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PUBLICATION_DATE=2011
1 / 152
1.1020110076268METHOD FOR MANUFACTURING ANHYROSUGAR ALCOHOLS OF DIOL FORM FROM HEXITOL
KR - 06.07.2011
Int.Class C07D 493/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
 Appl.No 1020090132933 Applicant SAMYANG GENEX CORPORATION Inventor RYU, HOON
PURPOSE: A method for manufacturing anhydosugar alcohol using hexitol is provided to enhance glass transition temperature of PET, polyester, polycarbonate and to improve strength. CONSTITUTION: A method or manufacturing anhydrosugar comprises a step of dehydrating of hexitol with mixed acid of first and second acids at 105-190°C for 1-10 hours. The first acid is sulfuric acid. The second acid is p-toluene sulfonic acid, methane sulfonic acid, ethane sulfonic acid, benzene sulfonic acid, naphthalene sulfonic acid, or aluminum sulfate. The hexitol is sorbitol, mannitol, or iditol. COPYRIGHT KIPO 2011
2.WO/2011/117353BIVALENT ANTISENSE OLIGONUCLEOTIDES
WO - 29.09.2011
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
 Appl.No PCT/EP2011/054545 Applicant MIRRX THERAPEUTICS A/S Inventor MOELLER, Thorleif
The present invention provides bivalent molecules comprising a first oligonucleotide linked to a second oligonucleotide. The first and the second oligonucleotide are preferably linked via a linking moiety. Preferably, both the first and/or the second oligonucleotide comprise an antisense sequence complementary to a cellular RNA such as mRNA or microRNA.
3.102015702Cyclic ethers
CN - 13.04.2011
Int.Class C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
 Appl.No 200880024304.4 Applicant 吉沃丹S.A.公司 Inventor 哈娜艾曼·萨卡萨·彼瑞那凯蒂
A process of preparing cyclic ethers is described. The process involves the reaction of at least one organic compound such as a dioi or a polyol which it has at least one pair of hydroxyl groups separated by 4 or 5 carbon atoms, and which is capable of being converted into an ether linkage, with an organic carbonate in the presence of a base. The base is an alkoxy, a carbonate or a hydroxide base or is a mixture of such bases. At least one of the hydroxyl groups of the organic compound is not a tertiary hydroxyl group.
4.2011501729環状エーテル
JP - 13.01.2011
Int.Class C07D 307/92
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
77ortho- or peri-condensed with carbocyclic rings or ring systems
92Naphthofurans; Hydrogenated naphthofurans
 Appl.No 2010515605 Applicant ジボダン　エス　エー Inventor ベヴィナカッティ　ハナマンサ　シャンカーサ

環状エーテルを調製するプロセスが記載される。このプロセスは、エーテル結合へと変換することができる、４つまたは５つの炭素原子によって隔てられた少なくとも一対のヒドロキシル基を有するジオールまたはポリオールなどの少なくとも１つ有機化合物と、有機カーボネートとの、塩基の存在下での反応を含む。この塩基はアルコキシ、炭酸塩または水酸化物塩基であるか、またはかかる塩基の混合物である。この有機化合物のヒドロキシル基のうちの少なくとも１つは三級ヒドロキシル基ではない。
【選択図】なし

5.20110092429Compositions and methods for producing gamma-carboxylated proteins
US - 21.04.2011
Int.Class C12N 5/07
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
 Appl.No 12950713 Applicant Fenge Christel Inventor Fenge Christel

The present invention relates to methods and tools for producing large quantities of gamma-carboxylated protein comprising: (i) culturing a cell adapted to express a protein which requires gamma-carboxylation and γ-glutamyl carboxylase in a ratio of at least 10:1, under conditions suitable for expression of both proteins, and (ii) isolating gamma-carboxylated protein.

6.2292748Method for producing gamma-carboxylated proteins
EP - 09.03.2011
Int.Class C12N 9/64
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
48acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50Proteinases
64derived from animal tissue, e.g. rennin
 Appl.No 10185166 Applicant MEDLMMUNE LTD Inventor FENGE CHRISTEL
The present invention relates to methods and tools for producing large quantities of gamma-carboxylated protein comprising: (i) culturing a cell adapted to express a protein which requires gamma-carboxylation and ³-glutamyl carboxylase in a ratio of at least 10:1, under conditions suitable for expression of both proteins, and (ii) isolating gamma-carboxylated protein
7.WO/2011/135280ENZYMES
WO - 03.11.2011
Int.Class C12N 9/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
 Appl.No PCT/GB2011/000583 Applicant MEDICAL RESEARCH COUNCIL Inventor HOLLIGER, Philipp
The invention relates to a nucleic acid polymerase capable of producing a non-DNA nucleotide polymer from a DNA nucleotide polymer template, said polymerase comprising amino acid sequence having at least 36% identity to the amino acid sequence of SEQ ID NO:1, wherein said amino acid sequence is mutated relative to the amino acid sequence of SEQ ID NO:1 at one or more residues of the thumb region, said residues selected from: amino acids 651 to 679 (patch 10A); wherein said amino acid sequence is mutated relative to the amino acid sequence of SEQ ID NO:1 at residue E664. In one embodiment said polymerase comprises the mutations Y409G and E664K. In one embodiment said polymerase comprises amino acid sequence corresponding to SEQ ID NO: 12. The invention also relates to A nucleic acid polymerase capable of reverse transcribing a HNA nucleotide polymer into a DNA nucleotide polymer, said polymerase comprising amino acid sequence having at least 36 % identity to the amino acid sequence of SEQ ID NO:1, wherein said amino acid sequence is mutated relative to the amino acid sequence of SEQ ID NO:1 at residue 1521.
8.WO/2011/121354THE THERAPEUTIC USE OF TETRATHIOMOLYBDATE
WO - 06.10.2011
Int.Class A61K 33/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
24Heavy metals; Compounds thereof
 Appl.No PCT/GB2011/050653 Applicant MAGNUS TTM IC Inventor SINGER, Mervyn
Tetrathiomolybdate is for use in therapy of a condition requiring reduced core temperature, e.g. ischemia-reperfusion injury.
9.WO/2011/014561EXTRACTS OF MEDICINAL PLANT AND USES THEREOF
WO - 03.02.2011
Int.Class A01N 65/00
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
65Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
 Appl.No PCT/US2010/043542 Applicant INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION Inventor HE, Johnny, J.
Extracts of traditional Chinese medicinal plants, Annonaceae, Artabotrys pilosus, Annonaceae, Dasymaschalon rostratum, Euphorbiaceae, Trigonostema xyphophylloides, and Dipterocarpaceae, Vatica astrotricha, are described. Pharmaceutical compositions comprising the extracts and treatment of HIV infection is described.
10.WO/2011/112791MODULATING AQUAPORINS WITH RELAXIN
WO - 15.09.2011
Int.Class A61K 38/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
 Appl.No PCT/US2011/027859 Applicant THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. Inventor PARRY, Laura
The present disclosure relates to methods of modulating aquaporin channels. Particularly, the disclosure provides methods of modulating aquaporin channels in a tissue of a mammal by administering relaxin.
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