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Analysis

1 / 28,091
1.WO/2026/019367COMPOUNDS, EXTRACELLULAR VESICLES AND USES THEREOF
WO - 22.01.2026
Int.Class C07D 417/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14containing three or more hetero rings
 Appl.No PCT/SG2025/050479 Applicant NATIONAL UNIVERSITY OF SINGAPORE Inventor WANG, Dandan
The present disclosure concerns a compound for in situ labelling and synchronously promoting the secretion of extracellular vesicles from cells. The compound comprises a sugar or glucosamine linked to a drug. The drug may be a photosensitizer. The present disclosure also concerns the extracellular vesicle thereof, and methods of treating a tumor and/or a proliferative disease.
2.WO/2026/019170CULTURE MEDIUM FOR ENHANCING CORDYCEPIN CONTENT USING HERMETIA ILLUCENS ADULT INSECTS AND METHOD FOR EXTRACTING CORDYCEPIN USING SAME
WO - 22.01.2026
Int.Class C07H 19/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
16Purine radicals
 Appl.No PCT/KR2025/010170 Applicant CIRCULAR BIO CO., LTD Inventor PARK, Hee Sok
Provided is a culture medium for enhancing the content of cordycepin from Cordyceps militaris, wherein the culture medium comprises Hermetia illucens adult insects. According to the present invention, the culture medium can ensure a significantly higher cordycepin yield than conventional grain-based media or pupa-based media by means of a method for extracting cordycepin from Cordyceps militaris cultured using Hermetia illucens adult insects as a host.
3.WO/2026/019365APTAMERS AND RIBOSWITCHES OF CANNABIELSOIN FOR IN VITRO AND IN VIVO SENSING
WO - 22.01.2026
Int.Class C07H 21/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
 Appl.No PCT/SG2025/050474 Applicant NATIONAL UNIVERSITY OF SINGAPORE Inventor ZHANG, Jingyun
Disclosed is an aptamer capable of binding to Cannabielsoin (CBE), wherein the aptamer is: an RNA aptamer having a nucleotide sequence of: CGCGGGCAGUGNNNUGCANNNNNNNNUGUGNNNUAUUAGC (SEQ ID NO: 1); or a DNA aptamer having a nucleotide sequence of: CGCGGGCAGTGNNNTGCANNNNNNNNTGTGNNNTATTAGC (SEQ ID NO: 2), wherein for SEQ ID NO: 1, N is one nucleotide selected from the group consisting of A, G, U and C, and wherein for SEQ ID NO: 2, N is one nucleotide selected from the group consisting of A, G, C and T. Also disclosed is a riboswitch and a DNA expression cassette comprising the aptamer, a composition thereof, and a microbe containing the riboswitch or DNA expression cassette. Further disclosed is a method of detecting CBE produced in a microbe using the aptamer or riboswitch as disclosed herein.
4.WO/2026/020020MICRONUTRIENT-STABILIZING MATERIALS
WO - 22.01.2026
Int.Class C07F 15/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
15Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
02Iron compounds
 Appl.No PCT/US2025/038083 Applicant MASSACHUSETTS INSTITUTE OF TECHNOLOGY Inventor LANGER, Robert, S.
Provided herein are metal-organic frameworks, and compositions, food products, beverages, nutritional supplements and kits thereof, as well as associated methods and uses. The metal-organic frameworks provided herein are biocompatible and are useful for delivery of guest molecules for the treatment and/or prevention of various diseases and conditions.
5.WO/2026/017514PROCESS FOR DE-HAZING OF POLYGLYCOSIDES
WO - 22.01.2026
Int.Class C11D 1/66
CCHEMISTRY; METALLURGY
11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
1Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
66Non-ionic compounds
 Appl.No PCT/EP2025/069625 Applicant BASF SE Inventor BUSCH, Stefan
Process for treating an aqueous solution of an alkyl polyglycoside, wherein the process comprises the following steps: (a) providing a melt or an aqueous solution of an alkyl polyglycoside with a concentration in the range of from 20 to 80 % by weight, (b) treating the solution at a pH value in the range of from 11 to 13 with peroxide, (c) adding a di-, tri- or polycarboxylic acid to the solution obtained from step (b) and thus adjusting the pH value to a value of from 6.0 to 7.0 and thus de-gassing, (d) re-adjusting the pH value of the de-gassed solution from step (c) to 8.5 to 12.0, thereby obtaining an aqueous solution of an alkyl polyglycoside with a concentration in the range of from 15 to 80% by weight and transparent for the naked human eye.
6.WO/2026/019822RETINOIC ACID CONJUGATE COMPOUNDS AND USES THEREOF
WO - 22.01.2026
Int.Class C07H 15/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
18Acyclic radicals, substituted by carbocyclic rings
 Appl.No PCT/US2025/037746 Applicant MASTERY BIOTECH CO., LTD. Inventor LIN, Bo-Lin
Provided are compositions including conjugate compounds of a retinoic acid and a covalently linked trisaccharide. Also provided are methods for prevention or treatment of cancer or viral infections.
7.WO/2026/017826PROTECTED TETRASACCHARIDES, THEIR PROCESS OF PREPARATION AND THEIR USE IN THE SYNTHESIS OF OLIGOSACCHARIDES REPRESENTING SEGMENTS OF O-ANTIGENS FROM DIVERSE SHIGELLA FLEXNERI SEROTYPES
WO - 22.01.2026
Int.Class C07H 15/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
18Acyclic radicals, substituted by carbocyclic rings
 Appl.No PCT/EP2025/070566 Applicant INSTITUT PASTEUR Inventor MULARD, Laurence
The present invention provides protected tetrasaccharides, their process of preparation and their use as common scaffold precursors in the synthesis of oligosaccharides representing segments of the O-antigens from diverse S. flexneri serotypes, comprising for example SF2a, SF3a, SF2b, SF1b, SFX and/or SFY.
8.20260015650Rapid Extraction of Nucleic Acids from Clinical Samples for Downstream Applications
US - 15.01.2026
Int.Class C12Q 1/6806
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction assay
 Appl.No 19253477 Applicant The Regents of the University of California Inventor Deborah Anne Dean

Disclosed herein are novel methods and compositions for rapidly extracting and amplifying nucleic acids from a sample where the sample is combined with an extraction reagent comprising a reducing agent to form a mixture and incubating said mixture at ambient temperature for a period of time not exceeding 30 minutes to generate a nucleic acid extract. In certain embodiments of the method, the nucleic acid extract is subjected to a nucleic acid amplification reaction. In certain aspects, oligonucleotide primers specific for nucleic acids of Chlamydia species and/or Neisseria species are added prior to initiating the amplification reaction.

9.WO/2026/014409METHOD FOR PRODUCING ALKYLATED URACIL DERIVATIVE
WO - 15.01.2026
Int.Class C07D 405/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
 Appl.No PCT/JP2025/024319 Applicant AGC INC. Inventor NOMURA, Yoshitaka
Provided is a method for synthesizing an N1-alkylated uracil derivative from a uracil derivative by one step, comprising a step for synthesizing, from a compound represented by general formula (1), a compound represented by general formula (2) by an alkylation reaction in the presence of a TMS group-containing compound. [In the formulas, is a hydrogen atom, an alkali metal atom, or -P(=O)(OR11)(OR12) (where R11 and R12 each independently represent a monovalent cation, an alkyl group which may have a substituent, or an acyl group); the ring A represents a 5- to 8-membered ring; when R1 is other than a hydrogen atom, the ring A is substituted with at least one hydroxy group; R2 is a group including a structure represented by formula (r2); and R3 represents a group including a structure represented by formula (r3) (where R31 is an alkyl group).]
10.WO/2026/0143655’ CAP ANALOG
WO - 15.01.2026
Int.Class C07H 19/20
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
16Purine radicals
20with the saccharide radical being esterified by phosphoric or polyphosphoric acids
 Appl.No PCT/JP2025/024109 Applicant NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM Inventor ABE, Hiroshi
Provided is a technique for more easily obtaining a 5’ capped polynucleotide which is purified and exhibits high translation activity. The 5' cap analog is characterized in that a hydroxy group at the 2’ and/or 3’ position of ribose contained in 7-methylguanylic acid is substituted with a non-photodegradable hydrophobic protecting group.
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