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1 / 54,952
1.WO/2026/005647MRNA VECTOR-BASED IMMUNOBIOLOGICAL AGENT FOR TREATING CANCEROUS DISEASES
WO - 02.01.2026
Int.Class A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
39Medicinal preparations containing antigens or antibodies
 Appl.No PCT/RU2025/000257 Applicant FEDERAL STATE BUDGETARY INSTITUTION "NATIONAL RESEARCH CENTER OF EPIDEMIOLOGY AND MICROBIOLOGY NAMED AFTER HONORARY ACADEMICIAN N.F. GAMALEI" OF THE MINISTRY OF HEALTH OF THE RUSSIAN FEDERATION Inventor GINTSBURG, Aleksandr Leonidovich
The group of inventions relates to immunology and oncology. The proposed immunobiological agent can be used in the treatment of patients with cancerous diseases of various origin and is based on an mRNA vector, where the mRNA contains: the sequence SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 8 at the 5’ end; an open reading frame encoding 1 to 80 tumour gene signatures; and the sequence SEQ ID NO: 6 or SEQ ID NO: 7 at the 3’ end. Also proposed are a method for producing said agent and a use of the agent. The proposed group of inventions broadens the existing range of means and methods for inducing an immune response in patients with cancerous diseases.
2.WO/2025/233928METHOD FOR FORMING A CURVED RAZOR BLADE
WO - 13.11.2025
Int.Class B21D 53/64
BPERFORMING OPERATIONS; TRANSPORTING
21MECHANICAL METAL-WORKING WITHOUT ESSENTIALLY REMOVING MATERIAL; PUNCHING METAL
DWORKING OR PROCESSING OF SHEET METAL OR METAL TUBES, RODS OR PROFILES WITHOUT ESSENTIALLY REMOVING MATERIAL; PUNCHING METAL
53Making other particular articles
60cutlery wares; garden tools or the like
64knives; scissors; cutting blades
 Appl.No PCT/IB2025/058640 Applicant ANGELOS, Komninos George Inventor LAWRENCE, Allen Preston
A method for forming a curved razor blade is provided, the method comprising providing a strip of metallic material, with the strip coil being in alignment with a feeding mechanism; drawing the strip through a notching tool to form a blade profile with at least one indent to identify, without severing the strip, the start and end of each blade; grinding the strip to form a cutting edge of the blade; bending the cutting edge of the blade to define a razor blade flange with the cutting edge being bent relative to the razor blade flange; cutting the strip to individual blade lengths, each individual blade length defining opposite outer ends, the cutting coinciding with the formed indents; and draw forming each individual blade length with the bent cutting edge to ultimately form a curved razor blade.
3.WO/2026/006860METAL DROPLET FORMATION USING MULTIPLE PLASMA ARCS
WO - 02.01.2026
Int.Class B22F 10/22
BPERFORMING OPERATIONS; TRANSPORTING
22CASTING; POWDER METALLURGY
FWORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
10Additive manufacturing of workpieces or articles from metallic powder
20Direct sintering or melting
22Direct deposition of molten metal
 Appl.No PCT/US2025/044473 Applicant FLUENT METAL INC. Inventor RAGHU, Shashank Holenarasipura
Systems and methods for controlling droplet properties in an additive manufacturing process are disclosed. The systems may be used for 3D printing. The method includes setting at least one parameter for a plurality of plasma arcs, applying the plasma arcs in succession to the tip of a feedstock to form a metal droplet, and ejecting the metal droplet from the feedstock towards a build platform, the ejected metal droplet having at least one desired property based on the at least one set parameter.
4.WO/2025/210622SYSTEMS AND METHODS FOR SESSION-SCOPED VIRTUAL IDENTITIES BOUND TO COMPLIANCE JURISDICTION TOKENS
WO - 09.10.2025
Int.Class H04L 9/00
HELECTRICITY
04ELECTRIC COMMUNICATION TECHNIQUE
LTRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
9Arrangements for secret or secure communications; Network security protocols
 Appl.No PCT/IB2025/058743 Applicant DAS, Sangam Inventor DAS, Sangam
A system for privacy-preserving communication and compliance enforcement is disclosed. The invention introduces Virtual Identities (VIs) and Virtual Numbers (VNs) cryptographically bound to Compliance Jurisdiction Tokens (CJTs) generated in secure enclaves. Each CJT carries session identifiers, expiry, consent artifacts, and jurisdictional codes covering GDPR (EU), CCPA (US), HIPAA, PSD2, PCI-DSS, FATF AML, the Digital Personal Data Protection Act (India), and the Personal Information Protection Law (China). Forwarding of calls, payments, or data packets is blocked unless VI–CJT validation and ledger anchoring succeed. Unlike tokenization, the system enforces real-time consent revocation, immutable regulator-verifiable audit, cross-border adequacy validation, and dual cryptographic signatures (RSA/ECC with post-quantum upgrade). Industrial use spans telecom, finance, healthcare, e-commerce, SaaS, and IoT, ensuring privacy-by-design and data protection obligations are enforced at protocol level.
5.WO/2025/256675SELF-SEALING CHEST DRAIN CONNECTOR THAT PREVENTS TUBING WINDING AND BEDRAIL PASSAGE
WO - 18.12.2025
Int.Class A61M 25/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
25Catheters; Hollow probes
01Introducing, guiding, advancing, emplacing or holding catheters
02Holding devices, e.g. on the body
 Appl.No PCT/CN2025/118646 Applicant HENAN CANCER HOSPITAL Inventor WU, Ning
Provided in the present invention is a self-sealing chest drain connector that prevents tubing winding and bedrail passage. The connector effectively solves the problems whereby when existing chest drains are in use, a patient needs to pass a drain through a bedrail when getting onto or off a bed, leading to difficult and cumbersome operations, and easily causing backflow into chests. In addition, the connector also solves the problem in the prior art whereby drains are easily triggered, causing secondary injuries. The technical solution to be solved by the present invention is: the connector comprises a main body, wherein a liquid outlet is provided at the right end of the main body, a three-way tube is provided on the left side of the main body, and two movable units are provided between the three-way tube and the main body; each movable unit comprises a rectangular rod, two rectangular rods being hinged by means of a torsion spring; an arc-shaped tube is provided at one end of each rectangular rod, a channel is provided in the main body, the left end of the arc-shaped tube is in communication with the three-way tube by means of a hose, and small holes are provided in a side wall of the right end of the arc-shaped tube; a sliding sleeve is mounted at the right end of the arc-shaped tube; and a rectangular cylinder is sleeved on each rectangular rod, rectangular cylinders in the two movable units are connected by means of a plurality of steel wires, a compression spring is sleeved on each rectangular rod, and a bent plate is provided on one side of the rectangular cylinder.
6.WO/2025/257860A GRAVITY AND BUOYANCY-BASED RENEWABLE ENERGY GENERATION SYSTEM
WO - 18.12.2025
Int.Class Appl.No PCT/IN2025/051611 Applicant KUMAR, Sanjay Inventor KUMAR, Sanjay
The present invention discloses a gravity and buoyancy-based renewable energy generation system (100), comprising vertically oriented J-shaped water columns (102) arranged in parallel rows with shared walls. Each column houses multiple steel buckets (104). A mechanical filling and transfer system (106), which includes a horizontal circular disk and straight transfer channel (112), facilitates continuous loading of buckets with the high-density material. Loaded buckets are stacked within an inclined gate stack (108) at a lower end of each column to initiate gravitational descent. Upon completing the energy cycle, emptied buckets form a vertical stack in an air pipe positioned above rim pulleys for redirection into the next descent cycle. Additionally, vertical lifting column (110) elevates discharged high-density materials using hydrostatic pressure derived from the surrounding water column. The system (100) converts vertical mass movement into mechanical power, enabling efficient and repeatable energy generation through synergistic use of gravity and buoyancy forces.
7.WO/2026/002309PIPELINE DEFECT DETECTION SYSTEM AND METHOD
WO - 02.01.2026
Int.Class G01N 27/90
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
72by investigating magnetic variables
82for investigating the presence of flaws
90using eddy currents
 Appl.No PCT/CN2025/117342 Applicant CHINA OIL & GAS PIPELINE NETWORK CORPORATION Inventor JIANG, Changliang
A pipeline defect detection system and method. The pipeline defect detection system comprises: a signal detection device and a smart terminal. The signal detection device is configured to: apply an unsaturated static magnetic field and an alternating electromagnetic field to a pipe wall at a position to be detected of a pipeline, collect a disturbance signal of the pipe wall at said position, and send the disturbance signal to the smart terminal. The smart terminal is configured to: analyze the disturbance signal to determine whether there is a defect in the pipe wall at said position.
8.WO/2026/003824HYBRID ELECTROCHEMICAL-FENTON-OZONATION SYSTEM FOR URBAN AND INDUSTRIAL WASTEWATER TREATMENT
WO - 02.01.2026
Int.Class C02F 1/00
CCHEMISTRY; METALLURGY
02TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
FTREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
1Treatment of water, waste water, or sewage
 Appl.No PCT/IB2025/059022 Applicant UNIVERSIDAD UTE Inventor HOJJATI-NAJAFABADI, Akbar
The present invention provides a comprehensive hybrid system for the treatment of urban and industrial wastewater, integrating electrochemical processes, Fenton oxidation, and ozonation The system is designed to efficiently remove a wide range of pollutants, including suspended solids, organic compounds, and refractory substances that are resistant to conventional biological treatment. The hybrid process begins with electrochemical treatment, which generates coagulant ions and promotes the removal of both dissolved and suspended contaminants. This is followed by Fenton oxidation, where hydroxyl radicals produced from hydrogen peroxide and iron ions degrade persistent organic compounds. The final stage involves ozonation, which further oxidizes remaining pollutants, increases dissolved oxygen levels, and disinfects the effluent.
9.WO/2025/262339A TURBINE WITH POROUS MATERIAL
WO - 26.12.2025
Int.Class F01D 1/36
FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
01MACHINES OR ENGINES IN GENERAL; ENGINE PLANTS IN GENERAL; STEAM ENGINES
DNON-POSITIVE-DISPLACEMENT MACHINES OR ENGINES, e.g. STEAM TURBINES
1Non-positive-displacement machines or engines, e.g. steam turbines
34characterised by non-bladed rotor, e.g. with drilled holes
36using fluid friction
 Appl.No PCT/EP2025/079899 Applicant FRÖLUNDA TECH HOLDING AB Inventor CLARK, Andreas
The invention regards a turbine (2) for transforming fluid energy, such as pressure energy and/or fluid velocity and/or thermal energy,of a fluid into rotational kinematic energy of a rotatable section, the turbine comprising a rotatable section (4) rotatable around an axis of rotation (102), the rotatable section comprising a periphery surrounding the rotatable section, a rotatable section inlet (52) configured to receive a fluid under pressure, a rotatable section outlet (12) configured to emit the fluid, and a conduit connecting the rotatable section inlet and the rotatable section outlet, wherein the conduit accommodates porous material (160, 162, 164), and wherein the conduit forms at least a part of a loop around the axis of rotation.
10.WO/2026/002312EFFECTIVE IDENTIFICATION METHOD FOR WATER-PRESERVING COAL MINING AREA IN WEATHERED BEDROCK AQUIFER
WO - 02.01.2026
Int.Class E21C 41/18
EFIXED CONSTRUCTIONS
21EARTH OR ROCK DRILLING; MINING
CMINING OR QUARRYING
41Methods of underground or surface mining; Layouts therefor
16Methods of underground mining; Layouts therefor
18for brown or hard coal
 Appl.No PCT/CN2025/125809 Applicant LIUPANSHUI NORMAL UNIVERSITY Inventor LI, Tao
The present application relates to the field of geological mining. Disclosed is an effective identification method for a water-preserving coal mining area in a weathered bedrock aquifer. The method comprises: classifying the types of stratum structures; when a target stratum area belongs to a first type, and the invasion degree of burnt rock in an aquitard is greater than or equal to a first set threshold value, making a determination on the basis of an initial hydraulic gradient of the aquitard, the hydraulic head height of an unconsolidated sand aquifer and the effective thickness of the aquitard; when the target stratum area belongs to a second type, and the invasion degree of burnt rock in a weathered bedrock aquifer is greater than or equal to a second set threshold value, making a determination on the basis of the water retention capacity and water abundance of the burnt rock in the weathered bedrock aquifer; when the target stratum area belongs to a third type, making a determination on the basis of the invasion degree of the burnt rock in the weathered bedrock aquifer and surface water bodies; and when the target stratum area belongs to a fourth type, directly making a determination. The present application realizes the effective identification of a water-preserving coal mining area in a weathered bedrock aquifer.
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