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Analysis

1 / 22
1.2024116290正確に改変した秘匿メッセンジャーＲＮＡ、及び、その他のポリヌクレオチド
JP - 27.08.2024
Int.Class C12N 15/62
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
62DNA sequences coding for fusion proteins
 Appl.No 2024093674 Applicant カーナル　バイオロジクス，　インコーポレイテッド Inventor ユスフ　アークル
【課題】ｍＲＮＡの自然免疫原性を抑制する方法を提供する。
【解決手段】本開示は、ポリヌクレオチド配列での免疫原性モチーフに正確な配列の改変により、長いポリヌクレオチド配列での免疫原性を抑制する方法に関する。さらに、本開示は、低度の自然免疫原性、改善した安定性、または、タンパク質の高発現をもたらす、改善した機能性を備えた、正確に配列を改変したポリヌクレオチドに関する。これらのポリヌクレオチドでは、免疫原性配列モチーフを除去しており、そして、残余の配列を保存している。全体的なヌクレオチドの変更と比較して、この標的を改変する手法は、天然または最適化したポリヌクレオチド配列の攪乱が少ないなどの独自の利点があり、それ故に、自然免疫受容体を秘匿する一方で、高い発現性を維持している。
【選択図】図１Ａ
2.1020240117650RNA 암 백신
KR - 01.08.2024
Int.Class A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
 Appl.No 1020247024776 Applicant 모더나티엑스, 인크. Inventor 밸리언트, 니콜라스
본 개시내용은 암 리보핵산(RNA) 백신뿐만 아니라 상기 백신을 이용하는 방법 및 상기 백신을 포함하는 조성물에 관한 것이다. 특히, 본 개시내용은 단일 mRNA 작제물 상에서 몇몇 암 에피토프를 암호화하는 연쇄동일서열 mRNA 암 백신, 즉, 폴리-에피토프 mRNA 작제물 또는 폴리-네오-에피토프 작제물에 관한 것이다. 본 개시내용은 추가로 p53 및 KRAS 돌연변이뿐만 아니라 면역 인핸서, 예컨대, STING, 예를 들어, 면역 자극제 또는 아쥬반트를 추가로 암호화하는 mRNA 작제물의 혼입에 관한 것이다. 본 개시내용은 추가로 향상된 면역 반응을 유발하기 위한 보편적 T 세포 에피토프, 예컨대 파상풍 또는 디프테리아 독소의 포함에 관한 것이다.
3.2024527344抗体応答を抗原に適合させるための抗体の利用
JP - 24.07.2024
Int.Class C12P 21/08
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
08Monoclonal antibodies
 Appl.No 2024500049 Applicant リジェネロン・ファーマシューティカルズ・インコーポレイテッド Inventor マーフィー，アンドリュー
本明細書に記載されるのは、抗原の１つ以上の第１のエピトープ（例えば、ワクチン抗原の免疫優性エピトープ）を標的とする１つ以上の抗体を投与することによって、対象における抗体応答を、その抗原の１つ以上の第１のエピトープを標的としないようにし、その抗原の１つ以上の第２のエピトープを標的とするようにする、方法及び組成物である。
【選択図】図１
4.20240238210POLYNUCLEOTIDES ENCODING CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR FOR THE TREATMENT OF CYSTIC FIBROSIS
US - 18.07.2024
Int.Class A61K 9/51
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
51Nanocapsules
 Appl.No 18471617 Applicant Moderna TX, Inc. Inventor Kerry Benenato

The invention relates to mRNA therapy for the treatment of cystic fibrosis. mRNAs for use in the invention, when administered in vivo, encode cystic fibrosis transmembrane conductance regulator (CFTR), isoforms thereof, functional fragments thereof, and fusion proteins comprising CFTR. mRNAs of the invention are preferably encapsulated in lipid nanoparticles (LNPs) to effect efficient delivery to cells and/or tissues in subjects, when administered thereto. mRNA therapies of the invention increase and/or restore deficient levels of CFTR expression and/or activity in subjects. mRNA therapies of the invention further decrease levels of toxic metabolites associated with deficient CFTR activity in subjects.

5.WO/2024/113009AGENTS, COMPOSITIONS AND METHODS FOR MODULATING IMMUNITY
WO - 06.06.2024
Int.Class A61K 38/44
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
44Oxidoreductases (1)
 Appl.No PCT/AU2023/051221 Applicant THE UNIVERSITY OF QUEENSLAND Inventor SWEET, Matt
Disclosed are agents, compositions and methods for treating, reducing or inhibiting, or slowing the progression of, unwanted or undesirable immune responses including pro-inflammatory responses. More particularly, the present disclosure relates to a therapeutic agent, therapeutic combinations and their use in compositions and methods for inhibiting or reducing pro-inflammatory activity of immune cells such as antigen-presenting cells (APC), wherein the therapeutic agent comprises D-ribulose-5-phosphate (RL5P), a RL5P analog, a RL5P analog-producing agent and/or a RL5P-producing agent, such as one selected from 6-phosphogluconate dehydrogenase (6PGD) and a nucleic acid molecule from which 6PGD is producible, and wherein the therapeutic combination comprises the therapeutic agent and an HDAC7-producing agent.
6.20240181011USE OF IFN-LAMBDA MRNA FOR TREATING VIRAL INFECTIONS
US - 06.06.2024
Int.Class A61K 38/21
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
21Interferons
 Appl.No 18035249 Applicant ethris GmbH Inventor Carsten Rudolph

The present invention relates to pharmaceutical compositions comprising an mRNA encoding an IFN-λ polypeptide for use in treating a viral-induced disorder, preferably a viral-induced respiratory disorder, such as COVID-19.

7.4379052MRNA PURIFICATION BY TANGENTIAL FLOW FILTRATION
EP - 05.06.2024
Int.Class C12N 15/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
 Appl.No 24165605 Applicant ETHRIS GMBH Inventor GEIGER JOHANNES
The present disclosure provides a method of purifying mRNA molecules comprising (Ia) purifying precipitated mRNA molecules from a suspension comprising precipitated mRNA molecules, (Ib) washing and dissolving the purified precipitated mRNA molecules, (IIa) purifying the mRNA molecules using a solution comprising a chelating agent, followed by (IIb) washing the purified mRNA molecules, wherein steps (Ia) to (IIb) are performed using tangential flow filtration.
8.20240173400HERPES SIMPLEX VIRUS VACCINE
US - 30.05.2024
Int.Class A61K 39/245
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
245Herpetoviridae, e.g. herpes simplex virus
 Appl.No 18481204 Applicant ModernaTX, Inc. Inventor Giuseppe Ciaramella

Provided herein are immunogenic compositions comprising mRNA encoding herpes simplex virus polypeptides, as well as methods of using the immunogenic compositions.

9.118076631Using antibodies to shape antibody responses to antigens
CN - 24.05.2024
Int.Class C07K 16/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
 Appl.No 202280058249.0 Applicant REGENERON PHARMACEUTICALS, INC. Inventor MURPHY ANDREW
Described herein are methods and compositions for directing an antibody in a subject to respond away from one or more first epitopes of an antigen (e.g., an immunodominant epitope of a vaccine antigen) and towards one or more second epitopes of the antigen by administering one or more antibodies targeting one or more first epitopes of the antigen.
10.20240156729FORMULATIONS FOR AEROSOL FORMATION AND AEROSOLS FOR THE DELIVERY OF NUCLEIC ACID
US - 16.05.2024
Int.Class A61K 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
 Appl.No 18277965 Applicant ethris GmbH Inventor Christian Dohmen

The invention relates to an aqueous suspension formulation for aerosol formation, said suspension formulation comprising lipid or lipidoid nanoparticles which are suspended in an aqueous vehicle solution,

wherein the lipid or lipidoid nanoparticles comprise the following components (a) and (b):

    • (a) a nucleic acid and
    • (b) an ionizable lipid or an ionizable lipidoid;
    • and wherein the aqueous vehicle solution comprises a triblock copolymer which contains one poly(propylene oxide) block and two poly(ethylene oxide) blocks. Moreover, the invention relates to an aerosol obtained from the formulation for aerosol formation.

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