WO/2017/039425 A METHOD FOR PREPARATION OF IBRUTINIB PRECURSOR||WO||09.03.2017|
||PCT/LV2015/000009||LATVIAN INSTITUTE OF ORGANIC SYNTHESIS||LEBEDEVS, Antons|
A method for the preparation of ibrutinib's precursor, 3-(4-phenoxyphenyl)-1-((3R)-piperidin-3-il)-1H-pyrazolof [3,4-d]|pyrimidin-4-amine, involving arylation of N-protected 1-(piperidin-3-yl)pyrazolo[3,4-d]pyrimidin-4-amine in the presence of palladium catalyst, nitrogen-containing ligand, and base, with subsequent removal of the protecting groups by known methods, is reported. (Formula (II))
WO/2017/034384 EPIDERMAL LIPID BARRIER RESTORING CREAM FOR FACIAL SKIN, NECK AND DECOLLETE AREA FOR METABOLIC SYNDROME PATIENTS||WO||02.03.2017|
||PCT/LV2015/000006||RĪGAS STRADIŅA UNIVERSITĀTE||VOICEHOVSKA, Jūlija|
The invention relates to the field of medicine, namely family medicine (general practitioners), therapy, endocrinology, gerontology, dermatology and cosmetology and solves the problem of restoration of epidermal lipid barrier in facial skin, decollete and the neck in metabolic syndrome patients. The goal of the invention is to develop a cream composition that restores epidermal lipid barrier and lipid layer of facial skin, neck and decollete for use in patients with metabolic syndrome. Set goals are achieved through the design of a specific ē cream composition, which contains seleno-L-methionine, Vitamin E alpha-tocopherol, squalane, methyl-4- hydroxybenzoate, glycerol monostearate 60, cetylalchol, middle chain triglyceride, white petrolatum, macrogol-20-glycerolmonostearate, 1,2-propanediol and distilled water in the certain ratios mass relationships.
WO/2017/010856 COMPOSITION FOR TREATMENT OF SUBCLINICAL MASTITIS OF COWS||WO||19.01.2017|
||PCT/LV2015/000005||RĪGAS STRADIŅA UNIVERSITĀTE||JERMOLAJEVS, Jevgeņijs|
The invention relates to veterinary medicine and biotechnology, especially with new, natural composition development for the treatment of subclinical mastitis in cows. The aim of invention is to create the effective compositions for the treatment of subclinical mastitis in cows, that can provide milk product quality and safety, which is not required for making of synthetic antibacterial agents. The aim is achieved with developing a new composition, which contains lactic acid, lysozyme, glycopeptides and 0,15M Na Cl physiological solution.
WO/2016/190723 THE DETERMINATION METHOD OF THE HIGH CARDIOVASCULAR RISK INDICATORS IN THE CASE OF CENTRAL OBSESITY IN PATIENTS FROM BALTIC SEA REGION||WO||01.12.2016|
||PCT/LV2016/000002||RÍGAS STRADIŅA UNIVERSITÁTE||VOICEHOVSKA, Júlija|
The invention relates to medicine, internal medicine, general medicine, general physicians, cardiology, endocrinology, gerontology, dermatology. A non-invasive, valid method for the assessment of high cardiovascular risk score in central obesity patients of the Baltic region is developed. Changes of 2 and more characteristics that contribute to skin appearance are definied, so if these include 6-8 and above papillomas, 2 or 3 and above keratosis and lentigo zones, and/or 4-6 gravitational wrinkles, high cardiovascular risk is established.
WO/2016/159746 NOVEL ETHYNYLXANTHINES, THEIR PREPARATION AND USE AS INHIBITORS OF MATRIX METALLOPROTEINASES AND ANGIOGENESIS||WO||06.10.2016|
||PCT/LV2015/000002||LATVIAN INSTITUTE OF ORGANIC SYNTHESIS||ARSENJANS, Pavels|
The present invention relates to a novel ethynylxanthine derivatives of formula (I) which exhibit ability selectively suppress matrix metalloproteinases and therefore may act as inhibitors of angiogenesis, methods for their synthesis and use for the treatment and/or prevention of various diseases and disorders caused by overexpression of matrix metalloproteinases by administration of such substances.
WO/2016/159745 ETHYNYLXANTHINES, PREPARATION AND USE FOR CANCER TREATMENT||WO||06.10.2016|
||PCT/LV2015/000001||LATVIAN INSTITUTE OF ORGANIC SYNTHESIS||ARSENJANS, Pavels|
The present invention relates to novel ethynylxanthine derivatives of formula (I) which exhibit high antiproliferative activity against various tumor cell lines, methods for their synthesis and use for the treatment and/or prevention of cancer.
WO/2016/159747 ETHYNYLXANTHINES, PREPARATION AND USE AS CALCIUM ION CHANNEL MODULATORS||WO||06.10.2016|
||PCT/LV2015/000003||LATVIAN INSTITUTE OF ORGANIC SYNTHESIS||ARSENJANS, Pavels|
The present invention relates to novel pharmaceutical compounds, which exhibit ability to act as calcium ion channel modulators, methods for their synthesis and the treatment and/or prevention of various diseases and disorders including deregulated calcium ion channel activity.
WO/2016/129983 NOVEL N-ACYL-ARYLSULFONAMIDE DERIVATIVES AS AMINOACYL-TRNA SYNTHETASE INHIBITORS||WO||18.08.2016|
||PCT/LV2016/000001||INHIBOX LIMITED||JIRGENSONS, Aigars|
The present invention relates to novel N-acyl-diarysulfonamides acting as inhibitors of bacterial aminoacyl-tRNA synthetase. These can be used as medicines or as constituent of medicines for the treatment of bacterial infections.
WO/2016/072824 A FOLD ABLE DEVICE FOR PREPARING FOOD ON AN OPEN FIRE||WO||12.05.2016|
||PCT/LV2015/000008||CVETKOVS, Andris||CVETKOVS, Andris|
The invention relates to devices for preparing food on an open fire. A device has been developed for preparing food on an open fire that is compact, fast and easy to assemble, and convenient for use, even on a hiking tour. The device, containing a barbecue grill which can be opened with a handle, additionally comprises two separate identical supports, where each support is designed as a pointed rod in order to fix it firmly in the soil and connected in the upper part by means of a U-shaped clamp to support the barbecue grill; and containing a rod-shaped grill holder, where one end is folded at a 90 degree angle forming a bracing element of the top edge of the grill, and the other end is folded at a 90 degree angle and sharpened in order to fix it firmly in the soil, and fitted with a handle; furthermore, the holder is divisible in its middle section.
WO/2016/039605 BRAIN TISSUE POST-MORTEM DETECTION TECHNIQUES FOR PATHOMORPHOLOGIC BRAIN EXAMINATION IN CASE OF ENCEPHALOPATHY||WO||17.03.2016|
||PCT/LV2014/000012||RĪGAS STRADIŅA UNIVERSITĀTE||ROGA, Silvija|
The invention relates to medicine, namely to pathomorphology, and it is associated with post-mortem pathomorphologic brain examination in cases of encephalopathy. The aim of the invention is to develop brain tissue post-mortem detection techniques for pathomorphologic brain examination in cases of encephalopathy, which would allow eliminating discrepancies and errors in post-mortem diagnosis of the disease. The goal is achieved by ensuring that during the pathomorphologic examination of post-mortem brain, it is removed from the skull, and the examination determines skull vault's largest span along the mid-line of the skull's inner surface CD, determines skull vault's largest span along the mid-line of the skull's outer surface GH, cuts a straight front-parietal line (starting from the frontal lobe) of the underside of the two hemispheres, exposing the brain's lateral and third ventricle, then placing it in the preparation bath, fixating both sides of the hemispheres and determining the outer distance between the brain's frontal horns AB, the distance along the midline EF of the lateral ventricle, and the ratio of the coefficient, thus determining post-mortem signs of encephalopathy.