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Analysis

1 / 28,066
1.WO/2026/006477OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF
WO - 02.01.2026
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
 Appl.No PCT/US2025/035290 Applicant WAVE LIFE SCIENCES LTD. Inventor LAKE, Stephen Lister
Among other tilings, the present disclosure provides various technologies including chirally controlled oligonucleotide compositions and technologies for manufacturing and using such oligonucleotide compositions. In some embodiments, the present disclosure provides technologies useful for allele-specific knockdown of mutant Huntingtin transcripts. In some embodiments, the present disclosure provides technologies usefill for reducing the expression, level, amount, and/or activity of mutant Huntingtin transcripts or products thereof. In some embodiments, the present disclosure provides methods for treating Huntington's disease.
2.WO/2026/003236AMORPHOUS FORM OF NATAMYCIN
WO - 02.01.2026
Int.Class C07H 17/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04Heterocyclic radicals containing only oxygen as ring hetero atoms
08Hetero rings containing eight or more ring members, e.g. erythromycins
 Appl.No PCT/EP2025/068190 Applicant DSM IP ASSETS B.V. Inventor DE HAAN, Ben Rudolf
The invention relates to a novel amorphous natamycin, compositions comprising it, the use of amorphous natamycin or of the compositions in food, feed, crop or pharmaceutical products, and a manufacturing process to obtain the amorphous natamycin.
3.WO/2026/002117BICYCLIC STRUCTURE AND OLIGONUCLEOTIDE COMPRISING SAME
WO - 02.01.2026
Int.Class C07H 21/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
02with ribosyl as saccharide radical
 Appl.No PCT/CN2025/103832 Applicant TUOJIE BIOTECH (SHANGHAI) CO., LTD. Inventor LIU, Haomiao
A bicyclic structure and an oligonucleotide comprising same, the oligonucleotide comprising at least one structure represented by formula (I').
4.WO/2026/006107NOVEL OLIGONUCLEOTIDES BEARING A "2-PROPYL" INTERNUCLEOSIDE LINKAGE
WO - 02.01.2026
Int.Class C07H 19/067
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
06Pyrimidine radicals
067with ribosyl as the saccharide radical
 Appl.No PCT/US2025/034479 Applicant ELI LILLY AND COMPANY Inventor BAWEL, Seth Andrew
Disclosed herein are nucleic acids containing a modified internucleotide linkage, which is the 2-propyl (PrON) linkage, to increase durability and exposure of therapeutic oligonucleotides, as well as nucleotides, phosphoramidites, and other intermediate compounds useful for making the same.
5.WO/2026/002251SCUTELLARIA BAICALENSIS EXTRACT, AND PREPARATION METHOD THEREFOR AND USE THEREOF
WO - 02.01.2026
Int.Class C07H 17/07
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04Heterocyclic radicals containing only oxygen as ring hetero atoms
06Benzopyran radicals
065Benzopyrans
07Benzopyran-4-ones
 Appl.No PCT/CN2025/104801 Applicant CHENGUANG BIOTECH GROUP CO., LTD. Inventor LU, Qingguo
The present invention relates to the technical field of plant extracts, and in particular to a Scutellaria baicalensis extract, and a preparation method therefor and a use thereof. The preparation method for a Scutellaria baicalensis extract provided by the present invention achieves a baicalin yield exceeding 88% and a baicalin content over 90% in the extract. The prepared Scutellaria baicalensis extract meets quality standard requirements and can be used in traditional Chinese medicine and formulations thereof, veterinary drugs and formulations thereof, food, and daily chemical products. In addition, the method of the present invention has a simpler, greener and more efficient process, and is easily applicable to industrial production.
6.WO/2026/000059NEURODEVELOPMENTAL DISORDER TREATMENT
WO - 02.01.2026
Int.Class A61K 31/7072
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
7064containing condensed or non-condensed pyrimidines
7068having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
7072having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
 Appl.No PCT/CA2025/050486 Applicant OTTAWA HOSPITAL RESEARCH INSTITUTE Inventor LACOSTE, Baptiste Jean Xavier
The present disclosure relates to the treatment and/or prevention of neurodevelopmental disorders, especially Autism Spectrum Disorders (ASD), using P2Y2 agonists such as: Diquafosol, Denufosol, MRS2698, MRS2768, PSB1114, ATP, ATP derivatives, UTP, UTP derivatives, 2-((ethyl(4-fluorobenzyl)amino)methyl)-7,8-dimethylquinolin-4(1H)-one, or a pharmaceutically acceptable salt or solvate thereof. Also disclosed herein are combination therapies, compositions, and kits for the treatment and/or prevention of neurodevelopmental disorders using said P2Y2 agonists.
7.WO/2026/006553COLORANTS AND METHODS OF MAKING AND USE THEREOF
WO - 02.01.2026
Int.Class C09B 57/02
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES; MORDANTS; LAKES
57Other synthetic dyes of known constitution
02Coumarine dyes
 Appl.No PCT/US2025/035425 Applicant OHIO STATE INNOVATION FOUNDATION Inventor VOSS, Danielle
Disclosed herein are colorants and methods of making and use thereof. For example, disclosed herein are colorant compositions comprising a hydroxyphenyl pyranoanthocyanin of Formula (I). Also disclosed herein are thermal degradation compounds derived via thermal degradation of any of the colorants disclosed herein. Also disclosed herein are thermal degradation compounds derived via thermal degradation of 10-catechyl-pyranocyanidin-3-O-β-glucoside. In some examples, the thermal degradation compound comprises 4-carboxy-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromenylium. Also disclosed herein are compositions, beverages, food products, edible products, cosmetic products, and/or dye sensitized solar cells comprising any of the colorants and/or thermal degradation compounds disclosed herein. Also disclosed herein are methods of making any of the colorants and/or thermal degradation compounds disclosed herein.
8.WO/2026/001270ENGINEERED TRNA MOLECULES AND METHODS
WO - 02.01.2026
Int.Class C12N 15/11
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
 Appl.No PCT/CN2025/091495 Applicant ZHUHAI CODONE BIOTECHNOLOGY CO., LTD. Inventor ZHU, Jianguo
The engineered transfer RNA (tRNA) molecules for carrying an arginine (Arg) amino acid (including, for example, a suppressor tRNA), the expression cassettes and vectors comprising nucleic acids encoding an engineered tRNA, pharmaceutical compositions comprising the expression cassettes, vectors, and/or the engineered tRNA, and methods of restoring translation and/or disease treatment involving engineered suppressor tRNA molecules are provided.
9.WO/2026/003215BASES CHEMICALLY MODIFIED WITH A CLEAVABLE GROUP AND METHODS OF SELECTING FUNCTIONAL NUCLEIC ACIDS COMPRISING SAME
WO - 02.01.2026
Int.Class C07H 19/073
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
06Pyrimidine radicals
073with 2-deoxyribosyl as the saccharide radical
 Appl.No PCT/EP2025/068153 Applicant COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES Inventor DUCONGE, Frédéric
The present invention concerns the field of modified nucleic acids, and in particular aptamer, ribozyme or deoxyribozyme functional nucleic acids, and methods for selecting (SELEX) such modified nucleic acids. The invention concerns nucleobases, nucleosides and nucleotides modified by a particular chemical group, and the uses thereof, in particular in methods for reverse transcription, amplification and selection of functional nucleic acids, regardless of the chemical group attached to the modified nucleic acids to be selected, provided that said group is cleavable via an SPICC reaction.
10.WO/2026/002240PREPARATION METHOD FOR SCUTELLARIA BAICALENSIS EXTRACT
WO - 02.01.2026
Int.Class C07H 17/07
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04Heterocyclic radicals containing only oxygen as ring hetero atoms
06Benzopyran radicals
065Benzopyrans
07Benzopyran-4-ones
 Appl.No PCT/CN2025/104738 Applicant CHENGUANG BIOTECH GROUP CO., LTD. Inventor XU, Meili
The present invention relates to the technical field of plant extracts, and in particular to a preparation method for a Scutellaria baicalensis extract. According to the preparation method for a Scutellaria baicalensis extract of the present invention, the yield of baicalin reaches 90% or above, the content of baicalin in the extract can be 85% or above, and the prepared Scutellaria baicalensis extract meets the quality standard requirements, and can be used in traditional Chinese medicines and preparations thereof, veterinary drugs and preparations thereof, foods, and daily chemical products. Moreover, the method of the present invention requires only a single acid precipitation treatment, involves simpler process, significantly improves the yield of baicalin, and has good prospects for application.
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