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1.WO/2012/165676A METHOD FOR PREPARATION OF ANHYDROSUGAR ALCOHOLS
WO 06.12.2012
Int.Class C07D 493/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Appl.No PCT/KR2011/004036 Applicant SAMYANG GENEX CORPORATION Inventor RYU, Hoon
Disclosed is a method for the preparation of an anhydrosugar alcohol using a starch-derived hexitol such as sorbitol or mannitol. Anhydrosugar alcohol is in the form of a diol having two hydroxyl groups in the molecule thereof and has a very high utility value as a physical property modifier which can be used primarily in plastics. Representative examples of anhydrosugar alcohols include isosorbide and isomannide. These anhydrosugar alcohols are capable of increasing a glass transition temperature of and improving strength of PET, polyesters, polycarbonates, etc., and are therefore highly valuable as biodegradable environmentally-friendly bioplastics.
2.102617287Method for preparing hexitol or hydroxy-acetone
CN 01.08.2012
Int.Class C07C 31/26
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
31Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
18Polyhydroxylic acyclic alcohols
26Hexahydroxylic alcohols
Appl.No 201210041343.3 Applicant Peking University Inventor Liu Haichao
The invention discloses a method for preparing hexitol or hydroxy-acetone, which comprises the steps as follows: cellulose reacts with glucose or fructose in water under the action of hydrogen atmosphere and catalytic agents, so as to obtain hexitol or hydroxy-acetone; the catalytic agents are supported metal catalysts; active constituents of the supported metal catalysts are metal modified by modifiers; the metal is any one of Pt, Ru, Ni and Cu; and a carrier of the supported metal catalysts is any one of Al2O3, TiO2, ZrO2, SiO2 and activated charcoal. The provided method selectively obtains hexitol or hydroxy-acetone through a one-pot reaction based on cellulose and glucose or fructose, achieves simple process, rapid reaction, high efficiency and energy conservation, and is easy to industrialize; the catalytic agents can be recovered and recycled, so that the cost is saved, and environmental protection can be achieved; in addition, the method has low requirements on equipment, cannot corrode equipment, and achieves low investment.
3.1020120104602난연제
KR 21.09.2012
Int.Class C09K 21/12
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
KMATERIALS FOR APPLICATIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
21Fireproofing materials
06Organic materials
12containing phosphorus
Appl.No 1020127018256 Applicant 바스프 에스이 Inventor 플렉켄스타인, 크리스토프
본 발명은 난연제로서의 하기 화학식 I의 인 화합물의 용도에 관한 것이다. <화학식 I> 상기 식에서, 화학식 I의 기호는 하기의 의미를 갖는다. A는 하기 기: <화학식 II> <화학식 III> 또는 <화학식 IV> 중 하나이고; Y 기는 -P(=X)RR, H, 직쇄형 또는 분지형 C-C-알킬 기, C-C-시클로알킬, C-C-아릴 또는 벤질이고, 여기서 마지막에 언급된 4개의 기들은 비치환되거나 C-C-알킬 또는 C-C-알케닐렌 기 중 하나 이상의 라디칼에 의해 치환되고; R, R, R 및 R는 동일하거나 상이하고, 수소, OH, C-C-알킬, C-C-알케닐, C-C-알콕시, C-C-알케녹시, C-C-시클로알킬, C-C-시클로알콕시, C-C-아릴, C-C-아릴옥시, C-C-아릴-C-C-알킬, C-C-아릴-C-C-알콕시, SR, COR, COOR, CONRR이거나, R, R, R 또는 R 중 두 개의 라디칼이 이들이 결합되어 있는 인 원자 또는 P-O-A-O-P 기와 함께 고리계를 형성하고; R, R, R 및 R은 동일하거나 상이하고, H, C-C-알킬, C-C-알케닐, C-C-알콕시, C-C-알케녹시이고; R, R, R, R, R은 동일하거나 상이하고, H, C-C-알킬, C-C-알케닐, C-C-아릴, C-C-아릴-C-C-알킬, C-C-아릴-C-C-알콕시이고; X 및 X는 동일하거나 상이하고 S 또는 O이고; r 및 s는 동일하거나 상이하고 0 또는 1이고; X, X, X 및 X은 동일하거나 상이하고 S 또는 O이고, n은 1 내지 50의 자연수이다. TIFF 112012056008219-pct00099.tif 23 45 TIFF 112012056008219-pct00100.tif 16 27 TIFF 112012056008219-pct00101.tif 15 35 TIFF 112012056008219-pct00102.tif 14 34 2 s 3 4 1 12 5 6 6 12 1 4 2 4 1 2 3 4 1 16 2 16 1 16 2 16 3 10 3 10 6 10 6 10 6 10 1 16 6 10 1 16 9 10 11 12 13 1 2 3 4 5 6 7 8 1 16 2 16 1 16 2 16 9 10 11 12 13 1 16 2 16 6 10 6 10 1 16 6 10 1 16 1 2 3 4 5 6
4.1020120066904DISTILLING METHOD OF ANHYDROSUGAR ALCOHOLS HAVING HIGH DISTILLATION YIELD, USING SUGAR IN DISTILLATION OF ANHYDROSUGAR ALCOHOLS, AND MANUFACTURING METHOD OF ANHYDROSUGAR ALHOHOLS USING THE SAME
KR 25.06.2012
Int.Class C07C 29/80
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
29Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
74Separation; Purification; Stabilisation; Use of additives
76by physical treatment
80by distillation
Appl.No 1020100128251 Applicant SAMYANG GENEX CORPORATION Inventor JUNG, YOUNG JAE
PURPOSE: A distilling method of anhydrosugar alcohols is provided to improve distillation yield without addition of facility and process, and to remarkably improve mobility of anhydrosugar, thereby facilitating processes. CONSTITUTION: A distilling method of anhydrosugar alcohols comprises: a step of conducting distillation by adding sugar into a mixture solution comprising anhydrosugar alcohols; a step of comprising one or more selected from monosaccharides, disaccharides, and sugar alcohol; a step of forming anhydrosugar alcohols by dehydration of sugar alcohol; and a step of distilling a mixture solution comprising the anhydrosugar alcohols by adding sugars. The sugar alcohol comprises hexitol. COPYRIGHT KIPO 2012
5.WO/2012/081785METHODS FOR DISTILLING AND MANUFACTURING ANHYDROSUGAR ALCOHOLS
WO 21.06.2012
Int.Class C07C 29/80
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
29Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
74Separation; Purification; Stabilisation; Use of additives
76by physical treatment
80by distillation
Appl.No PCT/KR2011/005222 Applicant SAMYANG GENEX CORPORATION Inventor JUNG, Young Jae
A method for distilling anhydrosugar alcohol and a method for manufacturing anhydrosugar alcohol by using the same are provided. The distillation method comprises a step of adding saccharide to a mixture solution containing anhydrosugar alcohol and distilling the resulting mixture, and the manufacturing method comprises a step of dehydrating sugar alcohol to form anhydrosugar alcohol and a step of adding saccharide to a mixture solution containing the anhydrosugar alcohol and distilling the resulting mixture. The saccharide may comprise one or more selected from monosaccharide, disaccharide and sugar alcohol.
6.102757747Aldehyde-free odorless environment-friendly and transparent polyvinyl alcohol (PVA) glue and preparation method thereof
CN 31.10.2012
Int.Class C09J 129/04
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
JADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
129Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal, or ketal radical; Adhesives based on hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Adhesives based on derivatives of such polymers
02Homopolymers or copolymers of unsaturated alcohols
04Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
Appl.No 201210275985.X Applicant Henan College of Traditional Chinese Medicine Inventor Liu Mengqi
The invention relates to aldehyde-free odorless environment-friendly and transparent polyvinyl alcohol (PVA) glue and a preparation method thereof, and can effectively solve the problem of complex technology or containing of harmful substances such as aldehydes in the prior art. The technical scheme includes that the glue is produced by the PVA, water, a modifier and a preservative, wherein, by weight, the PVA accounts for 1-15% of the glue, the modifier accounts for 0.5-10% of the PVA, the preservative accounts for 0.01-0.05% of the PVA and the balance water. The method includes mixing the PVA with the water at a room temperature of 18-25 DEG C, heating up to 85-100 DEG C after evenly stirring, cooling to 45-80 DEG C after completely dissolving, adding in the modifier and modifying for 0.5-2 hours at a temperature of 45-85 DEG C, cooling to the room temperature of 18-25 DEG C, adding in the preservative, and obtaining the glue. According to the PVA glue and the preparation method thereof, the reaction condition is relatively mild, the operation is simple, the glue is aldehyde-free, odorless, transparent, innovative, high in viscosity, low in production cost and prone to industrial production.
7.20120041007CDK inhibitor salts
US 16.02.2012
Int.Class A61K 31/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
Appl.No 13265918 Applicant Zampieri Massimo Inventor Zampieri Massimo

The present invention relates to novel crystalline form(s) of water-soluble salts and of free base of a cdk inhibitor. Such crystal salts are for example fumarate, L-malate, maleate, succinate, adipate, malonate, glycolate, phosphate, mesylate, L-lactate, hydrochloride, di-hydrochloride, tri-hydrochloride. Hydrates and polymorphs of such new salt forms, a process for their preparation, their utility in therapy and to the pharmaceutical compositions containing them are also claimed and described in the present application.

8.2417257TRICYCLO-DNA ANTISENSE OLIGONUCLEOTIDES, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF DISEASE
EP 15.02.2012
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Appl.No 10713338 Applicant ASS INST DE MYOLOGIE Inventor SCHÜMPERLI DANIEL
Provided are tricyclo-DNA (tc-DNA) AON and methods employing tc-DNA AON for modifying splicing events that occur during pre-mRNA processing. Tricyclo-DNA (tc-DNA) AON are described that may be used to facilitate exon skipping or to mask intronic silencer sequences and/or terminal stem-loop sequences during pre-mRNA processing and to target RNase-mediated destruction of processed mRNA. Tc-DNA AON described herein may be used in methods for the treatment of Duchenne Muscular Dystrophy by skipping a mutated exon 23 or exon 51 within a dystrophin gene to restore functionality of a dystrophin protein; in methods for the treatment of Spinal Muscular Atrophy by masking an intronic silencing sequence and/or a terminal stem-loop sequence within an SMN2 gene to yield modified functional SMN2 protein, including an amino acid sequence encoded by exon 7, which is capable of at least partially complementing a non-functional SMNl protein; and in methods for the treatment of Steinert's Myotonic Dystrophy by targeting the destruction of a mutated DMl mRNA comprising 3 '-terminal CUG repeats.
9.20120149756TRICYCLO-DNA ANTISENSE OLIGONUCLEOTIDES, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF DISEASE
US 14.06.2012
Int.Class A61K 31/712
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
712Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
Appl.No 13263949 Applicant Schümperli Daniel Inventor Schümperli Daniel

Provided are tricyclo-DNA (tc-DNA) AON and methods employing tc-DNA AON for modifying splicing events that occur during pre-mRNA processing. Tricyclo-DNA (tc-DNA) AON are described that may be used to facilitate exon skipping or to mask intronic silencer sequences and/or terminal stem-loop sequences during pre-mRNA processing and to target RNase-mediated destruction of processed mRNA. Tc-DNA AON described herein may be used in methods for the treatment of Duchenne Muscular Dystrophy by skipping a mutated exon 23 or exon 51 within a dystrophin gene to restore functionality of a dystrophin protein; in methods for the treatment of Spinal Muscular Atrophy by masking an intronic silencing sequence and/or a terminal stem-loop sequence within an SMN2 gene to yield modified functional SMN2 protein, including an amino acid sequence encoded by exon 7, which is capable of at least partially complementing a non-functional SMN1 protein; and in methods for the treatment of Steinert's Myotonic Dystrophy by targeting the destruction of a mutated DM1 mRNA comprising 3′-terminal CUG repeats.

10.WO/2012/071525COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING DISEASES AND DISORDERS ASSOCIATED WITH D-DT
WO 31.05.2012
Int.Class C12Q 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
Appl.No PCT/US2011/062062 Applicant YALE UNIVERSITY Inventor BUCALA, Richard, J.
The present invention relates to the discovery that altered levels of D- DT (also known as MIF-2) are associated with disorders and diseases. Thus, the present invention relates to compositions and methods useful of the assessment, diagnosis, characterization, prevention and treatment of disorders and diseases associated with an elevated level of D-DT, The present invention also relates to compositions and methods useful of the assessment, diagnosis, characterization, prevention and treatment of disorders and diseases associated with a reduced level of D-DT.