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1.WO/2021/181360NOVEL SALTS OF QUINOLONE COMPOUNDS
WO 16.09.2021
Int.Class C07D 215/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
Appl.No PCT/IB2021/052090 Applicant CADILA HEALTHCARE LIMITED Inventor SHARMA, Rajiv
The present invention relates to novel pharmaceutically acceptable salts of formula (Ia). The invention is also related to process for the preparation of the said novel salts and pharmaceutical composition of the same. Compounds of the present invention are prolyl hydroxylase inhibitors and are suitable for the treatment of anemia.
2.20210246166MASP INHIBITORY COMPOUNDS AND USES THEREOF
US 12.08.2021
Int.Class C07K 7/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
08having 12 to 20 amino acids
Appl.No 17138447 Applicant Bayer Aktiengesellschaft Inventor Donald BIERER

The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory compounds, as well as analogues and derivatives thereof, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.

3.WO/2021/154687METHODS FOR TREATING SARS COV-2 INFECTIONS
WO 05.08.2021
Int.Class A61K 31/7056
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
7056containing five-membered rings with nitrogen as a ring hetero atom
Appl.No PCT/US2021/015027 Applicant GILEAD SCIENCES, INC. Inventor CIHLAR, Tomas
Provided are methods for treating 2019-nCoV virus (SARS-CoV-2) infections by administering nucleosides and prodrugs thereof, of Formula (I), wherein the 1 ' position of the nucleoside sugar is substituted.
4.113164766RGMc选择性抑制剂及其用途
CN 23.07.2021
Int.Class A61P 7/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
06Antianaemics
Appl.No 201980081378.X Applicant 供石公司 Inventor S·N·尼科尔斯
描述了排斥性导向分子C(RGMc)的选择性抑制剂。还提供了相关方法,包括这些抑制剂的制备方法以及这些抑制剂在障碍如贫血治疗中的治疗用途。
5.202191122СЕЛЕКТИВНЫЕ К RGMc ИНГИБИТОРЫ И ИХ ПРИМЕНЕНИЕ
EA 19.07.2021
Int.Class A61P 7/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
06Antianaemics
Appl.No 202191122 Applicant СКОЛАР РОК, ИНК. Inventor Николлс Саманта

Описаны селективные ингибиторы молекулы отталкивающего действия С (RGMc). Также предусмотрены родственные способы, включающие в себя способы получения, а также терапевтического применения этих ингибиторов при лечении таких нарушений, как анемия.

6.WO/2021/067823A NEW TREATMENT FOR MEIBOMIAN GLAND DYSFUNCTION
WO 08.04.2021
Int.Class C12N 9/02
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
02Oxidoreductases (1.), e.g. luciferase
Appl.No PCT/US2020/054091 Applicant THE SCHEPENS EYE RESEARCH INSTITUTE, INC. Inventor LIU, Yang
The invention provides compositions and methods for reducing oxygen concentration in the environment of or promoting the expression or function of at least one hypoxia inducible factor (HIF) in one or more dysfunctional meibomian glands (MGs), utilizing a low oxygen mimetic agent capable of promoting the expression or function of at least one HIF and mimicking a low oxygen environment, or a combination thereof, to improve MG functions.
7.WO/2020/229761NOVEL CYTOPROTECTIVE MEDICAMENTS
WO 19.11.2020
Int.Class A61K 38/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12Cyclic peptides
Appl.No PCT/FR2020/050768 Applicant BALMES TRANSPLANTATION Inventor BERNA, Patrick
The invention relates to a pharmaceutical composition, comprising at least one compound of the echinocandin family and at least one other therapeutically active ingredient except for hypouricemic compounds, intended to be used as a cytoprotective medicament, particularly as a medicament for the prevention and/or protection and/or treatment of cell death and/or of degenerative pathological situations or processes which result in cell death, and even more particularly as a medicament for the prevention and/or protection and/or treatment of cell death and/or degenerative pathological situations or processes which result in cell death, when they are associated with ischaemia-reperfusion.
8.WO/2020/225095MASP INHIBITORY COMPOUNDS AND USES THEREOF
WO 12.11.2020
Int.Class C07K 7/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
08having 12 to 20 amino acids
Appl.No PCT/EP2020/062040 Applicant BAYER AKTIENGESELLSCHAFT Inventor BIERER, Donald
The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory compounds, as well as analogues and derivatives thereof, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.
9.WO/2020/172113SCAR REDUCING WOUND CLOSURE MATERIALS
WO 27.08.2020
Int.Class A61L 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
17Materials for surgical sutures or for ligaturing blood vessels
Appl.No PCT/US2020/018550 Applicant LANKENAU INSTITUTE FOR MEDICAL RESEARCH Inventor HEBER-KATZ, Ellen
A composition comprising a wound-closure material physically or chemically associated with an agent that reduces scarring and improves the integrity of skin and underlying tissue in a mammalian subject. Methods for reducing or eliminating scarring or improving mammalian skin integrity comprise closing a wound with a composition, such as a suture material associated with a PHD inhibitor molecule, e.g., 1,4-DPCA.
10.WO/2020/086736RGMC-SELECTIVE INHIBITORS AND USE THEREOF
WO 30.04.2020
Int.Class A61P 7/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
06Antianaemics
Appl.No PCT/US2019/057687 Applicant SCHOLAR ROCK, INC. Inventor NICHOLLS, Samantha
Selective inhibitors of repulsive guidance molecule C (RGMc), are described. Related methods, including methods for making, as well as therapeutic use of these inhibitors in the treatment of disorders, such as anemia, are also provided.