WO/2016/190770 NOVEL DERIVATIVES OF 3,5-DIVINYL-PYRAZOLE FOR MEDICAL APPLICATION||WO||01.12.2016|
||PCT/RU2015/000323||LIMITED LIABILITY COMPANY "NATIONAL PHARMACEUTICAL TECHNOLOGIES"||KOLOTOVA, Ekaterina Sergeevna|
The invention relates to medicine and specifically to pharmacology, and regards novel chemical compounds of general formula (I) or pharmaceutically acceptable salts, hydrates or solvates thereof, in which Rp, Rm, RA, RB Rx, R1, R2, R3 and R4 have values indicated in the description, and which are P-glycoprotein inhibitors. The present compounds may be used in the treatment of diseases of the central nervous system, and of infectious, allergic, autoimmune, oncological and other diseases. Specifically, the present compounds may be used for suppressing multiple drug resistance in patients receiving various medications over extended periods.
WO/2016/190768 STICK FOR MOVEMENT ON ROLLER SKIS||WO||01.12.2016|
||PCT/RU2015/000320||POSOKHIN, Sergey Viktorovich||POSOKHIN, Sergey Viktorovich|
The proposed stick is intended for use during rapid running on roller skis along a smooth and hard covering, and also along the ground. The aim of the proposed invention is to provide full contact of the lower plane of a support element with the smooth and hard underlying surface, and also with the ground surface in any ski-stick angular position necessary for a skier in an interval in the effect of a support load, and also to prevent the ski-stick from sliding to the maximum possible part of the operating stroke thereof. The stated aim is achieved in that, in a ski-stick comprising a rod and a support element, the lower end of the rod and the support element are connected by means of a three-stage hinge and also by means of flexible elements providing for the rod and the lower plane of the support element to be perpendicular and also for the longitudinal axis of the support element to be parallel to the plane of movement of the skier during the absence of a support load, wherein the three-stage hinge is a three-stage gimbal, and the actual support part is a flexible, for example rubber, body similar to a plumbing air-escape valve. The positive effect of using the proposed structural solutions will make it possible to reduce the load on the legs and, with lower general forces, to increase the speed of movement.
WO/2016/190769 METHOD OF INCREASING THE ENERGY EFFICIENCY OF MECHANICAL SYSTEMS||WO||01.12.2016|
||PCT/RU2015/000321||POSOKHIN, Sergey Viktorovich||POSOKHIN, Sergey Viktorovich|
The invention relates to the field of increasing the operating efficiency of mechanical systems. A method of increasing the energy efficiency of a mechanical system involves connecting the cyclically moving elements of a structure to one another and/or to a base by means of elastic couplings, the rigidity of which is selected so that a resonant or near-resonant self-oscillating mode occurs in the system, characterized by an absence of or significant reduction in reactive energy loss.
WO/2016/190771 INTEGRATED INERTIAL SATELLITE SYSTEM FOR ORIENTATION AND NAVIGATION||WO||01.12.2016|
||PCT/RU2015/000327||AKTSIONERNOE OBSCHESTVO "KONTSERN "TSENTRALNY NAUCHNO-ISSLEDOVATELSKY INSTITUT "ELEKTROPRIBOR"||BLAZHNOV, Boris Aleksandrovich|
The invention relates to the field of navigational instrument-making for aircraft and ships. The inertial satellite system for orientation contains a gimballess inertial measurement module with a measurement unit on "coarse" sensors, which comprises three micro-mechanical or fibre-optic gyroscopes, three accelerometers and a computer, which comprises a unit for generating orientation parameters, a unit for generating navigation parameters, an integrated information processing unit, and a unit for generation and disambiguation of differential phase measurements. The orientation system also includes a receiving apparatus of satellite navigation systems, said receiving apparatus comprising an antenna module containing two antennae spaced apart on a corresponding antenna base at a distance which is less than the wave length of the carrier frequency of a satellite signal. The technical result is an increase in the accuracy of the generation of object orientation parameters; an expansion in the capabilities with respect to calibration on a mobile object; and also a substantial reduction in the weight and size of the device.
WO/2016/190772 GEL BASE FOR PHARMACEUTICAL AND COSMETIC AGENTS||WO||01.12.2016|
||PCT/RU2015/000329||VORONCZOV, Oleg Arkad'evich||VORONCZOV, Oleg Arkad'evich|
The invention relates to medicine, and more particularly to the creation of a medicinal composition in the form of a gel for external application, which exhibits antiseptic, anti-inflammatory and wound healing effects and is intended for the pathogenetically based treatment of burns, wounds and trauma of various etiologies. The present medicinal composition in the form of a gel for external application can be used in the topical treatment of II-IIIa degree superficial thermal burns to the skin, chemical burns and dermatitides, non-healing trophic ulcers (wounds), wounds associated with diabetic foot syndrome, pressure sores, soft tissue trauma (haematoma, abrasions, contusions, etc.), and also a number of skin diseases of inflammatory etiology, in prehospital (preadmission) settings and also in hospital and ambulatory conditions.
WO/2016/190774 OPTIMIZED NUCLEOTIDE SEQUENCE AND PHARMACEUTICAL COMPOSITION BASED THEREON WITH PROLONGED VEGF TRANSGENE EXPRESSION||WO||01.12.2016|
||PCT/RU2015/000852||COMPANY LIMITED "NEXTGEN"||KISELEV, Sergey Lvovich|
Point changes to the 3'UTR nucleotide sequence of the VEGF gene which significantly increase the lifespan of the mRNA transcription product of said gene in mammalian cells have been identified. A gene construct with an optimal list of the identified mutations, which is characterized by a maximum mRNA lifespan, has been selected by experimentation. The biological effect of the gene construct developed and of a pharmaceutical composition based thereon have been confirmed in vitro and in vivo.
WO/2016/190775 METHOD OF PREDICTING THE DEVELOPMENT OF PLACENTAL INSUFFICIENCY IN LATE PREGNANCY||WO||01.12.2016|
||PCT/RU2015/000853||FEDERALNOE GOSUDARSTVENNOE BJUDZHETNOE UCHREZHDENIE "IVANOVSKIJJ NAUCHNO-ISSLEDOVATEL'SKIJJ INSTITUT MATERINSTVA I DETSTVA IMENI V.N.GORODKOVA" MINISTERSTVA ZDRAVOOKHRANENIJA ROSSIJJSKOJJ FEDERACII||MALYSHKINA, Anna Ivanovna|
The invention relates to medicine, and more particularly to midwifery and gynaecology, and enables early prediction of the development of placental insufficiency in late pregnancy. The essence of the invention is that in the 5th-12th week of gestation, the mother's serum concentration of DcR3 is determined. If the reading is above 0.87 pg/ml, this indicates a likelihood of the development of placental insufficiency in late pregnancy. The technical result is an increase in the arsenal of predictive tools, a simplified procedure, and an increase in the accuracy, sensitivity and specificity with which the development of placental insufficiency is predicted, making it possible to choose the right strategy for managing a pregnancy, to implement a series of preventive and curative measures and to reduce the risk of complications and adverse pregnancy outcomes.
WO/2016/190778 KNIFE STAND||WO||01.12.2016|
||PCT/RU2016/000212||ABDULIN, Igor Renatovich||ABDULIN, Igor Renatovich|
The utility model relates to consumer goods, and specifically to stands for tableware, particularly knifes. The technical result achieved by the utility model consists in the mounting of knives of various sizes in a stand, while reliably securing same therein. The technical result is achieved in that a knife stand contains a housing and a holder which are connected to one another, the holder having at least one vertical slot provided therein, the cross-section of which slot has a Y-shape, wherein a recess is provided on the side of the holder where the top end of the vertical slot is located. The claimed knife stand allows for streamlined manufacture, and is convenient to use, allowing for easy setup and for reliably securing knives.
WO/2016/190779 LIQUID PURIFICATION SYSTEM||WO||01.12.2016|
||PCT/RU2016/000267||AQUAPHOR PRODUCTION CORPORATION (AQUAPHOR PRODUCTION CORP.)||KNIZEL, Vadim Nikolaevich|
The invention relates to autonomous systems involving recirculation for the purification and/or desalination of liquid. An initial liquid container (1) is linked to an inlet of a liquid feed unit (2), an outlet of which is connected to an inlet of a liquid purification unit (6) which has an outlet for purified liquid, connected to one purified liquid container (7), and an outlet for drainage liquid, connected to an inlet of a drainage liquid return line (8), an outlet of which line is connected to the initial liquid container (1). The system is capable of automatically interrupting the liquid purification process when the level of liquid in the initial liquid container, in the process of system operations, reaches the level of an initial liquid outlet means. The liquid feed unit (2) is capable of automatically shutting-down a pressurization means (3) for preventing air from entering the liquid purification unit, in response to a signal coming from a blocking means (5), notifying of a moment when air has passed through the liquid outlet means from the initial liquid container into the pressurization means. The invention increases the reliability of a liquid purification system.
WO/2016/190780 EXTRACELLULAR DNA AS A THERAPEUTIC TARGET IN NEURODEGENERATION||WO||01.12.2016|
||PCT/RU2016/000284||GENKIN, Dmitry Dmitrievich||GENKIN, Dmitry Dmitrievich|
The invention relates to the use of deoxyribonuclease (DNase) enzyme for inhibiting progression and for prevention and treatment of neurodegeneration.