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Analysis

1.20220180975METHODS AND SYSTEMS FOR DETERMINING GENE EXPRESSION PROFILES AND CELL IDENTITIES FROM MULTI-OMIC IMAGING DATA
US 09.06.2022
Int.Class G16B 40/30
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
40ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
30Unsupervised data analysis
Appl.No 17553691 Applicant The Broad Institute, Inc. Inventor Aviv Regev

The present disclosure relates to systems and method of determining transcriptomic profile from omics imaging data. The systems and methods train machine learning methods with intrinsic and extrinsic features of a cell and/or tissue to define transcriptomic profiles of the cell and/or tissue. Applicants utilize a convolutional autoencoder to define cell subtypes from images of the cells.

2.20210298688Methods and systems for identifying presence of abnormal heart sounds of a subject
US 30.09.2021
Int.Class A61B 5/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes ; Identification of persons
Appl.No 17060009 Applicant Tata Consultancy Services Limited Inventor Rohan Banerjee

The disclosure generally relates to methods and systems for identifying presence of abnormal heart sounds from heart sound signals of a subject being monitored. Conventional Artificial intelligence (AI) based abnormal heart sounds detection models with supervised learning requires a substantial amount of accurate training datasets covering all heart disease types for the training, which is quiet challenging. The present methods and systems solve the problem solves the problem of identifying presence of the abnormal heart sounds using an efficient semi-supervised learning model. The semi-supervised learning model is generated based on probability distribution of spectrographic properties obtained from heart sound signals of healthy subjects. A Kullback-Leibler (KL) divergence between a predefined Gaussian distribution and an encoded probability distribution of the semi-supervised learning model is determined as an anomaly score for identifying the abnormal heart sounds.

3.WO/2023/154851INTEGRATED FRAMEWORK FOR HUMAN EMBRYO PLOIDY PREDICTION USING ARTIFICIAL INTELLIGENCE
WO 17.08.2023
Int.Class G06T 7/00
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
7Image analysis
Appl.No PCT/US2023/062368 Applicant CORNELL UNIVERSITY Inventor HAJIRASOULIHA, Iman
The present disclosure encompasses systems and methods for predicting embryo ploidy. Specific embodiments encompass methods of non-invasively predicting ploidy status of an embryo, by receiving a dataset with a static image of the embryo, analyzing the static image by one or more machine and/or deep learning model via one or more classification task applied to the dataset; and generating an output prediction of the ploidy status of the embryo. Particular methods relate to methods wherein the dataset additionally includes one or more clinical and/or morphological features for the embryo. Embodiments also relate to predicting embryo viability and/or improving embryo selection, such as during in vitro fertilization. and uses thereof.
4.20250391501INTEGRATED FRAMEWORK FOR HUMAN EMBRYO PLOIDY PREDICTION USING ARTIFICIAL INTELLIGENCE
US 25.12.2025
Int.Class G16B 20/10
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
20ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
10Ploidy or copy number detection
Appl.No 18834931 Applicant Cornell University Inventor Iman HAJIRASOULIHA

The present disclosure encompasses systems and methods for predicting embryo ploidy. Specific embodiments encompass methods of non-invasively predicting ploidy status of an embryo, by receiving a dataset with a static image of the embryo, analyzing the static image by one or more machine and/or deep learning model via one or more classification task applied to the dataset; and generating an output prediction of the ploidy status of the embryo. Particular methods relate to methods wherein the dataset additionally includes one or more clinical and/or morphological features for the embryo. Embodiments also relate to predicting embryo viability and/or improving embryo selection, such as during in vitro fertilization, and uses thereof.

5.2018101531Stock forecast model based on text news by random forest
AU 01.11.2018
Int.Class G06N 3/08
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
3Computing arrangements based on biological models
02Neural networks
08Learning methods
Appl.No 2018101531 Applicant CHANG, ZHIHAN MR Inventor CHANG, ZHIHAN
The main purpose of this project is to use random forest (RF) algorithm to analyze the correlation between the stock news on the historical days and the ups and downs of the stocks the next day. We then find out the information hidden behind these data by sorting and screening stocks, that is, the key words or key events related to the rise and fall of the stocks to predict the rise and fall of the stocks in the near future. By using this method, after entering the news data of the stock market on that day, we can predict the rise and fall of one stock the next day. This relatively accurate method can help shareholders get rid of the risk of stock investment and even can guarantee stable investment returns. This model uses random forest algorithm to carry out excavating and classifying the information of text news. Random forest is a combinatorial classifier, which can be used for the classification and screening of the stocks. The essence of it is a set of tree classifiers. Among them, the base classifier H (x, beta k) is a classification decision tree constructed by CART algorithm without pruning. x is the input vector and beta k is an independent and identically distributed random vector which determine the growth process of the single tree (base classifier). The output is determined by a simple majority voting method. Fig.1 General Flow-Chart
6.20220067558Artificial intelligence explaining for natural language processing
US 03.03.2022
Int.Class G06N 5/045
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
5Computing arrangements using knowledge-based models
04Inference or reasoning models
045Explanation of inference; Explainable artificial intelligence ; Interpretable artificial intelligence
Appl.No 17010887 Applicant International Business Machines Corporation Inventor Takumi Yanagawa

In an approach to AI explaining for natural language processing, responsive to receiving an input text for a machine learning model, an output is generated from the machine learning model. A plurality of alteration techniques are applied to the input text to generate one or more alternate outputs, where each alternate output corresponds to an alteration technique. A variation rate of the alternate output is calculated for each alteration technique. A preferred technique of generating neighboring data of the input text is generated based on a comparison of the variation rate of the alternate output for each alteration technique.

7.WO/2026/037781ANALYSIS OF HISTOPATHOLOGY SAMPLES
WO 19.02.2026
Int.Class G06V 10/774
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
10Arrangements for image or video recognition or understanding
70using pattern recognition or machine learning
77Processing image or video features in feature spaces; using data integration or data reduction, e.g. principal component analysis or independent component analysis or self-organising maps ; Blind source separation
774Generating sets of training patterns; Bootstrap methods, e.g. bagging or boosting
Appl.No PCT/EP2025/073017 Applicant THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW Inventor QUIROS, Adalberto Claudio
Computer-implemented methods of analysing a histopathology sample are described, comprising obtaining a plurality of tile representations using a tile representation machine learning model, assigning each of the plurality of tile representations to one of a predetermined set of histomorphological phenotype clusters, obtaining a whole slide image representation using a histomorphological phenotype cluster language model, and predicting one or more biological or clinical features associated with the sample using a task specific machine learning model, wherein the task specific machine learning model is a model that has been trained using training whole slide images and optionally associated one or more ground truth biological or clinical features of interest to predict the one or more biological or clinical feature of interest for a whole slide image using as input the whole slide image representation provided by the histomorphological cluster language model for the whole slide image.
8.20220383629Label-free cell classification and screening system based on hybrid transfer learning
US 01.12.2022
Int.Class G06V 10/82
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
10Arrangements for image or video recognition or understanding
70using pattern recognition or machine learning
82using neural networks
Appl.No 17804073 Applicant SHANDONG UNIVERSITY Inventor Xuantao Su

A label-free cell classification and screening system based on hybrid transfer learning, including a data preprocessing module for acquiring 2D light scattering video data and for digital cell filtering, is made public here; the data preprocessing module includes the label-free high-content video flow cytometry, which has the optical excitation module, the sheath flow control module, and the data acquisition and processing module; the image archiving module is used to sort and set labels for cells; in the feature extraction module, the first convolutional neural network is used to obtain image data feature vectors; in the cell classification and screening module, a support vector machine model is used to obtain the cell screening results.

9.5835893Class-based word clustering for speech recognition using a three-level balanced hierarchical similarity
US 10.11.1998
Int.Class G10L 3/00
GPHYSICS
10MUSICAL INSTRUMENTS; ACOUSTICS
LSPEECH ANALYSIS TECHNIQUES OR SPEECH SYNTHESIS; SPEECH RECOGNITION; SPEECH OR VOICE PROCESSING TECHNIQUES; SPEECH OR AUDIO CODING OR DECODING
3Details of devices which are not related to a specific method of analysis or synthesis
Appl.No 08634705 Applicant ATR Interpreting Telecommunications Research Labs Inventor Ushioda Akira

In a word clustering apparatus for clustering words, a plurality of words is clustered to obtain a total tree diagram of a word dictionary representing a word clustering result, where the total tree diagram includes tree diagrams of an upper layer, a middle layer and a lower layer. In a speech recognition apparatus, a microphone converts an input utterance speech composed of a plurality of words into a speech signal, and a feature extractor extracts predetermined acoustic feature parameters from the converted speech signal. Then, a speech recognition controller executes a speech recognition process on the extracted acoustic feature parameters with reference to a predetermined Hidden Markov Model and the obtained total tree diagram of the word dictionary, and outputs a result of the speech recognition.

10.WO/2023/091970LIVE-CELL LABEL-FREE PREDICTION OF SINGLE-CELL OMICS PROFILES BY MICROSCOPY
WO 25.05.2023
Int.Class G16B 25/10
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
25ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
10Gene or protein expression profiling; Expression-ratio estimation or normalisation
Appl.No PCT/US2022/079989 Applicant THE GENERAL HOSPITAL CORPORATION Inventor COMITER, Charles
Computer-implemented methods, computer program products, and systems determine an omics profiles of a cell using microscopy imaging data. In one aspect, a computer-implemented method determines an omics profiles of a cell using microscopy imaging data by a) receiving microscopy imaging data of a cell or a population of cells; b) determining a targeted expression profile of a set of target genes from the microscopy imaging data using a first machine learning model, the target genes identifying a cell type or cell state of interest; and c) determining a singlecell omics profile for the population of cells using a second machine learning algorithm model. The targeted expression profile and a reference single-cell RNA-seq data set are used as inputs for the second machine learning model.