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PUBLICATION_DATE=2013
1 / 149
1.0002497800METHOD OF CATALYTIC CONVERSION OF CELLULOSE IN HEXITOLS
RU - 10.11.2013
Int.Class C07C 31/26
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
31Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
18Polyhydroxylic acyclic alcohols
26Hexahydroxylic alcohols
 Appl.No 2012143179/04 Applicant Inventor Филатова Анастасия Евгеньевна (RU)
FIELD: chemistry. SUBSTANCE: invention relates to field of processing renewable raw material (in particular, cellulose) into raw material for chemical synthesis and biofuels. Method of catalytic conversion of cellulose in hexitols includes carrying out process of hydrolytic hydration of cellulose for 3-7 minutes at temperature 240-250°C under partial pressure of hydrogen 55-65 atm and with mixing of reaction medium in presence of ruthenium catalyst, according to invention as substrate for ruthenium catalyst applied is hypercrosslinked polystyrene of MN 270 grade, and content of ruthenium in catalyst constitutes from 1.0 to 1.5 wt % of catalyst weight. Mixing of reaction mixture is realised by propeller mixer, numbers of turns of which constitutes 580-620 rev/min. EFFECT: increased method efficiency. 2 cl, 16 ex
2.103270035取代的己糖醇例如卫康醇的合成方法
CN - 28.08.2013
Int.Class C07D 413/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
 Appl.No 201180050147.6 Applicant 德玛医药 Inventor 丹尼斯·M·布朗

本发明提供一种合成及纯化双脱水己糖醇(例如卫康醇)的有效方法。一般来说，当应用于卫康醇时，所述方法包含：(1)在约80°C的温度下，将卫矛醇与氢溴酸浓缩液起反应，以生成二溴卫矛醇；(2)将二溴卫矛醇与碳酸钾置入于叔丁醇中起反应，以生成卫康醇；以及(3)使用乙醚的浆料来纯化所述卫康醇，以生成纯化的卫康醇。

3.1020130126244PRODUCTION METHOD OF ANHYDROUS SUGAR ALCOHOL HAVING REMARKABLY REDUCED ION CONTENTS AND IMPROVED COLOR CHARACTERISTIC
KR - 20.11.2013
Int.Class C07C 29/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
29Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
03by addition of hydroxy groups to unsaturated carbon-to-carbon bonds, e.g. with the aid of H2O2
04by hydration of carbon-to-carbon double bonds
05with formation of absorption products in mineral acids and their hydrolysis
08the acid being phosphoric acid
 Appl.No 1020120050188 Applicant SAMYANG GENEX CORPORATION Inventor JUNG, YOUNG JAE
The present invention relates to a production method of anhydrous sugar alcohol having remarkably reduced ion contents and improved color characteristic, more specifically to a production method of the anhydrous sugar alcohol having remarkably reduced ion contents and conductivity, and improved color characteristic by dehydrating hydrogenated sugar ​(sugar alcohol) to obtain the anhydrous sugar alcohol, distilling the anhydrous sugar alcohol before decolorizing the distilled product with activated charcoal, and contacting the decolorized product with an ion exchange resin. COPYRIGHT KIPO 2014 >
4.1020130126303MANUFACTURING METHOD FOR HIGH PURITY ANHYDROSUGAR ALCOHOLS BY THIN FILM EVAPORATION
KR - 20.11.2013
Int.Class C07C 29/80
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
29Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
74Separation; Purification; Stabilisation; Use of additives
76by physical treatment
80by distillation
 Appl.No 1020120050316 Applicant SAMYANG GENEX CORPORATION Inventor KYUNG, DO HYUN
The invention relates to a manufacturing method for high purity anhydrosugar alcohols using hydrogenated sugar as raw materials and, more specifically, to a method for manufacturing high purity anhydrosugar alcohols (especially, isosorbide, isomannide, isoidide etc) with a purity of more than 97.5% (preferably, more than 98.5%) and a pH of a distillate of more than 3.7 (preferably, more than 4.0) in a distillation yield of more than 87% (preferably, more than 90%) by adding an acid to hexitol so as to convert the same into anhydrosugar alcohols, and single-stage distilling the converted products by using an internal condenser type thin film evaporator. COPYRIGHT KIPO 2014
5.20130079505BIVALENT ANTISENSE OLIGONUCLEOTIDES
US - 28.03.2013
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
 Appl.No 13636459 Applicant Moeller Thorleif Inventor Moeller Thorleif

The present invention provides bivalent molecules comprising a first oligonucleotide linked to a second oligonucleotide. The first and the second oligonucleotide are preferably linked via a linking moiety. Preferably, both the first and/or the second oligonucleotide comprise an antisense sequence complementary to a cellular RNA such as mRNA or microRNA.

6.2013534250ジアンヒドロガラクチトール等の置換ヘキシトールの合成方法
JP - 02.09.2013
Int.Class C07D 301/26
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
301Preparation of oxiranes
02Synthesis of the oxirane ring
24by splitting-off Hal-Y from compounds containing the radical Hal-C-C-OY
26Y being hydrogen
 Appl.No 2013524951 Applicant デル　マー　ファーマスーティカルズ Inventor デニス　エム　ブラウン

【課題】ジアンヒドロガラクチトール等のジアンヒドロヘキシトールを合成及び精製する効率的方法を提供する。
【解決手段】一般的に、ジアンヒドロガラクチトールに適用される、該方法は、（１）ジブロモガラクチトールを生成するために、約８０℃の温度で、ズルシトールと、臭化水素酸の濃縮液と、を反応させる工程と、（２）ジアンヒドロガラクチトールを生成するために、ｔ−ブタノール中でジブロモガラクチトールと、炭酸カリウムと、を反応させる工程と、（３）精製されたジアンヒドロガラクチトールを生成するために、エチルエーテルの懸濁液を用いて、ジアンヒドロガラクチトールを精製する工程と、を含む。

7.2013537552ジアンヒドロガラクチトール及びジアセチルジアンヒドロガラクチトール等の置換ヘキシトールを含む準最適に投与された化合物の治療的有効性を改良するための組成物及び置換ヘキシトールを含む薬剤を調製するための方法
JP - 03.10.2013
Int.Class A61K 31/336
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
336having three-membered rings, e.g. oxirane, fumagillin
 Appl.No 2013524950 Applicant デル　マー　ファーマスーティカルズ Inventor デニス　エム　ブラウン

【課題】準最適に投与された化合物及び治療組成物の治療的有効性を改善するための組成物及び方法を提供する。
【解決手段】本発明は、単独療法としての有効性を改善することによって、又は、副作用を低減させることによって、準最適な治療効果によって従前に制限された治療薬の治療的有効性を改善するための方法及び組成物に関する。そのような方法及び組成物は、ジアンヒドロガラクチトール及びジアセチルジアンヒドロガラクチトール等の置換ヘキシトールに、特に適用可能である。

8.WO/2013/089792BIO-BASED POLYOLS AND POLYMERS MADE THEREFROM
WO - 20.06.2013
Int.Class C07H 7/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
7Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
02Acyclic radicals
 Appl.No PCT/US2011/065639 Applicant CARGILL, INCORPORATED Inventor ABRAHAM, Timothy Walter
Compositions resulting from the dehydration and esterification of a sugar alcohol (i.e., an alditol). In some particular embodiments, the composition comprises mono-acylated sorbitan and/or mono-acylated isosorbide.
9.103476250Compositions and methods to improve the therapeutic benefit of suboptimally administered chemical compounds including substituted hexitols such as dianhydrogalactitol and diacetyldianhydrogalactitol
CN - 25.12.2013
Int.Class A01N 31/00
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
31Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
 Appl.No 201180050169.2 Applicant Del Mar Pharmaceuticals Inventor Brown Dennis M
The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutic agents previously limited by suboptimal therapeutic performance by either improving efficacy as monotherapy or reducing side effects. Such methods and compositions are particularly applicable to substituted hexitols such as dianhydrogalactitol and diacetyldianhydrogalactitol.
10.2578221The therapeutic use of tetrathiomolybdate
EP - 10.04.2013
Int.Class A61K 33/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
24Heavy metals; Compounds thereof
 Appl.No 11183830 Applicant MAGNUS INTELLECTUAL PROPERTY LTD Inventor
Tetrathiomolybdate is for use in therapy of myocardial infarction or stroke.
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