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Analysis

1 / 513
1.P/2012/0284Adjustable Angular Clay Brick Cutting Device
JO - 15.09.2015
Int.Class Appl.No P/2012/0284 Applicant الجمعية العلمية الملكية Inventor أيمن بسام أيوب قموة
the present invention relates to a device for cutting clay extrusions into smaller pieces of brick by using metallic cutting chords as cutting means. the device of the present invention comparises a static part including a base with two hinges, wherein such hinges have roller bearings , and a dynamic part including a four- sided frame with adjustable length, a plurality of metallic wires, a plurality of ajdustable sliding adapters, and a handle, wherein such wires, adapters, and handle are fixed on said frame is anglarly rotated about said hinges relative to and away from said base to make the clay extrusions passing on said base and then rotating the frame about said hinges relative to and towards said base; wherein the cuts happen at the places where said metallic wires acting as cutting chords meet the clay extrusions.
2.P/2013/0040Disclaimer passenger aircraft system
JO - 15.09.2015
Int.Class Appl.No P/2013/0040 Applicant أحمد تيسيرذيب سعسع Inventor أحمد تيسيرذيب سعسع
Boils down to this design to protect the passengers from air accidents, whether a fault plane or any reason construed to crash from the air to the ground or in cages of evacuation of the passengers white the plane at the airport. and raise the survival of the elderly, children and people with special needs relative to the percentage the same people healthy, as the design does not need to change the passenger sitting way or the internal distribution of the aircraft, but provides additional space allocated to the exploitation of space smuggler deliverance also facilitates the adjustment of old aircraft that system. This design depends to a ground plane split into two parts essential part of the first plane a fixed structure (Fixed and) along the length of the plane on the right and the north are two parallel lines of work are working railway. The second part is (Vehicle) acts as a vehicle train as describing the vehicles. one after the other on the plane along and prove a special clip on the hard ground to make up in the end and one floor for the user and demonstrate the seats on the vehicle and fixed ground-traditional form, as I mentioned In the event of a circumstance constitutes a danger to the passengers life what should the captain is to move the arm to operate a separate system from the basic plane devices minor ones to begin with providing a safe space on the vehicles, and moving vehicles, one after the other to the outside of the plane through the. .. emergency doors are present in the background of the plane It also is not limited to the use of design in the air disaster and only can be used to evacuate passengers from the plane at the airport also if there is an emergency reason for the evacuation of passengers from the plane.
3.P/2017/0165PLATFORM FOR PARABOLIC SOLAR COLLECTORS
JO - 30.01.2019
Int.Class Appl.No P/2017/0165 Applicant لوسيدا سولار ال تي دي. Inventor بيلجين، سينر
This invention is related to a carrier platform that is developed for installation and positioning of parabolic solar collectors used in solar thermal systems and that can move in two axes to enable perpendicularly tracking the sun all day long
4.P/2018/0021ANTI-PHF-TAU ANTIBODIES AND USES THEREOF
JO - 30.01.2019
Int.Class Appl.No P/2018/0021 Applicant جانسن بيوتك، انك Inventor مارك ميركن
Monoclonal anti-PHF-tau antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies and using the antibodies for treating or preventing conditions such as tauopathies.
5.P/2018/0029HETEROCYCLIC COMPOUND
JO - 30.01.2019
Int.Class Appl.No P/2018/0029 Applicant تاكيدا فارماسيوتيكال كومباني ليميتد Inventor شيزو كاساي
The present invention aims to provide a heterocyclic compound having an IP6K inhibitory action and expected to be useful as a prophylactic 5 or therapeutic agent for diseases such as cardiac failure, diabetes and the like. A compound represented by the formula (I): wherein each symbol is as defined in the SPECIFICATION, 10 or a salt thereof has an IP6K inhibitory action and is expected to be useful as a prophylactic or therapeutic agent for diseases such as cardiac failure, diabetes and the like.
6.P/2018/0027CHIMERIC POLYPEPTIDES AND METHODS OF ALTERING THE MEMBRANE LOCALIZATION OF THE SAME
JO - 30.01.2019
Int.Class Appl.No P/2018/0027 Applicant سيل ديزاين لابز، انك. Inventor سانتورو ، ستيفن
Methods and compositions are provided for reversibly localizing proteins to the exterior part of the cell surface. Compositions provided herein can include nucleic acids that encode polypeptides of interest and the ligand binding domain (LBD) of a nuclear hormone receptor. Upon addition of the ligand, the polypeptide can be localized to the extracellular side of the plasma membrane. Removal of the ligand can cause the polypeptide to be removed from the cell surface. In some embodiments, a nucleic acid construct having a LBD can be incorporated into a polypeptide having an antigen binding domain (e.g., a chimeric antigen receptor). In some embodiments, such a polypeptide can be introduced into a mammalian cell such that, upon introduction of ligand to the cell, the antigen binding domain of the polypeptide localizes to the extracellular side of the plasma membrane, and upon removal of the ligand, the antigen binding domain of the polypeptide is removed from the extracellular side of the plasma membrane. Medical applications are provided, including controlling the toxicity of CAR T cells.
7.P/2018/0125STABLE LIQUID PHARMACEUTICAL PREPARATION
JO - 30.01.2019
Int.Class Appl.No P/2018/0125 Applicant سيلتريوون إنك. Inventor أوه ، جون سوك

The present invention provides a stable liquid pharmaceutical formulation containing: an antibody or its antigen-binding fragment; a surfactant; a sugar or its derivative; and a buffer. The stable liquid pharmaceutical formulation according to the present invention has low viscosity while containing a high content of the antibody, has excellent long-term storage stability based on excellent stability under accelerated conditions and severe conditions, and may be administered subcutaneously.

8.P/2018/0123THERAPEUTIC COMPOUNDS USEFUL FOR THE PROPHYLACTIC OR THERAPEUTIC TREATMENT OF AN HIV VIRUS INFECTION
JO - 30.01.2019
Int.Class Appl.No P/2018/0123 Applicant جيليد ساينسيز، انك. Inventor رو، تشارلز وليام
The present disclosure relates to a compound of formula (Ia), (Ib), (IIa), and (IIb): which are useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.
9.P/2018/01161H-Pyrazolo[4,3-b]pyridines as PDE1 inhibitors
JO - 30.01.2019
Int.Class A61K 31/4745
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
4738ortho- or peri-condensed with heterocyclic ring systems
4745condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
 Appl.No P/2018/0116 Applicant أتش. لوندبيك ايه/اس Inventor جوهل، كارستن

The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

10.P/2019/0150PCSK9 ANTAGONIST COMPOUNDS
JO - 21.12.2019
Int.Class Appl.No P/2019/0150 Applicant ميرك شارب آند دوم كورب. Inventor إليزابيتا بيانكي

Disclosed are compounds of Formula I, or a salt thereof: Formula I, where A, B, D, X, R1, R2 and R8 are as defined herein, which compounds have properties for antagonizing PCSK9. Also described are pharmaceutical formulations comprising the compounds of Formula I or their salts, and methods of treating cardiovascular disease and conditions related to PCSK9 activity, e.g. atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome, or related cardiovascular disease and cardiometabolic conditions.

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