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Analysis

PUBLICATION_DATE=2015
1 / 152
1.104427984Use of substituted hexitols including dianhydrogalactitol and analogs to treat neoplastic disease and cancer stem cells including glioblastoma multforme and medulloblastoma
CN - 18.03.2015
Int.Class A61K 31/35
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
 Appl.No 201380015319.5 Applicant BROWN DENNIS Inventor BACHA JEFFREY
The use of dianhydrogalactitol provides a novel therapeutic modality for the treatment of glioblastoma multiforme and medulloblastoma. Dianhydrogalactitol acts as an alkylating agent on DNA that creates N7 methylation. Dianhydrogalactitol is effective in suppressing the growth of cancer stem cells and is active against tumors that are refractory to temozolomide; the drug acts independently of the MGMT repair mechanism.
2.104428274Production method for anhydro sugar alcohol having markedly reduced ion content and improved colour characteristics
CN - 18.03.2015
Int.Class C07C 29/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
29Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
03by addition of hydroxy groups to unsaturated carbon-to-carbon bonds, e.g. with the aid of H2O2
04by hydration of carbon-to-carbon double bonds
05with formation of absorption products in mineral acids and their hydrolysis
08the acid being phosphoric acid
 Appl.No 201380024022.5 Applicant 株式会社三养社 Inventor 郑英在
The present invention relates to a production method for an anhydro sugar alcohol having a markedly reduced ion content and improved colour characteristics, and, more specifically, relates to a method for producing an anhydrous sugar alcohol having a markedly reduced ion content, markedly lowered electrical conductivity and improved colour characteristics, which is obtained by subjecting hydrogenated sugar (sugar alcohol) to a dehydration reaction and thereby converting same to an anhydrous sugar alcohol and then subjecting distilled water, which has been isolated through a distillation step, to a decolourizing process using activated carbon, and subsequently bringing the resulting decolourized substance into contact with an ion exchange resin.
3.20150094477Production method for anhydro sugar alcohol having markedly reduced ion content and improved colour characteristics
US - 02.04.2015
Int.Class C07D 493/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
 Appl.No 14399026 Applicant SAMYANG CORPORATION Inventor Young Jae Jung

The present invention relates to a production method for an anhydro sugar alcohol having a markedly reduced ion content and improved color characteristics, and, more specifically, relates to a method for producing an anhydrous sugar alcohol having a markedly reduced ion content, markedly lowered electrical conductivity and improved color characteristics, which is obtained by subjecting hydrogenated sugar (sugar alcohol) to a dehydration reaction and thereby converting same to an anhydrous sugar alcohol and then subjecting distilled water, which has been isolated through a distillation step, to a decolorizing process using activated carbon, and subsequently bringing the resulting decolorized substance into contact with an ion exchange resin.

4.2015520749イオン含量が顕著に低減され、色特性が向上したアンヒドロ糖アルコールの製造方法
JP - 23.07.2015
Int.Class C07D 493/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
 Appl.No 2015511365 Applicant サムヤン　コーポレイション Inventor ジョン，ヨンゼ

本発明は、イオン含量が顕著に低減され、色特性が向上したアンヒドロ糖アルコールの製造方法に関し、さらに詳しくは、水素化糖（糖アルコール）を脱水反応に供し、それによってアンヒドロ糖アルコールに転換させた後、蒸留工程を経て分離された蒸留液を、活性炭を用いた脱色工程に供し、次いで、脱色された生成物をイオン交換樹脂と接触させることにより、イオン含量が顕著に低減され、伝導度が顕著に低く、色特性が向上したアンヒドロ糖アルコールを製造する方法に関する。

5.104768908Method for preparing high-purity anhydrosugar alcohol using sequential combination of thin film distillation and short path distillation
CN - 08.07.2015
Int.Class C07C 29/80
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
29Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
74Separation; Purification; Stabilisation; Use of additives
76by physical treatment
80by distillation
 Appl.No 201380058429.X Applicant 株式会社三养社 Inventor 柳熏
The present invention relates to a technique for preparing an anhydrosugar alcohol using hydrogenated sugar as a raw material and, more specifically, to a technique for preparing a high-purity anhydrosugar alcohol (in particular, isosorbide, isomannide, isoidide, and the like) having a purity of 98% or higher and containing less than 0.1% of sorbitol and a sorbitan isomer, which are impurities, in a high total distillation yield of 94% or higher (more preferably, 95% or higher) by adding an acid to hydrogenated sugar (for example, hexitol) to convert same to an anhydrosugar alcohol, and then distilling the converted liquid over two or more stages by sequentially using a combination of an external condenser type wiped film evaporator and an internal condenser type short path evaporator.
6.104470880Method for preparing high purity anhydrosugar alcohols by thin film distillation
CN - 25.03.2015
Int.Class C07C 29/80
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
29Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
74Separation; Purification; Stabilisation; Use of additives
76by physical treatment
80by distillation
 Appl.No 201380024324.2 Applicant SAMYANG GENEX CORPORATION Inventor KYUNG DO-HYUN
The present invention relates to a method for preparing high purity anhydrosugar alcohols using hydrogenated sugar, and more specifically, to a method for preparing high purity anhydrosugar alcohols (particularly, isosorbide, isomannide, isoidide, and the like) with a purity of 97.5% or higher (more preferably, 98.5% or higher) and a pH of a distillate of 3.7 or higher (more preferably, 4.0 or higher) in a distillation yield of 87% or higher (more preferably, 90% or higher) by adding an acid to hexitol so as to convert the same into anhydrosugar alcohols, and single-stage distilling the converted product by using an internal condenser type thin film evaporator.
7.2015516413薄膜蒸留による高純度アンヒドロ糖アルコールの製造方法
JP - 11.06.2015
Int.Class C07D 493/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
 Appl.No 2015511366 Applicant サムヤン　コーポレイション Inventor キョン，ドヒョン

本発明は、水素化糖を用いて高純度のアンヒドロ糖アルコールを製造する方法に関し、より詳しくは、ヘキシトールに酸を加えて、アンヒドロ糖アルコールに転換させた後、凝縮器内蔵型の薄膜蒸留器を用いて、転換生成物を１段階で蒸留することにより、純度９７．５％以上（より好ましくは、９８．５％以上）、蒸留液ｐＨ３．７以上（より好ましくは、４．０以上）、蒸留収率８７％以上（より好ましくは、９０％以上）で、高純度のアンヒドロ糖アルコール（特に、イソソルビド、イソマンニド、イソイジドなど）を製造する方法に関する。
【選択図】図１

8.2848601PRODUCTION METHOD FOR ANHYDRO SUGAR ALCOHOL HAVING MARKEDLY REDUCED ION CONTENT AND IMPROVED COLOUR CHARACTERISTICS
EP - 18.03.2015
Int.Class C07C 29/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
29Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
03by addition of hydroxy groups to unsaturated carbon-to-carbon bonds, e.g. with the aid of H2O2
04by hydration of carbon-to-carbon double bonds
05with formation of absorption products in mineral acids and their hydrolysis
08the acid being phosphoric acid
 Appl.No 13788148 Applicant SAMYANG CORP Inventor JUNG YOUNG JAE
The present invention relates to a production method for an anhydro sugar alcohol having a markedly reduced ion content and improved colour characteristics, and, more specifically, relates to a method for producing an anhydrous sugar alcohol having a markedly reduced ion content, markedly lowered electrical conductivity and improved colour characteristics, which is obtained by subjecting hydrogenated sugar (sugar alcohol) to a dehydration reaction and thereby converting same to an anhydrous sugar alcohol and then subjecting distilled water, which has been isolated through a distillation step, to a decolourizing process using activated carbon, and subsequently bringing the resulting decolourized substance into contact with an ion exchange resin.
9.1020150034209디안하이드로갈락티톨, 디아세틸디안하이드로갈락티톨, 디브로모둘시톨, 또는 그의 유사체 또는 유도체를 이용하여 유전학적 다형성이 있는 환자에 있어서 티로신-키나아제-억제제 내성 악성종양, AHI1 조절곤란 또는 돌연변이를 치료하는 방법
KR - 02.04.2015
Int.Class A61K 31/336
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
336having three-membered rings, e.g. oxirane, fumagillin
 Appl.No 1020157002161 Applicant 델 마 파마슈티컬스 인코포레이티드 Inventor 브라운, 데니스 엠.
티미딘키나아제 억제제의 활성을 차단하는 생식세포 결실 다형성을 갖는 대상자에서 종양 세포의 세포자멸사를 촉발하거나 유전자의 돌연변이 또는 조절곤란을 갖는 대상자의 악성종양의 치료에 적합한 방법 및 조성물이 개시된다. 이 방법들은 알킬화 헥시톨 유도체 예컨대 디안하이드로갈락티톨, 디안하이드로갈락티톨의 유도체 또는 유사체, 디아세틸디안하이드로갈락티톨, 디아세틸디안하이드로갈락티톨의 유도체 또는 유사체, 디브로모둘시톨, 및 디브로모둘시톨의 유도체 또는 유사체를 이용한다. 조성물은 그러한 알킬화 헥시톨 유도체들을 포함할 수 있다. 이 방법은 또한 BH3 미메틱의 투여를 더 포함할 수 있으며, 조성물은 BH3 미메틱을 더 포함할 수 있다. 유전자의 조절곤란을 겪는 대상자에서, 이 방법은, 유전자 또는 AHI1 단백질의 발현 또는 활성을 조절하는 물질을 투여하는 것을 더 포함할 수 있으며, 조성물은 그러한 물질을 더 포함할 수 있다. AHI1 AHI1 AHI1
10.2015535301薄膜蒸留と短行程蒸留を順に組み合わせて用いた高純度無水糖アルコールの製造方法
JP - 10.12.2015
Int.Class C07D 493/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
 Appl.No 2015541681 Applicant サムヤン　コーポレイション Inventor リュ，フン

本発明は、水素化糖を原料として、無水糖アルコールを製造する技術に関し、より詳細には、水素化糖（例えば、ヘキシトール）に酸を加え、無水糖アルコールに転換させた後、転換液を外部コンデンサ型ワイプドフィルム蒸発器と内部コンデンサ型短行程蒸発器を順に組み合わせて用いて、２段階以上蒸留する。本発明によれば、純度９８％以上、不純物であるソルビトール及びソルビタン異性体の含量が０．１％未満の高純度無水糖アルコール（特に、イソソルビド、イソマンニド、イソイジド等）を総蒸留収率９４％以上（より好ましくは、９５％以上）の高収率で製造することができる。
【選択図】図１

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