WO/2016/131431 SOLID FORMS OF EMPAGLIFLOZIN||WO||25.08.2016|
||PCT/CZ2016/000020||ZENTIVA, K.S.||OBADALOVA, Iva|
The invention relates to novel solid forms of empagliflozin of formula I, with the systematic name (2S,3R54R,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6- (hydroxy-methyl)oxane-3,4,5-triol. It deals with an amorphous or crystalline complex of empagliflozin with proline, a method of its preparation and use for the production of a drug form. The crystalline complex of empagliflozin with proline can be advantageously used to increase the purity of empagliflozin and its stabilization in terms of chemical and polymorphic purity. The invention further provides an amorphous form of empagliflozin and a method of its preparation.
WO/2016/127962 AN AMORPHOUS SOLID FORM OF SUVOREXANT WITH SULPHURIC ACID||WO||18.08.2016|
||PCT/CZ2016/000016||ZENTIVA, K.S.||DAMMER, Ondrej|
The invention relates to a novel, physically stable, solid form of suvorexant, chemically [(7R)- 4-(5-chloro- 1,3 -benzoxazol-2-yl)-7-methyl- 1,4-diazepan- 1 -yl] [5-methyl- 2-(2H-l,2;3-triazol-2-yl)phenyl]methanone with sulphuric acid, methods of its preparation and a physically stable pharmaceutical composition containing this solid form.
WO/2016/127964 METHOD AND DEVICE FOR CONTINUOUS MEASUREMENT OF COHESIVE FORCES IN ROVING OR A SIMILAR FIBER BUNDLE||WO||18.08.2016|
||PCT/CZ2016/000018||VUTS, a.s.||SKOP, Petr|
The invention relates to a method for the continuous measurement of the cohesive forces between the fibers of roving (3) or a similar fiber bundle, in which in the drafting zone (4) running roving (3) is acted upon by constant draft, as a result of which axial resistive force is induced in the roving (3) in the area of drafting against this drafting, whereby in the area of the action of the axial resistive force the trajectory of roving (3) is deflected from a straight-line path by a contact member (41) of a force sensor (42), upon which the roving (3) acts by the transverse force, which is measured. Deflection of the trajectory of the roving (3) from a straight-line path is performed within the drafting zone (4) at the shortest possible distance for the rollers (11,12) of the feeding device (1) and the length (L) of the drafting zone (4) is selected slightly greater than the length of the longest fiber in the roving (3), whereby the axial resistive force during constant drafting is determined from the size of the transverse force measured by the force sensor (42) by means of a suitable calibration of the force sensor (42) and changes in this axial resistive force are determined from the changes in the size of the transverse force during constant drafting, the axial resistive force corresponding to the cohesive force between the fibers of the roving (3). The invention also relates to a device for the continuous measurement of the cohesive forces of roving.
WO/2016/127960 IBRUTINIB SULPHATE SALT||WO||18.08.2016|
||PCT/CZ2016/000014||ZENTIVA, K.S.||ZVATORA, Pavel|
The invention relates to a solid form of the salt of l-[(3R-)-3-[4-amino-3-(4-phenoxyphenyl)- lH-pyrazolo[3,4-d]pyrimidin-l-yl]piperidin-l-yl]prop-2-en-l-one, known as ibrutinib, with sulphuric acid and a method of its preparation. Ibrutinib sulphate is in a crystalline form or amorphous form.
WO/2016/127965 SOLID FORMS OF DOLUTEGRAVIR SALTS AND A METHOD OF THEIR PREPARATION||WO||18.08.2016|
||PCT/CZ2016/000019||ZENTIVA, K.S.||OBADALOVA, Iva|
The invention relates to solid forms of salts of dolutegravir of formula I, (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, a method of their preparation and their use in a dosage form. For example, solid forms of dolutegravir with amines (e.g.diethylamine, N,N'-dibenzylethylenediamine, meglumine, ethanolamine, diethanolamine, tromethamine, tert-butylamine), potassium, magnesium and calcium are well usable. These salts can be conveniently used to increase purity of dolutegravir and its stabilization in terms of chemical as well as polymorphic purity.
WO/2016/127963 SOLID FORMS OF PALBOCICLIB SALTS||WO||18.08.2016|
||PCT/CZ2016/000017||ZENTIVA, K.S.||ZVATORA, Pavel|
The invention relates to a solid form a salt of palbociclib of formula I with an acid HA in the molar ratio of 1 :1 or 1 :2, the acid HA being selected from the group containing hydrobromic acid, sulphuric acid, oxalic acid, benzenesulfonic acid, salicylic acid, fumaric acid, 2,4-dihydroxybenzoic acid, benzoic acid. Another aspect of the invention is a process of preparing the palbociclib salts.
WO/2016/127959 SCINTILLATION DETECTOR FOR DETECTION OF IONISING RADIATION||WO||18.08.2016|
||PCT/CZ2016/000012||CRYTUR, SPOL. S R.O.||HOSPODKOVÁ, Alice|
The scintillation detector for the detection of ionising radiation, especially electron, X-ray or particle radiation, including a monocrystalline substrate (1), minimally one buffer layer (2), minimally one nitride semiconductor layer (3, 4, 5, 6) applied onto the substrate (1) with epitaxy which is described by the AlyInxGa1-x-yN general formula where 0 ≤ x ≤1, 0 ≤ y ≤1 and 0 ≤ x+y ≤1 is valid, where minimally two nitride semiconductor layers (3, 4) are arranged in a layered heterostructure, whose structure contains minimally one potential well for radiant recombinations of electrons and holes. In the structure there is arranged minimally one active couple of nitride semiconductor layers (3, 4) of principally the same polarisation consisting of the barrier layer (4) of the AlybInxbGa1-xb-ybN type and from layer (5) of the AlywInxwGa1-xw-ywN type representing a potential well where xb ≤ xw and yb ≤ yw is valid, or there is minimally one carrier attracting layer (7) of the AlydInxdGa1-xd-ydN type with the thickness (t3) less than 2 nm in which yd ≤ yw and xd ≥ xw+0,3 inserted in minimally one active couple of nitride semiconductor layers (4, 5) to decrease the luminescence decay time.
WO/2016/127961 TIMBER STRUCTURE||WO||18.08.2016|
||PCT/CZ2016/000015||TOMSA, Tomáš||TOMSA, Tomáš|
The wood boards - boards of irregular shape, advantageously of having holes for connection with further elements into triangles or multi-angle, when thanks to this variable structure, it is possible to create the building/structure with the possibility of placing in rough terrain without the need for a solid anchor, when thanks to the variability of the system it is possible to imitate natural features (e.g. rocks, hills, such as the Pravčička brána (Pravčice gate), Trosky (Trosky Castle)) alternatively also known construction with the preservation of the functionality of the building for leisure activities. The basic building element is always connected with at least two other elements and on these elements there can be mainly vertically placed additional elements assembled into a triangle or multi-angle (polygon). Advantageously there are created gaps between the individual structural elements by using washers/pads and/or using the embedded building elements. This design allows you to assemble or connect other components, such as bridges, slides, cable cars, ramps, tunnels, etc.
WO/2016/119763 DEVICE FOR SELECTIVE SHADING OF DAZZLING SOURCES OF LIGHT||WO||04.08.2016|
||PCT/CZ2015/000026||KYJOVSKY, David||KYJOVSKY, David|
This solution features a device for selective shading of dazzling sources of light, consisting of a transparent imaging panel (4), a camera system and an image processor (3), whose substance lies in the fact that transparent imaging panel (4), depicting, during the dazzling of the user (7), shading zone (5) of his right eye and shading zone (6) of his left eye for each source of light (1), is placed between the user (7) and the source of light (1) in the user's field of vision, while connected to transparent imaging panel (4) is image processor (3), which is connected to head-held digital camera (2). Connected to image processor (3) is at least one inner digital camera (8), which is turned towards the face of the user (7). Transparent imaging panel (4) is made by means of the LCD technology and/or another technology allowing for its transparency, and constitutes an integral part of the windshield of a car, an aircraft or a cabin of the user (7) in case of a working machine and/or as a supplementary accessory thereto. The device is destined for transport vehicles and other operating systems in which dazzling of their operators may be anticipated, such as, for example, control rooms, crane cabins etc. The device serves to enhance the safety of road, railway and air traffic, and the safety of industrial operations.
WO/2016/119764 THERMAL INSULATOR DESIGNED FOR BUILDING FACADE||WO||04.08.2016|
||PCT/CZ2015/000077||WIEDEN, Pavel||WIEDEN, Pavel|
The aim of the invention is the reduction of heat loss in the area of the joints in conversion from the cold into the warm zone. This aim is achieved by the structures, the material and the shape of the profiles of the heat insulator, when the desired insulator/profile is constructed from composite materials with low thermal conductivity, thereby the heat loss reduces, and with high strength, thus it is able to transmit all the loads from the panels to the supporting structure of the casing. Thermal insulator, one or multi-chamber is set between the fillings, passes from the cold zone and touches by at least one of its ends into the warm zone between the filling and the supporting profile.