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Results 1-10 of 12,837 for Criteria:CHEM:(FBPFZTCFMRRESA-UHFFFAOYSA-N) Office(s):all Language:en Stemming: false
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TitleCtrPubDate
Appl.NoApplicantInventorInt.Class
PROCESS FOR THE PREPARATION OF 1,5-DIDEOXY-1,5-IMINO HEXITOLS FROM OXIMES OR IMINES
KR27.03.2002
1020017011513MICHIGAN STATE UNIVERSITYHOLLINGSWORTH RAWLE I.
C07D 211/36
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
211
Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06
having no double bonds between ring members or between ring members and non-ring members
36
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.

© KIPO & WIPO 2007


제1 결정화 모액의 증발성 결정화 단계를 갖는 디안하이드로헥시톨 결정을 제조하기 위한 공정
KR19.12.2018
1020187028609로께뜨프레르비아르, 에르베
C07D 493/04
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
493
Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
본 발명은 적어도 하나의 헥시톨의 내부 탈수 생성물의 용액을 제조하고, 상기 용액을 증류하고, 결정화함으로써 1,4:3,6-디안하이드로헥시톨의 결정을 제조하기 위한 공정에 관한 것으로, 결정화 모액은 증발성 결정화 단계를 거치는 것을 특징으로 한다. 결정화 모액을 재생하려고 하는 선행 기술의 공정과는 달리, 증발성 결정화에 의해 경제적이고 효율적으로 적어도 하나의 농축 및 그 이후의 증류, 크로마토그래피 또는 결정화에 의한 적어도 하나의 증류 단계로 이루어진 일련의 단계가 대체된다.

박막 증발기 상에서의 증류 단계에 의해 디안하이드로헥시톨을 생산하기 위한 방법
KR28.11.2018
1020187026357로께뜨프레르비아르, 에르베
C07D 493/04
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
493
Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
본 발명은 1,4:3,6-디안하이드로헥시톨을 생산하기 위한 방법에 관한 것으로, 상기 방법은 a) 적어도 하나의 헥시톨을 공급하는 단계; b) 상기 헥시톨을 탈수시키는 단계; 및 c) 단계 b)에서 생산된 탈수 생성물을 증류하는 단계를 포함하되, 단계 a)에서 헥시톨은 수용액의 형태로 공급되고; 단계 c)에서 증류는 박막 증발기에 의해 실시되는 것을 특징으로 한다.

Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines
US02.05.2002
09971389Board of Trustees of Michigan State UniversityHollingsworth, Rawle I.
C07D 211/70
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
211
Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
68
having one double bond between ring members or between a ring member and a non-ring member
70
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

A process for the preparation of 1,5-dideoxy -1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.


Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines
US07.02.2002
09971383Board of Trustees of Michigan State UniversityHollingsworth, Rawle I.
C07D 213/75
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
213
Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02
having three double bonds between ring members or between ring members and non-ring members
04
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
72
Nitrogen atoms
75
Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.


METHOD FOR PRODUCING DIANHYDROHEXITOL WITH A STEP OF DISTILLATION ON A THIN-FILM EVAPORATOR
US28.03.2019
16085903ROQUETTE FRERESHervé WYART
C07D 493/04
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
493
Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems

A method for producing 1,4:3,6-dianhydrohexitols, including the steps of: a) supplying at least one hexitol, b) dehydrating the hexitol, and c) distillating the dehydration product produced in step b), wherein: the hexitol is supplied in the form of an aqueous solution in step a); and the distillation is carried out by means of a thin-film evaporator in step c).


薄膜蒸発器による蒸留工程を有するジアンヒドロヘキシトールの製造方法
JP28.03.2019
2018548850ロケット フレールエルヴェ ヴィアール
C07D 493/04
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
493
Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems

本発明は、１，４：３，６−ジアンヒドロヘキシトールの製造方法であって、ａ）少なくとも１種のヘキシトールを供給する工程と、ｂ）前記ヘキシトールを脱水する工程と、ｃ）工程ｂ）で製造された脱水生成物を蒸留する工程とを含む方法において、ヘキシトールは、工程ａ）において水溶液の形態で供給され、および前記蒸留は、工程ｃ）において薄膜蒸発器を用いて実施されることを特徴とする方法に関する。


Process for the preparation of 1, 5-dideoxy-1,5-imino hexitols from oximes or imines
US30.10.2003
10438491Board of Trustees of Michigan State UniversityHollingsworth, Rawle I.
C07D 211/54
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
211
Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06
having no double bonds between ring members or between ring members and non-ring members
36
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
54
Sulfur atoms

A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.


Dianhydrogalactitol together with radiation to treat non-small-cell carcinoma of the lung and glioblastoma multiforme
CN03.10.2017
201580071196.6DEL MAR PHARMACEUTICALSBACHA JEFFREY A
A61K 31/336
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
336
having three-membered rings, e.g. oxirane, fumagillin
The use of dianhydrogalactitol provides a novel therapeutic modality for the treatment of non-small-cell lung carcinoma (NSCLC) and for the treatment of glioblastoma multiforme (GBM). Dianhydrogalactitol acts as an alkylating agent on DNA that creates N7 methylation. Dianhydrogalactitol is effective in suppressing the growth of cancer stem cells and is active against tumors that are refractory to temozolomide; the drug acts independently of the MGMT repair mechanism.

Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines
US30.10.2003
10439033Board of Trustees of Michigan State UniversityHollingsworth, Rawle I.
C07C 251/00
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
251
Compounds containing nitrogen atoms doubly- bound to a carbon skeleton

A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.


Results 1-10 of 12,837 for Criteria:CHEM:(FBPFZTCFMRRESA-UHFFFAOYSA-N) Office(s):all Language:en Stemming: false
Filters
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