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Analysis

1 / 28,105
1.WO/2026/022256GALLIUM-APRAMYCIN COMPLEXES, METHODS OF PREPARATION THEREOF AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS
WO - 29.01.2026
Int.Class A61K 31/7036
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7034attached to a carbocyclic compound, e.g. phloridzin
7036having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
 Appl.No PCT/EP2025/071246 Applicant INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE Inventor TEWES, Frédéric
The present invention relates to novel complexes of gallium and apramycin. The complexes according to the invention are useful in the treatment of bacterial infections. The complexes are particularly suitable for administration by inhalation when they are provided in the form of spray-dried particles.
2.WO/2026/021467STEREOSPECIFIC LINKAGES DOUBLE STRANDED RNA AGENTS AND COMPOSITIONS
WO - 29.01.2026
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
 Appl.No PCT/CN2025/110030 Applicant SHANGHAI ARGO BIOPHARMACEUTICAL CO., LTD. Inventor SHU, Dongxu
The present disclosure provides a double-stranded nucleic acid, compositions, and methods relating thereto. The present disclosure encompasses the recognition that structural elements of double stranded nucleic acid, such as stereochemistry of backbone chiral centers (chiral internucleonic linkages), and/or patterns thereof, specially, double-stranded nucleic acid having one or more chirally enriched phosphorothioate internucleotide linkages can have significant impact on oligonucleotide properties and activities, e.g., RNA interference (RNAi) activity, stability, delivery, etc. The present disclosure also provides methods for treatment of diseases using provided double stranded nucleic acid compositions, for example, in RNA interference.
3.WO/2026/022036METHOD FOR MANUFACTURING L-FUCOSE POWDER BY SPRAY-DRYING AND SPRAY-DRIED L-FUCOSE POWDER
WO - 29.01.2026
Int.Class A23P 10/43
AHUMAN NECESSITIES
23FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; PREPARATION, TREATMENT OR PRESERVATION THEREOF
PSHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
10Shaping or working of foodstuffs characterised by the products
40Making free-flowing powder or instant powder, i.e. powder which is reconstituted rapidly when liquid is added
43using anti-caking agents or agents improving flowability, added during or after formation of the powder
 Appl.No PCT/EP2025/070686 Applicant CHR. HANSEN A/S Inventor VALENTINER, Borge
Disclosed is a spray-dried powder consisting essentially of L-fucose and an additive that enables spray-drying of L-fucose, said additive being maltodextrin or skimmed milk powder, a method of spray-drying L-fucose to obtain said spray-dried powder, and the use of the spray-dried powder for manufacturing nutritional compositions or pharmaceutical compositions.
4.WO/2026/025019SYNTHESIS OF MACROBICYCLIC THIOLINCOSAMINES
WO - 29.01.2026
Int.Class C07H 15/26
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
26Acyclic or carbocyclic radicals, substituted by hetero rings
 Appl.No PCT/US2025/039234 Applicant PRESIDENT AND FELLOWS OF HARVARD COLLEGE Inventor TRESCO, Ben, Calhoun
Provided herein are methods for preparing macrobicyclic thiolincosamines and associated synthetic intermediates. These routes allow access to lincosamide analogues, which are useful for the treatment and prevention of infectious diseases. The methods are scalable and provide access to multi-gram quantities of the aminooctose (northern) fragments of the lincosamide analogues.
5.WO/2026/021564FLAVONOID COMPOUND, AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USE THEREOF
WO - 29.01.2026
Int.Class C07D 311/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
04Benzo pyrans, not hydrogenated in the carbocyclic ring
22with oxygen or sulfur atoms directly attached in position 4
26with aromatic rings attached in position 2 or 3
28with aromatic rings attached in position 2 only
30not hydrogenated in the hetero ring, e.g. flavones
 Appl.No PCT/CN2025/110546 Applicant SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY COMPANY LIMITED Inventor ZHANG, Qingwen
Disclosed in the present invention are a flavonoid compound, and a preparation method therefor, a pharmaceutical composition comprising same, and a use thereof. The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof. The compound of the present invention has broad-spectrum activity against diseases caused by infection with α coronaviruses (e.g., PEDV) and δ coronaviruses (e.g., PDCoV), and/or the compound of the present invention has biological activity in treating tumors.
6.WO/2026/024156ANTIVIRAL COMPOSITION TARGETING RDRP AND NIRAN
WO - 29.01.2026
Int.Class C07H 19/067
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
06Pyrimidine radicals
067with ribosyl as the saccharide radical
 Appl.No PCT/KR2025/011192 Applicant SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION Inventor JEONG, Lak Shin
The present invention relates to a compound exhibiting an antiviral effect and, more particularly, to a novel compound that simultaneously targets RNA-dependent RNA polymerase (RdRP) and Nidovirus RdRP-Associated Nucleotidyltransferase (NiRAN). The compound of the present invention exhibits higher antiviral activity than existing drugs, and thus can be usefully used as a therapeutic agent for viral infections.
7.WO/2026/024784COMPOSITION AND METHOD FOR PREVENTING OR TREATING NEURODEGENERATIVE DISEASES
WO - 29.01.2026
Int.Class A61K 31/203
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
20having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
203Retinoic acids
 Appl.No PCT/US2025/038754 Applicant MASTERY BIOTECH CO., LTD. Inventor LIN, Bo-Lin
Provided are methods for prevention or treatment of neurodegenerative diseases. Also provided are compositions for use in preventing or treating neurodegenerative diseases.
8.WO/2026/019365APTAMERS AND RIBOSWITCHES OF CANNABIELSOIN FOR IN VITRO AND IN VIVO SENSING
WO - 22.01.2026
Int.Class C07H 21/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
 Appl.No PCT/SG2025/050474 Applicant NATIONAL UNIVERSITY OF SINGAPORE Inventor ZHANG, Jingyun
Disclosed is an aptamer capable of binding to Cannabielsoin (CBE), wherein the aptamer is: an RNA aptamer having a nucleotide sequence of: CGCGGGCAGUGNNNUGCANNNNNNNNUGUGNNNUAUUAGC (SEQ ID NO: 1); or a DNA aptamer having a nucleotide sequence of: CGCGGGCAGTGNNNTGCANNNNNNNNTGTGNNNTATTAGC (SEQ ID NO: 2), wherein for SEQ ID NO: 1, N is one nucleotide selected from the group consisting of A, G, U and C, and wherein for SEQ ID NO: 2, N is one nucleotide selected from the group consisting of A, G, C and T. Also disclosed is a riboswitch and a DNA expression cassette comprising the aptamer, a composition thereof, and a microbe containing the riboswitch or DNA expression cassette. Further disclosed is a method of detecting CBE produced in a microbe using the aptamer or riboswitch as disclosed herein.
9.WO/2026/019170CULTURE MEDIUM FOR ENHANCING CORDYCEPIN CONTENT USING HERMETIA ILLUCENS ADULT INSECTS AND METHOD FOR EXTRACTING CORDYCEPIN USING SAME
WO - 22.01.2026
Int.Class C07H 19/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
16Purine radicals
 Appl.No PCT/KR2025/010170 Applicant CIRCULAR BIO CO., LTD Inventor PARK, Hee Sok
Provided is a culture medium for enhancing the content of cordycepin from Cordyceps militaris, wherein the culture medium comprises Hermetia illucens adult insects. According to the present invention, the culture medium can ensure a significantly higher cordycepin yield than conventional grain-based media or pupa-based media by means of a method for extracting cordycepin from Cordyceps militaris cultured using Hermetia illucens adult insects as a host.
10.WO/2026/019367COMPOUNDS, EXTRACELLULAR VESICLES AND USES THEREOF
WO - 22.01.2026
Int.Class C07D 417/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14containing three or more hetero rings
 Appl.No PCT/SG2025/050479 Applicant NATIONAL UNIVERSITY OF SINGAPORE Inventor WANG, Dandan
The present disclosure concerns a compound for in situ labelling and synchronously promoting the secretion of extracellular vesicles from cells. The compound comprises a sugar or glucosamine linked to a drug. The drug may be a photosensitizer. The present disclosure also concerns the extracellular vesicle thereof, and methods of treating a tumor and/or a proliferative disease.
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