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Analysis

PUBLICATION_DATE=2016
1 / 144
1.1020160132130폐의 비소세포 암종 및 난소암을 치료하기 위한 디안하이드로갈락티톨 및 이의 유사체 또는 유도체
KR - 16.11.2016
Int.Class A61K 31/336
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
336having three-membered rings, e.g. oxirane, fumagillin
 Appl.No 1020167030879 Applicant 델 마 파마슈티컬스 Inventor 바차, 제프리, 에이.
디안하이드로갈락티톨의 사용은 비소세포 폐암종(NSCLC) 및 난소암의 치료를 위한 새로운 치료 양식을 제공한다. 디안하이드로갈락티톨은 DNA에 N 메틸화를 생성하는 알킬화제로서 작용한다. 디안하이드로갈락티톨은 암 줄기세포의 성장을 억제하는데 유효하고, 테모졸로미드, 시스플라틴, 및 티미딘 키나제 저해제에 대해 난치성인 종양에 대하여 활성이 있다; 이 약물은 MGMT 복구 메커니즘와 독립적으로 작용한다. 디안하이드로갈락티톨 다른 항신생물제와 함께 사용될 수 있으며, 부가적 또는 초부가적 효과를 가질 수 있다. 7
2.1020160065776재발성 악성 신경교종 또는 진행성 2차 뇌종양의 치료를 위한 디안히드로갈락티톨 및 그의 유사체 및 유도체의 용도
KR - 09.06.2016
Int.Class A61K 31/336
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
336having three-membered rings, e.g. oxirane, fumagillin
 Appl.No 1020157037286 Applicant 델 마 파마슈티컬스 인코포레이티드 Inventor 브라운, 데니스, 엠.
재발성 신경교종 및 진행성 2차 뇌종양과 같은 악성 종양의 치료에 적합한 방법 및 조성물이 개시된다. 이들 방법은 디안히드로갈락티톨, 디안히드로갈락티톨의 유도체 또는 유사체, 디아세틸디안히드로갈락티톨, 또는 디아세틸디안히드로갈락티톨의 유도체 또는 유사체와 같은 헥시톨 유도체를 사용한다. 조성물은 이러한 헥시톨 유도체를 포함할 수 있다.
3.105579044双脱水半乳糖醇及其类似物与衍生物用于治疗复发性恶性神经胶瘤或进行性继发脑瘤的用途
CN - 11.05.2016
Int.Class A61K 31/7024
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7024Esters of saccharides
 Appl.No 201480042784.2 Applicant 德玛医药 Inventor D·M·布朗

所揭露为适用于治疗恶性肿瘤诸如复发性神经胶瘤及进行性继发脑瘤的方法及组合物。这些方法采用己糖醇衍生物如双脱水半乳糖醇、双脱水半乳糖醇的衍生物或类似物、二乙酰双脱水半乳糖醇或二乙酰双脱水半乳糖醇的衍生物或类似物。该组合物可包含该等己糖醇衍生物。

4.3008059METHOD FOR PREPARING LONG-CHAIN ALKYL CYCLIC ACETALS MADE FROM SUGARS
EP - 20.04.2016
Int.Class C07D 407/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
407Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/183
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
 Appl.No 14733376 Applicant TEREOS STARCH & SWEETENERS BELGIUM Inventor GOZLAN CHARLOTTE
According to the present invention, it has been found that long-chain alkyl cyclic acetals made from sugars can be obtained by a method that comprises the steps consisting of: - dehydrating a hexitol in a mono-anhydro-hexitol substrate; - reacting the obtained mono-anhydro-hexitol substrate with an alkyl aldehyde reagent containing between 5 and 18 carbon atoms, by means of an acetalisation reaction with a substrate/reagent ratio of between 5:1 and 1:1, or with a derivative of an alkyl aldehyde reagent containing between 5 and 18 carbon atoms, via a trans-acetalisation reaction with a substrate/reagent ratio of between 1:1 and 1:3, in the presence of an acid catalyst and in an environment that is free of solvent or that consists of a non-aqueous polar solvent; - recovering the long-chain alkyl acetal hexitane from the obtained mixture.
5.1016632550000*COMPOSITION FOR PREPARING CONCENTRATED ANHYDROSUGAR ALCOHOL WITH IMPROVED STABILITY AND METHOD FOR CONCENTRATING ANHYDROSUGAR ALCOHOL
KR - 10.10.2016
Int.Class A61K 47/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
16containing nitrogen
18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
 Appl.No 1020150169247 Applicant 주식회사 삼양사 Inventor RYU, HOON
The present invention relates to a composition for preparing concentrated anhydrosugar alcohol having enhanced stability and a method for concentrating anhydrosugar alcohol. More particularly, the present invention relates to a composition for preparing concentrated anhydrosugar alcohol having enhanced stability by including anhydrosugar alcohol and an amine-based additive, and to a method for providing anhydrosugar alcohol performs concentration in the presence of an amine-based additive during concentration of anhydrosugar alcohol and thus increases heat stability of the anhydrosugar alcohol. The concentration process can be efficiently operated at a high temperature and, at the same time, decline of pH and UV transmittance of anhydrosugar alcohol during the high temperature concentration process is prevented. Accordingly, anhydrosugar alcohol having high quality with low cost and high efficiency can be obtained. COPYRIGHT KIPO 2016
6.20160130277Method for preparing long-chain alkyl cyclic acetals made from sugars
US - 12.05.2016
Int.Class C07D 493/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
 Appl.No 14898475 Applicant SYRAL BELGIUM NV Inventor Charlotte Gozlan

Long-chain alkyl cyclic acetals made from sugars are obtainable by a method that comprises the steps consisting of:

    • dehydrating a hexitol in a monoanhydrohexitol substrate;
    • reacting the monoanhydrohexitol substrate obtained with an alkyl aldehyde reagent containing 5 to 18 carbon atoms, by means of an acetalization reaction with a substrate/reagent ratio of between 5:1 and 1:1, or with a derivative of an alkyl aldehyde reagent containing 5 to 18 carbon atoms, by means of a transacetalization reaction with a substrate/reagent ratio of between 1:1 and 1:3, in the presence of acid catalyst and in an environment that is free of solvent or that consists of non-aqueous polar solvent;
    • collecting the long-chain alkyl acetal of hexitan from the mixture obtained.

7.1020160009796MANUFACTURING METHOD OF ANHYDROSUGAR ALCOHOL BY USING LAYER CRYSTALLIZATION
KR - 27.01.2016
Int.Class C07C 29/78
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
29Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
74Separation; Purification; Stabilisation; Use of additives
76by physical treatment
78by condensation or crystallisation
 Appl.No 1020140090002 Applicant SAMYANG GENEX CORPORATIONSAMYANG GENEX CORPORATION Inventor RYU, HOONRYU, HOON
The present invention relates to a manufacturing method of anhydrosugar alcohol by using non-solvent layer crystallization and, more specifically, to a method for manufacturing high purity anhydrosugar alcohol in a short period of time by an eco-friendly method without using a solvent. The method is capable of simplifying facilities and improving yields, by using a layer crystallization technique without using a solvent, and crystallizing distillate obtained by distilling and treating after converting to anhydrosugar alcohol by dehydrating hydrogenated sugar under specific crystallization conditions. COPYRIGHT KIPO 2016
8.1020160009797MANUFACTURING METHOD OF ANHYDROSUGAR ALCOHOL BY USING LAYER CRYSTALLIZATION WITH SOLVENT
KR - 27.01.2016
Int.Class C07C 29/78
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
29Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
74Separation; Purification; Stabilisation; Use of additives
76by physical treatment
78by condensation or crystallisation
 Appl.No 1020140090003 Applicant SAMYANG GENEX CORPORATIONSAMYANG GENEX CORPORATION Inventor RYU, HOONRYU, HOON
The present invention relates to a manufacturing method of anhydrosugar alcohol by using layer crystallization with a solvent and, more specifically, to a manufacturing method of high purity anhydrosugar alcohol, which has excellent energy efficiency in comparison with a non-solvent melt crystallization process. The method is capable of simplifying facilities and improving yields, by using a layer crystallization technique with a small amount of a solvent used, and crystallizing distillate obtained by distilling and treating after converting to anhydrosugar alcohol by dehydrating hydrogenated sugar under specific crystallization conditions. COPYRIGHT KIPO 2016
9.1016632640000*ANHYDROSUGAR ALCOHOL COMPOSITION HAVING IMPROVED STORAGE STABILITY AND METHOD FOR STORING ANHYDROSUGAR ALCOHOLS
KR - 10.10.2016
Int.Class A61K 47/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
16containing nitrogen
18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
 Appl.No 1020150169260 Applicant 주식회사 삼양사 Inventor RYU, HOON
The present invention relates to anhydrosugar alcohol composition having improved storage stability and a method for storing anhydrosugar alcohols. More specifically, the present invention relates to an anhydrosugar alcohol composition having improved storage stability, comprising anhydrosugar alcohols and an amine-based additive, and relates to a method for providing anhydrosugar alcohols with excellent quality, by storing anhydrosugar alcohols in the presence of the amine-based additive, thereby significantly improving the storage stability. COPYRIGHT KIPO 2016
10.105418624脱水糖醇的生产方法
CN - 23.03.2016
Int.Class C07D 493/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
 Appl.No 201510726119.1 Applicant 阿彻-丹尼尔斯-米德兰公司 Inventor A·J·森伯恩

提供了制备脱水糖醇的方法。所述方法涉及在酸催化剂存在下和在压力下加热糖醇或单脱水糖醇原料。任选地提纯产物。获得很高的纯度，在该方法中无需使用有机溶剂。

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