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1 / 479
1.WO/2026/017864TREATMENT OF OSTEOARTHRITIS AND/OR RHEUMATOID ARTHRITIS WITH PRO-CHONDROGENIC AND/OR CHONDROCYTE PROTECTIVE FACTORS
WO - 22.01.2026
Int.Class C12N 5/0775
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
077Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
0775Mesenchymal stem cells; Adipose-tissue derived stem cells
 Appl.No PCT/EP2025/070674 Applicant SMARTCELLA SOLUTIONS AB Inventor YANG, Ran
The present disclosure relates to mesenchymal stem cells (MSCs) for use in a method of treatment of arthritis. The MSCs are transfected with an mRNA construct encoding a pro-chondrogenic and/or chondrocyte protective factor. The pro-chondrogenic and/or chondrocyte protective factor can be TGFβ3.
2.WO/2026/018181IMMUNOGENIC COMPOSITIONS AND USES THEREOF
WO - 22.01.2026
Int.Class A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
 Appl.No PCT/IB2025/057203 Applicant PFIZER INC. Inventor HUANG, Bridget Yih Jiin
The present disclosure relates to RSV F, hMPV F, PIV3 F, PIV3 HN, PIV1 F and PIV1 HN protein mutants, nucleic acids or vectors encoding them, compositions comprising a RSV F, hMPV F, PIV3 F, PIV3 HN, PIV1 F and/or PIV1 HN nucleic acid or combinations thereof, and uses thereof.
3.WO/2026/019998VACCINES FOR KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS
WO - 22.01.2026
Int.Class A61K 39/245
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
245Herpetoviridae, e.g. herpes simplex virus
 Appl.No PCT/US2025/038046 Applicant THE CLEVELAND CLINIC FOUNDATION Inventor JUNG, Jae
Provided herein are compositions, systems, kits, and methods for immunizing a subject against Kaposi's sarcoma-associated herpesvirus (KSHV) with a composition: i) comprising a plurality of nanoparticles self-assembled from a plurality of fusion proteins that comprise: a) at least a portion of a Ferritin protein, and b) an immunogenic protein comprising at least a portion of: KSHV K8.1 protein, or ii) polynucleotides encoding said fusion proteins (e.g., human codon optimized mRNA sequences present in lipid nanoparticles). In other embodiments, provided herein are compositions, systems, and kits, and methods for immunizing a subject against KSHV employing a human codon optimized nucleic acid sequence (e.g., mRNA) encoding a KSHV K8.1 protein.
4.WO/2026/015937NOVEL TREATMENT FOR DIABETES AND OBESITY
WO - 22.01.2026
Int.Class A61K 38/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
 Appl.No PCT/AU2025/050761 Applicant THE UNIVERSITY OF MELBOURNE Inventor EKINCI, Elif Ilhan
The present invention relates to compositions for the prevention or treatment of a metabolic disorder. In one aspect, the invention relates to the regulation of blood glucose levels and/or lipid metabolism with a composition of the invention.
5.WO/2026/017857TREATMENT OF OSTEOARTHRITIS AND/OR RHEUMATOID ARTHRITIS WITH PRO-CHONDROGENIC AND/OR CHONDROCYTE PROTECTIVE FACTORS
WO - 22.01.2026
Int.Class C12N 5/0775
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
077Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
0775Mesenchymal stem cells; Adipose-tissue derived stem cells
 Appl.No PCT/EP2025/070648 Applicant SMARTCELLA SOLUTIONS AB Inventor YANG, Ran
The present disclosure relates to mesenchymal stem cells (MSCs) for use in a method of treatment of arthritis. The MSCs are transfected with an mRNA construct encoding a pro-chondrogenic and/or chondrocyte protective factor. The pro-chondrogenic and/or chondrocyte protective factor can be WNT3a.
6.WO/2026/019692IMMUNOMODULATORY FUSION PROTEINS AND RELATED METHODS
WO - 22.01.2026
Int.Class A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
38Medicinal preparations containing peptides
 Appl.No PCT/US2025/037499 Applicant FLAGSHIP PIONEERING INNOVATIONS VII, LLC Inventor BANDUKWALA, Hozefa Saifuddin
Provided herein are immunomodulatory fusion proteins and compositions (e.g., pharmaceutical compositions) comprising the same; as well as methods of making the immunomodulatory fusion proteins and compositions. The immunomodulatory fusion proteins provided herein are useful in pharmaceutical compositions and methods of use (including, e.g., methods of suppressing or reducing (e.g., preventing) a pro-inflammatory immune response in a subject).
7.WO/2026/015829SMALL REVERSE TRANSCRIPTASES AND GENE EDITING SYSTEMS COMPRISING SUCH
WO - 15.01.2026
Int.Class C12N 9/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
12transferring phosphorus containing groups, e.g. kinases (2.7)
 Appl.No PCT/US2025/037333 Applicant ARBOR BIOTECHNOLOGIES, INC. Inventor LAPAN, André P.
Small-sized reverse transcriptase (RT) polypeptides derived from SEQ ID NO: 2, SEQ ID NO: 3, or SEQ ID NO: 4 and fusion polypeptides comprising such an RT polypeptide and an RNA-guided nucleases. Also provided herein are gene editing systems comprising the RT polypeptide, the RNA-guided nucleases, a guide RNA, and an RT donor RNA for use in gene editing.
8.WO/2026/015876IMPROVED METHODS FOR IN VITRO TRANSCRIPTION
WO - 15.01.2026
Int.Class C12P 19/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
 Appl.No PCT/US2025/037414 Applicant ARCTURUS THERAPEUTICS, INC. Inventor HILL, Brett Dallas
Disclosed herein are methods of producing transcribed RNA product with increased yield and reduced RNA degradation.
9.WO/2026/015832REVERSE TRANSCRIPTASES AND GENE EDITING SYSTEMS COMPRISING SUCH
WO - 15.01.2026
Int.Class C12N 9/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
12transferring phosphorus containing groups, e.g. kinases (2.7)
 Appl.No PCT/US2025/037337 Applicant ARBOR BIOTECHNOLOGIES, INC. Inventor LAPAN, André P.
Reverse transcriptase (RT) polypeptides derived from SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, or SEQ ID NO: 5 and fusion polypeptides comprising such an RT polypeptide and an RNA-guided nuclease. Also provided herein are gene editing systems comprising the RT polypeptide, the RNA-guided nucleases, a guide RNA, and an RT donor RNA for use in gene editing.
10.WO/2026/012491COMPOUND COMPRISING LIPOPHILIC MONOMER FOR DELIVERY TO EYES AND CENTRAL NERVOUS SYSTEM, AND USE THEREOF
WO - 15.01.2026
Int.Class C12N 15/11
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
 Appl.No PCT/CN2025/108268 Applicant BEIJING WINSUNNY PHARMACEUTICAL CO., LTD Inventor WANG, Shucheng
One aspect of the present invention relates to a compound, wherein the compound is an oligonucleotide, and the compound comprises at least one lipophilic monomer. Another aspect of the present invention relates to a method for gene silencing, wherein the method comprises administering to a cell or a subject in need thereof a therapeutically effective amount of a compound conjugated with a lipophilic monomer.
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