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1 / 28,084
1.20260008806TECHNOLOGIES FOR OLIGONUCLEOTIDE PREPARATION
US - 08.01.2026
Int.Class C07H 21/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
02with ribosyl as saccharide radical
 Appl.No 19085460 Applicant WAVE LIFE SCIENCES LTD. Inventor Keith Andrew Bowman

Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.

2.WO/2026/009986METHOD FOR PRODUCING COMPOUND, AND COMPOUND
WO - 08.01.2026
Int.Class C07F 9/6558
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic Table
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6558containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
 Appl.No PCT/JP2025/024406 Applicant TOKYO UNIVERSITY OF SCIENCE FOUNDATION Inventor WADA Takeshi
Provided are: a method for producing a compound useful as a nucleic acid monomer; and a compound useful as a starting material or an intermediate in the production method.　The method for producing a compound according to the present invention involves: an aryl oxidation step for reacting a compound (1) with a phenol compound ArOH in the presence of an amino group-protecting agent to obtain a compound (2); an amination step for reacting the compound (2) with an amine compound HNR6R7 to obtain a compound (3); and an oxidative halogenation step for oxidatively halogenating the compound (3) with a halogenating agent to obtain a compound (4). In the formula, R1 is an aryl group having or not having a substituent, R2 to R4 are each a hydrogen atom or the like, R5 is a protecting group for an amino group, R6 and R7 are each a hydrogen atom or the like, Ar is an aryl group having or not having a substituent, X is a halogenyl group, Nu is a monovalent group (5) or (6), R11 to R15 are each a hydrogen atom or the like, R21 is a protecting group for an amino group, and Bs is a nucleic acid base which may have a protecting group.
3.20260009088COMPOSITIONS AND METHODS FOR ENHANCING AND/OR PREDICTING DNA AMPLIFICATION
US - 08.01.2026
Int.Class C12Q 1/6895
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6888for detection or identification of organisms
6895for plants, fungi or algae
 Appl.No 19083369 Applicant ENVIROLOGIX INC. Inventor Lars PETERS

The present invention features compositions and methods for amplifying a target oligonucleotide in a sample, including detection of the target oligonucleotide in real time.

4.WO/2026/0079055'-SPIROPHOSPHONATE MODIFIED NUCLEOTIDE
WO - 08.01.2026
Int.Class C07H 21/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
02with ribosyl as saccharide radical
 Appl.No PCT/CN2025/105717 Applicant CHENGDU XINZELI BIOSCIENCES CO., LTD. Inventor CHEN, Bo
The present invention relates to an oligonucleotide containing a nucleotide monomer having a structure as represented by formula (I), and further relates to an RNAi agent containing the nucleotide monomer. In addition, the present invention further relates to a composition containing the oligonucleotide or RNAi agent, a kit, and the related use.
5.20260007689GPX4 Inhibitors and Senolytic Compounds and Uses Thereof
US - 08.01.2026
Int.Class A61K 31/704
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7034attached to a carbocyclic compound, e.g. phloridzin
704attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
 Appl.No 19325750 Applicant Rubedo Life Sciences, Inc. Inventor Alberto Clemente Vitari

The present invention relates to compounds that kill senescent cells i.e., senolytic compounds and compounds which inhibit GPX4. The present invention also provides compounds and methods for treating senescence-associated diseases or disorders, and compounds and methods for treating diseases or disorders impacted by GPX4.

6.WO/2026/009929COMPOUND, RNA SYNTHESIS INITIATOR, AND USE THEREOF
WO - 08.01.2026
Int.Class C07H 21/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
02with ribosyl as saccharide radical
 Appl.No PCT/JP2025/023865 Applicant FUJIFILM CORPORATION Inventor NAKAGAWA Daisuke
The present invention addresses the problem of providing a compound that can be used as an RNA synthesis initiator having a desired transcriptional activity, an RNA synthesis initiator containing the compound, a kit, RNA, and a method for producing RNA. The present invention provides a compound represented by formula (1). In the formula, each symbol other than X1, X2, and X has a definition stated in the description, X1, X2, and X each independently represent -O- or -S-, and each X, if existing in a number more than one, may be the same or different from each other. At least one of X1, X2, and X represents -S-.
7.20260009062TRANSFER OF C2'-EPIMERIZED SUGARS TO THE AMPHOTERICIN B AGLYCONE
US - 08.01.2026
Int.Class C12P 19/18
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
18produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
 Appl.No 18992385 Applicant The Board of Trustees of the University of Illinois Inventor Martin D. Burke

Disclosed are polypeptides and methods of glycosylating the C19 hydroxyl group of AmdeB (i.e., amphotericin B lacking the sugar moiety) comprising contacting AmdeB with a saccharide in the presence of one of the polypeptides. The methods access compounds that are analogues of amphotericin B with a modified sugar moiety that have an improved therapeutic index, such as C2′epiAmB. Also disclosed are pharmaceutical compositions comprising the compounds and a pharmaceutically acceptable carrier.

8.WO/2026/010948COMPOUNDS USEFUL FOR THE TREATMENT OF DISORDERS AND METHODS RELATED THERETO
WO - 08.01.2026
Int.Class C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
 Appl.No PCT/US2025/036081 Applicant OTSUKA AMERICA PHARMACEUTICAL, INC. Inventor SLASSI, Abdelmalik
The present disclosure relates to naphthylethylamine, quinolylethylamine, isoquinolynethylamine, and cinnolynethylamine derivative compounds of general Formula (I), to processes for their preparation, to compositions including naphthylethylamine, quinolylethylamine, isoquinolynethylamine, and cinnolynethylamine derivative compounds of general Formula (I), and to their use for treating diseases, disorders, or conditions. The diseases, disorders, or conditions include, for example, mental illnesses and neurological disorders.
9.WO/2026/007903QUINOLONE DERIVATIVE OF MACROLIDE, PREPARATION METHOD THEREFOR, AND USE THEREOF
WO - 08.01.2026
Int.Class C07H 17/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04Heterocyclic radicals containing only oxygen as ring hetero atoms
08Hetero rings containing eight or more ring members, e.g. erythromycins
 Appl.No PCT/CN2025/105698 Applicant BEIJING INSTITUTE OF TECHNOLOGY Inventor LIANG, Jianhua
Provided are a compound represented by formula (I), a stereoisomer, tautomer, isotopic marker, nitrogen oxide, solvate, polymorph, metabolite, ester, pharmaceutically acceptable salt, or prodrug thereof, or a pharmaceutical composition. The compound has good antibacterial and anti-inflammatory effects, can be used as an antibiotic, can treat infections caused by pathogenic microorganisms resistant to erythromycin and telithromycin, and simultaneously acts on two targets, i.e., ribosomes and topoisomerase.
10.WO/2026/007963MACROPHAGE-TARGETING COMPOUND AND USE THEREOF
WO - 08.01.2026
Int.Class C07H 15/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
02Acyclic radicals, not substituted by cyclic structures
04attached to an oxygen atom of a saccharide radical
 Appl.No PCT/CN2025/106469 Applicant FUDAN UNIVERSITY Inventor CHEN, Guosong
The present invention relates to the technical field of biology, and specifically relates to a macrophage-targeting compound and a use thereof. The compound uses a saccharide as a raw material, and the problem of functional instability caused by the non-uniform structural composition of the compound is avoided while the high targeting performance of the compound is maintained. By selecting the basic unit of a saccharide as a targeting moiety and then linking to a hydrophobic chain, the aggregation of saccharide units in water is completed, ensuring the high targeting performance of the design material. The saccharide-containing compound and a complex thereof can specifically target macrophages in plaques without affecting other cells, thereby achieving in vivo specific targeting of macrophages.
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