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Analysis

1 / 28,060
1.WO/2025/263286METHOD FOR PRODUCING RIBOSE PHOSPHATE COMPOUND AND METHOD FOR PREVENTING SOLUTE DEPOSITION IN SUPERSATURATED REACTION SOLUTION
WO - 26.12.2025
Int.Class C07H 13/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
13Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
 Appl.No PCT/JP2025/019915 Applicant FUJIFILM WAKO PURE CHEMICAL CORPORATION Inventor SHIBUSAWA, Sho
Provided is a method for producing a ribose phosphate compound, the method comprising hydrolyzing a compound represented by general formula (3) in the presence of an acidic compound by a pressurized flow reaction, thereby producing a ribose phosphate compound represented by general formula (1). R1 represents a hydrogen atom, a hydroxy group, or OR11, and R11 represents a group represented by general formula (2). R2 and R3 each represent a hydrogen atom or a group represented by general formula (2). The two R12 each represent a hydrogen atom or an alkali metal ion. * indicates a bonding part with an oxygen atom. R5 represents an adenyl group, a guanyl group, a cytosyl group, a uracil group, or a thyminyl group.　The compounds represented by general formulae (1) and (3) each have at least one group represented by general formula (2) per molecule.
2.WO/2025/264546LIPID-POLYNUCLEIC ACID CONJUGATE COMPOSITIONS AND USES THEREOF
WO - 26.12.2025
Int.Class A61K 31/7105
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
 Appl.No PCT/US2025/033759 Applicant SIRIUS THERAPEUTICS, INC. Inventor BRADSHAW, Curt W.
Disclosed herein are polynucleic acid conjugate compositions comprising a polynucleic acid molecule and one or more targeting moiety such as an asialoglycoprotein receptor targeting moiety and a lipophilic moiety, for targeted delivery of the polynucleic acid molecule to a target cell. Disclosed herein are also pharmaceutical compositions comprising polynucleic acid conjugate composition. Further, provided herein are methods and/or uses of polynucleic acid conjugate composition and pharmaceutical composition comprising polynucleic acid conjugate composition described herein.
3.WO/2025/260577CHEMICAL SYNTHESIS METHOD FOR VIBRIO CHOLERAE SEROTYPE O100 O-ANTIGEN OLIGOSACCHARIDE, AND USE
WO - 26.12.2025
Int.Class C07H 15/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
02Acyclic radicals, not substituted by cyclic structures
04attached to an oxygen atom of a saccharide radical
 Appl.No PCT/CN2024/127376 Applicant JIANGNAN UNIVERSITY Inventor YIN, Jian
Disclosed are a chemical synthesis method for Vibrio cholerae serotype O100 O-antigen oligosaccharide, and a use, belonging to the technical field of chemistry. The present invention uses three monosaccharide building blocks and five kinds of carboxylic acid derivative, and under the effects of solvent, temperature and neighboring group participation, through orthogonal protection, selective assembly and amide coupling, five Vibrio cholerae serotype O100 O-antigen oligosaccharide fragments are synthesized. Using the synthesized oligosaccharide fragments, combined with NMR analysis and carbohydrate chip technology, the absolute configuration and immunological function of the 3,5-dihydroxyhexanoyl group in the O-antigen trisaccharide are clarified, providing a theoretical basis for further structure-activity research and minimal antigen epitope screening. The present invention has promising applications in the synthesis of Vibrio cholerae glycoconjugate vaccines and the development of new drugs.
4.WO/2025/260576SPECIFIC SUGAR FRAGMENT FOR RESEARCH AND DEVELOPMENT OF VIBRIO CHOLERAE VACCINES
WO - 26.12.2025
Int.Class A61K 31/785
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
31Medicinal preparations containing organic active ingredients
74Synthetic polymeric materials
785Polymers containing nitrogen
 Appl.No PCT/CN2024/127370 Applicant JIANGNAN UNIVERSITY Inventor HU, Jing
The present invention relates to a specific sugar fragment for the research and development of Vibrio cholerae vaccines. By means of a chemical synthesis method and sugar fragments related to the Vibrio cholerae O100 serotype O antigen trisaccharide, combined with sugar chip technology, the structure-activity relationship between different sugar fragments and the antigenicity thereof is evaluated at the molecular level. Sugar chip screening shows that 3-hydroxybutyryl is a key structural feature of the O antigen. The non-reducing terminal disaccharide carrying 3-hydroxybutyryl is the smallest potential antigen epitope. The disaccharide has a strong ability to bind to an antibody, has a simple structure, and can be used as a specific sugar fragment for the research and development of vaccines. Sugar-conjugated vaccines designed on the basis of the specific sugar fragment can solve challenges such as difficult culture of pathogenic bacteria and inhomogeneous sugar antigens in naturally extracted polysaccharide vaccines. The present invention has good application prospects in the research and development of Vibrio cholerae sugar-conjugated vaccines, the detection of infections, the development of novel drugs, etc.
5.WO/2025/263591CRYSTALLINE FORM OF ORAL DNMT INHIBITOR
WO - 26.12.2025
Int.Class C07H 23/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
23Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
 Appl.No PCT/JP2025/022214 Applicant OHARA PHARMACEUTICAL CO., LTD. Inventor SAKO Magoichi
The present disclosure relates to a crystalline form of a hemihydrate of 5'- O-triethylsilyl -2'- deoxy-5-azacytidine, a method for preparing the same, and a pharmaceutical composition containing the crystalline form.
6.WO/2025/261399WHITENING AND SPOT-FADING COMPOSITION BASED ON MOLECULAR DOCKING TECHNOLOGY AND PREPARATION METHOD THEREFOR
WO - 26.12.2025
Int.Class A61K 8/49
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
8Cosmetics or similar toiletry preparations
18characterised by the composition
30containing organic compounds
49containing heterocyclic compounds
 Appl.No PCT/CN2025/101759 Applicant RENHE QUANYU (SHANGHAI) GREAT HEALTH RESEARCH INSTITUTE CO., LTD. Inventor LIN, Menggan
A whitening and spot-fading composition based on molecular docking technology and a preparation method therefor. The composition comprises atractylenolide I, pachymic acid, paeoniflorin and glabridin, wherein the mass ratio of the atractylenolide I, pachymic acid, paeoniflorin and glabridin is 50-600:100-700:600-2000:10-200. On the basis of the docking binding energy of active ingredients in four plants Atractylodes macrocephala, Paeonia lactiflora, poria cocos and licorice to a key target molecule of a disease, it is found by screening that compounding the atractylenolide I, pachymic acid, paeoniflorin and glabridin as active ingredients can obtain the composition having a remarkable whitening and spot-fading effect, the melanin synthesis inhibition rate of the composition reaches 69.4%-83.6%, and the tyrosinase activity inhibition rate of the composition reaches 76.8%-91.3%.
7.WO/2025/264834DNA (RNA) ASSEMBLY MEDIATED BY CHARGED AND CHARGE-SWITCHING PEPTIDES
WO - 26.12.2025
Int.Class C12P 19/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
 Appl.No PCT/US2025/034222 Applicant ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY Inventor LIU, Di
A positively-charged peptide was able to fold both 2D and 3D DNA origami structures under a physiological environment with high yield. In-situ investigation of the folding dynamics showed that the isothermal folding pathway was catalyzed by the short peptides. By adding phosphate to the arginine groups in the peptide, the positive charges on the peptide could be enzymatically controlled to control the folding of DNA structure pathways. This approach provides a method for creating adaptive DNA nanomachines with dynamic folding pathways under physiological environments.
8.WO/2025/264140TRINUCLEOTIDE CAPPING REAGENT, METHOD FOR PRODUCING SAME AND USE
WO - 26.12.2025
Int.Class C07H 21/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
 Appl.No PCT/RU2025/000171 Applicant FEDERAL STATE BUDGETARY INSTITUTION "NATIONAL RESEARCH CENTRE FOR EPIDEMIOLOGY AND MICROBIOLOGY NAMED AFTER THE HONORARY ACADEMICIAN N.F. GAMALEYA" OF THE MINISTRY OF HEALTH OF THE RUSSIAN FEDERATION Inventor GINTSBURG, Aleksandr Leonidovich
The group of inventions relates to the field of molecular biology, virology and medicine, and more particularly to novel reagents for the cotranscriptional capping of synthetic mRNA and to a method for producing same. The proposed reagent can be used to produce functional mRNA containing a 5' cap structure analog. The group of inventions makes it possible to create an mRNA cap structure analog that is cotranscriptionally incorporated into the structure of the mRNA and provides for more efficient mRNA translation.
9.WO/2025/261379MODIFIED NUCLEOSIDE COMPOUND, AND USE THEREOF IN OLIGONUCLEOTIDES
WO - 26.12.2025
Int.Class C07H 19/073
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
06Pyrimidine radicals
073with 2-deoxyribosyl as the saccharide radical
 Appl.No PCT/CN2025/101633 Applicant LEADERNA THERAPEUTICS, LTD. Inventor YU, Shuowen
Provided is a deuterated nucleoside phosphoramidite compound. The compound can be used for preparing an oligonucleotide drug, and can improve the stability, long-acting property, and efficacy of the oligonucleotide drug.
10.WO/2025/264933SYSTEM AND METHOD TO CONVERT CELLULOSIC MATERIALS INTO SUGAR
WO - 26.12.2025
Int.Class B01J 8/12
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
8Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
08with moving particles
12moved by gravity in a downward flow
 Appl.No PCT/US2025/034387 Applicant BLUE BIOFUELS, INC Inventor SLAGER, Benjamin
A system for converting cellulosic feedstock to sugar is disclosed and has a reactor chamber configured receive the cellulosic feedstock, a crusher assembly configured to receive the cellulose feedstock wherein the crusher assembly is configured to grind the mixture under pressure to induce a reaction between the cellulosic feedstock and a natural occurring griding element in the feedstock to produce a grinded mixture and sugar, wherein the crusher assembly comprises rollers.
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