WO/2016/108204 CO-CRYSTAL OF CARFILZOMIB WITH MALEIC ACID AND PROCESS FOR THE PREPARATION OF PURE CARFILZOMIB||WO||07.07.2016|
||PCT/IB2015/060064||DR. REDDY'S LABORATORIES LIMITED||NADGOUD, Ramesh Kumar|
Aspects of the present application relates to co-crystal of carfilzomib with maleic acid, process for the preparation of co-crystal of carfilzomib with maleic acid, process for the preparation of pure carfilzomib from co-crystal of carfilzomib with maleic acid and process for the preparation of amorphous carfilzomib.
WO/2016/103139 METHOD FOR REDUCTION OF AGGREGATES||WO||30.06.2016|
||PCT/IB2015/059815||DR. REDDY'S LABORATORIES||M K, Jobby|
The invention provides a method for aggregate or dimer reduction/removal from antibody composition. More particularly, the invention relates to the importance of buffer concentration for reduction/ removal of aggregates in chromatographic purification of antibodies.
WO/2016/079590 MODIFIED RELEASE DOXYCYCLINE COMPOSITION||WO||26.05.2016|
||PCT/IB2015/002337||DR. REDDY'S LABORATORIES LTD. ||BAHETI, Ankit |
Doxycycline formulations with a reduced food effect are disclosed. Particularly disclosed are modified release formulations which can be administered once a day and exhibit a reduced food effect. Methods of treating inflammatory conductions such as rosacea or inflammatory symptoms such as the papules and pustules of rosacea or acne vulgaris are also disclosed.
WO/2016/009401 PREPARATION OF TEDIZOLID PHOSPHATE||WO||21.01.2016|
||PCT/IB2015/055428||DR. REDDY'S LABORATORIES LIMITED ||SUD, Abhishek |
The present application relates to processes for the preparation of tedizolid phosphate.
WO/2016/005960 PROCESS FOR PREPARATION OF LIRAGLUTIDE||WO||14.01.2016|
||PCT/IB2015/055273||DR. REDDY'S LABORATORIES LIMITED ||GANDAVADI, Sunil Kumar |
The present application relates to improved processes for the preparation of Liraglutide.
WO/2016/001851 PREPARATION OF TICAGRELOR||WO||07.01.2016|
||PCT/IB2015/054947||DR. REDDY'S LABORATORIES LIMITED ||DAHANUKAR, Vilas |
The present application relate to processes for preparing Ticagrelor and to intermediates that are useful in the processes.
WO/2015/200341 SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF PAIN||WO||30.12.2015|
||PCT/US2015/037214||DR. REDDY'S LABORATORIES LTD. ||SASMAL, Pradip, Kumar |
The present application relates to a series of substituted imidazo[l,2-a]pyridine compounds of formula (I), pharmaceutically acceptable salts, pharmaceutically acceptable solvates or stereoisomers thereof, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.
WO/2015/193786 METHOD OF PURIFYING ANTI-IDIOTYPIC ANTIBODIES||WO||23.12.2015|
||PCT/IB2015/054502||DR. REDDY'S LABORATORIES LIMITED ||MEDISETTY, Rajesh |
The present invention discloses a method for purifying anti-idiotypic antibodies using a series of purification via chromatographic columns, wherein the columns comprise targeted antibody coupled affigel hydrazide column; human IgG coupled affigel hydrazide column; and human IgG coupled NHS activated sepharose. Further, the anti-idiotypic antibodies obtained from the said method contains higher specificity and negligible cross reactivity.
WO/2015/151056 MAB-FCRN ASSAY||WO||08.10.2015|
||PCT/IB2015/052429||DR. REDDY'S LABORATORIES ||SUBRAMANYAM, Satyam|
The present invention relates to methods and means for determining the relative binding activity of a therapeutic antibody based on the affinity of said antibody for a specific binding partner thereof. In particular, this invention relates to methods and means for use in FcRn binding assays wherein the competitive binding assay is performed between labelled Mab with F(ab')2 immune complex and unlabeled therapeutic X-Mab with the F(ab')2 immune complex to bind to the FcRn receptors. The assay as disclosed in tthe present invention picks up changes in Fc region like oxidation that impact FcRn binding. The assay is not influenced by minor differences in percent aggregates between therapeutic samples and hence be used for comparability assessment of one or more samples for binding to FcRn.
WO/2015/140700 CELL CULTURE PROCESS||WO||24.09.2015|
||PCT/IB2015/051930||DR. REDDY'S LABORATORIES LIMITED||THUDUPPATHY, Guru|
The invention discloses a cell culture process comprising culturing cells in the presence of betaine to obtain a glycoprotein with a glycoform composition comprising increased percentage of afucosylated glycans. Further, the invention 5 discloses a cell culture process comprising manganese, galactose and betaine for obtaining a glycoprotein with a glycoform composition comprising target values of mannosylated, galactosylated and afucosylated glycans.