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Analysis

1.120898004用于预测和/或监测心血管疾病及其干预的方法和组合物
CN 04.11.2025
Int.Class C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
Appl.No 202480021199.8 Applicant 心脏诊断公司 Inventor M·V·多甘
本文档描述了用于预测心血管疾病(CVD)的方法和组合物。具体地,本文档描述了用于确定至少一个CpG基因座的甲基化状态和至少一个单核苷酸多态性(SNP)的序列的方法和组合物,所述甲基化状态和所述序列可预测CVD的检测或从CVD中存活的估计。
2.120858179ROSA26安全港位点敲入的策略
CN 28.10.2025
Int.Class C12N 15/90
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
90Stable introduction of foreign DNA into chromosome
Appl.No 202480020352.5 Applicant 埃门多生物公司 Inventor R·伊曼纽尔
包含具有SEQ ID NO:1‑25686中任一项所示序列中的17‑50个连续核苷酸的向导序列部分的RNA分子及其组合物、方法和用途。
3.2025531296PDCD1の両アレルノックアウト
JP 19.09.2025
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Appl.No 2025516217 Applicant エメンドバイオ・インコーポレイテッド Inventor エマニュエル、ラフィ
配列番号1~6215のいずれかに示す配列内の連続する17~50ヌクレオチドを有するガイド配列部分を含むRNA分子を含有する組成物、方法及びその使用。
4.2025131687アンチコドンループを延長した合成転移RNA
JP 09.09.2025
Int.Class C12N 15/11
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
Appl.No 2025092679 Applicant アークタラス テラピュウティクス、インク Inventor イグナトヴァ、ゾヤ
【課題】フレームシフト変異に関連する遺伝子疾患、例えば神経線維腫症を治療するためのフレームシフト変異抑制因子を提供する。
【解決手段】4ヌクレオチドアンチコドンまたは5ヌクレオチドアンチコドンを有する延長アンチコドンループを含むことを特徴とした合成転移RNAであって、コード配列に変異を有するmRNA上のコドン、及び後続のコドン(-1フレームシフトの場合)または先行するコドン(+1フレームシフトの場合)の残りの部分と塩基対合し、担持されるアミノ酸が成長アミノ酸鎖に組み込まれ、リーディングフレームが修正されるフレームシフト変異抑制因子。
【選択図】図1
5.2025529547CIITAの両アレルノックアウト
JP 04.09.2025
Int.Class C12N 15/55
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
52Genes encoding for enzymes or proenzymes
55Hydrolases (3)
Appl.No 2025516207 Applicant エメンドバイオ・インコーポレイテッド Inventor エマニュエル、ラフィ
配列番号1~34194のいずれかに示す配列内の連続する17~50ヌクレオチドを有するガイド配列部分を含むRNA分子を含有する組成物、方法及びその使用。
6.2025529546CISHの両アレルノックアウト
JP 04.09.2025
Int.Class C12N 15/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
Appl.No 2025516206 Applicant エメンドバイオ・インコーポレイテッド Inventor エマニュエル、ラフィ
配列番号1~6833のいずれかに示す配列内の連続する17~50ヌクレオチドを有するガイド配列部分を含むRNA分子を含有する組成物、方法及びその使用。
7.20250277202KNOCKOUT OF A MUTANT ALLELE OF AN ELANE GENE
US 04.09.2025
Int.Class C12N 9/64
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
48acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50Proteinases
64derived from animal tissue, e.g. rennin
Appl.No 19059992 Applicant EmendoBio Inc. Inventor David BARAM

Methods for inactivating in a cell a mutant allele of the elastase, neutrophil expressed gene (ELANE gene) gene having a mutation associated with severe congenital neutropenia (SCN) or cyclic neutropenia (CyN).

8.2025529223B2Mセーフハーバー部位でのノックイン戦略
JP 04.09.2025
Int.Class A61K 38/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
Appl.No 2025513061 Applicant エメンドバイオ・インコーポレイテッド Inventor エマニュエル、ラフィ
配列番号1~28998のいずれかに示す配列内の連続する17~50ヌクレオチドを有するガイド配列部分を含むRNA分子及び組成物、方法及びその使用。
9.2025529544CTLA4の両アレルノックアウト
JP 04.09.2025
Int.Class C12N 15/11
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
Appl.No 2025516204 Applicant エメンドバイオ・インコーポレイテッド Inventor エマニュエル、ラフィ
配列番号1~4886のいずれかに示す配列内の連続する17~50ヌクレオチドを有するガイド配列部分を含むRNA分子を含有する組成物、方法及びその使用。
10.2025529545FASLGの両アレルノックアウト
JP 04.09.2025
Int.Class C12N 5/0783
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
0783T cells; NK cells; Progenitors of T or NK cells
Appl.No 2025516205 Applicant エメンドバイオ・インコーポレイテッド Inventor エマニュエル、ラフィ
配列番号1~11121のいずれかに示す配列内の連続する17~50ヌクレオチドを有するガイド配列部分を含むRNA分子を含有する組成物、方法及びその使用。