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Analysis

1 / 1
1.WO/2004/000810A PROCESS FOR THE PRODUCTION OF SUBSTITUTED PHENYL ETHERS
WO - 31.12.2003
Int.Class C07D 213/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
24with substituted hydrocarbon radicals attached to ring carbon atoms
28Radicals substituted by singly-bound oxygen or sulfur atoms
30Oxygen atoms
 Appl.No PCT/TR2002/000025 Applicant EOS ECZACIBASI OZGUN KIMYASAL URUNLER SANYI VE TICARET A.S. Inventor ADIYAMAN, Mustafa
The present invention provides a process to prepare substituted phenyl ethers. More particularly the present invention provides a process to produce a compound represented by the Formula I: wherein H1 is a substituted pyridyl group and R1 can be an aldehyde, cyano or nitro group.The compound I is a key intermediate in the preparation of pharmaceutically useful thiazolidinedione derivatives such as pioglitazone, rosiglitazone, etc.
2.WO/2002/028857POLYMORPHS OF PIOGLITAZONE HYDROCHLORIDE AND THEIR USE AS ANTIDIABETICS
WO - 11.04.2002
Int.Class C07D 417/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
 Appl.No PCT/US2001/029899 Applicant DR. REDDY'S RESEARCH FOUNDATION Inventor POTLAPALLY, Rajender, Kumar
This invention relates to novel polymorphic/pseudopolymorphic forms of 5-[4-[2-(5-ethyl-2-pyridyl)benzyl]thiazolidine-2,4-dione hydrochloride having formula (I). The invention also relates to a pharmaceutical composition comprising the novel polymorphic forms or its mixture and a pharmacuetically acceptable carrier. The polymorphic forms of th epresent invention ar emore active, as an antidiabetic than the hitherto known 5-[4-[2-(5-ethyl-2-pyridyl)ethoxyl]benzyl]thiazolidene-2,4-dione hydrochloride.
3.1999158103PRODUCTION OF AROMATIC ETHER
JP - 15.06.1999
Int.Class C07C 43/205
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
43Ethers; Compounds having groups, groups or groups
02Ethers
20having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
205the aromatic ring being a non-condensed ring
 Appl.No 1997323196 Applicant TOSOH CORP Inventor WATANABE MASATO

PROBLEM TO BE SOLVED: To provide a process for the synthesis of an aromatic ether in high activity and selectivity.

SOLUTION: An aromatic ether can be produced by reacting a compound expressed by the general, formula ArXn (Ar is a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group having at least one kind of hetero atom selected from nitrogen, oxygen and sulfur or a substituted or unsubstituted ferrocenyl group; X is Cl, Br, I or F; (n) is an integer of 1-6) with a compound expressed by the general formula ROM (R is a 1-20C alkyl, group, a substituted or unsubstituted aryl group or a 3-10C trialkylsilyl group; M is an alkali metal) in the presence of a catalyst containing tri(t-butyl)phosphine and a palladium compound as essential components.

COPYRIGHT: (C)1999,JPO

4.5554758Method for producing ethers
US - 10.09.1996
Int.Class C07D 213/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
24with substituted hydrocarbon radicals attached to ring carbon atoms
28Radicals substituted by singly-bound oxygen or sulfur atoms
30Oxygen atoms
 Appl.No 08474133 Applicant Takeda Chemical Industries, Ltd. Inventor Mizuno Yukio

A compound of the formula: EQU A--CH.sub.2 CH.sub.2 --O--B PAL [wherein A stands for an aromatic ring residue, a group shown by R.sup.1 --CO-- (wherein R.sup.1 stands for an aliphatic hydrocarbon residue, aromatic hydrocarbon residue, a heterocyclic residue, an aromatic alipahtic hydrocarbon residue or an alicyclic hydrocarbon residue) or R.sup.2 --CH.dbd.CH-- (wherein R.sup.2 stands for an aliphatic hydrocarbon residue an aromatic hydrocarbon residue a heterocyclic residue an aromatic aliphatic hydrocarbon residue or an alicyclic hydrocarbon residue), and B stands for an aromatic ring residue], can be obtained in high yield, at high purity level by short reaction time, by reacting a compound of the formula: EQU A--CH.sub.2 CH.sub.2 --X PAL (wherein A is of the same meaning as defined above, and X stands for a leaving group) with a compound represented by the general formula: EQU MO--B PAL (wherein M stands for an alkali metal atom or an alkaline earth metal atom and B is of the same meaning as defined above) in a non-aqueous solvent.

5.1993112483エーテル類の製造法
JP - 07.05.1993
Int.Class C07C 43/20
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
43Ethers; Compounds having groups, groups or groups
02Ethers
20having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
 Appl.No 1992066368 Applicant 武田薬品工業株式会社 Inventor 水野　行雄
6.0506273Method for producing ethers.
EP - 30.09.1992
Int.Class C07D 213/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
24with substituted hydrocarbon radicals attached to ring carbon atoms
28Radicals substituted by singly-bound oxygen or sulfur atoms
30Oxygen atoms
 Appl.No 92302233 Applicant TAKEDA CHEMICAL INDUSTRIES LTD Inventor ARITA MIICHIRO
A compound of the formula: A-CH2CH2-O-B [wherein A stands for an aromatic ring residue, a group shown by R<1>-CO- (wherein R<1> stands for an aliphatic hydrocarbon residue, aromatic hydrocarbon residue, a heterocyclic residue, an aromatic alipahtic hydrocarbon residue or an alicyclic hydrocarbon residue) or R<2>-CH=CH- (wherein R<2> stands for an aliphatic hydrocarbon residue an aromatic hydrocarbon residue a heterocyclic residue an aromatic aliphatic hydrocarbon residue or an alicyclic hydrocarbon residue), and B stands for an aromatic ring residue], can be obtained in high yield, at high purity level by short reaction time, by reacting a compound of the formula: A-CH2CH2-X (wherein A is of the same meaning as defined above, and X stands for a leaving group) with a compound represented by the general formula: MO-B (wherein M stands for an alkali metal atom or an alkaline earth metal atom and B is of the same meaning as defined above) in a non-aqueous solvent.
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