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Analysis

1.WO/2025/255972COMPOUND FOR TARGETED DELIVERY OF OLIGONUCLEOTIDE DRUG, CONJUGATE, AND USE
WO 18.12.2025
Int.Class C07H 15/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
02Acyclic radicals, not substituted by cyclic structures
04attached to an oxygen atom of a saccharide radical
Appl.No PCT/CN2024/116620 Applicant BEBETTER MED INC. Inventor WENG, Yunwo
Provided are a compound for targeted delivery of an oligonucleotide drug, and a conjugate formed by binding the compound to the oligonucleotide drug, for use in delivering one or more different oligonucleotide drugs. The compound has a structure as shown in formula (I), formula (II), or formula (III).
2.WO/2025/257997METHOD FOR SYNTHESIZING OLIGO- OR POLY-NUCLEOTIDES
WO 18.12.2025
Int.Class C07H 21/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04with deoxyribosyl as saccharide radical
Appl.No PCT/JP2024/021414 Applicant TKG THERAPEUTICS, INC. Inventor OKAMOTO Akimitsu
The present invention addresses the problem of providing a method for solid-phase nucleic acid synthesis using a smaller amount of free nucleosides than those in conventional methods. Provided is a method for synthesizing oligo- or poly-nucleotides by adding activated free nucleosides to immobilized nucleosides, the method comprising a coupling step in which the immobilized nucleosides are exposed to a solution of the activated free nucleosides for coupling hydroxyl groups of the immobilized nucleosides with activated groups of the activated free nucleosides, the coupling step being performed using a solution used once or more for coupling.
3.WO/2025/2599925'-MODIFIED MONOMERS, OLIGONUCLEOTIDES AND DOUBLE-STRANDED RNAS
WO 18.12.2025
Int.Class C07H 19/067
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
06Pyrimidine radicals
067with ribosyl as the saccharide radical
Appl.No PCT/US2025/033557 Applicant ALNYLAM PHARMACEUTICALS, INC. Inventor SALINAS, Juan
The technology described herein relates to 5'-modified nucleosides, nucleotides, oligonucleotides and double-stranded RNAs, e.g., siRNAs, and kits comprising them and methods of their use for inhibiting target genes.
4.WO/2025/259961PROCESSES FOR THE PREPARATION OF ANHYDROSUGARS
WO 18.12.2025
Int.Class C07H 3/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
3Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
10Anhydrosugars, e.g. epoxides
Appl.No PCT/US2025/033504 Applicant UNIVERSITY OF PUERTO RICO Inventor HORTAL-SÁNCHEZ, Isabel
Disclosed herein are methods for preparing anhydrosugars from aldohexoses and preparations of anhydrosugars prepared using the disclosed methods. In particular, the disclosure relates to processes for preparing anhydrosugars in polar aprotic solutions and in the presence of an acidic heterogeneous catalyst.
5.WO/2025/259570METHODS AND COMPOSITIONS FOR INHIBITING VIRUS
WO 18.12.2025
Int.Class C07H 21/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
02with ribosyl as saccharide radical
Appl.No PCT/US2025/032784 Applicant ALIGOS THERAPEUTICS, INC. Inventor THATIKONDA, Santhosh Kumar
The present application relates to derivatives of STOPS™ antiviral compounds having enhanced helicity, wherein the compounds are S-antigen transport inhibiting oligonucleotide polymers. This application further relates to processes for making the compounds and methods of using them to treat diseases and conditions. In some embodiments, the diseases and conditions are related to hepatitis B and/or hepatitis D.
6.WO/2025/257401NOVEL ISOPHTHALATE COMPOUNDS FOR THE TREATMENT OF A VIRAL LUNG INFECTION
WO 18.12.2025
Int.Class C07C 63/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
63Compounds having carboxyl groups bound to carbon atoms of six-membered aromatic rings
14Monocyclic dicarboxylic acids
15all carboxyl groups bound to carbon atoms of the six-membered aromatic ring
241,3-Benzenedicarboxylic acid
Appl.No PCT/EP2025/066598 Applicant UNIVERSITE DE TOURS Inventor HADJ MOHAMED, Ameni
The present invention relates to a compound of formula (I) and its use in a method of treatment of a viral infection, particularly of a viral lung infection. The present invention further relates to pharmaceutical compositions comprising the compound of formula (I).
7.WO/2025/259726METHODS FOR SEPARATING DIASTEREOMERS OF DOUBLE-STRANDED OLIGONUCLEOTIDES
WO 18.12.2025
Int.Class C12N 15/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
Appl.No PCT/US2025/033091 Applicant AMGEN INC. Inventor GUAN, Lianxiu
Provided herein are methods of separating diastereomers of a double-stranded oligonucleotide. In exemplary embodiments, the method comprises: (a) applying a sample comprising diastereomers of a double-stranded oligonucleotide to an anion exchange (AEX) chromatographic matrix, wherein each strand of the double-stranded oligonucleotide comprises at least one phosphorothioate internucleotide linkage; and (B) applying a mobile phase to the AEX chromatographic matrix to elute the diastereomers of the double-stranded oligonucleotide from the matrix, wherein the mobile phase comprises a buffer and an elution salt and has a pH of greater than 10.
8.WO/2025/2600115'-MODIFIED MONOMERS, OLIGONUCLEOTIDES AND DOUBLE-STRANDED RNAS
WO 18.12.2025
Int.Class C07H 19/067
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
06Pyrimidine radicals
067with ribosyl as the saccharide radical
Appl.No PCT/US2025/033588 Applicant ALNYLAM PHARMACEUTICALS, INC. Inventor SALINAS, Juan
The technology described herein relates to 5'-modified nucleosides, nucleotides, oligonucleotides and double-stranded RNAs, e.g., siRNAs, and kits comprising them and methods of their use for inhibiting target genes.
9.WO/2025/257280METHOD FOR PURIFICATION OF RNA
WO 18.12.2025
Int.Class C12N 15/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
Appl.No PCT/EP2025/066312 Applicant MERCK PATENT GMBH Inventor YUSUKE, Akai
The present invention relates to a method for the chromatographic purification of mRNA. For this anion exchange chromatography is performed with dual pH and salt concentration change as well as a chaotrope in the elution buffer.
10.WO/2025/257400SYNTHESIS OF BRANCHED CHAIN OLIGOSACCHARIDES
WO 18.12.2025
Int.Class C12P 19/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
04Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
Appl.No PCT/EP2025/066596 Applicant DSM IP ASSETS B.V. Inventor ZEUNER, Birgitte
This invention relates to enzymatic reactions to make oligosaccharides with branched chain using trans-lacto-N-biosidase.