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Analysis

1 / 4
1.20230295165COMPOUNDS
US - 21.09.2023
Int.Class C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
 Appl.No 18018388 Applicant The Provost, Fellows, Foundation Scholars, and the other members of Board, of the College of the Hol Inventor John SOUTHERN

The present invention provides a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein: Y is selected from C or N; X is selected from O or S; R1 is selected from hydrogen or methyl; Z is CR2R3, wherein R2 and R3 are each independently selected from hydrogen and (1-5C)alkyl, or R2 and R3 are taken together with the carbon atom to which they are attached to form a cyclopropyl or cyclobutyl ring; Z1 is selected from CR4R5, O, S, C(O) or NR6, wherein R4 and R5 are each independently selected from hydrogen, OH, (1-5C)alkyl and phenyl, or R4 and R5 are taken together with the carbon atom to which they are attached to form a cyclopropyl ring, and R6 is selected from hydrogen and (1-5C)alkyl, provided that one, but not both, of Z and Z1 is CH2.

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2.116783197Compounds
CN - 19.09.2023
Int.Class C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
 Appl.No 202180066204.3 Applicant THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY Inventor CANNON SEAN
The present invention provides a compound of formula (I): # imgabs0 # or a pharmaceutically acceptable salt or solvate thereof, wherein: Y is selected from C or N; x is O; the bond a is a single bond or a double bond; x is 1 when a is a single bond and x is 0 when a is a double bond; r1 is selected from hydrogen and methyl; r2 (when present) is selected from hydrogen and methyl; r3 is selected from the group consisting of hydrogen, (1 to 6C) alkyl and (1 to 6C) alkyl-phenyl wherein the phenyl is optionally substituted with one or more (e.g., 1 to 3) substituents each independently selected from the group consisting of hydroxyl, (1 to 6C) alkoxy, (1 to 6C) alkyl and halogens (e.g., chlorine and fluorine).
3.20230286987COMPOUNDS
US - 14.09.2023
Int.Class C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
 Appl.No 18018359 Applicant The Provost, Fellows, Foundation Scholars, and the other members of Board, of the College of the Inventor Stephen CONNON

The present invention provides a compound of formula (I), or pharmaceutically acceptable salt or solvate thereof, wherein: Y is selected from C or N; X is O; bond a is a single or double bond; x is 1 when a is a single bond and x is 0 when a is a double bond; R1 is selected from hydrogen and methyl; R2 (when present) is selected from hydrogen and methyl; R3 is selected from hydrogen, (1-6C)alkyl and (1-6C)alkyl-phenyl, wherein said phenyl is optionally substituted by one or more (for example 1 to 3) substituents each independently selected from hydroxy, (1-6C)alkoxy, (1-6C)alkyl and halo (such as chloro and fluoro).

embedded image

4.2023535621化合物
JP - 18.08.2023
Int.Class A61K 31/519
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
 Appl.No 2023505950 Applicant ザ　プロボースト，フェローズ，ファンデーション　スカラーズ，アンド　ジ　アザー　メンバーズ　オブ　ボード，オブ　ザ　カレッジ　オブ　ザ　ホーリー　アンド　アンディバイデッド　トリニティ　オブ　クイーン　エリザベス　ニア　ダブリン Inventor コノン，スティーヴン
本発明は、式（Ｉ）：
TIFF 2023535621000022.tif 54 161
（式中、
Ｙは、Ｃ又はＮから選択され；
ＸはＯであり；
結合ａは、単結合又は二重結合であり；
ａが単結合の場合、ｘは１であり、ａが二重結合の場合、ｘは０であり；
Ｒ１は、水素及びメチルから選択され；
Ｒ２（存在する場合）は、水素及びメチルから選択され；
Ｒ３は、水素、（１－６Ｃ）アルキル及び（１－６Ｃ）アルキル－フェニルから選択され、
ここで、前記フェニルは、ヒドロキシ、（１－６Ｃ）アルコキシ、（１－６Ｃ）アルキル及びハロ（例えば、クロロ及びフルオロ）からそれぞれ独立して選択される１つ以上（例えば、１から３個）の置換基により任意選択的に置換される）
の化合物、又はその薬学的に許容され得る塩又は溶媒和物を提供する。
5.4188553COMPOUNDS
EP - 07.06.2023
Int.Class A61P 37/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
 Appl.No 21759028 Applicant PROVOST FELLOWS FOUND SCHOLARS & OTHER MEMBERS BOARD COLLEGE HOLY & UND Inventor CONNON STEPHEN
The present invention provides a compound of formula (I), or pharmaceutically acceptable salt or solvate thereof, wherein: Y is selected from C or N; X is O; bond a is a single or double bond; x is 1 when a is a single bond and x is 0 when a is a double bond; R1 is selected from hydrogen and methyl; R2 (when present) is selected from hydrogen and methyl; R3 is selected from hydrogen, (1-6C)alkyl and (1-6C)alkyl-phenyl, wherein said phenyl is optionally substituted by one or more (for example 1 to 3) substituents each independently selected from hydroxy, (1-6C)alkoxy, (1-6C)alkyl and halo (such as chloro and fluoro).
6.20230040247COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES
US - 09.02.2023
Int.Class A61K 31/7068
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
7064containing condensed or non-condensed pyrimidines
7068having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
 Appl.No 17641197 Applicant Amabiotics Inventor Nicole McKnight

The present invention relates to a compound of the following formula (I): or a pharmaceutically acceptable salt or hydrate thereof, for use in the prevention or treatment of a neurodegenerative disease selected from the group consisting of a-synucleinopathy, in particular Lewy body disease, Huntington's disease, frontotemporal neurocognitive disorder, and amyotrophic lateral sclerosis in an individual.

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7.2022062191TREATMENTS FOR AUTOIMMUNE DISEASE
JP - 19.04.2022
Int.Class A61P 37/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
06Immunosuppressants, e.g. drugs for graft rejection
 Appl.No 2022016315 Applicant PROVOST FELLOWS FOUNDATION SCHOLARS AND THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY AND UNDEVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN Inventor VINCENT KELLY

PROBLEM TO BE SOLVED: To provide a novel approach to treatment of autoimmune diseases, particularly multiple sclerosis.

SOLUTION: To provided a molecule capable of acting as substrate for a queuine-insertase enzyme complex for use in treatment of autoimmune diseases. The molecule is not a substrate for hypoxanthine- guanine phosphoribosyl transferase and the molecule has an effect of lowering interferon gamma. Preferably the autoimmune disease is multiple sclerosis.

SELECTED DRAWING: None

COPYRIGHT: (C)2022,JPO&INPIT

8.WO/2022/023433COMPOUNDS
WO - 03.02.2022
Int.Class A61P 37/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
 Appl.No PCT/EP2021/071185 Applicant THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN Inventor CONNON, Stephen
The present invention provides a compound of formula (I), or pharmaceutically acceptable salt or solvate thereof, wherein: Y is selected from C or N; X is O; bond a is a single or double bond; x is 1 when a is a single bond and x is 0 when a is a double bond; R1 is selected from hydrogen and methyl; R2 (when present) is selected from hydrogen and methyl; R3 is selected from hydrogen, (1-6C)alkyl and (1-6C)alkyl-phenyl, wherein said phenyl is optionally substituted by one or more (for example 1 to 3) substituents each independently selected from hydroxy, (1-6C)alkoxy, (1-6C)alkyl and halo (such as chloro and fluoro).
9.WO/2022/023438COMPOUNDS
WO - 03.02.2022
Int.Class C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
 Appl.No PCT/EP2021/071193 Applicant THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN Inventor SOUTHERN, John
The present invention provides a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein: Y is selected from C or N; X is selected from O or S; R1 is selected from hydrogen or methyl; Z is CR2R3, wherein R2 and R3 are each independently selected from hydrogen and (1-5C)alkyl, or R2 and R3 are taken together with the carbon atom to which they are attached to form a cyclopropyl or cyclobutyl ring; Z1 is selected from CR4R5, O, S, C(O) or NR6, wherein R4 and R5 are each independently selected from hydrogen, OH, (1-5C)alkyl and phenyl, or R4 and R5 are taken together with the carbon atom to which they are attached to form a cyclopropyl ring, and R6 is selected from hydrogen and (1-5C)alkyl, provided that one, but not both, of Z and Z1 is CH2.
10.WO/2021/048430COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES
WO - 18.03.2021
Int.Class A61K 31/519
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
 Appl.No PCT/EP2020/075581 Applicant AMABIOTICS Inventor MCKNIGHT, Nicole
The present invention relates to a compound of the following formula (I): or a pharmaceutically acceptable salt or hydrate thereof, for use in the prevention or treatment of a neurodegenerative disease selected from the group consisting of a-synucleinopathy, in particular Lewy body disease, Huntington's disease, frontotemporal neurocognitive disorder, and amyotrophic lateral sclerosis in an individual.
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