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CHEM:(VZQXUWKZDSEQRR-SDBHATRESA-N)

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Analysis

1 / 1
1.115943307MR1 ligands and pharmaceutical compositions for immunomodulation
CN - 07.04.2023
Int.Class G01N 33/50
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
 Appl.No 202180009423.8 Applicant UNIVERSITY OF BASEL Inventor DE LIBORO GIANLARO
The present invention relates to a method of modulating the interaction between an MR1 polypeptide and an MR1-specific T cell receptor molecule, whereby the MR1 polypeptide is contacted with an MR1 ligand compound, the MR1 ligand compound being a nucleobase adduct product reflecting the distress state of cellular metabolism. The invention further relates to the use of a compound identified as an MR1 ligand for vaccination or modulation of an MR1-limited immune response.
2.20230099822MR1 LIGANDS AND PHARMACEUTICAL COMPOSITIONS FOR IMMUNOMODULATION
US - 30.03.2023
Int.Class G01N 33/50
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
 Appl.No 17793419 Applicant UNIVERSITÄT BASEL Inventor Gennaro DE LIBERO

The invention relates to a method for modulating an interaction between an MR1 polypeptide and an MR1-specific T cell receptor molecule, whereby a MR1 polypeptide is contacted with a MR1 ligand compound that is a nucleobase adduct product reflecting a state of metabolic distress of a cell.

The invention further relates to the use of compounds identified as MR1 ligands in vaccination or modulation of an MR1-restricted immune response.

3.2023510599免疫調節用のＭＲ１リガンド及び医薬組成物
JP - 14.03.2023
Int.Class C12N 15/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
 Appl.No 2022543399 Applicant ウニヴェルズィテート　バーゼル Inventor デ　リベロ，ジェンナーロ
本発明は、ＭＲ１ポリペプチドとＭＲ１特異的Ｔ細胞受容体分子との間の相互作用を調節するための方法に関し、本方法に従い、ＭＲ１ポリペプチドを、細胞の代謝障害の状態を反映する核酸塩基付加体生成物であるＭＲ１リガンド化合物と接触させる。本発明はさらに、ＭＲ１拘束性免疫応答のワクチン接種またはその調節におけるＭＲ１リガンドとして同定された化合物の使用に関する。
【選択図】なし
4.3889602MR1 LIGANDS AND PHARMACEUTICAL COMPOSITIONS FOR IMMUNOMODULATION
EP - 06.10.2021
Int.Class G01N 33/50
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
 Appl.No 20166918 Applicant UNIV BASEL Inventor
The invention relates to a method for modulating an interaction between an MR1 polypeptide and an MR1-specific T cell receptor molecule, whereby a MR1 polypeptide is contacted with a MR1 ligand compound that is a nucleobase adduct product reflecting a state of metabolic distress of a eukaryotic cell.The invention further relates to the use of compounds identified as MR1 ligands in vaccination or modulation of an MR1-restricted immune response.
5.2021006049RECOMBINANT NUCLEOTIDE-SPECIFIC RIBONUCLEASE AND METHOD FOR PRODUCING AND METHOD FOR USING THE SAME
JP - 21.01.2021
Int.Class C12N 15/54
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
52Genes encoding for enzymes or proenzymes
54Transferases (2)
 Appl.No 2020163486 Applicant UNIV OF CINCINNATI Inventor BALASUBRAHMANYAM ADDEPALLI

PROBLEM TO BE SOLVED: To provide a recombinant ribonuclease.

SOLUTION: Recombinant ribonuclease is produced by the processes of: introducing a recombinant DNA sequence into a host; activating expression of a recombinant DNA sequence in the host to produce recombinant ribonuclease; and isolating recombinant ribonuclease from the host. Further, a method for analyzing an RNA sequence includes the processes of: digesting RNA by first recombinant ribonuclease to obtain a digested product containing nucleotide of a RNA sequence; and analyzing the digested product by using an analysis method to obtain identity of at least several pieces of nucleotide. Recombinant ribonuclease contains at least one of uridine-specific recombinant RNaseMC1 and cytidine-specific recombinant RNase Cusativin.

SELECTED DRAWING: None

COPYRIGHT: (C)2021,JPO&INPIT

6.20200115689Recombinant nucleoside-specific ribonuclease and method of producing and using same
US - 16.04.2020
Int.Class C12N 9/22
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
16acting on ester bonds (3.1)
22Ribonucleases
 Appl.No 16681078 Applicant University of Cincinnati Inventor Sarah Venus

A recombinant ribonuclease is disclosed. The recombinant ribonuclease is produced by introducing a recombinant DNA sequence into a host; activating expression of the recombinant DNA sequence within the host to produce the recombinant ribonuclease; and isolating the recombinant ribonuclease from the host. Additionally, a method of analyzing an RNA sequence includes digesting the RNA with a first recombinant ribonuclease to give digestion products comprising nucleotides of the RNA sequence; and analyzing the digestion products using an analytical method to provide the identity of at least some of the nucleotides. The recombinant ribonuclease includes at least one of a uridine-specific recombinant RNase MC1 and a cytidine-specific recombinant RNase Cusativin.

7.20180320154Recombinant nucleoside-specific ribonuclease and method of producing and using same
US - 08.11.2018
Int.Class C12N 9/22
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
16acting on ester bonds (3.1)
22Ribonucleases
 Appl.No 15568260 Applicant University Of Cincinnati Inventor Sarah Venus

A recombinant ribonuclease is disclosed. The recombinant ribonuclease is produced by introducing a recombinant DNA sequence into a host; activating expression of the recombinant DNA sequence within the host to produce the recombinant ribonuclease; and isolating the recombinant ribonuclease from the host. Additionally, a method of analyzing an RNA sequence includes digesting the RNA with a first recombinant ribonuclease to give digestion products comprising nucleotides of the RNA sequence; and analyzing the digestion products using an analytical method to provide the identity of at least some of the nucleotides. The recombinant ribonuclease includes at least one of a uridine-specific recombinant RNase MC1 and a cytidine-specific recombinant RNase Cusativin.

8.2018512883組換え型ヌクレオシド特異的リボヌクレアーゼ及びその生成法と使用法
JP - 24.05.2018
Int.Class C12N 9/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
 Appl.No 2017555346 Applicant ユニバーシティ・オブ・シンシナティ Inventor バラスブラマニヤム・アッデパッリ

組換え型リボヌクレアーゼを開示する。組換え型リボヌクレアーゼは、宿主に組換え型DNA配列を導入する工程、宿主内の組換え型DNA配列の発現を活性化し組換え型リボヌクレアーゼを生成する工程、及び宿主から組換え型リボヌクレアーゼを単離する工程によって生成される。更に、RNA配列を分析する方法は、第一の組換え型リボヌクレアーゼでRNAを消化しRNA配列のヌクレオチドを含む消化産物を得る工程、及び分析法を使用して消化産物を分析し少なくとも数個のヌクレオチドの同一性を得る工程を含む。組換え型リボヌクレアーゼはウリジン特異的組換え型RNaseMC1とシチジン特異的組換え型RNaseクサチビンの少なくとも1つを含む。

9.WO/2016/172678RECOMBINANT NUCLEOTIDE-SPECIFIC RIBONUCLEASE AND METHOD OF PRODUCING AND USING SAME
WO - 27.10.2016
Int.Class C12N 9/22
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
16acting on ester bonds (3.1)
22Ribonucleases
 Appl.No PCT/US2016/029151 Applicant UNIVERSITY OF CINCINNATI Inventor ADDEPALLI, Balasubrahmanyam
A recombinant ribonuclease is disclosed. The recombinant ribonuclease is produced by introducing a recombinant DNA sequence into a host; activating expression of the recombinant DNA sequence within the host to produce the recombinant ribonuclease; and isolating the recombinant ribonuclease from the host. Additionally, a method of analyzing an RNA sequence includes digesting the RNA with a first recombinant ribonuclease to give digestion products comprising nucleotides of the RNA sequence; and analyzing the digestion products using an analytical method to provide the identity of at least some of the nucleotides. The recombinant ribonuclease includes at least one of a uridine-specific recombinant RNase MCI and a cytidine-specific recombinant RNase Cusativin.
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