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CHEM:(USVMJSALORZVDV-SDBHATRESA-N)

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Analysis

1.WO/2025/259572INTEGRIN BETA 6 (ITGB6) TARGETING TRISPECIFIC PROTEIN FOR TREATMENT OF CANCER
WO 18.12.2025
Int.Class C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
Appl.No PCT/US2025/032813 Applicant HARPOON THERAPEUTICS, INC. Inventor AUSTIN, Richard J.
Provided herein are ITGB6 binding proteins, pharmaceutical compositions comprising such proteins or fragments thereof, as well as nucleic acids, recombinant expression vectors and host cells for making such ITGB6 binding proteins. Also disclosed are methods of using the disclosed ITGB6 binding proteins in the prevention, and/or treatment diseases, conditions and disorders associated with ITGB6.
2.WO/2025/259802COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF CANCER
WO 18.12.2025
Int.Class A61K 47/69
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
Appl.No PCT/US2025/033231 Applicant UNIVERSITY OF MASSACHUSETTS Inventor ATUKORALE, Prabhani
The present disclosure relates to compositions comprising a population of immunomodulatory lipid nanoparticles, as well as methods of using thereof to treat and/or prevent cancer (e.g., via local administration to the lymph nodes) and methods of using thereof to treat and/or prevent cancer metastasis in a subject.
3.20250376689OLIGONUCLEOTIDES HAVING 6-THIO-2'-DEOXYGUANOSINE RESIDUES AND USES THEREOF
US 11.12.2025
Int.Class C12N 15/117
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
117Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
Appl.No 18686588 Applicant City of Hope Inventor Marcin Tomasz Kortylewski

The disclosure provides, inter alia, oligonucleotides comprising 6-thio-2′-deoxy-guanosine residues. The oligonucleotides comprising said residues are used in pharmaceutical compositions and methods for treating cancer. The invention also includes CpG oligodeoxynucleotides in combination with the 6-thio-2-deoxy-guanosine residues in said pharmaceutical compositions and methods for treating cancer. Oligonucleotides of the invention may also include additional therapeutic moieties or exonuclease resistant moieties. The compositions and methods of the invention may employ additional pharmaceutical entities for the treatment of cancer.

4.WO/2025/250823DNA-ENCODED MULTIVALENT ANTIBODIES TARGETING CARBONIC ANHYDRASE 9 AND METHODS OF USE IN CANCER THERAPEUTICS
WO 04.12.2025
Int.Class C07K 16/40
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
40against enzymes
Appl.No PCT/US2025/031479 Applicant THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY Inventor O'CONNELL, Ryan
Disclosed herein are methods of treating or preventing renal cell carcinoma comprising administering compositions comprising a recombinant nucleic acid sequence encoding a therapeutic antibody targeting CA9, a fragment thereof, a variant thereof, or a combination thereof.
5.20250368677CD73 INHIBITORS
US 04.12.2025
Int.Class C07H 19/23
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
23Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14-C07H19/22222
Appl.No 19234635 Applicant ORIC Pharmaceuticals, Inc. Inventor Xiaohui DU

Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.

6.WO/2025/250826PERSISTENT T-CELL ENGAGERS TARGETING FSHR AND METHODS OF USE IN CANCER THERAPEUTICS
WO 04.12.2025
Int.Class C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
Appl.No PCT/US2025/031483 Applicant THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY Inventor BORDOLOI, Devivasha
Disclosed herein are compositions comprising persistent bispecific anti-FSHR T cell engagers and a persistent multivalent anti-FSHR T cell engagers, fragments thereof, variants thereof, combinations thereof, and recombinant nucleic acid sequences encoding the same, fragments thereof, variants thereof, combinations thereof, and methods of use thereof.
7.WO/2025/250977CANCER THERAPY USING IL-2 PRODRUG
WO 04.12.2025
Int.Class A61K 38/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
20Interleukins
Appl.No PCT/US2025/031709 Applicant WEREWOLF THERAPEUTICS, INC. Inventor MORRIS, Kristin, R.
This disclosure relates to methods and compositions for treating cancer using an inducible IL-2 prodrug, wherein the subject in need thereof has a solid tumor that comprises activated intratumoral effector T cells prior to administration of the IL-2 prodrug.
8.WO/2025/242026CANCER VACCINES AND USES THEREOF
WO 27.11.2025
Int.Class C12N 15/62
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
62DNA sequences coding for fusion proteins
Appl.No PCT/CN2025/095665 Applicant EVEREST MEDICINES (CHINA) CO., LTD. Inventor XIE, Liang
Provided herein are nucleic acids, pharmaceutical compositions and vaccines that express two or more cancer antigens. Also provided herein are methods for treating a cancer.
9.20250361315HUMANIZED ANTI-CD84 RECOMBINANT PROTEIN COMPOSITIONS
US 27.11.2025
Int.Class C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
Appl.No 19204241 Applicant CITY OF HOPE Inventor John C. WILLIAMS

Provided herein are, inter alia, recombinant proteins and humanized antibodies (e.g., bispecific antibodies, chimeric antigen receptors and humanized antibodies), which bind Cluster of Differentiation 84 (CD84) with high efficiency and specificity. The compositions provided herein include novel light and heavy chain domain CDRs and framework regions and are, inter alia, useful for treating cancer and other CD84-related diseases.

10.20250361203PROCESSES OF MAKING 3-FLUORO-5-(((1S,2AR)-1,3,3,4,4 PENTAFLUORO-2A-HYDROXY-2,2A,3,4-TETRAHYDRO-1H-CYCLOPENTA[CD]INDEN-7-YL)OXY)BENZONITRILE AND POLYMORPHS THEREOF
US 27.11.2025
Int.Class C07C 255/54
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
255Carboxylic acid nitriles
49having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
54containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
Appl.No 19293755 Applicant NiKang Therapeutics, Inc. Inventor Charles M. COOK

The present disclosure provides certain processes of making 3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro- 1H-cyclopenta[cd]inden-7-yl)oxy)-benzonitrile (Compound 1) and certain polymorphs thereof. Also provided are pharmaceutical compositions comprising a crystalline polymorph form of Compound 1 and processes for preparing such polymorph forms.