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1 / 27,972
1.WO/2025/191337OLIGONUCLEOTIDE TERMINAL PHOSPHATE DERIVATIVES AND METHOD OF USE
WO - 18.09.2025
Int.Class C07H 19/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
06Pyrimidine radicals
10with the saccharide radical being esterified by phosphoric or polyphosphoric acids
 Appl.No PCT/IB2025/000088 Applicant SYNERK BIOTECH LIMITED Inventor YU, Dong
The present invention provides a nucleotide derivative that stabilizes the terminal monophosphate of an oligonucleotide and oligonucleotides comprising the derivative. This monophosphate derivative according to the invention can be used to improve the targeted gene silencing efficiency of oligonucleotide drugs and has broad application prospects for drug research and development.
2.WO/2025/193167BIOORTHOGONAL URINE TEST
WO - 18.09.2025
Int.Class C08B 37/08
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
BPOLYSACCHARIDES; DERIVATIVES THEREOF
37Preparation of polysaccharides not provided for in groups C08B1/-C08B35/110; Derivatives thereof
08Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
 Appl.No PCT/SG2025/050174 Applicant NANYANG TECHNOLOGICAL UNIVERSITY Inventor PU, Kanyi
Disclosed herein are a bioorthogonal urinary reporter for cancer detection, a bioorthogonal urinary reporter for treatment-associated kidney injury, a bioorthogonal fluorescence indicator, and kits of parts thereof. Also disclosed herein are methods for detecting cancer in a subject, for detecting treatment-associated kidney injury in a subject, and for cancer detection and for detecting treatment-associated kidney injury.
3.WO/2025/192761COMPOUNDS FOR INDUCING NICOTINAMIDE ADENINE DINUCLEOTIDE, COMPOSITION COMPRISING SAME, AND DERMATOLOGICAL TOPICAL AGENT
WO - 18.09.2025
Int.Class C07H 19/048
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
048Pyridine radicals
 Appl.No PCT/KR2024/003132 Applicant REMYBIO CORP. Inventor LEE, Dong Hee
The present disclosure relates to a nicotinic acid riboside derivative compound or a nicotinamide riboside derivative compound. The derivative compound has excellent heat stability and efficiently induces the biosynthesis of nicotinamide adenine dinucleotide (NAD+). The derivative compound, a physiologically acceptable salt thereof and/or a stereoisomer thereof may be utilized as an effective ingredient or an active ingredient of an anti-inflammatory composition, a composition for alleviating or improving inflammation, an anti-aging composition and/or an anti-aging dermatological topical agent.
4.WO/2025/193841POLYSACCHARIDES AND METHODS OF PREPARING SAME
WO - 18.09.2025
Int.Class C08B 37/00
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
BPOLYSACCHARIDES; DERIVATIVES THEREOF
37Preparation of polysaccharides not provided for in groups C08B1/-C08B35/110; Derivatives thereof
 Appl.No PCT/US2025/019585 Applicant THE TRUSTEES OF BOSTON COLLEGE Inventor NIU, Jia
Disclosed are L-polysaccharides including 5 to 10000 repeating units linked through a β-1,4-glycosidic bond to an adjacent unit, in which each of the repeating units contains an L-monosaccharide residue derived from L-glucose, L-mannose, L- galactose, L-N-acetylglucosamine, or any combination thereof. Also disclosed are precision polysaccharides, methods of preparing these polysaccharides, and pharmaceutical compositions containing such polysaccharides.
5.WO/2025/190989TARGETED PRODRUGS FOR THE RESOLUTION OF BACTERIAL INFECTIONS
WO - 18.09.2025
Int.Class A61K 47/55
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
54the modifying agent being an organic compound
55the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
 Appl.No PCT/EP2025/056703 Applicant AARHUS UNIVERSITET Inventor ZELIKIN, Alexander N.
The present invention relates to compounds comprising a glycopeptide antibiotic, such as vancomycin, dalbavancin or teicoplanin, or a mitomycin C, one or more antibacterial agents, and a biodegradable linker linking the glycopeptide antibiotic, such as vancomycin, dalbavancin or teicoplanin, or the mitomycin C and the one or more antibacterial agents.
6.WO/2025/189691METHOD FOR SYNTHESIZING N2-C6 AMINO-MODIFIED DEOXYGUANOSINE MONOMER
WO - 18.09.2025
Int.Class C07H 19/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
16Purine radicals
 Appl.No PCT/CN2024/114540 Applicant SANGON BIOTECH (SHANGHAI) CO., LTD. Inventor BAI, Qifan
The present invention belongs to the technical field of DNA synthesis. Provided is a method for synthesizing an N2-C6 amino-modified deoxyguanosine monomer. The synthesis method comprises: performing a silylation protection reaction on deoxyguanosine under the protection of a silanization reagent so as to obtain a first intermediate; performing a Mitsunobu reaction on a second reaction raw material to obtain a second intermediate; performing a nucleophilic substitution reaction on the first intermediate and the second intermediate to obtain a third intermediate; and performing a desilylation protection reaction and a protective group introduction reaction, followed by an activation coupling reaction to obtain a final product. In the synthesis method, the final product is prepared by performing the silylation protection reaction, the Mitsunobu reaction, the nucleophilic substitution reaction, the protective group introduction reaction and the activation coupling reaction on the raw materials. The synthesis method has the advantages of the chemical raw materials used being simple and readily available, and being low cost; having mild reaction conditions, and easy to scale-up production; high stability of the intermediate obtained; and being a simple purification method and easily operated.
7.WO/2025/193786OLIGONUCLEOTIDES FOR PRNP MODULATION
WO - 18.09.2025
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
 Appl.No PCT/US2025/019501 Applicant UNIVERSITY OF MASSACHUSETTS Inventor GENTILE, Juliana
This disclosure relates to novel PRNP targeting sequences. Novel PRNP targeting oligonucleotides for the treatment of neurodegenerative diseases are also provided.
8.WO/2025/189705METHOD FOR PREPARING TREHALOSE FROM STARCH
WO - 18.09.2025
Int.Class C12P 19/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
12Disaccharides
 Appl.No PCT/CN2024/117960 Applicant SHANDONG TIANLI PHARMACEUTICAL CO., LTD Inventor ZHAO, Peipei
A method for preparing trehalose from starch, relating to the technical field of trehalose. The method comprises the steps of: starch milk preparation; liquification; carrier preparation; enzymatic hydrolysis; filtering, decolorization and ion exchange; crystallization; and centrifugal drying. The step of carrier preparation comprises the steps of mixed sulfuric acid solution preparation, reaction, post-treatment and modification. The step of mixed sulfuric acid solution preparation comprises: mixing cetyltrimethylammonium bromide and carboxymethyl cellulose with sodium dodecyl sulfate, then carrying out ultrasonic treatment, controlling the ultrasonic time to be 10-14 min and the ultrasonic frequency to be 10-12 kHz, and after the ultrasonic treatment, adding the mixture to a sulfuric acid solution and uniformly stirring same to obtain a mixed sulfuric acid solution. The prepared trehalose has high purity and excellent yield, and a composite enzyme immobilized on modified silica has good reusability after recovery, significantly reducing the use amount of an enzyme, and lowering the production cost.
9.WO/2025/193694COMPOSITIONS AND METHODS FOR RESETTING BIOLOGY OF CELLS
WO - 18.09.2025
Int.Class A61K 31/7076
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
7064containing condensed or non-condensed pyrimidines
7076containing purines, e.g. adenosine, adenylic acid
 Appl.No PCT/US2025/019366 Applicant EGACEUTICAL CORPORATION Inventor HUIZENGA, Joel Timothy
A composition for administering to a subject includes a first compound chosen from S-5'-adenosyl-L-methionine (SAM), methionine, betaine, choline, folate, vitamin B12, glycine, serine, threonine, and any combination thereof, and a second compound chosen from spermidine, spermine, calcium peroxide, zinc, N-Acetylcysteine, cysteine, α-ketoglutarate, fucoidans, harmine, taurine, ergothioneine, urolithin A, terpenoids, berberine, O3, H2O2, hydrogen sulfide (H2S), sodium hydrosulfide (NaSH), sodium sulfide (Na2S), metformin, acetaminophen, curcumin, quercetin, ginseng, R-alpha-lipoic acid, apigenin, fisetin, melatonin, ginger, astaxanthin methylene blue and optionally, a carrier, and any combination thereof
10.WO/2025/193889SOYBEAN WITH IMPROVED NODULATION
WO - 18.09.2025
Int.Class C12N 15/82
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
82for plant cells
 Appl.No PCT/US2025/019676 Applicant INARI AGRICULTURE TECHNOLOGY, INC. Inventor MEI, Wenbin
The disclosure relates to novel soybean plants, plant parts, and nucleotide sequences in soybean plants comprising a mutated RIC1 gene, along with methods of using and making the same.
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