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1 / 265,215
1.WO/2021/009002NEW STABLE FORMULATIONS OF 1-Z-BROMOALK-1-ENE COMPOUNDS AND USE THEREOF IN THE MANUFACTURE OF PHEROMONES
WO - 21.01.2021
Int.Class C07C 17/42
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
17Preparation of halogenated hydrocarbons
38Separation; Purification; Stabilisation; Use of additives
42Use of additives, e.g. for stabilisation
 Appl.No PCT/EP2020/069399 Applicant MELCHIOR MATERIAL AND LIFE SCIENCE FRANCE Inventor GUERRET, Olivier
The present invention concerns new stable compositions of 1-Z-bromoalk-1-ene compounds of general formula (A). These compositions are characterized in that they also comprise either at least one cyclic ether compound comprising between 4 and 6 carbon atoms, or at least one ether of general formula (B) in which R1 and R2 are identical or different and selected from the group consisting of: a linear or branched alkyl group containing 1 to 8 carbon atoms.
2.WO/2021/009047ANTIBODIES WHICH BIND TO CANCER CELLS AND TARGET RADIONUCLIDES TO SAID CELLS
WO - 21.01.2021
Int.Class C07K 16/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
 Appl.No PCT/EP2020/069561 Applicant F. HOFFMANN-LA ROCHE AG Inventor UMAÑA, Pablo
The present invention relates to antibodies which bind to antigens on target cells and which target radionuclides to said cells, and to methods of using the same.
3.WO/2021/009212ANTIBACTERIAL QUINOLONE DERIVATIVES
WO - 21.01.2021
Int.Class C07D 519/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/ or C07D455/257
 Appl.No PCT/EP2020/069978 Applicant IDORSIA PHARMACEUTICALS LTD Inventor RITZ, Daniel
The invention relates to compounds of Formula I which are useful as antibacterial agents in medicine.
4.WO/2021/009242HYBRID HTIRNA/NANOPARTICLE COMPLEX AND USE THEREOF FOR TREATING A DISEASE OF THE DIGESTIVE SYSTEM
WO - 21.01.2021
Int.Class C07H 21/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
 Appl.No PCT/EP2020/070022 Applicant COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES Inventor NAVARRO Y GARCIA, Fabrice
The invention relates to a hybrid DNA/RNA molecule, to the complex thereof with at least one nanoparticle and to the use of this complex for the prevention or treatment of a disease, in particular a disease of the digestive system.
5.WO/2021/009362BENZOTHIOPHENE, THIENOPYRIDINE AND THIENOPYRIMIDINE DERIVATIVES FOR THE MODULATION OF STING
WO - 21.01.2021
Int.Class A61P 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
 Appl.No PCT/EP2020/070326 Applicant CTXT PTY LIMITED Inventor MORROW, Benjamin Joseph
A compound of formula (I); wherein: W is O or NH; A1 is CRA or N; A2 is CRB or N; A3 is CRC or N; A4 is CRD or N; where no more than two of A1, A2, A3, and A4 may be N; one or two of RA, RB, RC and RD, (if present) are selected from H, F, Cl, Br, Me, CF3, cyclopropyl, cyano, OMe, OEt, CH2OH, CH2OMe and OH; the remainder of R A, RB, RC and RD, (if present) are H; RN1 is H or Me; one of RC2 and RC3 is C(=O)NH2; the other is selected from H, Cl, F, Br, Me, OMe, OEt, cyano, CF3, CH2OH, CH2OMe, C2-4 alkenyl and C5heterocyclyl; RC1 and RC4 are independently selected from H, Cl, F, Br, Me, OMe, OEt, cyano, CF3, CH2OH, CH2OMe, C2-4 alkenyl and C5heterocyclyl.
6.WO/2021/009422METHOD FOR SELF-ASSEMBLY OF A PROTEIN ON A SUBSTRATE IN A THREE-DIMENSIONAL HONEYCOMB STRUCTURE
WO - 21.01.2021
Int.Class C07K 14/415
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
415from plants
 Appl.No PCT/FR2020/050932 Applicant COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES Inventor ELCHINGER, Pierre-Henri
Method for self-assembly of a protein in a three-dimensional honeycomb structure, comprising the following consecutive steps: - providing a solution comprising a solvent and a protein, the protein comprising a sequence of amino acids corresponding to an oligomerisation domain of a LEAFY protein, for example to the oligomerisation domain of Ginkgo biloba, in fusion with a tag, - placing the solution in contact with a substrate, - evaporating the solvent in order to crystallise the protein, the oligomerisation domain crystallising in the form of a primary helix, each primary helix interacting with six other primary helixes, whereby a three-dimensional honeycomb protein structure is obtained perpendicular to the substrate, the protein structure being attached to the substrate by the tag.
7.WO/2021/009692TRIPARTITE SYSTEMS FOR PROTEIN DIMERIZATION AND METHODS OF USE
WO - 21.01.2021
Int.Class A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
 Appl.No PCT/IB2020/056657 Applicant MEDIMMUNE LIMITED Inventor BAMBER, Lisa
The disclosure provides compositions and methods that make use of a target protein that is capable of binding to a small molecule in order to form a complex, and a binding member that specifically binds to the complex, wherein the target protein is derived from a non-human protein and the small molecule is an inhibitor of the non-human protein. The non-human protein may be derived from a viral, bacterial, fungal or protozoal protein. These compositions and methods permit the controlled interaction of polypeptides that are individually fused to the target protein and binding member, respectively, and can be used to control the activity of dimerization-inducible proteins such as split transcription factors and split chimeric antigen receptors through the addition of the small molecule. The disclosure provides expression vectors, binding members, dimerization-inducible proteins, nucleic acids, cells, viral particles, kits, systems and methods that involve these components.
8.WO/2021/010337LIGHT-EMITTING COMPOUND OR SALT THEREOF, AND POLARIZED LIGHT-EMITTING ELEMENT, POLARIZED LIGHT-EMITTING PLATE, AND DISPLAY DEVICE CONTAINING SAME
WO - 21.01.2021
Int.Class C07C 309/51
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
309Sulfonic acids; Halides, esters, or anhydrides thereof
01Sulfonic acids
28having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
45containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
51at least one of the nitrogen atoms being part of any of the groups X being a hetero atom, Y being any atom
 Appl.No PCT/JP2020/027074 Applicant NIPPON KAYAKU KABUSHIKI KAISHA Inventor NAKAMURA Mitsunori
The invention is the light-emitting compound represented by formula (1), or a salt thereof.
9.WO/2021/010532METHOD FOR PREPARING LONG-ACTING DRUG CONJUGATE THROUGH PREPARATION OF NOVEL INTERMEDIATE
WO - 21.01.2021
Int.Class C07K 14/575
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
 Appl.No PCT/KR2019/008912 Applicant HANMI PHARM. CO., LTD. Inventor SHIN, Cheongbyeol
The present invention relates to a novel method for preparing a long-acting drug conjugate, and a long-acting drug conjugate prepared by the method.
10.WO/2021/010712ANTI-TAU ANTIBODY AND USE OF SAME
WO - 21.01.2021
Int.Class C07K 16/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
 Appl.No PCT/KR2020/009207 Applicant ADEL, INC. Inventor YOON, Seung-Yong
The present invention relates to an anti-tau antibody specifically binding to a tau protein, and a use of same. The anti-tau antibody according to the present invention specifically binds to a tau protein in which lysine at position 280 is acetylated and can suppress abnormal aggregation of tau proteins. In addition, the anti-tau antibody according to the present invention, when administered to an animal model of induced dementia, can improve locomotor activity and cognitive ability in the animal model. Therefore, the anti-tau antibody according to the present invention may be utilized in the prevention or treatment of neurodegenerative diseases.
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