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Analysis

IPC=A61P
1 / 1,408
1.4959215Ifosfamide-mesna lyophilizate and process for its preparation
US - 25.09.1990
Int.Class A61K 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
 Appl.No 07325883 Applicant Asta Pharma AG Inventor Sauerbier Dieter

An ifosfamide-mesna lyophilizate consists substantially of ifosfamide, 0.1-1.0 parts by weight of mesna and 0.1 to 17 parts by weight of hexitol. The product is obtained by freeze drying an aqueous or aqueous-ethanolic solution of ifosfamide and mesna.

2.115778934Use of substituted hexitols for treatment of malignancies
CN - 14.03.2023
Int.Class A61K 31/336
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
336having three-membered rings, e.g. oxirane, fumagillin
 Appl.No 202211320632.7 Applicant DERMA CO., LTD. Inventor BASHA JEFFREY
The present invention relates to the use of substituted hexitols for the treatment of malignancies. The use of dianhydrogalactitol provides a novel way of treatment to treat glioblastoma multiforme and neuroblastoma. The dianhydrogalactitol is used as an alkylating agent to act on DNA (deoxyribonucleic acid) to cause N7 methylation. The dianhydrogalactitol is effective in inhibiting the growth of cancer stem cells and has the activity of resisting temozolomide-resistant tumors; the drug effect is irrelevant to MGMT repair mechanism.
3.110711188Use of substituted hexitols to treat malignant tumors
CN - 21.01.2020
Int.Class A61K 31/336
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
336having three-membered rings, e.g. oxirane, fumagillin
 Appl.No 201910649595.6 Applicant DELMAR PHARMACEUTICALS INC. Inventor BACHA JEFFREY
Use of substituted hexitols to treat malignant tumors. The use of dianhydrogalactitol provides a novel therapeutic modality for the treatment of glioblastoma multiforme and medulloblastoma. Dianhydrogalactitol acts as an alkylating agent on DNA that creates N7 methylation. Dianhydrogalactitol is effective in suppressing the growth of cancer stem cells and is active against tumors that are refractory to temozolomide; the drug acts independently of the MGMT repair mechanism.
4.115813902Use of substituted hexitols for treatment of malignancies
CN - 21.03.2023
Int.Class A61K 31/336
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
336having three-membered rings, e.g. oxirane, fumagillin
 Appl.No 202211319179.8 Applicant DERMA CO., LTD. Inventor BASHA JEFFREY
The present invention relates to the use of substituted hexitols for the treatment of malignancies. The use of dianhydrogalactitol provides a novel way of treatment to treat glioblastoma multiforme and neuroblastoma. The dianhydrogalactitol is used as an alkylating agent to act on DNA (deoxyribonucleic acid) to cause N7 methylation. The dianhydrogalactitol is effective in inhibiting the growth of cancer stem cells and has the activity of resisting temozolomide-resistant tumors; the drug effect is irrelevant to MGMT repair mechanism.
5.WO/2024/098032USE OF DIANHYDROGALACTITOL IN TREATING EPENDYMOMA
WO - 10.05.2024
Int.Class A61K 31/047
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
047having two or more hydroxy groups, e.g. sorbitol
 Appl.No PCT/US2023/078737 Applicant DEL MAR PHARMACEUTICALS (BC) LTD. Inventor BROWN, Dennis M.
Compositions and methods for treating ependymoma, including RELA fusion‑positive ependymoma refractory to temozolomide-based regimens. Methods comprise administering a therapeutically effective amount of an alkylating hexitol or derivative (such as dianhydrogalacitol, diacetyldianhydrogalactitol, and dibromodulcitol). The methods can further comprise administration of other agents or treatments such as anti-cancer agents or treatments.
6.1020220021013폐의 비소세포 암종 및 난소암을 치료하기 위한 디안하이드로갈락티톨 및 이의 유사체 또는 유도체
KR - 21.02.2022
Int.Class A61K 31/336
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
336having three-membered rings, e.g. oxirane, fumagillin
 Appl.No 1020227003524 Applicant 델 마 파마슈티컬스 Inventor 바차, 제프리, 에이.
디안하이드로갈락티톨의 사용은 비소세포 폐암종(NSCLC) 및 난소암의 치료를 위한 새로운 치료 양식을 제공한다. 디안하이드로갈락티톨은 DNA에 N 메틸화를 생성하는 알킬화제로서 작용한다. 디안하이드로갈락티톨은 암 줄기세포의 성장을 억제하는데 유효하고, 테모졸로미드, 시스플라틴, 및 티미딘 키나제 저해제에 대해 난치성인 종양에 대하여 활성이 있다; 이 약물은 MGMT 복구 메커니즘와 독립적으로 작용한다. 디안하이드로갈락티톨 다른 항신생물제와 함께 사용될 수 있으며, 부가적 또는 초부가적 효과를 가질 수 있다. 7
7.0051467HEXITOL DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EP - 12.05.1982
Int.Class A61K 31/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
 Appl.No 81305161 Applicant CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. Inventor ELEKES, ILONA
Hexitols of the general formula (wherein the hexitol skeleton corresponds to dulcitol, mannitol or iditol, R@ represents a halogen atom, R<3> represents a hydroxy group, or R<2> and R<3> together form an oxygen atom; R represents a free carboxy containing saturated or unsaturated alkylcarbonyl group with 4 to 10 carbon atoms, a free carboxy containing arylcarbonyl group with 8 to 12 carbon atoms or a free carboxy containing satiurated or unsaturated aralkylcarbonyl group with 9 to 11 carbon atoms) and Rs@ represents a hydrogen atom, a free carboxy containing saturated or unsaturated alkylcarbonyl group with 4 to 10 carbon atoms, a saturated or unsaturated C2-10 alkylcarbonyl group, an alkoxycarbonyl containing saturated or unsaturated alkylcarbonyl group with 4 to 10 carbon atoms, a saturated or unsaturated C8-10 aralkylcarbonyl group, a free carboxy containing arylcarbonyl group with 8 to 12 carbon atoms or a free carboxy containing saturated or unsaturated aralkylcarbonyl group with 9 to 11 carbon atoms) and salts thereof possess tumour inhibiting activity. The hexitols of the present invention are prepared by hydrogenation of a corresponding benzyloxycarbonyl containing 1,2-5,6-dianhydrohexitol, reaction of 1,2-5,6-dianhydrohexitol with a dicarboxylic acid anhydride and halogenation of a corresponding 1,2-5,6-dianhydrohexitol.
8.115414480结合放射用于治疗非小细胞肺癌和多形性胶质母细胞瘤的二去水卫矛醇
CN - 02.12.2022
Int.Class A61K 41/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation
 Appl.No 202211009952.0 Applicant 德玛医药 Inventor 杰佛利·A·巴察
二去水卫矛醇的应用提供了治疗非小细胞肺癌(NSCLC)和治疗多形性胶质母细胞瘤(GBM)的新型治疗方式。二去水卫矛醇充当产生N7甲基化的DNA上的烷基化剂。二去水卫矛醇可有效抑制癌症干细胞的生长，并且对替莫唑胺难治的肿瘤具有活性；该药物独立于MGMT修复机制作用。
9.0334083IFOSFAMIDE-MESNA-LYOPHILIZED COMPOSITION AND PROCESS TO PREPARE IT
EP - 27.09.1989
Int.Class A61K 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
 Appl.No 89103844 Applicant ASTA PHARMA AKTIENGESELLSCHAFT Inventor SAUERBIER, DIETER
The ifosfamide-mesna lyophilisate consists essentially of ifosfamide, 0.1 - 1.0 part by weight of mesna and 0.1 to 17 parts by weight of hexitol.
10.1020230124765재발성 악성 신경교종 또는 진행성 2차 뇌종양의 치료를위한 디안히드로갈락티톨 및 그의 유사체 및 유도체의 용도
KR - 25.08.2023
Int.Class A61K 31/336
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
336having three-membered rings, e.g. oxirane, fumagillin
 Appl.No 1020237027741 Applicant 델 마 파마슈티컬스 Inventor 브라운, 데니스, 엠.
재발성 신경교종 및 진행성 2차 뇌종양과 같은 악성 종양의 치료에 적합한 방법 및 조성물이 개시된다. 이들 방법은 디안히드로갈락티톨, 디안히드로갈락티톨의 유도체 또는 유사체, 디아세틸디안히드로갈락티톨, 또는 디아세틸디안히드로갈락티톨의 유도체 또는 유사체와 같은 헥시톨 유도체를 사용한다. 조성물은 이러한 헥시톨 유도체를 포함할 수 있다.
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