Specification covers new algorithms, methods, and systems for artificial intelligence, soft computing, and deep learning/recognition, e.g., image recognition (e.g., for action, gesture, emotion, expression, biometrics, fingerprint, facial, OCR (text), background, relationship, position, pattern, and object), Big Data analytics, machine learning, training schemes, crowd-sourcing (experts), feature space, clustering, classification, SVM, similarity measures, modified Boltzmann Machines, optimization, search engine, ranking, question-answering system, soft (fuzzy or unsharp) boundaries/impreciseness/ambiguities/fuzziness in language, Natural Language Processing (NLP), Computing-with-Words (CWW), parsing, machine translation, sound and speech recognition, video search and analysis (e.g. tracking), image annotation, geometrical abstraction, image correction, semantic web, context analysis, data reliability, Z-number, Z-Web, Z-factor, rules engine, control system, autonomous vehicle, self-diagnosis and self-repair robots, system diagnosis, medical diagnosis, biomedicine, data mining, event prediction, financial forecasting, economics, risk assessment, e-mail management, database management, indexing and join operation, memory management, data compression, event-centric social network, Image Ad Network.

The present disclosure relates to systems and method of determining transcriptomic profile from omics imaging data. The systems and methods train machine learning methods with intrinsic and extrinsic features of a cell and/or tissue to define transcriptomic profiles of the cell and/or tissue. Applicants utilize a convolutional autoencoder to define cell subtypes from images of the cells.

Specification covers new algorithms, methods, and systems for: Artificial Intelligence; the first application of General-AI (versus Specific, Vertical, or Narrow-AI) (as humans can do); addition of reasoning, inference, and cognitive layers/engines to learning module/engine/layer; soft computing; Information Principle; Stratification; Incremental Enlargement Principle; deep-level/detailed recognition, e.g., image recognition (e.g., for action, gesture, emotion, expression, biometrics, fingerprint, tilted or partial-face, OCR, relationship, position, pattern, and object); Big Data analytics; machine learning; crowd-sourcing; classification; clustering; SVM; similarity measures; Enhanced Boltzmann Machines; Enhanced Convolutional Neural Networks; optimization; search engine; ranking; semantic web; context analysis; question-answering system; soft, fuzzy, or un-sharp boundaries/impreciseness/ambiguities/fuzziness in class or set, e.g., for language analysis; Natural Language Processing (NLP); Computing-with-Words (CWW); parsing; machine translation; music, sound, speech, or speaker recognition; video search and analysis (e.g. tracking); image annotation; image or color correction; data reliability; Z-Number; Z-Web; Z-Factor; rules engine; playing games; control system; autonomous vehicles or drones; self-diagnosis and self-repair robots; system diagnosis; medical diagnosis; genetics; drug discovery; biomedicine; data mining; event prediction; financial forecasting (e.g., for stocks); economics; risk assessment; fraud detection (e.g., for cryptocurrency); e-mail management; database management; indexing and join operation; memory management; data compression; event-centric social network; social behavior; and Image Ad and Referral Networks.

Provided is a process that includes: obtaining a corpus of unstructured natural language text statements and corresponding responses by responding users, wherein the corresponding responses are responsive natural language text statements or responding-user-expressed scores; obtaining demographic features associated with the responding users; scoring the corresponding responses based on whether the corresponding responses indicate offense to the unstructured natural language text statements to which the corresponding responses correspond in order to form offensiveness scores; forming a training set at least in part by: labeling the unstructured natural language text statements, or n-grams therein, with labels based on the offensiveness scores; and associating the labels with corresponding demographic features of the responding users; and causing a machine learning model to be trained based on the training set, wherein the machine learning model is configured to at least one of: classify natural language utterances as offensive or non-offensive, or generate utterances.