WO/2016/015690 METHOD FOR SEPARATION OF BIOPOLYMER MOLECULES AND A CARRIER FOR APPLICATION OF THIS METHOD||WO||04.02.2016|
||PCT/CZ2015/000081||UNIVERZITA PARDUBICE ||KUPCIK, Rudolf |
The invention relates to a method for separation of biopolymer molecules, particularly biopolymer molecules from the group consisting of mono- a multi-phosphorylated peptides, recombinant peptides/proteins with a polyhistidine tag (His-tag) or with another chemically similar biospecific tag, cysteine-containing peptides/proteins and nucleic acids, in which a biopolymer molecule is bound in a binding solution by a specific binding to a carrier, which contains a core with dimensions in nano- and/or submicro- and/or microscale, which is composed of oxide of at least one transition metal and/or silicon oxide, on whose surface is deposited at least one continuous or non-continuous layer and/or nanoparticles of magnetic metal oxide and/or such nanoparticles are deposited in its inner structure, and subsequently undesirable and non- specifically bound components are washed off at least once from the carrier- bound biomolecules by a washing solution, whereupon biopolymer molecules are eluted from it by changing pH and/or by using an elution solution. The invention also relates to a carrier for application of this method.
WO/2016/015691 A PHARMACEUTICAL COMPOSITION HAVING ANTIBACTERIAL AND VIRUCIDAL EFFECTS||WO||04.02.2016|
||PCT/CZ2015/050002||SARKESSYAN, Albert ||SARKESSYAN, Albert |
A pharmaceutical composition having antibacterial and virucidal activity, containing iodine, potassium or sodium iodide, a synthetic polymer soluble in water, carbohydrates and halogenated carbohydrates and water and additionally rutin and ascorbic acid in the following composition: iodine 1-5 25 g/l, potassium or sodium iodide 1.5-25 g/l, synthetic water-soluble polymer 1-10 g/l, carbohydrates 10-200 g/l, halogenated carbohydrates 0.01-100 g/l, rutin 1-10 g/l, ascorbic acid 1-10 g/l, water up to 1 litre. The preferred synthetic water-soluble polymer is polyvinylpyrrolidone.
WO/2016/015689 EXTENSION FOR INCREASING OF THE UPPER LIMIT OF APPLICATION OF POLYURETHAN FOAM FROM A DOSE||WO||04.02.2016|
||PCT/CZ2015/000080||MISLER, Jaroslav ||MISLER, Jaroslav |
Extension (1) for increasing of the upper limit of application of polyurethan foam from a dose (2), including a connection socket (3) connected with a swinging controller (4), where on the connection socket (3) a lower bending (6) is connected, on which a tube prolongation (7) is connected, on which an upper bending (8) is connected and on it an application ending (9) is connected.
WO/2016/008461 A NEW FORM OF SOFOSBUVIR AND A METHOD OF ITS PREPARATION||WO||21.01.2016|
||PCT/CZ2015/000078||ZENTIVA, K.S. ||STEFKO, Martin |
The crystalline Form Z-1 of sofosbuvir, characterized by the following diffraction peaks: 8.0; 12.3; 17.1; 19.9 and 20.8 ±0,2° 2-theta with the use of CuKα radiation, and a method of its preparation.
WO/2016/008460 METHOD OF CONTINUOUS PRODUCTION OF LIQUID AND GASEOUS FUELS FROM THE PART OF ORGANIC SUBSTANCES IN THE WASTE||WO||21.01.2016|
||PCT/CZ2015/000074||ALPAJAR GROUP S.R.O. ||VAŠÍČEK, Alois |
Method of continuous production of liquid and gaseous fuels from the part of organic substances in the waste, in particular in the industrial, agricultural and municipal waste, including their mixtures, consists in thermic decomposition of these wastes into fuels - usable low-molecular hydrocarbons, as well as other residual inorganic or other parts intended for recycling or to any landfill, where the treated waste with a content of organic substances, especially in the form of paper, plastics, rubber, including non-crushed used tires, wooden elements, sawdust, rests of meals and fats, and their packaging, in a hermetically sealed reaction space with non-access of air thermically decomposes by the heated gaseous inert medium. By the influence of the electrostatic charge, resulting from the decomposition of organic, in particular polymeric substances, pass from them decomposed low-molecular substances in the form of hydrocarbons altogether in the mixture with gaseous inert medium as the carrier gas in the aerosol, which is then further conducted to its cooling, precipitation and the mutual separation in it contained gaseous, and liquid low-molecular hydrocarbons. After the decomposition of all of the parts of organic substances from the hermetically closed reaction space, all the residual inorganic or other parts of the processed waste are gradually being removed.
WO/2016/008458 MULTI-PURPOSE DIABETIC SHOES WITH OPTIMIZED CONSTRUCTION||WO||21.01.2016|
||PCT/CZ2015/000067||MARTINEC, Petr ||MARTINEC, Petr |
Footwear for diabetics is charaterized by the mixture of following construction points in its new iteration: derb vamp of the footwear has got lowered derb with closing mechanism able to compensate for possible minor foot deformations; the stiffening vamp elements, especially heel enforcement and welt, are manufactured from elastic thermoplastic materials with shape memory; the inner equipment of the shoe consists of sewable insole with lower non-wowen fibrous layer and upper lightened layer with open pores and shape memory, complimented by insertable insole consisting of lower layer, which has heigthened formed gel components on its lower side in the areas of the highest foot stress, especially in the area under the fingers, under the metatarzal bones, area under the middle and rear side parts and under the heel bone; these heightened components with gel filaments can be embedded by pressure in the upper lightened layer of the sewable insole with shape memory; the insertable insole contains middle layer based on the dampening foam with shape memory and upper textile layer while the glued outsole part contains midsole based on the lightened polyurethane and contact layer based on compact thermolastic polyurethane
WO/2016/008459 METHOD OF CONSTRUCTING DIGITAL TERRAIN MODEL||WO||21.01.2016|
||PCT/CZ2015/000072||R.O.G. s.r.o. ||PRIKRYL, Marek |
PROBLEM: Efficiently generating digital terrain model (DTM) having high elevation surface accuracy and high point density, and suitable for controlling pavement milling machines during road repairs. SOLUTION: Combination of motorized levelling and Stop-Go mobile laser scanning system, including train of three vehicles, which are at standstill during measurements, and which move in unison in between measurements. Middle vehicle carries laser scanner, elevation sight, and GNSS receiver. Front and rear vehicle each carry levelling rod; front vehicle also carries GNSS receiver. During measurement cycle, laser scanner generates point cloud, while GNSS positions of middle and front vehicles and elevations at the resp. positions of front and rear vehicles are determined. After measurement cycle, vehicle train moves until rear vehicle halts at previous GNSS position of front vehicle, etc. When all measurement cycles are completed, collected data is integrated and transformed into a DTM.
WO/2016/004907 A METHOD FOR SOLAR DISTILLATION OF SALTWATER FOR ACQUIRING FRESH WATER AND A DEVICE FOR CARRYING OUT THIS METHOD||WO||14.01.2016|
||PCT/CZ2015/000070||ZÁTOPEK, Zdeněk ||ZÁTOPEK, Zdeněk |
The method and device (1) for the distillation of saltwater (23) for acquiring fresh water (18) solves the problem of removing salt and minerals from saltwater (23) in areas with a shortage of fresh water (18) for drinking and utility use. The device (1) uses solar radiation (4) which supplies energy to the distillation process, wherein the gained thermal energy is managed so as to maximize the profitability of the fresh water (18).
WO/2016/004910 METHOD OF PREPARING ABIRATERONE ACETATE OF HIGH PURITY APPLICABLE ON INDUSTRIAL SCALE||WO||14.01.2016|
||PCT/CZ2015/000075||ZENTIVA, K.S. ||CERNA, Igor |
The solution relates to a method of preparing abiraterone acetate of formula I, which comprises: a) preparation of abiraterone of formula II by the Suzuki reaction of 3-pyridyldiethylborane and a halo steroid of formula VI or VII in the presence of a palladium catalytic system, a base, and a solvent; b) acetylation of abiraterone with formation of abiraterone acetate of formula I; c) isolation of abiraterone acetate by crystallization, wherein the palladium catalytic system consists of the catalyst palladium acetate - Pd(OAc)2 and the ligand triphenylphosphine - Ph3P.
WO/2016/004911 A COCRYSTAL OF IVABRADINE HYDROCHLORIDE AND (R)-MANDELIC ACID AND ITS PHARMACEUTICAL COMPOSITION||WO||14.01.2016|
||PCT/CZ2015/000076||ZENTIVA, K.S. ||DAMMER, Ondrej |
The present invention relates to a new solid form of ivabradine hydrochloride and (R)-mandelic acid of formula (II) hi the molar ratio of 1:1. The method of preparing the above mentioned cocrystal consists in mixing or grinding the individual components in the presence of a solvent The present invention also relates to a polymorphically stable pharmaceutical composition and a granulate, which contains the cocrystal and a pharmaceutically acceptable excipient.