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Results 1-10 of 80 for Criteria:CHEM:(FBPFZTCFMRRESA-UHFFFAOYSA-N) Office(s):all Language:en Stemming: false
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TitleCtrPubDate
Appl.NoApplicantInventorInt.Class
Deazapurine derivatives; a new class of CRF1 specific ligands
US08.12.1998
08881960Neurogen CorporationYuan Jun
C07D 487/02
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings

Disclosed are compounds of the formula ##STR1## wherein Ar represents an aryl or heteroaryl group; and PA1 R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 represent organic or inorganic substituents, which compounds are highly selective partial agonists or antagonists at human CRF1 receptors and, thus, are useful in the diagnosis and treatment of treating stress related disorders such as post trumatic stress disorder (PTSD) as well as depression, headache and anxiety.


Certain pyrrolopyridine derivatives; novel CRF1 specific ligands
US17.10.2000
09368541Neurogen CorporationHorvath Raymond F.
C07D 471/04
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems

Disclosed are compounds of the formula: ##STR1## wherein Ar is optionally substituted aryl or heteroaryl PA1 R.sub.1 is hydrogen or alkyl; PA1 R.sub.7 is hydrogen or alkyl; PA1 R.sub.2 is hydrogen, halogen, alkyl or alkoxy; or PA1 R.sub.1 and R.sub.2 taken together with the ring to which they are attached form a 5-9 membered saturated or aromatic ring optionally having a hetero atom selected from oxygen, sulfur or nitrogen; PA1 R.sub.3 and R.sub.4 are independently hydrogen, alkyl, cycloalkyl, aryl or heteroaryl groups; or PA1 R.sub.3 and R.sub.4 together with the nitrogen atom to which they are attached form a 5-8 membered ring; and PA1 R.sub.5 is hydrogen, halogen, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy or thioalkoxy having 1-6 carbon atoms, PA1 which compounds are highly selective partial agonists or antagonists at human Corticotropin-Releasing Factor 1 (CRF1) receptors and are useful in the diagnosis and treatment of treating stress related disorders such as post trumatic stress disorder (PTSD) as well as depression, headache and anxiety.


Deazapurine derivatives; a new class of CRF1 specific ligands
US01.02.2000
08776147Neurogen CorporationYuan Jun
C07D 487/14
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems

Disclosed are compounds of formula (I), wherein Ar represents an aryl or heteroaxyl group; and R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 represent organic or inorganic substituents, which compounds are highly selective partial agonists or antagonists at human CRF1 receptors and, thus, are useful in the diagnosis and treatment of treating stress related disorders such as post traunatic stress disorder (PTSD) as well as depression, headache and anxety. ##STR1##


Deazapurine derivatives: a new class of CRF1 specific ligands
US08.09.1998
08476689Neurogen CorporationYuan Jun
C07D 487/04
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems

Disclosed are compounds of the formula ##STR1## wherein Ar represents an aryl or heteroaryl group; and PAL R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 represent organic or inorganic substituents, PAL which compounds are highly selective partial agonists or antagonists at human CRF1 receptors and, thus, are useful in the diagnosis and treatment of treating stress related disorders such as post trumatic stress disorder (PTSD) as well as depression, headache and anxiety.


Certain aryl and cycloalkyl fused imidazopyrazinediones; a new class of GABA brain receptor ligands
US24.11.1998
08465693Neurogen CorporationShaw Kenneth
C07D 471/14
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems

##STR1## The present invention encompasses compounds of formula (I), and the pharmaceutical acceptable non-toxic salts thereof wherein: where X represents hydrogen or lower alkyl; W represents an aryl group unsubstituted or substituted with various organic and inorganic substituents; (a) represents (b); (c); (d) or (e) or (a) represents (f), where A, B, C, D, and E represent carbon or nitrogen substituted with hydrogen or various organic and inorganic substituents; and n is 0, 1, or 2; Y, R.sub.3, R.sub.4, R.sub.12, and R.sub.13 are various organic and inorganic substituents. These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs thereof and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorders, overdose with benzodiazepine drugs, and enhancement of memory.


Certain aryl a cycloalkyl fused imidazopyrazinols; and new class of GABA brain receptor ligands
US26.04.1994
07936589Neurogen CorporationAlbaugh Pamela
C07D 487/14
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems

The present invention encompasses structures of the formula: ##STR1## and the pharmaceutically acceptable non-toxic salts thereof wherein: ##STR2## where W represents an aromatic group substituted with various organic and inorganic substituents; PA1 X, Y are hydrogen, halogen, hydroxy or amino with the proviso that at least X or Y is hydroxy; PA1 A, B C, and D, represent nitrogen or a carbon atom substituted with various organic and inorganic substituents; PA1 E represents oxygen, sulfur or substituted nitrogen; PA1 R.sub.3, R.sub.4, R.sub.12, and R.sub.13 are variables representing various organic and inorganic substituents; and PA1 n is 0, 1, or 2.


Certain aryl and cycloalkyl fused imidazopyrazinediones; a new class of GABA brain receptor ligands
US30.11.1993
07876502Neurogen CorporationShaw Kenneth
C07D 487/14
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems

The present invention encompasses compounds of the formula: ##STR1## and the pharmaceutically acceptable non-toxic salts thereof wherein: where X represents hydrogen of lower alkyl; PA0 W represents an aryl group unsubstituted or substituted with various organic and inorganic substitutents; ##STR2## where A, B, C, D, and E represent carbon or nitrogen substituted with hydrogen or various organic and inorganic substituents; and PA0 n is 0, 1, or 2, Y, R.sub.3, R.sub.4, R.sub.12, and R.sub.13 are various organic and inorganic substituents. PAL These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs thereof and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorders, overdose with benzodiazepine drugs, and enhancement of memory.


Certain aryl and cycloalkyl fused imidazopyrazinediones; a new class of GaBa brain receptor ligands
US02.12.1997
08331561Neurogen CorporationShaw Kenneth
C07D 471/14
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems

Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable salts thereof wherein: X is hydrogen or lower alkyl having 1-6 carbon atoms; and PA1 W is an optionally substituted aryl group as defined herein.


Deazapurine derivatives; a new class of CRF1 specific ligands
US01.07.1997
08439874Neurogen CorporationYuan Jun
C07D 487/02
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings

Disclosed are compounds of the formula ##STR1## wherein Ar represents an aryl or heteroaryl group; and PA1 R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 represent organic or inorganic substituents, PAL which compounds are highly selective partial agonists or antagonists at human CRF1 receptors and, thus, are useful in the diagnosis and treatment of treating stress related disorders such as post trumatic stress disorder (PTSD) as well as depression, headache and anxiety.


Certain aryl substituted imidazopyrazinones: a new class of GABA brain receptor ligands
US28.04.1998
08788924Neurogen CorporationBlum Charles
C07D 471/14
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems

This invention encompasses compounds of formula I: ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein: ##STR2## represents: ##STR3## where n is 0, 1, or 2; R.sub.1 and R.sub.2 are hydrogen or straight or branched chain alkyl groups; PA0 Y represents various organic and inorganic substituents; PA0 W represents an aromatic group substituted with various organic and inorganic substituents; PA0 A is CH or N; PA0 B is a substituted or unsubstituted carbon or N; and PA0 E is hydrogen or straight or branched alkyl groups. PAL These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs thereof and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorders, overdose with benzodiazepine type drugs, and enhancement of alertness.


Results 1-10 of 80 for Criteria:CHEM:(FBPFZTCFMRRESA-UHFFFAOYSA-N) Office(s):all Language:en Stemming: false
Filters
1 2 3 4 5 6 7 8
Page: / 8