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Analysis

1 / 1
1.WO/2006/011719N-SUBSTITUTED-SULFAMOYLBENZOIC ACID DERIVATIVES, METHOD FOR PREPARING THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
WO - 02.02.2006
Int.Class C07D 413/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
 Appl.No PCT/KR2005/002257 Applicant B & C BIOPHARM CO., LTD. Inventor KIM, Jong Woo
The present invention relates to N-substituted-sulfamoylbenzoic acid derivatives useful as an antiviral agent, and more particularly the present invention relates to novel N-substituted-sulfamoylbenzoic acid derivatives having an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and pharmaceutically acceptable salts thereof, a preparation method thereof, and an antiviral pharmaceutical composition comprising the compound as an effective component. The N-substituted-sulfamoylbenzoic acid derivatives according to the present invention have an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.
2.1020060010370N-SUBSTITUTED-SULFAMOYLBENZOIC ACID DERIVATIVE, METHOD FOR PREPARING THEREOF, AND ANTIVIRAL PHARMACEUTICAL COMPOSITION FOR TREATING AND PREVENTING HEPATITIC C COMPRISING THE SAME
KR - 02.02.2006
Int.Class C07D 413/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
 Appl.No 1020040059038 Applicant B.N.C BIO PARM CO., LTD. Inventor KIM, JONG WOO

PURPOSE: A novel N-substituted-sulfamoylbenzoic acid derivative or pharmaceutically acceptable salt thereof and a method for preparing thereof are provided. Also a pharmaceutical composition comprising the N-substituted-sulfamoylbenzoic acid derivative as an effective ingredient is provided to economically treat and prevent hepatitic C by inhibiting effectively hepatitic C virus proliferation without causing any side effects to human body.

CONSTITUTION: The N-substituted-sulfamoylbenzoic acid derivative is represented by formula 1. In the formula 1, R1 is hydroxyl group or NR2R3 group, where R2 is H, C1-C4 alkyl group, or -(CH2)m-R4(where R4 is phenyl group or heterocyclic ring and m is an integer of 0-4) and R3 is C1-C4 alkyl group or -(CH2)n-R5(where R5 is C2-C6 dialkylamino group, heterocyclic ring, or heterocyclic ring substituted by C1-C4 alkyl group and n is an integer of 0-4). The pharmaceutical composition for treating and preventing hepatitic C comprises the N-substituted-sulfamoylbenzoic acid derivative or pharmaceutically acceptable salts thereof as an effective ingredient.

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