide G and/or M by means of a 1,4-glycosidic bond. The dehydroxylated brown algae oligosaccharide derivative and the dehydroxylated brown algae oligosaccharide acid derivative designed and synthesized in the present invention both have relatively good treatment effects on inflammatory diseases such as acute kidney injury, chronic kidney diseases, gout, ulcerative colitis, Crohn’s disease, oral ulcer, rhinitis, and liver injury.
7.WO/2025/247944SYNTHETIC CARBOHYDRATE COMPOSITION
WO - 04.12.2025
Int.Class A61K 31/7016
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7016Disaccharides, e.g. lactose, lactulose
 Appl.No PCT/EP2025/064730 Applicant DSM IP ASSETS B.V. Inventor HADDAD, Mariss
The present invention relates to a synthetic carbohydrate composition, methods and uses of the synthetic carbohydrate composition.
8.WO/2025/250953LINKAGE MODIFIED OLIGOMERIC AGENTS AND USES THEREOF
WO - 04.12.2025
Int.Class C07H 21/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04with deoxyribosyl as saccharide radical
 Appl.No PCT/US2025/031677 Applicant IONIS PHARMACEUTICALS, INC. Inventor WAN, W. Brad
The present disclosure provides oligomeric compounds (including oligomeric compounds that are antisense agents or portions thereof) comprising a modified oligonucleotide having at least one modified internucleoside linking group.
9.WO/2025/247382DOUBLE-STRANDED CIRCULAR SIRNA ASSEMBLY FOR GENE SILENCING
WO - 04.12.2025
Int.Class C12N 15/867
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
867Retroviral vectors
 Appl.No PCT/CN2025/098440 Applicant BEIJING SUPRACIRC BIOTECHNOLOGY CO. LTD. Inventor SUN, Yangyang
A double-stranded circular siRNA assembly, which is assembled from one circular sense strand (circSS strand) and one or more antisense strands (AS strands). The cyclization elements in the circular sense strand (circSS strand) comprise a key motif, a cyclization promoter and a lock motif. By relying on complementary base pairing interaction between the cyclization motifs, the 3' end and 5' end of an RNA sequence are very close to each other in terms of space and are ligated via an RNA ligase to complete cyclization of a target RNA. Further provided is the use of the double-stranded circular siRNA assembly in inhibiting the expression of a target gene in a subject.
10.WO/2025/245773FUCOIDAN OLIGOSACCHARIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF
WO - 04.12.2025
Int.Class C07H 7/033
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
7Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
02Acyclic radicals
033Uronic acids
 Appl.No PCT/CN2024/096273 Applicant HAITANG (JIANGSU) BIOTECHNOLOGY COMPANY, LTD. Inventor LIU, Zhende
The present invention relates to a fucoidan oligosaccharide derivative, a preparation method therefor, and a use thereof. The fucoidan oligosaccharide derivative provided by the present invention is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, where n is an integer, and n=1-8, preferably n=1-3. The fucoidan oligosaccharide derivative designed and synthesized in the present invention has good therapeutic effects on inflammatory diseases such as acute kidney injury, chronic kidney disease, gout, liver injury, oral ulcers, and rhinitis, and has good stability under different acidic and basic conditions. In addition, the present invention also provides a compound represented by formula (II) or a pharmaceutically acceptable salt thereof, which is constructed by the connection of monosaccharide G and/or M by means of 1,4-glycosidic bonds, and a compound represented by formula (III) or a pharmaceutically acceptable salt thereof, which is constructed by the connection of monosaccharide Δ and G and/or M by means of 1,4-glycosidic bonds, as well as a use of said compounds or salts in the preparation of a medicament for preventing and/or treating certain inflammatory diseases.
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