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Results 1-10 of 1,276 for Criteria:CHEM:(FBPFZTCFMRRESA-UHFFFAOYSA-N) Office(s):all Language:en Stemming: false
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TitleCtrPubDate
Appl.NoApplicantInventorInt.Class
Method for preparing hexitol or hydroxy-acetone
CN01.08.2012
201210041343.3Peking UniversityLiu Haichao
C07C 31/26
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
31
Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
18
Polyhydroxylic acyclic alcohols
26
Hexahydroxylic alcohols
The invention discloses a method for preparing hexitol or hydroxy-acetone, which comprises the steps as follows: cellulose reacts with glucose or fructose in water under the action of hydrogen atmosphere and catalytic agents, so as to obtain hexitol or hydroxy-acetone; the catalytic agents are supported metal catalysts; active constituents of the supported metal catalysts are metal modified by modifiers; the metal is any one of Pt, Ru, Ni and Cu; and a carrier of the supported metal catalysts is any one of Al2O3, TiO2, ZrO2, SiO2 and activated charcoal. The provided method selectively obtains hexitol or hydroxy-acetone through a one-pot reaction based on cellulose and glucose or fructose, achieves simple process, rapid reaction, high efficiency and energy conservation, and is easy to industrialize; the catalytic agents can be recovered and recycled, so that the cost is saved, and environmental protection can be achieved; in addition, the method has low requirements on equipment, cannot corrode equipment, and achieves low investment.

난연제
KR21.09.2012
1020127018256바스프 에스이플렉켄스타인, 크리스토프
C09K 21/12
C CHEMISTRY; METALLURGY
09
DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
K
MATERIALS FOR APPLICATIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
21
Fireproofing materials
06
Organic materials
12
containing phosphorus
본 발명은 난연제로서의 하기 화학식 I의 인 화합물의 용도에 관한 것이다. <화학식 I> 상기 식에서, 화학식 I의 기호는 하기의 의미를 갖는다. A는 하기 기: <화학식 II> <화학식 III> 또는 <화학식 IV> 중 하나이고; Y 기는 -P(=X)RR, H, 직쇄형 또는 분지형 C-C-알킬 기, C-C-시클로알킬, C-C-아릴 또는 벤질이고, 여기서 마지막에 언급된 4개의 기들은 비치환되거나 C-C-알킬 또는 C-C-알케닐렌 기 중 하나 이상의 라디칼에 의해 치환되고; R, R, R 및 R는 동일하거나 상이하고, 수소, OH, C-C-알킬, C-C-알케닐, C-C-알콕시, C-C-알케녹시, C-C-시클로알킬, C-C-시클로알콕시, C-C-아릴, C-C-아릴옥시, C-C-아릴-C-C-알킬, C-C-아릴-C-C-알콕시, SR, COR, COOR, CONRR이거나, R, R, R 또는 R 중 두 개의 라디칼이 이들이 결합되어 있는 인 원자 또는 P-O-A-O-P 기와 함께 고리계를 형성하고; R, R, R 및 R은 동일하거나 상이하고, H, C-C-알킬, C-C-알케닐, C-C-알콕시, C-C-알케녹시이고; R, R, R, R, R은 동일하거나 상이하고, H, C-C-알킬, C-C-알케닐, C-C-아릴, C-C-아릴-C-C-알킬, C-C-아릴-C-C-알콕시이고; X 및 X는 동일하거나 상이하고 S 또는 O이고; r 및 s는 동일하거나 상이하고 0 또는 1이고; X, X, X 및 X은 동일하거나 상이하고 S 또는 O이고, n은 1 내지 50의 자연수이다. TIFF 112012056008219-pct00099.tif 23 45 TIFF 112012056008219-pct00100.tif 16 27 TIFF 112012056008219-pct00101.tif 15 35 TIFF 112012056008219-pct00102.tif 14 34 2 s 3 4 1 12 5 6 6 12 1 4 2 4 1 2 3 4 1 16 2 16 1 16 2 16 3 10 3 10 6 10 6 10 6 10 1 16 6 10 1 16 9 10 11 12 13 1 2 3 4 5 6 7 8 1 16 2 16 1 16 2 16 9 10 11 12 13 1 16 2 16 6 10 6 10 1 16 6 10 1 16 1 2 3 4 5 6

DISTILLING METHOD OF ANHYDROSUGAR ALCOHOLS HAVING HIGH DISTILLATION YIELD, USING SUGAR IN DISTILLATION OF ANHYDROSUGAR ALCOHOLS, AND MANUFACTURING METHOD OF ANHYDROSUGAR ALHOHOLS USING THE SAME
KR25.06.2012
1020100128251SAMYANG GENEX CORPORATIONJUNG, YOUNG JAE
C07C 29/80
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
29
Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
74
Separation; Purification; Stabilisation; Use of additives
76
by physical treatment
80
by distillation
PURPOSE: A distilling method of anhydrosugar alcohols is provided to improve distillation yield without addition of facility and process, and to remarkably improve mobility of anhydrosugar, thereby facilitating processes. CONSTITUTION: A distilling method of anhydrosugar alcohols comprises: a step of conducting distillation by adding sugar into a mixture solution comprising anhydrosugar alcohols; a step of comprising one or more selected from monosaccharides, disaccharides, and sugar alcohol; a step of forming anhydrosugar alcohols by dehydration of sugar alcohol; and a step of distilling a mixture solution comprising the anhydrosugar alcohols by adding sugars. The sugar alcohol comprises hexitol. COPYRIGHT KIPO 2012

Aldehyde-free odorless environment-friendly and transparent polyvinyl alcohol (PVA) glue and preparation method thereof
CN31.10.2012
201210275985.XHenan College of Traditional Chinese MedicineLiu Mengqi
C09J 129/04
C CHEMISTRY; METALLURGY
09
DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
J
ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
129
Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal, or ketal radical; Adhesives based on hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Adhesives based on derivatives of such polymers
02
Homopolymers or copolymers of unsaturated alcohols
04
Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
The invention relates to aldehyde-free odorless environment-friendly and transparent polyvinyl alcohol (PVA) glue and a preparation method thereof, and can effectively solve the problem of complex technology or containing of harmful substances such as aldehydes in the prior art. The technical scheme includes that the glue is produced by the PVA, water, a modifier and a preservative, wherein, by weight, the PVA accounts for 1-15% of the glue, the modifier accounts for 0.5-10% of the PVA, the preservative accounts for 0.01-0.05% of the PVA and the balance water. The method includes mixing the PVA with the water at a room temperature of 18-25 DEG C, heating up to 85-100 DEG C after evenly stirring, cooling to 45-80 DEG C after completely dissolving, adding in the modifier and modifying for 0.5-2 hours at a temperature of 45-85 DEG C, cooling to the room temperature of 18-25 DEG C, adding in the preservative, and obtaining the glue. According to the PVA glue and the preparation method thereof, the reaction condition is relatively mild, the operation is simple, the glue is aldehyde-free, odorless, transparent, innovative, high in viscosity, low in production cost and prone to industrial production.

CDK inhibitor salts
US16.02.2012
13265918Zampieri MassimoZampieri Massimo
A61K 31/505
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim

The present invention relates to novel crystalline form(s) of water-soluble salts and of free base of a cdk inhibitor. Such crystal salts are for example fumarate, L-malate, maleate, succinate, adipate, malonate, glycolate, phosphate, mesylate, L-lactate, hydrochloride, di-hydrochloride, tri-hydrochloride. Hydrates and polymorphs of such new salt forms, a process for their preparation, their utility in therapy and to the pharmaceutical compositions containing them are also claimed and described in the present application.


TRICYCLO-DNA ANTISENSE OLIGONUCLEOTIDES, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF DISEASE
US14.06.2012
13263949Schümperli DanielSchümperli Daniel
A61K 31/712
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
712
Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose

Provided are tricyclo-DNA (tc-DNA) AON and methods employing tc-DNA AON for modifying splicing events that occur during pre-mRNA processing. Tricyclo-DNA (tc-DNA) AON are described that may be used to facilitate exon skipping or to mask intronic silencer sequences and/or terminal stem-loop sequences during pre-mRNA processing and to target RNase-mediated destruction of processed mRNA. Tc-DNA AON described herein may be used in methods for the treatment of Duchenne Muscular Dystrophy by skipping a mutated exon 23 or exon 51 within a dystrophin gene to restore functionality of a dystrophin protein; in methods for the treatment of Spinal Muscular Atrophy by masking an intronic silencing sequence and/or a terminal stem-loop sequence within an SMN2 gene to yield modified functional SMN2 protein, including an amino acid sequence encoded by exon 7, which is capable of at least partially complementing a non-functional SMN1 protein; and in methods for the treatment of Steinert's Myotonic Dystrophy by targeting the destruction of a mutated DM1 mRNA comprising 3′-terminal CUG repeats.


TRICYCLO-DNA ANTISENSE OLIGONUCLEOTIDES, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF DISEASE
EP15.02.2012
10713338ASS INST DE MYOLOGIESCHÜMPERLI DANIEL
C12N 15/113
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Provided are tricyclo-DNA (tc-DNA) AON and methods employing tc-DNA AON for modifying splicing events that occur during pre-mRNA processing. Tricyclo-DNA (tc-DNA) AON are described that may be used to facilitate exon skipping or to mask intronic silencer sequences and/or terminal stem-loop sequences during pre-mRNA processing and to target RNase-mediated destruction of processed mRNA. Tc-DNA AON described herein may be used in methods for the treatment of Duchenne Muscular Dystrophy by skipping a mutated exon 23 or exon 51 within a dystrophin gene to restore functionality of a dystrophin protein; in methods for the treatment of Spinal Muscular Atrophy by masking an intronic silencing sequence and/or a terminal stem-loop sequence within an SMN2 gene to yield modified functional SMN2 protein, including an amino acid sequence encoded by exon 7, which is capable of at least partially complementing a non-functional SMNl protein; and in methods for the treatment of Steinert's Myotonic Dystrophy by targeting the destruction of a mutated DMl mRNA comprising 3 '-terminal CUG repeats.

Flame Retardant
CN19.12.2012
201080062708.X巴斯夫欧洲公司C·福莱肯斯坦
C08K 5/53
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
K
USE OF INORGANIC OR NON-MACROMOLECULAR ORGANIC SUBSTANCES AS COMPOUNDING INGREDIENTS
5
Use of organic ingredients
49
Phosphorus-containing compounds
51
Phosphorus bound to oxygen
53
bound to oxygen and to carbon only
The invention relates to the use of a phosphorous compound of formula (I) as a flame retardant, wherein the symbols of formula (I) have the following meanings: a group Y is -P(=X2)SR3R4, H, a straight-chain or branched C1-C12 alkyl group, C5-C6 cycloalkyl, C6-C12 aryl, benzyl, wherein the four last cited groups are unsubstituted or substituted by one or more radicals from the groupC1-C4 alkylorC2-C4 alkenylene; R1, R2, R3 and R4 are the same or different hydrogen, OH, C1-C16-Alkyl, C2- C16-Alkenyl, C1-C16-Alkoxy, C2-C16-Alkenoxy, C3-C10-Cycloalkyl, C3-C10-Cycloalkoxy, C6-C10-Aryl, C6-C10-Aryloxy, C6-C10-Aryl-C1- C16-Alkyl, C6-C10-Aryl-C1-C16-Alkoxy, SR9 COR10, COOR11, CONR12R13 or two radicals R1, R2, R3, R4 form a ring system together with the phosphorous atom to which they are bound or the group P-O-A-O-P; R5, R6, R7, and R8 are the same or different H, C1-C16-Alkyl, C2-C16-Alkenyl, C1-C16-Alkoxy, C2-C16-Alkenoxy; R9, R10, R11, R12, and R13 are the same or different H d-de-Alkyl, C2-C16- Alkenyl, C6-C10-Aryl, C6-C10-Aryl-C1-C16-Alkyl, C6-C10- Aryl-C1-C16-Alkoxy; X1, and X2 are the same or different S or O; r, and s are the same or different 0 or 1; and X3, X4, X5, and X6 are the same or different S or O and n is a whole number from 1 to 50.

A METHOD FOR PREPARATION OF ANHYDROSUGAR ALCOHOLS
WO06.12.2012
PCT/KR2011/004036SAMYANG GENEX CORPORATIONRYU, Hoon
C07D 493/04
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
493
Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Disclosed is a method for the preparation of an anhydrosugar alcohol using a starch-derived hexitol such as sorbitol or mannitol. Anhydrosugar alcohol is in the form of a diol having two hydroxyl groups in the molecule thereof and has a very high utility value as a physical property modifier which can be used primarily in plastics. Representative examples of anhydrosugar alcohols include isosorbide and isomannide. These anhydrosugar alcohols are capable of increasing a glass transition temperature of and improving strength of PET, polyesters, polycarbonates, etc., and are therefore highly valuable as biodegradable environmentally-friendly bioplastics.

Hot Flash Relief Compositions and Methods
US20.09.2012
13422441Raede JeanneRaede Jeanne
A61K 31/045
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
045
Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates

Topical compositions and methods for treating hot flashes and night sweats are disclosed. As disclosed herein, a menthol-based composition is topically sprayed onto the back of the neck in order to alleviate symptoms associated with hot flashes and night sweats.


Results 1-10 of 1,276 for Criteria:CHEM:(FBPFZTCFMRRESA-UHFFFAOYSA-N) Office(s):all Language:en Stemming: false
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