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Results 1-10 of 217 for Criteria:CHEM:(FBPFZTCFMRRESA-UHFFFAOYSA-N) Office(s):all Language:en Stemming: false
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Analysis
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TitleCtrPubDate
Appl.NoApplicantInventorInt.Class
Selective oestrogen therapy for perimenopausal or postmenopausal conditions
US02.02.1993
07362043Imperial Chemical Industries PLCDukes Michael
A61K 38/22
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
22
Hormones

The invention relates to a therapeutic product comprising an oestrogen and a pure antioestrogen for simultaneous, sequential or separate use in selective oestrogen therapy of perimenopausal or postmenopausal conditions; to a process for the manufacture of said product and to a pharmaceutical composition containing said product. The invention also relates to a pharmaceutical composition comprising an oestrogen and a pure antioestrogen and to a process for the manufacture of said composition.


Isoindoline nitromethane derivatives
US17.03.1992
07474935Imperial Chemical Industries PLCMallion Keith B.
C12N 9/99
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
99
Enzyme inactivation by chemical treatment

The invention concerns pharmaceutially useful heterocyclic nitromethane compounds of the formula I: ##STR1## in which ring Q is a heterocycle of 4 to 7 ring atoms, the fragment completing the ring Q having 2 to 5 atoms, one of which is carbon, oxygen, sulphur or a group of the formula --NRa--, and the remainder are carbon; Ra is hydrogen, (1-6C)alkyl, (2-6C)alkanoyl, trifluoroacetyl, phenyl, benzoyl, or phenyl(1-4C)alkyl, the latter three optionally substituted; and R.sup.1 R.sup.2 and R.sup.3 are independently hydrogen, hydroxy, (1-6C)alkyl, (1-6C)alkoxy, phenyl, phenoxy or phenyl(1-4C)alkyl, the last three optionally substituted, or two of R.sup.1, R.sup.2 and R.sup.3 situated on adjacent ring carbon atoms and together with said carbon atoms form a benzene ring fused to ring Q, the benzene ring itself optionally substituted, provided that when the fragment completion ring Q is of 3 atoms then at least one of R.sup.1, R.sup.2 and R.sup.3 is hydrogen; and salts thereof. Other aspects of the invention include the production of the novel compounds by analogy processes and pharmaceutical compositions of the novel compounds and of N-(nitromethylsulphonyl)morpholine for use in the treatment of diabetic complications.


Amidobenzene derivatives, compositions and use
US05.10.1993
07999690Imperial Chemical Industries PLCBrittain David R.
A61K 31/165
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
165
having aromatic rings, e.g. colchicine, atenolol, progabide

The invention concerns novel phenoxy- and phenylthio-acetyl derivatives of (4-amino-2,6-dimethylphenylsulphonyl)nitromethane and pharmaceutically acceptable salts thereof which are inhibitors of the enzyme aldose reductase and are of value, for example, in the treatment of certain peripheral effects of diabetes and galactosemia. Also disclosed are pharmaceutical compositions containing one of the derivatives and processes for the manufacture and use of the derivatives.


Insecticides
US18.02.1992
07446607Imperial Chemical Industries PLCTapolczay David J.
A01N 43/34
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43
Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
34
having rings with one nitrogen atom as the only ring hetero atom

A method of killing or controlling insect, mite or nematode pests which comprises applying to the pest or to the locus thereof an effective amount of a compound of formula (I): ##STR1## in which R.sup.1 is hydrogen or alkyl; R.sup.2 is hydrogen, halogen, alkyl, alkoxy, aryl, heteroaryl, arylalkyl, heteroarylalkyl, aryloxy, heteroaryloxy, arylalkenyl, heteroarylalkenyl, aryloxyalkyl, heteroaryloxyalkyl, arylalkoxy, heteroarylalkoxy, --CO.sub.2 R.sup.5, alkylCO.sub.2 R.sup.6, monoalkylamino or dialkylamino; R.sup.3 is hydrogen, halogen, alkyl, alkoxy, hydroxy, monoalkylamino, dialkylamino, --CO.sub.2 R.sup.4 or nitro; and R.sup.4, R.sup.5 and R.sup.6 are hydrogen or alkyl; any of the foregoing aliphatic moieties are optionally substituted with one or more of halogen, hydroxy, alkoxy, or haloalkoxy; any of the foregoing aryl or heteroaryl moieties are optionally substituted with one or more of halogen, alkyl, alkoxy, haloalkyl or haloalkoxy.


Biologically active heterocyclic compounds
US21.02.1984
06356801Imperial Chemical Industries PLCKay Ian T.
C07D 333/20
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
333
Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
02
not condensed with other rings
04
not substituted on the ring sulfur atom
06
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
14
Radicals substituted by singly bound hetero atoms other than halogen
20
by nitrogen atoms

N-Heterocyclylmethyl amides of formula (I): ##STR1## wherein R.sup.1 is optionally substituted alkyl, alkenyl, aryl, or heterocyclyl; R.sup.2 is hydrogen, C.sub.1-4 alkyl, or C.sub.3-4 alkenyl. E is CN, CSNH.sub.2, alkoxycarbonyl, or --CONR.sup.4 R.sup.5 wherein R.sup.4 and R.sup.5 are H or optionally substituted alkyl or alkenyl; X is oxygen or sulphur; and R.sup.3 is H, or one or more Me or Cl. The compounds are useful as herbicides and fungicides.


Aminonitrile intermediates
US19.03.1985
06555541Imperial Chemical Industries PLCKay Ian T.
C07D 333/24
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
333
Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
02
not condensed with other rings
04
not substituted on the ring sulfur atom
06
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
24
Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

N-Heterocyclylmethyl amides of the formula (I) ##STR1## wherein R.sup.1 is an optionally substituted alkyl, alkenyl, aryl, or heterocyclyl radical; PA1 R.sup.2 is hydrogen, or an optionally substituted C.sub.1-4 alkyl, or C.sub.3-4 alkenyl group; PA1 E is --CN, --CSNH.sub.2, alkoxycarbonyl, or a --CONR.sup.4 R.sup.5 group wherein R.sup.4 and R.sup.5 may each be hydrogen or an optionally substituted alkyl or alkenyl radical; PA1 X is oxygen or sulphur, and PA1 R.sup.3 represents hydrogen or one or more substituents which may be for example methyl or chlorine. PAL The compounds are herbicidally and fungicidally active.


Pharmaceutical compositions
US17.01.1989
06497768Imperial Chemical Industries PLCGlen John B.
A61K 31/05
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
045
Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05
Phenols

Sterile pharmaceutical compositions for parenteral administration containing the compound 2,6-diisopropylphenol, and a method for producing anaesthesia in a warm-blooded animal by parenteral administration of said compound.


Anaesthetic compositions containing 2,6-diisopropylphenol
US05.06.1984
05834292Imperial Chemical Industries PLCGlen John B.
A61K 9/08
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
08
Solutions

Sterile pharmaceutical compositions for parenteral administration containing the compound 2,6-diisopropylphenol, and a method for producing anaesthesia in a warm-blooded animal by parenteral administration of said compound.


Urea derivatives, compositions and use
US23.02.1993
07831434Imperial Chemical Industries PLCBrittain David R.
A61K 31/21
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates

The invention concerns novel (oxamido- and ureido-phenylsulfonyl)nitromethane derivatives and pharmaceutically acceptable salts thereof which are inhibitors of the enzyme aldose reductase and are of value, for example, in the treatment of certain peripheral effects of diabetes and galactosemia. Also disclosed are pharmaceutical compositions containing one of the derivatives and processes for the manufacture and use of the derivatives.


Novel antidoted herbicidal composition
US09.07.1991
07151282Imperial Chemical Industries PLCBarton John E. D.
A01N 25/32
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
25
Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
32
Ingredients for reducing the noxious effect of the active substances to organisms other than pests, e.g. toxicity reducing compositions, self-destructing compositions

The present invention relates to a process for protecting crop plants against phytotoxic side effects of compounds of formula: ##STR1## which comprises treating the plants, parts of plants or fertile soils for plants with compounds of the formula: ##STR2## before, after or at the same time.


Results 1-10 of 217 for Criteria:CHEM:(FBPFZTCFMRRESA-UHFFFAOYSA-N) Office(s):all Language:en Stemming: false
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