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Analysis

1 / 281
1.WO/2026/015876IMPROVED METHODS FOR IN VITRO TRANSCRIPTION
WO - 15.01.2026
Int.Class C12P 19/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
 Appl.No PCT/US2025/037414 Applicant ARCTURUS THERAPEUTICS, INC. Inventor HILL, Brett Dallas
Disclosed herein are methods of producing transcribed RNA product with increased yield and reduced RNA degradation.
2.WO/2026/013643METHODS AND COMPOSITIONS FOR DESIGNING EPITOPE STRINGS WITH LINKERS
WO - 15.01.2026
Int.Class G16B 30/10
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
30ICT specially adapted for sequence analysis involving nucleotides or amino acids
10Sequence alignment; Homology search
 Appl.No PCT/IB2025/057068 Applicant BIONTECH SE Inventor ROONEY, Michael
The present disclosure provides computational methods for designing superior T cell epitopes followed by experimental verification, feedback and further improvement of cleavage linkers between certain epitopes.
3.WO/2026/015882HSV ANTIGEN FRAGMENTS AND RELATED METHODS
WO - 15.01.2026
Int.Class C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
 Appl.No PCT/US2025/037424 Applicant BIONTECH SE Inventor FURTADO, Raquel Mariska
The present disclosure provides compositions for delivery of HSV antigens and related technologies (e.g., components thereof and/or methods relating thereto).
4.WO/2026/015857VACCINE COMPOSITION FOR ELICITING AN EBV-SPECIFIC CD8+ T CELL RESPONSE
WO - 15.01.2026
Int.Class C12N 7/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
 Appl.No PCT/US2025/037383 Applicant BIONTECH SE Inventor KRIENKE, Christina
The present invention relates to a polynucleotide encoding a polypeptide, wherein the polypeptide comprises at least 25 fragments of at least two EBV proteins, each fragment having a length of at most 15 amino acids, and one or more cleavage-enhancing linker, each located between two fragments.
5.WO/2026/010855MODIFIED RNA FOR INCREASING PROTEIN EXPRESSION
WO - 08.01.2026
Int.Class C12N 15/67
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
67General methods for enhancing the expression
 Appl.No PCT/US2025/035891 Applicant TRILINK BIOTECHNOLOGIES, LLC Inventor XU, Chunping
Described herein are modified RNA molecules where a modified NTP is covalently attached to the 3' end of the poly-A region of the RNA molecule. Methods of synthesizing said RNAs are also provided herein.
6.WO/2026/010842USE OF LIPID NANOPARTICLE MRNA FOR TERT SPECIFIC CANCER IMMUNOTHERAPY
WO - 08.01.2026
Int.Class A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
39Medicinal preparations containing antigens or antibodies
 Appl.No PCT/US2025/035853 Applicant THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA Inventor VONDERHEIDE, Robert H.
The present invention relates to compositions for inducing an immune response against a tumor antigen in a subject, the composition comprising at least one mRNA encoding at least one tumor antigen selected from the group consisting of hTERT, mTERT, and KRASG12D, encapsulated in a lipid nanoparticle.
7.WO/2026/008025IDO1 CANCER VACCINES AND USES THEREOF
WO - 08.01.2026
Int.Class A61K 38/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08Peptides having 5 to 11 amino acids
 Appl.No PCT/CN2025/106892 Applicant EVEREST MEDICINES (CHINA) CO., LTD. Inventor KAUDER, Steven
Provided herein are nucleic acids, pharmaceutical compositions and vaccines that express a cancer antigen comprising IDO1. Also provided herein are methods for treating a cancer.
8.WO/2026/008026PD-L1 CANCER VACCINES AND USES THEREOF
WO - 08.01.2026
Int.Class A61K 38/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08Peptides having 5 to 11 amino acids
 Appl.No PCT/CN2025/106893 Applicant EVEREST MEDICINES (CHINA) CO., LTD. Inventor KAUDER, Steven
Provided herein are nucleic acids, pharmaceutical compositions and vaccines that express a cancer antigen comprising PD-L1. Also provided herein are methods for treating a cancer.
9.WO/2026/008017CANCER VACCINES AND USES THEREOF
WO - 08.01.2026
Int.Class C12N 15/62
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
62DNA sequences coding for fusion proteins
 Appl.No PCT/CN2025/106856 Applicant EVEREST MEDICINES (CHINA) CO., LTD. Inventor KAUDER, Steven
Provided herein are nucleic acids, pharmaceutical compositions and vaccines that express one or more cancer antigen comprising PD-L1 and/or IDO1. Also provided herein are methods for treating a cancer.
10.WO/2026/006483SNCA VECTORS AND ENGINEERED GUIDE RNAS
WO - 02.01.2026
Int.Class C12N 15/864
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
864Parvoviral vectors
 Appl.No PCT/US2025/035296 Applicant SHAPE THERAPEUTICS INC. Inventor BURLEIGH, Stephen
Disclosed herein are plasmids encoding engineered guide RNAs and compositions comprising the same. Also disclosed herein are AAVs containing engineered guide RNAs. Also disclosed herein are methods of treating diseases or conditions in a subject by administering engineered guide RNAs or pharmaceutical compositions described herein.
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